Detailed information for compound 57428

Basic information

Technical information
  • TDR Targets ID: 57428
  • Name: 2-(1,4-diazepan-1-yl)-6-nitroquinoline
  • MW: 272.302 | Formula: C14H16N4O2
  • H donors: 1 H acceptors: 3 LogP: 2.18 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: [O-][N+](=O)c1ccc2c(c1)ccc(n2)N1CCNCCC1
  • InChi: 1S/C14H16N4O2/c19-18(20)12-3-4-13-11(10-12)2-5-14(16-13)17-8-1-6-15-7-9-17/h2-5,10,15H,1,6-9H2
  • InChiKey: DKLQZCAIKFJPKG-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 2-(1,4-diazepan-1-yl)-6-nitro-quinoline

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Rattus norvegicus Serotonin transporter Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma japonicum Sodium-dependent dopamine transporter, putative Get druggable targets OG5_128364 All targets in OG5_128364
Schistosoma japonicum IPR000175,Sodium:neurotransmitter symporter,domain-containing Get druggable targets OG5_128364 All targets in OG5_128364
Schistosoma japonicum Sodium-dependent dopamine transporter, putative Get druggable targets OG5_128364 All targets in OG5_128364
Loa Loa (eye worm) norepinephrine transporter Get druggable targets OG5_128364 All targets in OG5_128364
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128364 All targets in OG5_128364
Schistosoma japonicum Sodium-dependent noradrenaline transporter, putative Get druggable targets OG5_128364 All targets in OG5_128364
Schistosoma mansoni norepinephrine/norepinephrine transporter Get druggable targets OG5_128364 All targets in OG5_128364
Treponema pallidum sodium- and chloride- dependent transporter Get druggable targets OG5_128364 All targets in OG5_128364
Echinococcus multilocularis serotonin transporter Get druggable targets OG5_128364 All targets in OG5_128364
Schistosoma japonicum Sodium-dependent dopamine transporter, putative Get druggable targets OG5_128364 All targets in OG5_128364
Brugia malayi Sodium:neurotransmitter symporter family protein Get druggable targets OG5_128364 All targets in OG5_128364
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128364 All targets in OG5_128364
Loa Loa (eye worm) serotonin transporter b Get druggable targets OG5_128364 All targets in OG5_128364
Echinococcus granulosus serotonin transporter Get druggable targets OG5_128364 All targets in OG5_128364
Schistosoma mansoni sodium/chloride dependent transporter Get druggable targets OG5_128364 All targets in OG5_128364
Loa Loa (eye worm) solute carrier family 6 member 4 Get druggable targets OG5_128364 All targets in OG5_128364
Schistosoma japonicum Sodium-dependent dopamine transporter, putative Get druggable targets OG5_128364 All targets in OG5_128364
Schistosoma japonicum Sodium-dependent dopamine transporter, putative Get druggable targets OG5_128364 All targets in OG5_128364
Schistosoma japonicum ko:K05336 solute carrier family 6 (neurotransmitter transporter), invertebrate, putative Get druggable targets OG5_128364 All targets in OG5_128364
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128364 All targets in OG5_128364
Onchocerca volvulus Get druggable targets OG5_128364 All targets in OG5_128364
Schistosoma japonicum Sodium-dependent dopamine transporter, putative Get druggable targets OG5_128364 All targets in OG5_128364
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Schistosoma mansoni sodium/chloride dependent transporter Serotonin transporter   630 aa 552 aa 41.5 %
Drosophila melanogaster CG1698 gene product from transcript CG1698-RA Serotonin transporter   630 aa 585 aa 34.2 %
Echinococcus granulosus sodium and chloride dependent glycine Serotonin transporter   630 aa 617 aa 39.4 %
Schistosoma japonicum ko:K05046 solute carrier family 6 (neurotransmitter transporter, GABA), member, putative Serotonin transporter   630 aa 581 aa 40.1 %
Plasmodium vivax hypothetical protein, conserved Serotonin transporter   630 aa 528 aa 21.2 %
Drosophila melanogaster CG13796 gene product from transcript CG13796-RD Serotonin transporter   630 aa 638 aa 25.1 %
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein Serotonin transporter   630 aa 582 aa 35.2 %
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein Serotonin transporter   630 aa 576 aa 31.8 %
Toxoplasma gondii Sodium:neurotransmitter symporter family protein Serotonin transporter   630 aa 509 aa 28.3 %
Onchocerca volvulus Serotonin transporter   630 aa 611 aa 26.4 %
Brugia malayi Sodium:neurotransmitter symporter family protein Serotonin transporter   630 aa 576 aa 30.9 %
Echinococcus multilocularis sodium and chloride dependent glycine Serotonin transporter   630 aa 617 aa 39.4 %
Plasmodium knowlesi transporter, putative Serotonin transporter   630 aa 514 aa 20.2 %
Schistosoma japonicum ko:K05042 solute carrier family 6 (neurotransmitter transporter, glycine),, putative Serotonin transporter   630 aa 520 aa 36.2 %
Schistosoma mansoni sodium/chloride dependent transporter Serotonin transporter   630 aa 605 aa 37.7 %
Onchocerca volvulus High affinity copper uptake protein 1 homolog Serotonin transporter   630 aa 629 aa 47.1 %
Onchocerca volvulus Transmembrane protein 120 homolog Serotonin transporter   630 aa 571 aa 31.2 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus serotonin transporter 0.0073 0.0535 0.0535
Entamoeba histolytica protein kinase, putative 0.005 0.0317 1
Entamoeba histolytica PH domain containing protein kinase, putative 0.0033 0.0155 0.4899
Loa Loa (eye worm) hypothetical protein 0.0073 0.0535 0.0535
Giardia lamblia Kinase, AGC PKA 0.0033 0.0155 0.5
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.005 0.0317 0.0317
Trichomonas vaginalis AGC family protein kinase 0.005 0.0317 1
Onchocerca volvulus 0.106 1 1
Echinococcus granulosus nervana 2 0.0033 0.0152 0.0152
Trichomonas vaginalis AGC family protein kinase 0.005 0.0317 1
Echinococcus granulosus calcium:calmodulin dependent protein kinase 0.0033 0.0155 0.0155
Echinococcus multilocularis rac serine:threonine kinase 0.0033 0.0155 0.0155
Entamoeba histolytica protein kinase, putative 0.005 0.0317 1
Loa Loa (eye worm) norepinephrine transporter 0.0073 0.0535 0.0535
Trichomonas vaginalis AGC family protein kinase 0.005 0.0317 1
Plasmodium vivax rac-beta serine/threonine protein kinase, putative 0.0033 0.0155 0.5
Echinococcus multilocularis serotonin transporter 0.0073 0.0535 0.0535
Echinococcus multilocularis Glutaredoxin protein 5 0.0033 0.0152 0.0152
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0073 0.0535 0.0535
Echinococcus granulosus sodium:potassium dependent atpase beta subunit 0.0033 0.0152 0.0152
Trichomonas vaginalis AGC family protein kinase 0.005 0.0317 1
Schistosoma mansoni sodium-bile acid cotransporter 0.063 0.5878 0.5878
Entamoeba histolytica protein kinase 2, putative 0.0033 0.0155 0.4899
Echinococcus multilocularis nervana 2 0.0033 0.0152 0.0152
Loa Loa (eye worm) solute carrier family 6 member 4 0.0073 0.0535 0.0535
Schistosoma mansoni sodium-bile acid cotransporter related 0.043 0.3957 0.3957
Echinococcus multilocularis nervana 2 0.0033 0.0152 0.0152
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit 0.0033 0.0152 0.0152
Brugia malayi Protein kinase domain containing protein 0.005 0.0317 0.0317
Schistosoma mansoni sodium/chloride dependent transporter 0.0073 0.0535 0.0535
Trypanosoma cruzi Protein kinase B 0.0033 0.0155 0.5
Echinococcus granulosus sodium bile acid cotransporter 0.106 1 1
Toxoplasma gondii AGC kinase 0.005 0.0317 0.5
Echinococcus granulosus sodium bile acid cotransporter 0.106 1 1
Brugia malayi p70 ribosomal S6 kinase beta 0.005 0.0317 0.0317
Entamoeba histolytica protein kinase, putative 0.005 0.0317 1
Trichomonas vaginalis AGC family protein kinase 0.005 0.0317 1
Entamoeba histolytica PH domain containing protein kinase, putative 0.0033 0.0155 0.4899
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0033 0.0155 0.5
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0073 0.0535 0.0535
Echinococcus multilocularis serine threonine protein kinase nrc serine threonine protein kinase gad 0.0033 0.0155 0.0155
Loa Loa (eye worm) serotonin transporter b 0.0073 0.0535 0.0535
Loa Loa (eye worm) AGC/AKT protein kinase 0.005 0.0317 0.0317
Echinococcus granulosus serine/threonine protein kinase 0.0033 0.0155 0.0155
Echinococcus granulosus Glutaredoxin protein 5 0.0033 0.0152 0.0152
Trichomonas vaginalis AGC family protein kinase 0.005 0.0317 1
Schistosoma mansoni sodium-bile acid cotransporter related 0.106 1 1
Trypanosoma brucei rac serine-threonine kinase, putative 0.005 0.0317 0.5
Echinococcus granulosus serine threonine protein kinase nrc 0.0033 0.0155 0.0155
Echinococcus multilocularis sodium bile acid cotransporter 0.106 1 1
Loa Loa (eye worm) hypothetical protein 0.106 1 1
Echinococcus granulosus sodium bile acid cotransporter 0.106 1 1
Schistosoma mansoni serine/threonine-protein kinase 0.0033 0.0155 0.0155
Echinococcus multilocularis sodium bile acid cotransporter 0.106 1 1
Loa Loa (eye worm) hypothetical protein 0.0073 0.0535 0.0535
Schistosoma mansoni serine/threonine-protein kinase 0.0033 0.0155 0.0155
Echinococcus granulosus nervana 2 0.0033 0.0152 0.0152
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0033 0.0155 0.5
Trichomonas vaginalis AGC family protein kinase 0.005 0.0317 1
Loa Loa (eye worm) hypothetical protein 0.0073 0.0535 0.0535
Plasmodium falciparum RAC-beta serine/threonine protein kinase 0.0033 0.0155 0.5
Echinococcus multilocularis sodium bile acid cotransporter 0.106 1 1
Treponema pallidum sodium- and chloride- dependent transporter 0.0073 0.0535 0.5

Activities

Activity type Activity value Assay description Source Reference
Ki (binding) = 1.9 nM Inhibition of [3H]-citalopram binding to Serotonin transporter of rat cerebral cortex ChEMBL. 10915050
Ki (binding) = 1.9 nM Inhibition of [3H]-citalopram binding to Serotonin transporter of rat cerebral cortex ChEMBL. 10915050

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.