Detailed information for compound 576563

Basic information

Technical information
  • TDR Targets ID: 576563
  • Name: (2S,3R,4S,6S)-6-(aminomethyl)-2-methoxy-tetra hydropyran-3,4-diol
  • MW: 177.198 | Formula: C7H15NO4
  • H donors: 3 H acceptors: 2 LogP: -1.88 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: CO[C@H]1O[C@H](CN)C[C@@H]([C@H]1O)O
  • InChi: 1S/C7H15NO4/c1-11-7-6(10)5(9)2-4(3-8)12-7/h4-7,9-10H,2-3,8H2,1H3/t4-,5-,6+,7-/m0/s1
  • InChiKey: DVBYBXUVLOMEQG-YTLHQDLWSA-N  


Substructure search Similarity search

Network

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Synonyms

  • (2S,3R,4S,6S)-6-(aminomethyl)-2-methoxytetrahydropyran-3,4-diol
  • (2S,3R,4S,6S)-6-(aminomethyl)-2-methoxy-oxane-3,4-diol
  • (2S,3R,4S,6S)-6-(aminomethyl)-2-methoxyoxane-3,4-diol
  • methyl-6-amino-4,6-dideoxy alpha-D-glucopyranoside
  • 66274-55-3
  • alpha-D-Xylo-hexopyranoside, methyl 6-amino-4,6-dideoxy-

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Onchocerca volvulus 0.0014 0.0058 0.019
Trypanosoma cruzi PAB1-binding protein , putative 0.0081 0.0899 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0048 0.0486 0.2677
Brugia malayi Calcitonin receptor-like protein seb-1 0.0049 0.0495 0.1529
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.014 0.1635 0.1621
Entamoeba histolytica acetyltransferase, GNAT family 0.0038 0.0353 0.082
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0038 0.0353 0.3921
Schistosoma mansoni transcription factor LCR-F1 0.0109 0.124 0.3254
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0048 0.0486 0.2568
Trichomonas vaginalis bromodomain-containing protein, putative 0.0041 0.0396 0.0939
Loa Loa (eye worm) acetyltransferase 0.014 0.1635 0.4303
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0014 0.0058 0.0643
Trypanosoma cruzi PAB1-binding protein , putative 0.0081 0.0899 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0301 0.3658 1
Plasmodium falciparum ataxin-2 like protein, putative 0.0081 0.0899 1
Echinococcus multilocularis GPCR, family 2 0.0016 0.0075 0.0059
Trichomonas vaginalis ran, putative 0.0021 0.0149 0.0252
Brugia malayi hypothetical protein 0.0053 0.0538 0.1665
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0038 0.0353 0.3504
Trichomonas vaginalis glucosylceramidase, putative 0.018 0.2141 0.5787
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0016 0.0075 0.0155
Brugia malayi latrophilin 2 splice variant baaae 0.0034 0.0301 0.0908
Loa Loa (eye worm) hypothetical protein 0.0081 0.0899 0.2348
Loa Loa (eye worm) hypothetical protein 0.0029 0.0245 0.0608
Brugia malayi TAR-binding protein 0.0259 0.312 0.9904
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0041 0.0396 0.4017
Schistosoma mansoni tar DNA-binding protein 0.0259 0.312 0.8251
Schistosoma mansoni ran 0.0021 0.0149 0.0352
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0038 0.0353 0.1888
Toxoplasma gondii Erv1 / Alr family protein 0.0035 0.0323 0.3154
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0014 0.0058 0.0111
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0021 0.0149 0.1078
Schistosoma mansoni ap endonuclease 0.0038 0.0353 0.0895
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0014 0.0058 0.0146
Loa Loa (eye worm) hypothetical protein 0.0036 0.0333 0.0842
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0021 0.0149 0.1078
Trypanosoma brucei PAB1-binding protein , putative 0.0081 0.0899 1
Onchocerca volvulus Glucosylceramidase homolog 0.0171 0.2025 0.9145
Loa Loa (eye worm) hypothetical protein 0.0036 0.0333 0.0842
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0301 0.3658 1
Brugia malayi AMP-binding enzyme family protein 0.0014 0.0058 0.0133
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 4 0.0035 0.0323 0.3594
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0014 0.0058 0.0146
Echinococcus granulosus tar DNA binding protein 0.0259 0.312 0.8251
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0048 0.0486 0.2568
Loa Loa (eye worm) hypothetical protein 0.0036 0.0333 0.0842
Trichomonas vaginalis glucosylceramidase, putative 0.0261 0.315 0.8589
Plasmodium vivax acyl-CoA synthetase, putative 0.0036 0.0333 0.3268
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0048 0.0486 0.2677
Echinococcus multilocularis importin subunit beta 1 0.0029 0.0245 0.0229
Echinococcus granulosus GTP binding nuclear protein Ran 0.0021 0.0149 0.0352
Brugia malayi hypothetical protein 0.0109 0.124 0.3906
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0036 0.0333 0.1649
Echinococcus granulosus histone acetyltransferase KAT2B 0.0136 0.1585 0.4172
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0038 0.0353 0.0895
Onchocerca volvulus 0.0014 0.0058 0.019
Mycobacterium ulcerans acyl-CoA synthetase 0.0048 0.0486 0.2568
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.0075 0.0155
Loa Loa (eye worm) hypothetical protein 0.0048 0.0486 0.1249
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0186 0.2213 1
Trypanosoma cruzi ERV/ALR sulfhydryl oxidase domain-containing protein 0.0035 0.0323 0.3594
Leishmania major importin beta-1 subunit, putative 0.0024 0.0176 0.1956
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0014 0.0058 0.0643
Loa Loa (eye worm) hypothetical protein 0.0014 0.0058 0.0111
Plasmodium vivax importin-beta 2, putative 0.0029 0.0245 0.2224
Schistosoma mansoni acetyl-CoA synthetase 0.0014 0.0058 0.0111
Entamoeba histolytica hypothetical protein 0.0024 0.0176 0.0328
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0021 0.0149 0.0352
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0038 0.0353 0.3504
Loa Loa (eye worm) hypothetical protein 0.0036 0.0333 0.0842
Schistosoma mansoni tar DNA-binding protein 0.0259 0.312 0.8251
Entamoeba histolytica acyl-CoA synthetase, putative 0.0048 0.0486 0.119
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0036 0.0337 0.0321
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0049 0.0495 0.1274
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0014 0.0058 0.0146
Brugia malayi AMP-binding enzyme family protein 0.0014 0.0058 0.0133
Brugia malayi RNA recognition motif domain containing protein 0.0259 0.312 0.9904
Leishmania major 4-coumarate:coa ligase-like protein 0.0048 0.0486 0.5405
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0301 0.3658 1
Schistosoma mansoni ran 0.0021 0.0149 0.0352
Leishmania major hypothetical protein, conserved 0.0081 0.0899 1
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0014 0.0058 0.0146
Trichomonas vaginalis importin beta-1, putative 0.0024 0.0176 0.0328
Brugia malayi AMP-binding enzyme family protein 0.0014 0.0058 0.0133
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0016 0.0075 0.0155
Brugia malayi N-terminal motif family protein 0.0186 0.2213 0.7011
Onchocerca volvulus 0.0014 0.0058 0.019
Echinococcus multilocularis snurportin 1 0.0311 0.3778 0.3768
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0301 0.3658 1
Brugia malayi RNA binding protein 0.0259 0.312 0.9904
Brugia malayi hypothetical protein 0.0081 0.0899 0.2818
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0014 0.0058 0.0146
Schistosoma mansoni tar DNA-binding protein 0.0259 0.312 0.8251
Plasmodium falciparum histone acetyltransferase GCN5 0.0038 0.0353 0.3506
Mycobacterium ulcerans hypothetical protein 0.0048 0.0486 0.2568
Echinococcus granulosus histone acetyltransferase KAT2B 0.0041 0.0396 0.101
Trichomonas vaginalis ap endonuclease, putative 0.0038 0.0353 0.0819
Brugia malayi Augmenter of liver regeneration 0.0035 0.0323 0.098
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0014 0.0058 0.0643
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0041 0.0396 0.0939
Loa Loa (eye worm) hypothetical protein 0.0048 0.0486 0.1249
Loa Loa (eye worm) hypothetical protein 0.0048 0.0486 0.1249
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0014 0.0058 0.0146
Leishmania major GTP-binding protein, putative 0.0021 0.0149 0.1652
Brugia malayi AMP-binding enzyme family protein 0.0014 0.0058 0.0133
Trichomonas vaginalis glucosylceramidase, putative 0.0171 0.2025 0.5466
Toxoplasma gondii exonuclease III APE 0.0038 0.0353 0.3504
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0014 0.0058 0.0146
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0014 0.0058 0.0111
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0041 0.0396 0.4017
Brugia malayi AMP-binding enzyme family protein 0.0048 0.0486 0.15
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0014 0.0058 0.0133
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 4 0.0035 0.0323 0.3594
Schistosoma mansoni hypothetical protein 0.0034 0.0301 0.0756
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0036 0.0333 0.1771
Trichomonas vaginalis glucosylceramidase, putative 0.0261 0.315 0.8589
Loa Loa (eye worm) hypothetical protein 0.0186 0.2213 0.5842
Leishmania major hypothetical protein, conserved 0.0035 0.0323 0.3594
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.014 0.1635 0.4303
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0301 0.3658 1
Brugia malayi AMP-binding enzyme family protein 0.0048 0.0486 0.15
Echinococcus granulosus snurportin 1 0.0311 0.3778 1
Toxoplasma gondii HEAT repeat-containing protein 0.0029 0.0245 0.2224
Schistosoma mansoni hypothetical protein 0.0016 0.0075 0.0155
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0176 0.0328
Trichomonas vaginalis ap endonuclease, putative 0.0038 0.0353 0.0819
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0036 0.0333 0.5
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0034 0.0308 0.1625
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0049 0.0495 0.1529
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0109 0.124 0.3254
Schistosoma mansoni hypothetical protein 0.0036 0.0337 0.0853
Brugia malayi Importin beta-1 subunit 0.0029 0.0245 0.073
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0147 0.1725 1
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0038 0.0353 0.0895
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0021 0.0149 0.1078
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0014 0.0058 0.0146
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0041 0.0396 0.4017
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0245 0.2224
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0301 0.3658 1
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0021 0.0149 0.0423
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0014 0.0058 0.0146
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0034 0.0308 0.1625
Schistosoma mansoni tar DNA-binding protein 0.0259 0.312 0.8251
Echinococcus granulosus GPCR family 2 0.0016 0.0075 0.0155
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0014 0.0058 0.0643
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0147 0.1725 1
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0014 0.0058 0.0146
Schistosoma mansoni hypothetical protein 0.0109 0.124 0.3254
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0048 0.0486 0.2568
Leishmania major acetyl-CoA synthetase, putative 0.0014 0.0058 0.0643
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0038 0.0353 0.3921
Leishmania major acetyl-CoA synthetase, putative 0.0014 0.0058 0.0643
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0038 0.0353 0.5
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0038 0.0353 0.3921
Entamoeba histolytica hypothetical protein 0.0109 0.124 0.3284
Trichomonas vaginalis glucosylceramidase, putative 0.0171 0.2025 0.5466
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0038 0.0353 0.0819
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0301 0.3658 1
Trichomonas vaginalis glucosylceramidase, putative 0.0261 0.315 0.8589
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0259 0.312 0.8251
Loa Loa (eye worm) hepatopoietin HPO2 0.0035 0.0323 0.0817
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0149 0.1652
Schistosoma mansoni hypothetical protein 0.0311 0.3778 1
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0261 0.315 0.8331
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0038 0.0353 0.0582
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0034 0.0308 0.1625
Giardia lamblia Histone acetyltransferase GCN5 0.0038 0.0353 0.0582
Onchocerca volvulus 0.0048 0.0486 0.2139
Trichomonas vaginalis glucosylceramidase, putative 0.018 0.2141 0.5787
Leishmania major 4-coumarate:coa ligase-like protein 0.0048 0.0486 0.5405
Trichomonas vaginalis glucosylceramidase, putative 0.0171 0.2025 0.5466
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0301 0.3658 1
Trichomonas vaginalis glucosylceramidase, putative 0.0171 0.2025 0.5466
Entamoeba histolytica acyl-CoA synthetase, putative 0.0048 0.0486 0.119
Toxoplasma gondii LsmAD domain-containing protein 0.0081 0.0899 1
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0048 0.0486 0.2568
Entamoeba histolytica Ran family GTPase 0.0021 0.0149 0.0252
Entamoeba histolytica acyl-coA synthetase, putative 0.0048 0.0486 0.119
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0261 0.315 1
Schistosoma mansoni ap endonuclease 0.0038 0.0353 0.0895
Loa Loa (eye worm) hypothetical protein 0.0036 0.0333 0.0842
Leishmania major 4-coumarate:coa ligase-like protein 0.0048 0.0486 0.5405
Trichomonas vaginalis glucosylceramidase, putative 0.0261 0.315 0.8589
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0016 0.0075 0.0059
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0301 0.3658 1
Toxoplasma gondii Erv1 / Alr family protein 0.0035 0.0323 0.3154
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0014 0.0058 0.0643
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0014 0.0058 0.0111
Plasmodium vivax FAD-linked sulfhydryl oxidase ERV1, putative 0.0035 0.0323 0.3154
Loa Loa (eye worm) hypothetical protein 0.0016 0.0075 0.0155
Brugia malayi RNA, U transporter 1 0.0083 0.0918 0.2878
Plasmodium vivax ataxin-2 like protein, putative 0.0081 0.0899 1
Trypanosoma brucei ERV/ALR sulfhydryl oxidase domain-containing protein 0.0035 0.0323 0.3154
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0301 0.3658 1
Echinococcus granulosus importin subunit beta 1 0.0029 0.0245 0.0608
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0038 0.0353 0.1768
Plasmodium falciparum FAD-linked sulfhydryl oxidase ERV1, putative 0.0035 0.0323 0.3154
Schistosoma mansoni tar DNA-binding protein 0.0259 0.312 0.8251
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.0075 0.0186
Mycobacterium ulcerans acyl-CoA synthetase 0.0048 0.0486 0.2568
Loa Loa (eye worm) hypothetical protein 0.0014 0.0058 0.0111
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0014 0.0058 0.0133
Loa Loa (eye worm) hypothetical protein 0.0049 0.0495 0.1274
Loa Loa (eye worm) hypothetical protein 0.0034 0.0301 0.0756
Treponema pallidum fructose-bisphosphate aldolase 0.0301 0.3658 1
Brugia malayi acetyltransferase, GNAT family protein 0.014 0.1635 0.5164
Brugia malayi AMP-binding enzyme family protein 0.0048 0.0486 0.15
Plasmodium falciparum importin beta, putative 0.0029 0.0245 0.2224
Trichomonas vaginalis glucosylceramidase, putative 0.0261 0.315 0.8589
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0021 0.0149 0.0133
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0245 0.2224
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0176 0.0328
Entamoeba histolytica hypothetical protein 0.0109 0.124 0.3284
Trichomonas vaginalis glucosylceramidase, putative 0.0171 0.2025 0.5466
Entamoeba histolytica hypothetical protein 0.0109 0.124 0.3284
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0149 0.1652
Schistosoma mansoni hypothetical protein 0.0016 0.0075 0.0155
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0048 0.0486 0.2568
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0109 0.124 0.1226
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0016 0.0075 0.0059
Schistosoma mansoni hypothetical protein 0.0016 0.0075 0.0155
Brugia malayi exodeoxyribonuclease III family protein 0.0038 0.0353 0.1074
Echinococcus multilocularis FAD linked sulfhydryl oxidase ALR 0.0035 0.0323 0.0308
Echinococcus multilocularis tar DNA binding protein 0.0259 0.312 0.3109
Entamoeba histolytica hypothetical protein 0.0109 0.124 0.3284
Loa Loa (eye worm) oxidoreductase 0.0014 0.0058 0.0111
Giardia lamblia Fructose-bisphosphate aldolase 0.0301 0.3658 1
Brugia malayi Latrophilin receptor protein 2 0.0016 0.0075 0.0186
Plasmodium falciparum acyl-CoA synthetase 0.0036 0.0333 0.3268
Onchocerca volvulus 0.0014 0.0058 0.019
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0036 0.0337 0.0853
Trichomonas vaginalis glucosylceramidase, putative 0.0171 0.2025 0.5466
Schistosoma mansoni hypothetical protein 0.0016 0.0075 0.0155
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0038 0.0353 0.3504
Echinococcus granulosus FAD linked sulfhydryl oxidase ALR 0.0035 0.0323 0.0817
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0038 0.0353 0.0337
Mycobacterium ulcerans acyl-CoA synthetase 0.0048 0.0486 0.2568
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0021 0.0149 0.1078
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0034 0.0308 0.1625
Trypanosoma cruzi importin beta-1 subunit, putative 0.0024 0.0176 0.1956
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0048 0.0486 0.2568
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0147 0.1725 1
Trichomonas vaginalis glucosylceramidase, putative 0.0261 0.315 0.8589
Trichomonas vaginalis glucosylceramidase, putative 0.0171 0.2025 0.5466
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0311 0.3778 1
Loa Loa (eye worm) RNA binding protein 0.0259 0.312 0.8251
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0014 0.0058 0.0146
Schistosoma mansoni importin beta-1 0.0029 0.0245 0.0608
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0014 0.0058 0.0042
Loa Loa (eye worm) TAR-binding protein 0.0259 0.312 0.8251
Plasmodium falciparum ataxin-2 like protein, putative 0.0081 0.0899 1

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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