Detailed information for compound 583407

Basic information

Technical information
  • TDR Targets ID: 583407
  • Name: 2-amino-9-[3,4-dihydroxy-5-(hydroxymethyl)tet rahydrofuran-2-yl]purine-6-selenolate; platin um(2+)
  • MW: 887.481 | Formula: C20H26N10O8PtSe2
  • H donors: 8 H acceptors: 12 LogP: -4.03 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 4
  • SMILES: OCC1OC(C(C1O)O)n1cnc2c1nc(N)nc2[SeH-].OCC1OC(C(C1O)O)n1cnc2c1nc(N)nc2[SeH-].[Pt+2]
  • InChi: 1S/2C10H13N5O4Se.Pt/c2*11-10-13-7-4(8(20)14-10)12-2-15(7)9-6(18)5(17)3(1-16)19-9;/h2*2-3,5-6,9,16-18H,1H2,(H3,11,13,14,20);/q;;+2/p-2
  • InChiKey: MHMICAZQRNCLDV-UHFFFAOYSA-L  


Substructure search Similarity search

Network

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Synonyms

  • 2-amino-9-[3,4-dihydroxy-5-(hydroxymethyl)-2-tetrahydrofuranyl]-6-purineselenolate; platinum(2+)
  • 2-azanyl-9-[3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]purine-6-selenolate; platinum(2+)
  • 2-amino-9-(3,4-dihydroxy-5-methylol-tetrahydrofuran-2-yl)purine-6-selenolate; platinum(2+)
  • 2-amino-9-[3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]purine-6-selenolate; platinum(2+)
  • selenoguanosine platinum(II)
  • 2-amino-9-[3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]purine-6-selenolate; platinum(+2) cation
  • 2-amino-9-[3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]purine-6-selenolate; platinum(+2) cation
  • 2-amino-9-[3,4-dihydroxy-5-(hydroxymethyl)-2-tetrahydrofuranyl]-6-purineselenolate; platinum(+2) cation
  • 2-amino-9-(3,4-dihydroxy-5-methylol-tetrahydrofuran-2-yl)purine-6-selenolate; platinum(+2) cation
  • 79084-82-5
  • Platinum selenoguanosine
  • Platinum, bis(6-selenoguanosinato-N7,Se6)-, (SP-4-1)-
  • Selenoguanosine Pt(II)

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0049 0.2057 0.2006
Plasmodium vivax cyclin dependent kinase 7 (cdk7), putative 0.0116 0.5605 0.5961
Trypanosoma brucei pyruvate kinase 1 0.0034 0.1257 0.0978
Schistosoma mansoni hypothetical protein 0.0167 0.83 1
Trypanosoma cruzi fatty acid desaturase, putative 0.0183 0.9146 0.9119
Echinococcus multilocularis pyruvate kinase 0.0017 0.038 0.0127
Leishmania major pyruvate kinase 0.0034 0.1257 0.0978
Leishmania major fatty-acid desaturase, putative 0.0199 1 1
Plasmodium vivax stearoyl-CoA desaturase (acyl-CoA desaturase, faty acid desaturase), putative 0.0183 0.9146 1
Schistosoma mansoni pyruvate kinase 0.0034 0.1257 0.122
Onchocerca volvulus 0.0199 1 1
Echinococcus granulosus pyruvate kinase 0.0017 0.038 0.0127
Echinococcus multilocularis pyruvate kinase 0.0034 0.1257 0.122
Trypanosoma brucei fatty acid desaturase, putative 0.0199 1 1
Echinococcus multilocularis Peptidase M, neutral zinc metallopeptidases, zinc binding site 0.0016 0.0308 0.0038
Trypanosoma brucei pyruvate kinase 1, putative 0.0034 0.1257 0.0978
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.2624 1
Brugia malayi Calcitonin receptor-like protein seb-1 0.0049 0.2057 0.2249
Brugia malayi Latrophilin receptor protein 2 0.0016 0.0278 0.0304
Toxoplasma gondii pyruvate kinase PyK1 0.0034 0.1257 0.1938
Entamoeba histolytica pyruvate kinase, putative 0.0024 0.0711 0.5
Plasmodium falciparum pyruvate kinase 0.0034 0.1257 0.1
Trichomonas vaginalis pyruvate kinase, putative 0.0034 0.1257 0.5
Brugia malayi Fatty acid desaturase family protein 0.0016 0.0308 0.0337
Trichomonas vaginalis pyruvate kinase, putative 0.0034 0.1257 0.5
Schistosoma mansoni fatty acid desaturase 0.0016 0.0308 0.0038
Onchocerca volvulus 0.0199 1 1
Echinococcus multilocularis pyruvate kinase 0.0034 0.1257 0.122
Brugia malayi Delta5 fatty acid desaturase 0.0016 0.0308 0.0337
Toxoplasma gondii cell-cycle-associated protein kinase, putative 0.0108 0.52 1
Echinococcus granulosus Sphingolipid delta4 desaturase DES1 0.0016 0.0308 0.0038
Trypanosoma cruzi fatty acid desaturase, putative 0.0183 0.9146 0.9119
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.006 0.2624 0.2925
Loa Loa (eye worm) pyruvate kinase 0.0034 0.1257 0.1103
Echinococcus multilocularis Fatty acid desaturase, type 1 0.0016 0.0308 0.0038
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0034 0.1257 0.4094
Loa Loa (eye worm) fatty acid desaturase 0.0016 0.0308 0.0034
Echinococcus multilocularis pyruvate kinase 0.0017 0.038 0.0127
Toxoplasma gondii aldehyde dehydrogenase 0.006 0.2624 0.4734
Schistosoma mansoni pyruvate kinase 0.0034 0.1257 0.122
Echinococcus multilocularis pyruvate kinase 0.0017 0.038 0.0127
Mycobacterium ulcerans pyruvate kinase 0.0034 0.1257 0.4094
Loa Loa (eye worm) pyruvate kinase 0.0034 0.1257 0.1103
Brugia malayi Fatty acid desaturase family protein 0.0016 0.0308 0.0337
Plasmodium vivax pyruvate kinase, putative 0.0034 0.1257 0.1
Schistosoma mansoni aldehyde dehydrogenase 0.006 0.2624 0.2925
Brugia malayi acyl-CoA desaturase 0.0183 0.9146 1
Brugia malayi Pyruvate kinase, M2 isozyme 0.0034 0.1257 0.1374
Plasmodium falciparum MO15-related protein kinase 0.0116 0.5605 0.5961
Trypanosoma cruzi pyruvate kinase 2, putative 0.0034 0.1257 0.0978
Mycobacterium leprae Probable pyruvate kinase PykA 0.0034 0.1257 0.5
Leishmania major pyruvate kinase 0.0034 0.1257 0.0978
Echinococcus granulosus pyruvate kinase 0.0034 0.1257 0.122
Echinococcus granulosus geminin 0.0167 0.83 1
Trypanosoma cruzi pyruvate kinase 2, putative 0.0034 0.1257 0.0978
Loa Loa (eye worm) acyl-CoA desaturase 0.0183 0.9146 1
Echinococcus multilocularis Peptidase M, neutral zinc metallopeptidases, zinc binding site 0.0016 0.0308 0.0038
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.2624 1
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.006 0.2624 0.239
Echinococcus granulosus pyruvate kinase 0.0017 0.038 0.0127
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.2624 1
Loa Loa (eye worm) pyruvate kinase 0.0034 0.1257 0.1103
Onchocerca volvulus Pyruvate kinase homolog 0.0034 0.1257 0.0978
Echinococcus multilocularis pyruvate kinase 0.0027 0.0877 0.0747
Brugia malayi Pyruvate kinase, muscle isozyme 0.0034 0.1257 0.1374
Loa Loa (eye worm) hypothetical protein 0.0016 0.0308 0.0034
Trypanosoma cruzi fatty acid desaturase, putative 0.0199 1 1
Giardia lamblia Pyruvate kinase 0.0034 0.1257 1
Brugia malayi latrophilin 2 splice variant baaae 0.0034 0.1234 0.1349
Loa Loa (eye worm) hypothetical protein 0.0034 0.1234 0.1077
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.006 0.2624 0.2925
Onchocerca volvulus Pyruvate kinase homolog 0.0034 0.1257 0.0978
Schistosoma mansoni aldehyde dehydrogenase 0.006 0.2624 0.2925
Plasmodium falciparum stearoyl-CoA desaturase 0.0183 0.9146 1
Loa Loa (eye worm) hypothetical protein 0.0024 0.0711 0.0489
Echinococcus granulosus pyruvate kinase 0.0034 0.1257 0.122
Schistosoma mansoni pyruvate kinase 0.0017 0.038 0.0127
Schistosoma mansoni hypothetical protein 0.0034 0.1234 0.1191
Toxoplasma gondii pyruvate kinase PyKII 0.0017 0.038 0.0146
Loa Loa (eye worm) hypothetical protein 0.0034 0.1257 0.1103
Echinococcus granulosus Fatty acid desaturase type 1 0.0016 0.0308 0.0038
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0049 0.2057 0.2006
Chlamydia trachomatis pyruvate kinase 0.0034 0.1257 0.5
Onchocerca volvulus Pyruvate kinase homolog 0.0034 0.1257 0.0978
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.0278 0.0304
Loa Loa (eye worm) FAT-3 protein 0.0016 0.0308 0.0034
Schistosoma mansoni hypothetical protein 0.0167 0.83 1
Loa Loa (eye worm) fatty acid desaturase 0.0016 0.0308 0.0034
Echinococcus multilocularis geminin 0.0167 0.83 1
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.006 0.2624 1
Loa Loa (eye worm) pyruvate kinase-PB 0.0024 0.0711 0.0489
Echinococcus granulosus pyruvate kinase 0.0017 0.038 0.0127
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0049 0.2057 0.2249

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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