Detailed information for compound 583513

Basic information

Technical information
  • TDR Targets ID: 583513
  • Name: 2,9-dibromobenzo[a]phenalen-7-one
  • MW: 388.053 | Formula: C17H8Br2O
  • H donors: 0 H acceptors: 1 LogP: 5.69 Rotable bonds: 0
    Rule of 5 violations (Lipinski): 1
  • SMILES: Brc1ccc2c(c1)C(=O)c1c3c2cc(Br)cc3ccc1
  • InChi: 1S/C17H8Br2O/c18-10-4-5-12-14-8-11(19)6-9-2-1-3-13(16(9)14)17(20)15(12)7-10/h1-8H
  • InChiKey: UEGNJEQZORJLBN-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2,9-dibromo-7-benzo[a]phenalenone
  • 2,9-dibromobenzanthrone
  • 79381-26-3
  • 7H-Benz(de)anthracen-7-one, 2,9-dibromo-

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni gabp alpha 0.0072 0.03 0.03
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0037 0.0039 0.5
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0037 0.0039 0.5
Loa Loa (eye worm) hypothetical protein 0.0034 0.0021 0.0078
Brugia malayi Ets-domain containing protein 0.0072 0.03 0.1131
Brugia malayi Calcitonin receptor-like protein seb-1 0.0099 0.0505 0.1903
Trypanosoma cruzi fatty acid desaturase, putative 0.0388 0.2656 0.9119
Loa Loa (eye worm) acyl-CoA desaturase 0.0388 0.2656 1
Echinococcus multilocularis Peptidase M, neutral zinc metallopeptidases, zinc binding site 0.0034 0.0021 0.0021
Schistosoma mansoni hypothetical protein 0.0068 0.0271 0.0271
Leishmania major stearic acid desaturase, putative 0.0422 0.291 1
Trypanosoma cruzi fatty acid desaturase, putative 0.0388 0.2656 0.9119
Schistosoma mansoni fatty acid desaturase 0.0034 0.0021 0.0021
Mycobacterium tuberculosis Possible electron transfer protein FdxB 0.0034 0.0021 1
Brugia malayi Delta5 fatty acid desaturase 0.0034 0.0021 0.0078
Brugia malayi Inositol-1 0.0037 0.0039 0.0145
Mycobacterium tuberculosis Probable conserved membrane protein 0.0034 0.0021 1
Echinococcus multilocularis Fatty acid desaturase, type 1 0.0034 0.0021 0.0021
Plasmodium vivax stearoyl-CoA desaturase (acyl-CoA desaturase, faty acid desaturase), putative 0.0388 0.2656 0.5
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0099 0.0505 0.1903
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0037 0.0039 0.5
Loa Loa (eye worm) fatty acid desaturase 0.0034 0.0021 0.0078
Brugia malayi Fli-1 protein 0.0218 0.1388 0.5227
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0037 0.0039 1
Mycobacterium tuberculosis Probable transmembrane alkane 1-monooxygenase AlkB (alkane 1-hydroxylase) (lauric acid omega-hydroxylase) (omega-hydroxylase) (f 0.0034 0.0021 1
Loa Loa (eye worm) hypothetical protein 0.0049 0.0135 0.0507
Schistosoma mansoni microtubule-associated protein tau 0.1374 1 1
Brugia malayi Fatty acid desaturase family protein 0.0034 0.0021 0.0078
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0039 0.0062
Schistosoma mansoni cellular tumor antigen P53 0.0049 0.0135 0.0135
Echinococcus multilocularis inositol monophosphatase 1 0.0037 0.0039 0.0039
Loa Loa (eye worm) transcription factor SMAD2 0.0119 0.0656 0.2469
Loa Loa (eye worm) MH2 domain-containing protein 0.0119 0.0656 0.2469
Echinococcus granulosus GA binding protein alpha chain 0.0072 0.03 0.03
Brugia malayi MH2 domain containing protein 0.0119 0.0656 0.2469
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0033 0.001 0.5
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0039 0.0062
Schistosoma mansoni inositol monophosphatase 0.0037 0.0039 0.0039
Brugia malayi acyl-CoA desaturase 0.0388 0.2656 1
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0072 0.03 0.1131
Schistosoma mansoni ets-related 0.0218 0.1388 0.1388
Loa Loa (eye worm) inositol-1 0.0037 0.0039 0.0145
Loa Loa (eye worm) fli-1 protein 0.0218 0.1388 0.5227
Leishmania major fatty-acid desaturase, putative 0.0422 0.291 1
Loa Loa (eye worm) hypothetical protein 0.0099 0.0505 0.1903
Echinococcus granulosus inositol monophosphatase 1 0.0037 0.0039 0.0039
Brugia malayi latrophilin 2 splice variant baaae 0.0068 0.0271 0.1022
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0037 0.0039 1
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0037 0.0039 0.5
Echinococcus granulosus Fatty acid desaturase type 1 0.0034 0.0021 0.0021
Echinococcus multilocularis microtubule associated protein 2 0.1374 1 1
Trypanosoma cruzi fatty acid desaturase, putative 0.0422 0.291 1
Trichomonas vaginalis inositol monophosphatase, putative 0.0037 0.0039 0.5
Onchocerca volvulus 0.0422 0.291 1
Loa Loa (eye worm) FAT-3 protein 0.0034 0.0021 0.0078
Brugia malayi Fatty acid desaturase family protein 0.0034 0.0021 0.0078
Plasmodium falciparum stearoyl-CoA desaturase 0.0388 0.2656 0.5
Echinococcus granulosus tumor protein p63 0.0338 0.2284 0.2284
Schistosoma mansoni inositol monophosphatase 0.0037 0.0039 0.0039
Echinococcus multilocularis tumor protein p63 0.0338 0.2284 0.2284
Echinococcus multilocularis GA binding protein alpha chain 0.0072 0.03 0.03
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0039 0.0062
Loa Loa (eye worm) hypothetical protein 0.0061 0.0223 0.0839
Trypanosoma brucei fatty acid desaturase, putative 0.0422 0.291 1
Echinococcus granulosus Sphingolipid delta4 desaturase DES1 0.0034 0.0021 0.0021
Onchocerca volvulus 0.0049 0.0135 0.0395
Loa Loa (eye worm) fatty acid desaturase 0.0034 0.0021 0.0078
Echinococcus multilocularis Peptidase M, neutral zinc metallopeptidases, zinc binding site 0.0034 0.0021 0.0021
Brugia malayi Ets-domain containing protein 0.0072 0.03 0.1131
Loa Loa (eye worm) hypothetical protein 0.0068 0.0271 0.1022
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0099 0.0505 0.1903
Onchocerca volvulus 0.0422 0.291 1
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0039 0.0062

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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