Detailed information for compound 583759

Basic information

Technical information
  • TDR Targets ID: 583759
  • Name: tetramethylenedisulfotetramine
  • MW: 240.261 | Formula: C4H8N4O4S2
  • H donors: 0 H acceptors: 4 LogP: -1.67 Rotable bonds: 0
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=S1(=O)N2CN3CN1CN(C2)S3(=O)=O
  • InChi: 1S/C4H8N4O4S2/c9-13(10)5-1-6-3-8(13)4-7(2-5)14(6,11)12/h1-4H2
  • InChiKey: AGGKEGLBGGJEBZ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 80-12-6
  • 2,4-Dithia-1,3,5,7-tetraazaadamantane, 2,2,4,4-tetraoxide (8CI)
  • 2,6-Dithia-1,3,5,7-tetraazaadamantane, 2,2,6,6-tetraoxide
  • 2,6-Dithia-1,3,5,7-tetraazatricyclo(3.3.1.13,7)decane, 2,2,6,6-tetraoxide (9CI)
  • 2,6-Dithia-1,3,5,7-tetrazatricyclo(3.3.1.1(sup 3,7))decane-2,2,6,6-tetraoxide
  • 4-27-00-09647 (Beilstein Handbook Reference)
  • BRN 0257816
  • NSC 172824
  • TETS
  • Tetramethylenedisulphotetramine
  • Tetramine (adamantane derivative)
  • 2,4-Dithia-1,3,5,7-tetraazaadamantane, 2,2,4,4-tetraoxide
  • 2,6-Dithia-1,3,5,7-tetraazatricyclo[3.3.1.13,7]decane, 2,2,6,6-tetraoxide
  • 2,6-Dithia-1,3,5,7-tetrazatricyclo[3.3.1.1(sup 3,7)]decane-2,2,6,6-tetroxide
  • NSC172824
  • WLN: T66 B6 A B- C 1B I ASWN DNSWN HNTJ

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0058 0.0183 0.8824
Leishmania major cathepsin L-like protease 0.0063 0.0205 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0205 1
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0017 0.0017 0.006
Brugia malayi Cathepsin L-like precursor 0.0017 0.0017 0.0219
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0203 0.0631
Loa Loa (eye worm) ctsf protein 0.0017 0.0017 0.006
Trichomonas vaginalis conserved hypothetical protein 0.0088 0.0303 1
Schistosoma mansoni hypothetical protein 0.0165 0.0611 0.2015
Schistosoma mansoni hypothetical protein 0.0033 0.0083 0.0223
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0017 0.0017 0.2761
Onchocerca volvulus 0.0017 0.0017 0.1147
Mycobacterium ulcerans hypothetical protein 0.0711 0.2804 1
Schistosoma mansoni hypothetical protein 0.0085 0.029 0.0928
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0017 0.0017 0.006
Trichomonas vaginalis bmru protein, putative 0.0028 0.0061 0.155
Trichomonas vaginalis diacylglycerol kinase, zeta, iota, putative 0.0028 0.0061 0.155
Echinococcus multilocularis acylglycerol kinase, mitochondrial 0.0028 0.0061 0.0044
Echinococcus granulosus tar DNA binding protein 0.0063 0.0203 0.0631
Trypanosoma cruzi diacylglycerol kinase, putative 0.0028 0.0061 0.2363
Loa Loa (eye worm) ceramide kinase 0.0028 0.0061 0.0219
Brugia malayi MH2 domain containing protein 0.012 0.0432 0.5592
Loa Loa (eye worm) hypothetical protein 0.0049 0.0147 0.0526
Schistosoma mansoni hypothetical protein 0.0028 0.0061 0.0151
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0017 0.0017 0.2761
Leishmania major sphingosine kinase A, B, putative 0.0028 0.0061 0.2363
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0063 0.0203 0.0723
Echinococcus multilocularis tumor protein p63 0.0336 0.1298 0.1284
Schistosoma mansoni hypothetical protein 0.0033 0.0083 0.0223
Onchocerca volvulus Cathepsin L homolog 0.0017 0.0017 0.1147
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0205 1
Echinococcus multilocularis tar DNA binding protein 0.0063 0.0203 0.0186
Schistosoma mansoni proteasome subunit alpha 6 (T01 family) 0.0028 0.0061 0.0151
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0033 0.0083 0.107
Schistosoma mansoni hypothetical protein 0.0085 0.029 0.0928
Onchocerca volvulus 0.0017 0.0017 0.1147
Loa Loa (eye worm) hypothetical protein 0.0028 0.0061 0.0219
Leishmania major diacylglycerol kinase, putative 0.0028 0.0061 0.2363
Echinococcus granulosus microtubule associated protein 2 0.0751 0.2963 1
Toxoplasma gondii diacylglycerol kinase, putative 0.0028 0.0061 1
Entamoeba histolytica diacylglycerol kinase, putative 0.0028 0.0061 0.0159
Trichomonas vaginalis diacylglycerol kinase, putative 0.0028 0.0061 0.155
Loa Loa (eye worm) hypothetical protein 0.0017 0.0017 0.006
Schistosoma mansoni hypothetical protein 0.0033 0.0083 0.0223
Trichomonas vaginalis sphingosine kinase, putative 0.0028 0.0061 0.155
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0205 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0205 1
Entamoeba histolytica hypothetical protein, conserved 0.0711 0.2804 1
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0205 0.0773 0.2712
Loa Loa (eye worm) hypothetical protein 0.0108 0.0383 0.1364
Brugia malayi Papain family cysteine protease containing protein 0.0017 0.0017 0.0219
Schistosoma mansoni hypothetical protein 0.0085 0.029 0.0928
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0104 0.0369 0.4775
Echinococcus multilocularis protein dispatched 1 0.01 0.0353 0.0337
Schistosoma mansoni diacylglycerol kinase theta 0.0028 0.0061 0.0151
Echinococcus granulosus geminin 0.0165 0.0611 0.2015
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0033 0.0083 0.0223
Plasmodium vivax diacylglycerol kinase, putative 0.0028 0.0061 1
Brugia malayi diacylglycerol kinase 0.0028 0.0061 0.0793
Schistosoma mansoni hypothetical protein 0.0071 0.0236 0.0745
Onchocerca volvulus 0.0017 0.0017 0.1147
Plasmodium falciparum diacylglycerol kinase, putative 0.0028 0.0061 1
Echinococcus multilocularis Niemann Pick C1 protein 0.0293 0.1126 0.1111
Trypanosoma cruzi diacylglycerol kinase-like protein, putative 0.0028 0.0061 0.2363
Echinococcus granulosus Diacylglycerol kinase theta 0.0028 0.0061 0.0151
Brugia malayi Cathepsin L-like precursor 0.0017 0.0017 0.0219
Loa Loa (eye worm) MH2 domain-containing protein 0.012 0.0432 0.1541
Onchocerca volvulus 0.0049 0.0147 1
Loa Loa (eye worm) hypothetical protein 0.0104 0.0369 0.1316
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0104 0.0369 0.1316
Brugia malayi Cathepsin L-like precursor 0.0017 0.0017 0.0219
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0033 0.0083 0.0066
Brugia malayi Niemann-Pick C1 protein precursor 0.0205 0.0773 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0205 1
Plasmodium falciparum cysteine proteinase falcipain 3 0.0017 0.0017 0.2761
Onchocerca volvulus 0.0028 0.0061 0.4157
Brugia malayi Cathepsin L-like precursor 0.0017 0.0017 0.0219
Brugia malayi Cathepsin L-like precursor 0.0017 0.0017 0.0219
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0033 0.0083 0.0066
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0203 0.0631
Mycobacterium tuberculosis Conserved protein 0.0711 0.2804 1
Echinococcus granulosus tumor protein p63 0.0336 0.1298 0.4349
Echinococcus multilocularis sphingosine kinase 1 0.0711 0.2804 0.2792
Entamoeba histolytica diacylglycerol kinase, putative 0.0028 0.0061 0.0159
Trypanosoma cruzi hypothetical protein, conserved 0.0028 0.0061 0.2363
Loa Loa (eye worm) hypothetical protein 0.0028 0.0061 0.0219
Onchocerca volvulus 0.0017 0.0017 0.1147
Loa Loa (eye worm) eye-specific diacylglycerol kinase 0.0028 0.0061 0.0219
Brugia malayi Latrophilin receptor protein 2 0.0033 0.0083 0.107
Echinococcus multilocularis sterol regulatory element binding protein 0.0088 0.0303 0.0287
Onchocerca volvulus 0.0017 0.0017 0.1147
Echinococcus granulosus sterol regulatory element binding protein 0.0088 0.0303 0.0972
Trypanosoma cruzi Sphingosine kinase 0.0028 0.0061 0.2363
Onchocerca volvulus Ceramide kinase 1 homolog 0.0028 0.0061 0.4157
Echinococcus multilocularis Niemann Pick C1 protein 0.0205 0.0773 0.0757
Echinococcus multilocularis GPCR, family 2 0.0033 0.0083 0.0066
Echinococcus granulosus ceramide kinase 0.0028 0.0061 0.0151
Leishmania major hypothetical protein, conserved 0.0028 0.0061 0.2363
Loa Loa (eye worm) hypothetical protein 0.0033 0.0083 0.0295
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0088 0.0303 0.1081
Echinococcus granulosus expressed conserved protein 0.0193 0.0723 0.2396
Toxoplasma gondii cathepsin CPL 0.0017 0.0017 0.2761
Schistosoma mansoni cellular tumor antigen P53 0.0049 0.0147 0.0443
Plasmodium falciparum diacylglycerol kinase, putative 0.0028 0.0061 1
Trichomonas vaginalis diacylglycerol kinase, putative 0.0028 0.0061 0.155
Plasmodium vivax vivapain-2 0.0017 0.0017 0.2761
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0203 0.0631
Plasmodium vivax vivapain-2 0.0017 0.0017 0.2761
Loa Loa (eye worm) diacylglycerol kinase 2 0.0028 0.0061 0.0219
Loa Loa (eye worm) transcription factor SMAD2 0.012 0.0432 0.1541
Echinococcus granulosus Niemann Pick C1 protein 0.0293 0.1126 0.3764
Trypanosoma cruzi Diacylglycerol kinase catalytic domain containing protein, putative 0.0028 0.0061 0.2363
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0061 0.155
Echinococcus multilocularis protein patched 0.0088 0.0303 0.0287
Trypanosoma cruzi major cysteine proteinase, putative 0.005 0.015 0.7098
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0205 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0205 1
Loa Loa (eye worm) fibroinase 0.0017 0.0017 0.006
Plasmodium vivax diacylglycerol kinase, putative 0.0028 0.0061 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0205 1
Schistosoma mansoni hypothetical protein 0.0165 0.0611 0.2015
Echinococcus granulosus sphingosine kinase 1 0.0711 0.2804 0.9461
Leishmania major cathepsin L-like protease 0.0063 0.0205 1
Brugia malayi latrophilin 2 splice variant baaae 0.0071 0.0236 0.306
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0033 0.0083 0.0223
Leishmania major diacylglycerol kinase-like protein 0.0028 0.0061 0.2363
Loa Loa (eye worm) RNA binding protein 0.0063 0.0203 0.0723
Loa Loa (eye worm) hypothetical protein 0.0028 0.0061 0.0219
Loa Loa (eye worm) cysteine protease 0.0017 0.0017 0.006
Trypanosoma cruzi cysteine peptidase, putative 0.0063 0.0205 1
Schistosoma mansoni microtubule-associated protein tau 0.0751 0.2963 1
Trichomonas vaginalis bmru protein, putative 0.0028 0.0061 0.155
Trichomonas vaginalis diacylglycerol kinase, zeta, iota, putative 0.0028 0.0061 0.155
Echinococcus multilocularis Diacylglycerol kinase theta 0.0028 0.0061 0.0044
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0208 0.0786 0.2609
Brugia malayi diacylglycerol kinase 0.0028 0.0061 0.0793
Brugia malayi Ceramide kinase 0.0028 0.0061 0.0793
Trypanosoma cruzi cysteine peptidase, putative 0.0063 0.0205 1
Loa Loa (eye worm) TAR-binding protein 0.0063 0.0203 0.0723
Loa Loa (eye worm) hypothetical protein 0.0088 0.0303 0.1081
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0205 1
Loa Loa (eye worm) hypothetical protein 0.0071 0.0236 0.0843
Loa Loa (eye worm) hypothetical protein 0.0711 0.2804 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0205 1
Brugia malayi Diacylglycerol kinase protein 2 0.0028 0.0061 0.0793
Trypanosoma cruzi cruzipain precursor, putative 0.0063 0.0205 1
Toxoplasma gondii diacylglycerol kinase accessory domain (presumed) domain-containing protein 0.0028 0.0061 1
Echinococcus multilocularis microtubule associated protein 2 0.0751 0.2963 0.2951
Echinococcus granulosus Protein patched homolog 1 0.0088 0.0303 0.0972
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0203 0.0631
Schistosoma mansoni diacylglycerol kinase theta 0.0028 0.0061 0.0151
Echinococcus multilocularis Diacylglycerol kinase zeta 0.0028 0.0061 0.0044
Leishmania major cathepsin L-like protease 0.0063 0.0205 1
Schistosoma mansoni hypothetical protein 0.0033 0.0083 0.0223
Onchocerca volvulus Cathepsin F homolog 0.0017 0.0017 0.1147
Echinococcus granulosus acylglycerol kinase mitochondrial 0.0028 0.0061 0.0151
Trichomonas vaginalis diacylglycerol kinase, epsilon, putative 0.0028 0.0061 0.155
Brugia malayi RNA recognition motif domain containing protein 0.0063 0.0203 0.2625
Brugia malayi Calcitonin receptor-like protein seb-1 0.0104 0.0369 0.4775
Trypanosoma cruzi diacylglycerol kinase-like protein, putative 0.0028 0.0061 0.2363
Schistosoma mansoni sphingosine kinase A B 0.0711 0.2804 0.9461
Brugia malayi hypothetical protein 0.0028 0.0061 0.0793
Onchocerca volvulus Cathepsin L homolog 0.0017 0.0017 0.1147
Loa Loa (eye worm) latrophilin receptor protein 2 0.0033 0.0083 0.0295
Echinococcus multilocularis geminin 0.0165 0.0611 0.0595
Brugia malayi CHE-14 protein 0.0088 0.0303 0.3923
Brugia malayi RNA binding protein 0.0063 0.0203 0.2625
Entamoeba histolytica diacylglycerol kinase, putative 0.0028 0.0061 0.0159
Brugia malayi TAR-binding protein 0.0063 0.0203 0.2625
Onchocerca volvulus 0.0017 0.0017 0.1147
Schistosoma mansoni diacylglycerol kinase zeta iota 0.0028 0.0061 0.0151
Echinococcus granulosus Niemann Pick C1 protein 0.0205 0.0773 0.2566
Brugia malayi Eye-specific diacylglycerol kinase 0.0028 0.0061 0.0793
Schistosoma mansoni patched 1 0.0088 0.0303 0.0972
Echinococcus granulosus GPCR family 2 0.0033 0.0083 0.0223
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0205 1
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0203 0.0631
Brugia malayi Cathepsin L-like precursor 0.0017 0.0017 0.0219
Echinococcus granulosus Diacylglycerol kinase zeta 0.0028 0.0061 0.0151
Toxoplasma gondii diacylglycerol kinase catalytic domain-containing protein 0.0028 0.0061 1
Loa Loa (eye worm) hypothetical protein 0.0205 0.0773 0.2756
Trypanosoma cruzi cysteine peptidase, putative 0.0063 0.0205 1
Trypanosoma cruzi Sphingosine kinase 0.0028 0.0061 0.2363
Schistosoma mansoni sphingoid long chain base kinase 0.0711 0.2804 0.9461
Trypanosoma cruzi diacylglycerol kinase, putative 0.0028 0.0061 0.2363
Onchocerca volvulus 0.0017 0.0017 0.1147
Echinococcus multilocularis ceramide kinase 0.0028 0.0061 0.0044
Trichomonas vaginalis sphingosine kinase, putative 0.0028 0.0061 0.155
Entamoeba histolytica diacylglycerol kinase, putative 0.0028 0.0061 0.0159
Echinococcus multilocularis expressed conserved protein 0.0193 0.0723 0.0707
Leishmania major hypothetical protein, conserved 0.0028 0.0061 0.2363
Schistosoma mansoni hypothetical protein 0.0085 0.029 0.0928

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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