Detailed information for compound 585583

Basic information

Technical information
  • TDR Targets ID: 585583
  • Name: [(3R,5S,8R,9S,10S,13S,14S)-10,13-dimethyl-17- oxo-1,2,3,4,5,6,7,8,9,11,12,14,15,16-tetradec ahydrocyclopenta[a]phenanthren-3-yl] 2-bromoa cetate
  • MW: 411.373 | Formula: C21H31BrO3
  • H donors: 0 H acceptors: 2 LogP: 5.23 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: BrCC(=O)O[C@@H]1CC[C@]2([C@H](C1)CC[C@@H]1[C@@H]2CC[C@]2([C@H]1CCC2=O)C)C
  • InChi: 1S/C21H31BrO3/c1-20-9-7-14(25-19(24)12-22)11-13(20)3-4-15-16-5-6-18(23)21(16,2)10-8-17(15)20/h13-17H,3-12H2,1-2H3/t13-,14+,15-,16-,17-,20-,21-/m0/s1
  • InChiKey: MHVSXHSVOGMZQU-DQACUKESSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 2-bromoacetic acid [(3R,5S,8R,9S,10S,13S,14S)-10,13-dimethyl-17-oxo-1,2,3,4,5,6,7,8,9,11,12,14,15,16-tetradecahydrocyclopenta[a]phenanthren-3-yl] ester
  • [(3R,5S,8R,9S,10S,13S,14S)-10,13-dimethyl-17-oxo-1,2,3,4,5,6,7,8,9,11,12,14,15,16-tetradecahydrocyclopenta[a]phenanthren-3-yl] 2-bromoethanoate
  • 2-bromoacetic acid [(3R,5S,8R,9S,10S,13S,14S)-17-keto-10,13-dimethyl-1,2,3,4,5,6,7,8,9,11,12,14,15,16-tetradecahydrocyclopenta[a]phenanthren-3-yl] ester
  • 3-bromoacetoxyandrostan-17-one
  • 83456-59-1
  • 3-((Bromoacetyl)oxy)androstan-17-one (3alpha,5alpha)-
  • 3alpha-Bromoacetoxyandrosterone
  • Androstan-17-one, 3-((bromoacetyl)oxy)-, (3alpha,5alpha)-
  • BrAnd

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0031 0.0443 0.0915
Trichomonas vaginalis dullard protein, putative 0.0012 0.0113 0.0113
Brugia malayi Nuclear hormone receptor-like 1 0.0016 0.0185 0.0383
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0015 0.0154 0.0319
Loa Loa (eye worm) hypothetical protein 0.0015 0.0154 0.0319
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0031 0.0443 0.0915
Loa Loa (eye worm) hypothetical protein 0.0016 0.0185 0.0383
Toxoplasma gondii aldose reductase, putative 0.0281 0.484 1
Brugia malayi hypothetical protein 0.0015 0.0154 0.0319
Loa Loa (eye worm) hypothetical protein 0.0015 0.0154 0.0319
Trichomonas vaginalis aldo-keto reductase, putative 0.0281 0.484 0.484
Trichomonas vaginalis nuclear lim interactor-interacting factor, putative 0.0012 0.0113 0.0113
Loa Loa (eye worm) hypothetical protein 0.0281 0.484 1
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0042 0.064 0.064
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0031 0.0443 0.0915
Trichomonas vaginalis aldo/keto reductase, putative 0.0281 0.484 0.484
Loa Loa (eye worm) hypothetical protein 0.0015 0.0154 0.0319
Toxoplasma gondii aldo-keto reductase 0.0081 0.1329 0.2572
Trichomonas vaginalis aldo-keto reductase, putative 0.0281 0.484 0.484
Loa Loa (eye worm) glutamate-cysteine ligase modifier subunit 0.0081 0.1329 0.2745
Loa Loa (eye worm) hypothetical protein 0.0148 0.25 0.5166
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0031 0.0443 0.0915
Trichomonas vaginalis aldo-keto reductase, putative 0.0281 0.484 0.484
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0016 0.0185 0.0383
Mycobacterium tuberculosis Probable oxidoreductase 0.0281 0.484 1
Trichomonas vaginalis dullard protein, putative 0.0012 0.0113 0.0113
Loa Loa (eye worm) oxidoreductase 0.0281 0.484 1
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0016 0.0172 0.0355
Trichomonas vaginalis aldo-keto reductase, putative 0.0281 0.484 0.484
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0281 0.484 1
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0281 0.484 1
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0031 0.0443 0.0915
Plasmodium falciparum histone acetyltransferase GCN5 0.0039 0.0578 0.3823
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0031 0.0443 0.0915
Schistosoma mansoni nuclear receptor nhr-48 0.0015 0.0154 0.0319
Echinococcus multilocularis muscleblind protein 0.0148 0.25 0.5166
Trichomonas vaginalis aldo-keto reductase, putative 0.0081 0.1329 0.1329
Schistosoma mansoni nuclear receptor 0.0015 0.0154 0.0319
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0042 0.064 0.1114
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0016 0.0172 0.0355
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0117 0.1957 0.4044
Schistosoma mansoni hypothetical protein 0.0012 0.011 0.0228
Leishmania major aldo/keto reductase, putative,aldo/keto reductase family-like protein 0.0081 0.1329 0.2745
Schistosoma mansoni protein tyrosine phosphatase n11 (shp2) 0.0117 0.1957 0.4044
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0031 0.0443 0.0915
Echinococcus multilocularis aldo keto reductase 0.0281 0.484 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0031 0.0443 0.0915
Onchocerca volvulus 0.0281 0.484 1
Plasmodium falciparum aldo-keto reductase, putative 0.0081 0.1329 1
Onchocerca volvulus 0.0281 0.484 1
Brugia malayi nuclear receptor RXR 0.0015 0.0154 0.0319
Echinococcus granulosus aldo keto reductase 0.0281 0.484 1
Trichomonas vaginalis aldo-keto reductase, putative 0.0281 0.484 0.484
Onchocerca volvulus 0.0015 0.0154 0.0319
Brugia malayi nuclear hormone receptor 0.0015 0.0154 0.0319
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.0172 0.0355
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0016 0.0172 0.0355
Echinococcus multilocularis aldo keto reductase 0.0281 0.484 1
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0117 0.1957 0.4044
Leishmania major prostaglandin f2-alpha synthase/D-arabinose dehydrogenase 0.0281 0.484 1
Schistosoma mansoni hypothetical protein 0.0016 0.0172 0.0355
Entamoeba histolytica aldose reductase, putative 0.0281 0.484 0.484
Schistosoma mansoni nuclear receptor 0.0015 0.0154 0.0319
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0031 0.0443 0.0915
Brugia malayi latrophilin 2 splice variant baaae 0.0034 0.0491 0.1014
Trichomonas vaginalis nuclear lim interactor-interacting factor, putative 0.0012 0.0113 0.0113
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0031 0.0443 0.0915
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0015 0.0154 0.0319
Echinococcus granulosus ecdysone induced protein 78C 0.0031 0.0443 0.0915
Echinococcus multilocularis 0.0012 0.0113 0.0234
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0281 0.484 0.484
Brugia malayi acetyltransferase, GNAT family protein 0.0143 0.2423 0.5006
Brugia malayi ecdysteroid receptor 0.0031 0.0443 0.0915
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0031 0.0443 0.0915
Brugia malayi NADH-dependent xylose reductase 0.0081 0.1329 0.2745
Loa Loa (eye worm) hypothetical protein 0.0034 0.0491 0.1014
Leishmania major prostaglandin f synthase, putative 0.0281 0.484 1
Brugia malayi Nuclear hormone receptor E75 0.0015 0.0154 0.0319
Loa Loa (eye worm) hypothetical protein 0.0015 0.0154 0.0319
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0031 0.0443 0.0915
Onchocerca volvulus Protein ultraspiracle homolog 0.0031 0.0443 0.0915
Entamoeba histolytica aldose reductase, putative 0.0281 0.484 0.484
Schistosoma mansoni thyroid hormone receptor 0.0031 0.0443 0.0915
Trichomonas vaginalis aldo-keto reductase, putative 0.0281 0.484 0.484
Trichomonas vaginalis aldo-keto reductase, putative 0.0281 0.484 0.484
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0281 0.484 0.484
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0031 0.0443 0.0915
Loa Loa (eye worm) hypothetical protein 0.0015 0.0154 0.0319
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0016 0.0185 0.0383
Onchocerca volvulus Bile acid receptor homolog 0.0031 0.0443 0.0915
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0281 0.484 1
Leishmania major aldehyde reductase, putative,oxidoreductase, putative 0.0281 0.484 1
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0117 0.1957 0.4044
Brugia malayi Nuclear hormone receptor E75 0.0015 0.0154 0.0319
Loa Loa (eye worm) hypothetical protein 0.0015 0.0154 0.0319
Echinococcus multilocularis ecdysone induced protein 78C 0.0031 0.0443 0.0915
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0281 0.484 1
Entamoeba histolytica aldose reductase, putative 0.0281 0.484 0.484
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0015 0.0154 0.0319
Echinococcus multilocularis aldehyde reductase 0.0199 0.3408 0.7042
Echinococcus multilocularis aldo keto reductase 0.0281 0.484 1
Brugia malayi Steroid receptor seven-up type 2 0.0031 0.0443 0.0915
Loa Loa (eye worm) hypothetical protein 0.0031 0.0443 0.0915
Trichomonas vaginalis dullard protein, putative 0.0012 0.0113 0.0113
Echinococcus granulosus Carboxy terminal domain RNA polymerase II 0.0012 0.0113 0.0234
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0016 0.0185 0.0383
Onchocerca volvulus 0.0081 0.1329 0.2745
Echinococcus granulosus FTZ F1 alpha 0.0031 0.0443 0.0915
Trichomonas vaginalis aldo-keto reductase, putative 0.0281 0.484 0.484
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0281 0.484 1
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0031 0.0443 0.0915
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0031 0.0443 0.0915
Brugia malayi nuclear hormone receptor 0.0031 0.0443 0.0915
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0015 0.0154 0.0319
Echinococcus granulosus Nuclear hormone receptor HR96 0.0015 0.0154 0.0319
Onchocerca volvulus 0.0015 0.0154 0.0319
Echinococcus granulosus CTD small phosphatase protein like 0.0012 0.0113 0.0234
Loa Loa (eye worm) hypothetical protein 0.0015 0.0154 0.0319
Loa Loa (eye worm) hypothetical protein 0.0012 0.0113 0.0234
Echinococcus granulosus GPCR family 2 0.0016 0.0172 0.0355
Giardia lamblia Aldose reductase 0.0281 0.484 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0031 0.0443 0.0915
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0031 0.0443 0.0915
Loa Loa (eye worm) hypothetical protein 0.0016 0.0172 0.0355
Echinococcus granulosus aldo keto reductase 0.0281 0.484 1
Brugia malayi glutamate-cysteine ligase modifier subunit 0.0081 0.1329 0.2745
Trypanosoma brucei Mitochondrial import inner membrane translocase subunit TIM50 0.0012 0.0113 0.0234
Trichomonas vaginalis aldo-keto reductase, putative 0.0081 0.1329 0.1329
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0016 0.0185 0.0383
Onchocerca volvulus 0.0281 0.484 1
Schistosoma mansoni potassium channel beta 0.0081 0.1329 0.2745
Loa Loa (eye worm) hypothetical protein 0.0015 0.0154 0.0319
Brugia malayi hypothetical protein 0.0016 0.0185 0.0383
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0117 0.1957 0.4044
Loa Loa (eye worm) DR-78 0.0015 0.0154 0.0319
Brugia malayi Muscleblind-like protein 0.0148 0.25 0.5166
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0281 0.484 1
Leishmania major hypothetical protein, conserved 0.0012 0.0113 0.0234
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0031 0.0443 0.0915
Trypanosoma brucei aldo-keto reductase, putative 0.0281 0.484 1
Schistosoma mansoni hypothetical protein 0.0016 0.0172 0.0355
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0049 0.0766 0.1582
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0042 0.064 0.4332
Schistosoma mansoni nuclear hormone receptor 0.0031 0.0443 0.0915
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0031 0.0443 0.0915
Entamoeba histolytica alcohol dehydrogenase, putative 0.0081 0.1329 0.1329
Echinococcus multilocularis Carboxy terminal domain RNA polymerase II 0.0012 0.0113 0.0234
Brugia malayi nuclear receptor RXR 0.0016 0.0185 0.0383
Echinococcus granulosus aldo keto reductase 0.0281 0.484 1
Toxoplasma gondii oxidoreductase, aldo/keto reductase family protein 0.0081 0.1329 0.2572
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0015 0.0154 0.0319
Schistosoma mansoni RAR-like nuclear receptor 0.0031 0.0443 0.0915
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0016 0.0172 0.0355
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0281 0.484 1
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0281 0.484 1
Brugia malayi nuclear hormone receptor family member nhr-6 0.0015 0.0154 0.0319
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0031 0.0443 0.0915
Loa Loa (eye worm) hypothetical protein 0.0031 0.0443 0.0915
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0281 0.484 0.484
Mycobacterium ulcerans oxidoreductase 0.0281 0.484 1
Trypanosoma cruzi aldo/keto reductase, putative 0.0281 0.484 1
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0031 0.0443 0.0915
Brugia malayi Nuclear hormone receptor-like 1 0.0031 0.0443 0.0915
Onchocerca volvulus 0.0281 0.484 1
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0015 0.0154 0.0319
Loa Loa (eye worm) hypothetical protein 0.0031 0.0443 0.0915
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0281 0.484 1
Loa Loa (eye worm) hypothetical protein 0.0015 0.0154 0.0319
Onchocerca volvulus 0.0031 0.0443 0.0915
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0031 0.0443 0.0915
Mycobacterium leprae PROBABLE OXIDOREDUCTASE 0.0281 0.484 1
Trichomonas vaginalis aldo-keto reductase, putative 0.0281 0.484 0.484
Loa Loa (eye worm) nuclear hormone receptor 0.0015 0.0154 0.0319
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0281 0.484 1
Loa Loa (eye worm) hypothetical protein 0.0015 0.0154 0.0319
Loa Loa (eye worm) hypothetical protein 0.0148 0.25 0.5166
Brugia malayi nuclear receptor NHR-88 0.0031 0.0443 0.0915
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0031 0.0443 0.0915
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0031 0.0443 0.0915
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0117 0.1957 0.4044
Loa Loa (eye worm) oxidoreductase 0.0281 0.484 1
Trichomonas vaginalis bromodomain-containing protein, putative 0.0042 0.064 0.064
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0031 0.0443 0.0915
Loa Loa (eye worm) hypothetical protein 0.0016 0.0185 0.0383
Trypanosoma cruzi aldo-keto reductase 0.0281 0.484 1
Trypanosoma cruzi hypothetical protein, conserved 0.0012 0.0113 0.0234
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0031 0.0443 0.0915
Loa Loa (eye worm) nuclear receptor NHR-67 0.0015 0.0154 0.0319
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0031 0.0443 0.0915
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0015 0.0154 0.0319
Schistosoma mansoni hypothetical protein 0.0034 0.0491 0.1014
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0281 0.484 1
Echinococcus multilocularis thyroid hormone receptor alpha 0.0031 0.0443 0.0915
Echinococcus multilocularis nuclear receptor nhr 48 0.0015 0.0154 0.0319
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0031 0.0443 0.0915
Loa Loa (eye worm) hypothetical protein 0.0031 0.0443 0.0915
Echinococcus granulosus aldehyde reductase 0.0199 0.3408 0.7042
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0117 0.1957 0.4044
Loa Loa (eye worm) acetyltransferase 0.0143 0.2423 0.5006
Brugia malayi tailless protein 0.0015 0.0154 0.0319
Echinococcus multilocularis GPCR, family 2 0.0016 0.0172 0.0355
Schistosoma mansoni pol-related 0.0281 0.484 1
Giardia lamblia Aldose reductase 0.0281 0.484 1
Echinococcus granulosus nuclear receptor nhr 48 0.0015 0.0154 0.0319
Entamoeba histolytica acetyltransferase, GNAT family 0.0039 0.0578 0.0578
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0281 0.484 1
Schistosoma mansoni thyroid hormone receptor 0.0031 0.0443 0.0915
Echinococcus granulosus muscleblind protein 0.0148 0.25 0.5166
Trichomonas vaginalis nuclear lim interactor-interacting factor, putative 0.0012 0.0113 0.0113
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0016 0.0185 0.0383
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0015 0.0154 0.0319
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0143 0.2423 0.5006
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0281 0.484 1
Schistosoma mansoni aldo-keto reductase 0.0281 0.484 1
Mycobacterium leprae Conserved hypothetical protein 0.0199 0.3408 0.5922
Schistosoma mansoni nuclear hormone receptor 0.0015 0.0154 0.0319
Brugia malayi nuclear hormone receptor family member odr-7 0.0015 0.0154 0.0319
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0015 0.0154 0.0319
Schistosoma mansoni nuclear lim interactor-interacting factor (nli-interacting factor) (nli-if) 0.0012 0.0113 0.0234
Leishmania major aldo-keto reductase-like protein 0.0281 0.484 1
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0281 0.484 1
Trypanosoma brucei aldo/keto reductase, putative 0.0081 0.1329 0.2745
Brugia malayi conserved hypotetical protein 0.0015 0.0154 0.0319
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0281 0.484 1
Trypanosoma cruzi aldo/keto reductase, putative 0.0081 0.1329 0.2745
Plasmodium falciparum aldehyde reductase, putative 0.0081 0.1329 1
Brugia malayi orphan nuclear receptor NR2E1 0.0015 0.0154 0.0319
Toxoplasma gondii aldo/keto reductase family oxidoreductase 0.0081 0.1329 0.2572
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0281 0.484 1
Echinococcus granulosus Nuclear hormone receptor HR96 0.0015 0.0154 0.0319
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0281 0.484 1
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0281 0.484 1
Onchocerca volvulus 0.0281 0.484 1
Brugia malayi hypothetical protein 0.0015 0.0154 0.0319
Schistosoma mansoni aldo-keto reductase 0.0281 0.484 1
Plasmodium vivax oxidoreductase, aldo/keto reductase domain containing protein 0.0081 0.1329 1
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0281 0.484 1
Schistosoma mansoni hypothetical protein 0.0016 0.0172 0.0355
Trichomonas vaginalis alcohol dehydrogenase, putative 0.0081 0.1329 0.1329
Brugia malayi hypothetical protein 0.0016 0.0185 0.0383
Brugia malayi photoreceptor-specific nuclear receptor 0.0031 0.0443 0.0915
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0031 0.0443 0.0915
Echinococcus multilocularis aldo keto reductase 0.0281 0.484 1
Trichomonas vaginalis aldo-keto reductase, putative 0.0281 0.484 0.484
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0031 0.0443 0.0915
Brugia malayi Calcitonin receptor-like protein seb-1 0.0049 0.0766 0.1582
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0143 0.2423 0.5006
Echinococcus multilocularis FTZ F1 alpha 0.0031 0.0443 0.0915
Loa Loa (eye worm) steroid hormone receptor 0.0031 0.0443 0.0915
Loa Loa (eye worm) hypothetical protein 0.0015 0.0154 0.0319
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0031 0.0443 0.0915
Loa Loa (eye worm) hypothetical protein 0.0031 0.0443 0.0915
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0031 0.0443 0.0915
Giardia lamblia Histone acetyltransferase GCN5 0.0039 0.0578 0.1194
Trypanosoma brucei prostaglandin f synthase 0.0281 0.484 1
Loa Loa (eye worm) oxidoreductase 0.0281 0.484 1
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.0172 0.0355
Schistosoma mansoni steroid hormone receptor ad4bp 0.0031 0.0443 0.0915
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0281 0.484 1
Loa Loa (eye worm) oxidoreductase 0.0281 0.484 1
Schistosoma mansoni nuclear lim interactor-interacting factor (nli-interacting factor) (nli-if) 0.0012 0.0113 0.0234
Giardia lamblia Nuclear LIM interactor-interacting factor 1 0.0012 0.0113 0.0234
Loa Loa (eye worm) hypothetical protein 0.0031 0.0443 0.0915
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0031 0.0443 0.0915
Onchocerca volvulus 0.0281 0.484 1
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0031 0.0443 0.0915
Trichomonas vaginalis aldo-keto reductase, putative 0.0281 0.484 0.484
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0281 0.484 1
Trichomonas vaginalis aldo/keto reductase, putative 0.0281 0.484 0.484
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0031 0.0443 0.0915
Loa Loa (eye worm) hypothetical protein 0.0016 0.0185 0.0383
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0015 0.0154 0.0319
Loa Loa (eye worm) hypothetical protein 0.0031 0.0443 0.0915
Brugia malayi steroid hormone receptor 0.0031 0.0443 0.0915
Schistosoma mansoni nuclear hormone receptor 0.0015 0.0154 0.0319
Echinococcus multilocularis muscleblind protein 1 0.0148 0.25 0.5166
Trichomonas vaginalis conserved hypothetical protein 0.0081 0.1329 0.1329
Echinococcus granulosus histone acetyltransferase KAT2B 0.0139 0.2352 0.486
Brugia malayi Carboxy-terminal domain RNA polymerase II polypeptide A smallphosphatase 1 0.0012 0.0113 0.0234
Loa Loa (eye worm) hypothetical protein 0.0015 0.0154 0.0319
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0031 0.0443 0.0915
Brugia malayi Latrophilin receptor protein 2 0.0016 0.0172 0.0355
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0015 0.0154 0.0319
Trichomonas vaginalis aldo/keto reductase, putative 0.0281 0.484 0.484
Schistosoma mansoni retinoic acid receptor RXR 0.0031 0.0443 0.0915
Echinococcus granulosus voltage gated potassium channel subunit 0.0081 0.1329 0.2745
Plasmodium vivax aldehyde reductase, putative 0.0081 0.1329 1
Loa Loa (eye worm) hypothetical protein 0.0049 0.0766 0.1582
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0281 0.484 1
Trichomonas vaginalis aldo-keto reductase, putative 0.0281 0.484 0.484
Entamoeba histolytica NLI interacting factor-like phosphatase domain-containing protein 0.0012 0.0113 0.0113
Schistosoma mansoni hypothetical protein 0.0016 0.0172 0.0355
Entamoeba histolytica alcohol dehydrogenase, putative 0.0081 0.1329 0.1329
Trichomonas vaginalis pps1 dual specificty phosphatase, putative 0.0574 1 1
Schistosoma mansoni zinc finger protein 0.0015 0.0154 0.0319
Schistosoma mansoni coup transcription factor 0.0031 0.0443 0.0915
Loa Loa (eye worm) hypothetical protein 0.0016 0.0185 0.0383
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0042 0.064 0.1114
Brugia malayi Nuclear hormone receptor-like 1 0.0016 0.0185 0.0383
Echinococcus granulosus thyroid hormone receptor alpha 0.0015 0.0154 0.0319
Loa Loa (eye worm) hypothetical protein 0.0031 0.0443 0.0915
Echinococcus granulosus aldo keto reductase family 1, member B4 0.0081 0.1329 0.2745
Trichomonas vaginalis nuclear lim interactor-interacting factor, putative 0.0012 0.0113 0.0113
Brugia malayi ecdysone receptor 0.0015 0.0154 0.0319
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0049 0.0766 0.1582
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0031 0.0443 0.0915
Echinococcus granulosus hypothetical protein 0.0281 0.484 1
Trichomonas vaginalis aldo-keto reductase, putative 0.0081 0.1329 0.1329
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0031 0.0443 0.0915
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0281 0.484 1
Brugia malayi nuclear receptor NHR-88 0.0015 0.0154 0.0319
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0031 0.0443 0.0915
Loa Loa (eye worm) hypothetical protein 0.0012 0.011 0.0228
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0015 0.0154 0.0319
Loa Loa (eye worm) hypothetical protein 0.0016 0.0185 0.0383
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0281 0.484 1
Brugia malayi nuclear receptor NHR-67 0.0015 0.0154 0.0319
Loa Loa (eye worm) oxidoreductase 0.0281 0.484 1
Echinococcus granulosus histone acetyltransferase KAT2B 0.0042 0.064 0.1322
Loa Loa (eye worm) hypothetical protein 0.0015 0.0154 0.0319
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0031 0.0443 0.0915
Echinococcus multilocularis voltage gated potassium channel subunit 0.0081 0.1329 0.2745
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0015 0.0154 0.0319

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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