Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Entamoeba histolytica | protein kinase, putative | 0.0057 | 0.009 | 0.0211 |
Echinococcus multilocularis | serine:threonine protein kinase PAK 3 | 0.0109 | 0.0883 | 0.0816 |
Trichomonas vaginalis | STE family protein kinase | 0.0109 | 0.0883 | 1 |
Echinococcus granulosus | serine:threonine protein kinase PAK 3 | 0.0109 | 0.0883 | 0.0883 |
Echinococcus granulosus | neural Wiskott Aldrich syndrome protein | 0.0056 | 0.0073 | 0.0073 |
Loa Loa (eye worm) | hypothetical protein | 0.0107 | 0.0866 | 0.2653 |
Giardia lamblia | Kinase, STE STE20 | 0.0109 | 0.0883 | 0.5 |
Brugia malayi | Protein kinase domain | 0.0109 | 0.0883 | 0.2706 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0233 | 0.2805 | 0.5 |
Schistosoma mansoni | microtubule-associated protein tau | 0.0699 | 1 | 1 |
Entamoeba histolytica | protein kinase, putative | 0.0057 | 0.009 | 0.0211 |
Echinococcus multilocularis | microtubule associated protein 2 | 0.0699 | 1 | 1 |
Brugia malayi | MH2 domain containing protein | 0.0121 | 0.1074 | 0.3303 |
Loa Loa (eye worm) | STE/STE20/PAKB protein kinase | 0.026 | 0.3217 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0056 | 0.0073 | 0.0056 |
Echinococcus multilocularis | tumor protein p63 | 0.0342 | 0.4492 | 0.4451 |
Echinococcus granulosus | serine:threonine protein kinase PAK 4 | 0.0204 | 0.2351 | 0.2351 |
Echinococcus granulosus | tumor protein p63 | 0.0342 | 0.4492 | 0.4492 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0121 | 0.1074 | 0.3303 |
Echinococcus granulosus | p21 activated protein kinase 1 Dpak1 | 0.0109 | 0.0883 | 0.0883 |
Loa Loa (eye worm) | P21-Rho-binding domain-containing protein | 0.0056 | 0.0073 | 0.0174 |
Schistosoma mansoni | protein kinase | 0.0109 | 0.0883 | 0.0867 |
Brugia malayi | P21-Rho-binding domain containing protein | 0.0056 | 0.0073 | 0.0174 |
Schistosoma mansoni | hypothetical protein | 0.0056 | 0.0073 | 0.0056 |
Entamoeba histolytica | protein kinase, putative | 0.0109 | 0.0883 | 1 |
Echinococcus granulosus | PAK box P21 Rho binding | 0.0056 | 0.0073 | 0.0073 |
Schistosoma mansoni | protein kinase | 0.0056 | 0.0073 | 0.0056 |
Trichomonas vaginalis | STE family protein kinase | 0.0109 | 0.0883 | 1 |
Trypanosoma cruzi | STE/STE20 serine/threonine-protein kinase, putative | 0.0052 | 0.0017 | 0.5 |
Entamoeba histolytica | p21-activated kinase | 0.0109 | 0.0883 | 1 |
Trypanosoma cruzi | p21-activated kinase 3, putative | 0.0052 | 0.0017 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0056 | 0.0073 | 0.0056 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0121 | 0.1074 | 0.3303 |
Echinococcus multilocularis | p21 activated protein kinase 1 Dpak1 | 0.0109 | 0.0883 | 0.0816 |
Schistosoma mansoni | hypothetical protein | 0.0056 | 0.0073 | 0.0056 |
Trichomonas vaginalis | STE family protein kinase | 0.0109 | 0.0883 | 1 |
Echinococcus granulosus | 3'partial|serine:threonine protein kinase PAK 2 | 0.0056 | 0.0073 | 0.0073 |
Echinococcus granulosus | serine:threonine protein kinase PAK 3 | 0.0109 | 0.0883 | 0.0883 |
Schistosoma mansoni | protein kinase | 0.0109 | 0.0883 | 0.0867 |
Schistosoma mansoni | wiskott-aldrich syndrome protein | 0.0056 | 0.0073 | 0.0056 |
Echinococcus multilocularis | serine:threonine protein kinase PAK 4 | 0.0204 | 0.2351 | 0.2295 |
Trichomonas vaginalis | STE family protein kinase | 0.0057 | 0.009 | 0.084 |
Schistosoma mansoni | protein kinase | 0.0057 | 0.009 | 0.0073 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0107 | 0.0866 | 0.9803 |
Trichomonas vaginalis | STE family protein kinase | 0.0109 | 0.0883 | 1 |
Entamoeba histolytica | protein kinase, putative | 0.0057 | 0.009 | 0.0211 |
Echinococcus multilocularis | PAK box P21 Rho binding | 0.0057 | 0.009 | 0.0017 |
Brugia malayi | serine/threonine-protein kinase PAK 7 | 0.026 | 0.3217 | 1 |
Brugia malayi | WH1 domain containing protein | 0.0056 | 0.0073 | 0.0174 |
Echinococcus multilocularis | serine:threonine protein kinase PAK 3 | 0.0109 | 0.0883 | 0.0816 |
Brugia malayi | P21-Rho-binding domain containing protein | 0.0056 | 0.0073 | 0.0174 |
Schistosoma mansoni | tyrosine kinase | 0.0056 | 0.0073 | 0.0056 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.