Detailed information for compound 586368

Basic information

Technical information
  • TDR Targets ID: 586368
  • Name: 8-[(E)-dimethylaminoazo]-7-ethyl-1,3-dimethyl -purine-2,6-dione
  • MW: 279.298 | Formula: C11H17N7O2
  • H donors: 0 H acceptors: 3 LogP: 0.88 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCn1c(N=NN(C)C)nc2c1c(=O)n(c(=O)n2C)C
  • InChi: 1S/C11H17N7O2/c1-6-18-7-8(12-10(18)13-14-15(2)3)16(4)11(20)17(5)9(7)19/h6H2,1-5H3/b14-13+
  • InChiKey: OAQSALGVFQVOGT-BUHFOSPRSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 8-[(E)-dimethylaminoazo]-7-ethyl-1,3-dimethylpurine-2,6-dione
  • 8-[(E)-dimethylaminodiazenyl]-7-ethyl-1,3-dimethyl-purine-2,6-dione
  • 8-[(E)-dimethylaminoazo]-7-ethyl-1,3-dimethyl-xanthine
  • 8-[(E)-dimethylaminodiazenyl]-7-ethyl-1,3-dimethylpurine-2,6-dione
  • etheofazine

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni smad1 5 8 and 0.0008 0.0354 0.0452
Brugia malayi RNA recognition motif domain containing protein 0.0062 0.5093 0.5093
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.005 0.4028 0.5672
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0007 0.0286 0.0365
Schistosoma mansoni inositol monophosphatase 0.0036 0.2856 0.3647
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.023 0.0571
Trypanosoma cruzi PAB1-binding protein , putative 0.0049 0.4009 0.9837
Schistosoma mansoni hypothetical protein 0.0031 0.2386 0.3046
Schistosoma mansoni smad1 5 8 and 0.0008 0.0354 0.0452
Toxoplasma gondii histone lysine methyltransferase SET1 0.0055 0.4512 0.8015
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0093 0.7832 0.7832
Loa Loa (eye worm) hypothetical protein 0.0031 0.2386 0.2386
Brugia malayi Latrophilin receptor protein 2 0.0031 0.2386 0.2386
Entamoeba histolytica hypothetical protein 0.0071 0.5892 1
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.006 0.4922 0.6284
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.005 0.4028 1
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.005 0.4028 0.4028
Schistosoma mansoni hypothetical protein 0.0031 0.2386 0.3046
Echinococcus multilocularis mothers against decapentaplegic 5 0.0008 0.0354 0.0452
Trypanosoma brucei PAB1-binding protein , putative 0.0049 0.4009 0.9837
Echinococcus granulosus tar DNA binding protein 0.0062 0.5093 0.6502
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0007 0.0286 0.0365
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.005 0.4028 1
Loa Loa (eye worm) hypothetical protein 0.0004 0.0039 0.0039
Trichomonas vaginalis CMGC family protein kinase 0.005 0.4028 1
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0008 0.0354 0.0452
Schistosoma mansoni tar DNA-binding protein 0.0062 0.5093 0.6502
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0004 0.0017 0.0021
Echinococcus multilocularis GPCR, family 2 0.0031 0.2386 0.3046
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0093 0.7832 1
Brugia malayi MH2 domain containing protein 0.0008 0.0354 0.0354
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0031 0.2386 0.2386
Toxoplasma gondii aldehyde dehydrogenase 0.006 0.4922 1
Schistosoma mansoni tar DNA-binding protein 0.0062 0.5093 0.6502
Brugia malayi MH1 domain containing protein 0.0004 0.0039 0.0039
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.023 0.0571
Trichomonas vaginalis inositol monophosphatase, putative 0.0036 0.2856 0.7091
Schistosoma mansoni smad1 5 8 and 0.0008 0.0354 0.0452
Schistosoma mansoni hypothetical protein 0.0031 0.2386 0.3046
Leishmania major hypothetical protein, conserved 0.0049 0.4009 0.5579
Echinococcus multilocularis smad 0.0008 0.0354 0.0452
Loa Loa (eye worm) Smad1 0.0008 0.0354 0.0354
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.005 0.4028 0.5672
Brugia malayi MH1 domain containing protein 0.0008 0.0354 0.0354
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0031 0.2386 0.3046
Trichomonas vaginalis CMGC family protein kinase 0.005 0.4028 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.023 0.0571
Toxoplasma gondii LsmAD domain-containing protein 0.0049 0.4009 0.5579
Brugia malayi Smad1 0.0008 0.0354 0.0354
Echinococcus multilocularis cpg binding protein 0.0031 0.2362 0.3015
Schistosoma mansoni hypothetical protein 0.0067 0.5563 0.7102
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0093 0.7832 1
Brugia malayi hypothetical protein 0.0032 0.2463 0.2463
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0062 0.5093 0.6503
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0031 0.2386 0.3046
Echinococcus granulosus mitogen activated protein kinase 0.005 0.4028 0.5142
Schistosoma mansoni inositol monophosphatase 0.0036 0.2856 0.3647
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0093 0.7832 1
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.2856 0.7091
Plasmodium falciparum ataxin-2 like protein, putative 0.0049 0.4009 0.5
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.2856 0.7091
Echinococcus granulosus GPCR family 2 0.0031 0.2386 0.3046
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0062 0.5093 0.5093
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0033 0.252 0.5
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.023 0.0571
Echinococcus granulosus TGF beta signal transducer SmadC 0.0008 0.0354 0.0452
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0093 0.7832 1
Schistosoma mansoni hypothetical protein 0.0022 0.1604 0.2048
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.023 0.0571
Schistosoma mansoni cpg binding protein 0.0031 0.2362 0.3015
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0093 0.7832 1
Echinococcus multilocularis Smad4 0.0008 0.0354 0.0452
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0031 0.2386 0.3046
Brugia malayi hypothetical protein 0.0049 0.4009 0.4009
Brugia malayi MH1 domain containing protein 0.0008 0.0354 0.0354
Brugia malayi latrophilin 2 splice variant baaae 0.0067 0.5563 0.5563
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.023 0.0571
Trichomonas vaginalis CMGC family protein kinase 0.005 0.4028 1
Brugia malayi Inositol-1 0.0036 0.2856 0.2856
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0008 0.0354 0.0452
Schistosoma mansoni hypothetical protein 0.0031 0.2386 0.3046
Schistosoma mansoni tar DNA-binding protein 0.0062 0.5093 0.6502
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0443 0.0565
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0007 0.0286 0.0365
Echinococcus granulosus Smad4 0.0008 0.0354 0.0452
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.4922 1
Trypanosoma cruzi PAB1-binding protein , putative 0.0049 0.4009 0.9837
Entamoeba histolytica hypothetical protein 0.0071 0.5892 1
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0007 0.023 0.0571
Echinococcus granulosus inositol monophosphatase 1 0.0036 0.2856 0.3647
Entamoeba histolytica hypothetical protein 0.0071 0.5892 1
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.023 0.0571
Echinococcus multilocularis tar DNA binding protein 0.0062 0.5093 0.6502
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0093 0.7832 1
Brugia malayi MH2 domain containing protein 0.0008 0.0354 0.0354
Loa Loa (eye worm) inositol-1 0.0036 0.2856 0.2856
Loa Loa (eye worm) hypothetical protein 0.0067 0.5563 0.5563
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.023 0.0571
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.023 0.0571
Schistosoma mansoni aldehyde dehydrogenase 0.006 0.4922 0.6284
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0443 0.0565
Brugia malayi MH1 domain containing protein 0.0004 0.0039 0.0039
Brugia malayi CXXC zinc finger family protein 0.0029 0.2215 0.2215
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.2215 0.2215
Echinococcus granulosus mixed lineage leukemia protein mll 0.0007 0.0286 0.0365
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.023 0.0571
Trichomonas vaginalis CMGC family protein kinase 0.005 0.4028 1
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0098 0.83 0.83
Loa Loa (eye worm) MH2 domain-containing protein 0.0117 1 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0093 0.7832 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.023 0.0571
Schistosoma mansoni transcription factor LCR-F1 0.0071 0.5892 0.7523
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0093 0.7832 0.7832
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0031 0.2386 0.3046
Echinococcus granulosus mothers against decapentaplegic 5 0.0008 0.0354 0.0452
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0022 0.1604 0.2048
Trypanosoma brucei protein kinase, putative 0.005 0.4028 1
Echinococcus granulosus cpg binding protein 0.0031 0.2362 0.3015
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0036 0.2856 0.4847
Brugia malayi RNA binding protein 0.0062 0.5093 0.5093
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.006 0.4922 1
Brugia malayi Calcitonin receptor-like protein seb-1 0.0098 0.83 0.83
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.4922 1
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0036 0.2856 0.5
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0071 0.5892 0.7523
Loa Loa (eye worm) RNA binding protein 0.0062 0.5093 0.5093
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0098 0.83 0.83
Echinococcus multilocularis inositol monophosphatase 1 0.0036 0.2856 0.3647
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.023 0.0571
Schistosoma mansoni tar DNA-binding protein 0.0062 0.5093 0.6502
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.023 0.0571
Echinococcus multilocularis mitogen activated protein kinase 3 0.005 0.4028 0.5142
Plasmodium falciparum ataxin-2 like protein, putative 0.0049 0.4009 0.5
Brugia malayi TAR-binding protein 0.0062 0.5093 0.5093
Loa Loa (eye worm) nuclear factor I 0.0004 0.0039 0.0039
Onchocerca volvulus 0.0029 0.2215 1
Schistosoma mansoni cpg binding protein 0.0029 0.2215 0.2829
Plasmodium vivax ataxin-2 like protein, putative 0.0049 0.4009 0.5
Loa Loa (eye worm) latrophilin receptor protein 2 0.0031 0.2386 0.2386
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.006 0.4922 1
Schistosoma mansoni Smad4 0.0008 0.0354 0.0452
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.023 0.0571
Loa Loa (eye worm) histone methyltransferase 0.0009 0.0443 0.0443
Loa Loa (eye worm) hypothetical protein 0.0049 0.4009 0.4009
Schistosoma mansoni serine/threonine protein kinase 0.005 0.4028 0.5142
Loa Loa (eye worm) TAR-binding protein 0.0062 0.5093 0.5093
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0022 0.1604 0.2048
Schistosoma mansoni cpg binding protein 0.0031 0.2362 0.3015
Loa Loa (eye worm) MH1 domain-containing protein 0.0008 0.0354 0.0354
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.023 0.0571
Loa Loa (eye worm) hypothetical protein 0.0098 0.83 0.83
Loa Loa (eye worm) MH2 domain-containing protein 0.0008 0.0354 0.0354
Echinococcus granulosus smad 0.0008 0.0354 0.0452
Echinococcus multilocularis mitogen activated protein kinase 0.005 0.4028 0.5142
Echinococcus granulosus mitogen activated protein kinase 3 0.005 0.4028 0.5142
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.005 0.4028 0.5672
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.005 0.4028 1
Brugia malayi F/Y-rich N-terminus family protein 0.0009 0.0433 0.0433
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0007 0.0286 0.0365
Schistosoma mansoni hypothetical protein 0.0071 0.5892 0.7523
Trichomonas vaginalis helicase, putative 0.0007 0.023 0.0571
Schistosoma mansoni aldehyde dehydrogenase 0.006 0.4922 0.6284
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.4922 1
Brugia malayi hypothetical protein 0.0071 0.5892 0.5892
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.005 0.4028 1
Brugia malayi MAP kinase sur-1 0.005 0.4028 0.4028
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.006 0.4922 0.6284
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0071 0.5892 0.7523
Entamoeba histolytica hypothetical protein 0.0071 0.5892 1
Schistosoma mansoni smad 0.0008 0.0354 0.0452
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.005 0.4028 1
Schistosoma mansoni tar DNA-binding protein 0.0062 0.5093 0.6502
Loa Loa (eye worm) transcription factor SMAD2 0.0117 1 1
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0007 0.023 0.0571
Giardia lamblia Kinase, CMGC MAPK 0.005 0.4028 0.5

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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