TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 434.491 | Formula: C23H26N6O3
H donors: 3 H acceptors: 3 LogP: 3.38 Rotable bonds: 9
Rule of 5 violations (Lipinski): 1
SMILES: COc1ccc(cc1)Nc1nccc(n1)N1CCC(C1)NC(=O)Nc1cccc(c1)OC
InChi: 1S/C23H26N6O3/c1-31-19-8-6-16(7-9-19)25-22-24-12-10-21(28-22)29-13-11-18(15-29)27-23(30)26-17-4-3-5-20(14-17)32-2/h3-10,12,14,18H,11,13,15H2,1-2H3,(H,24,25,28)(H2,26,27,30)
InChiKey: BGYUWAMAYYAXRQ-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0074	0.033	0.1824
Loa Loa (eye worm)	hypothetical protein	0.0072	0.0319	0.2513
Onchocerca volvulus		0.0046	0.0158	0.4777
Brugia malayi	TAR-binding protein	0.0061	0.0253	0.1995
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0046	0.0158	0.0158
Schistosoma mansoni	amine GPCR	0.0046	0.0158	0.0314
Echinococcus granulosus	PHD finger protein rhinoceros	0.0028	0.005	0.0092
Schistosoma mansoni	ATP-binding cassette transporter	0.0226	0.1271	0.253
Loa Loa (eye worm)	hypothetical protein	0.0074	0.033	0.2596
Echinococcus granulosus	serotonin receptor	0.0046	0.0158	0.0288
Schistosoma mansoni	cellular tumor antigen P53	0.0049	0.0178	0.0355
Brugia malayi	G-protein coupled receptor	0.0046	0.0158	0.124
Echinococcus granulosus	fmrfamide receptor	0.0046	0.0158	0.0288
Mycobacterium tuberculosis	Probable esterase LipL	0.0074	0.033	0.0807
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0046	0.0158	0.0314
Schistosoma mansoni	ap endonuclease	0.0039	0.0116	0.023
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.01	0.0492	0.3868
Echinococcus multilocularis	tumor protein p63	0.0335	0.1938	0.1938
Chlamydia trachomatis	glutamine binding protein	0.023	0.1291	0.5
Echinococcus multilocularis	peregrin	0.0028	0.005	0.005
Echinococcus granulosus	Ribosomal protein S1 RNA binding domain	0.014	0.074	0.1355
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0037	0.0107	0.0213
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0072	0.0319	0.2513
Brugia malayi	Receptor family ligand binding region containing protein	0.0072	0.0319	0.2513
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0046	0.0158	0.0288
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0074	0.033	0.0657
Schistosoma mansoni	hypothetical protein	0.0032	0.0071	0.0142
Echinococcus granulosus	g-protein coupled receptor	0.0046	0.0158	0.0288
Brugia malayi	hypothetical protein	0.0046	0.0158	0.124
Echinococcus granulosus	jumonji domain containing protein	0.0039	0.0118	0.0216
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0046	0.0158	0.0158
Brugia malayi	hypothetical protein	0.0046	0.0158	0.124
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0178	0.1404
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0074	0.033	0.0807
Brugia malayi	Glutamate receptor 2 precursor	0.0226	0.1271	1
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0061	0.0253	0.1995
Brugia malayi	G-protein coupled receptor	0.0046	0.0158	0.124
Echinococcus granulosus	glutamate receptor subunit protein glur	0.014	0.074	0.1355
Schistosoma mansoni	glutamate receptor kainate	0.0226	0.1271	0.253
Trypanosoma brucei	hypothetical protein, conserved	0.0074	0.033	1
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0094	0.0454	0.0454
Loa Loa (eye worm)	glutamate receptor 2	0.0226	0.1271	1
Loa Loa (eye worm)	hypothetical protein	0.0074	0.033	0.2596
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0094	0.0454	0.3576
Brugia malayi	Dopamine receptor protein 2	0.0046	0.0158	0.124
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0109	0.0548	1
Echinococcus multilocularis	sex peptide receptor	0.0046	0.0158	0.0158
Echinococcus multilocularis	fmrfamide receptor	0.0046	0.0158	0.0158
Echinococcus granulosus	sex peptide receptor	0.0046	0.0158	0.0288
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0158	0.124
Loa Loa (eye worm)	hypothetical protein	0.0074	0.033	0.2596
Echinococcus granulosus	orexin receptor type 2	0.0046	0.0158	0.0288
Brugia malayi	beta-lactamase family protein	0.0074	0.033	0.2596
Onchocerca volvulus		0.0046	0.0158	0.4777
Brugia malayi	exodeoxyribonuclease III family protein	0.0039	0.0116	0.091
Echinococcus granulosus	Transcription factor JmjC domain containing protein	0.0092	0.0445	0.0814
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0158	0.124
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0158	0.124
Onchocerca volvulus		0.0074	0.033	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0046	0.0158	0.0314
Brugia malayi	RE15519p	0.0046	0.0158	0.124
Brugia malayi	G protein-coupled receptor	0.0046	0.0158	0.124
Loa Loa (eye worm)	hypothetical protein	0.01	0.0492	0.3868
Echinococcus granulosus	7tm_1 domain containing protein	0.0046	0.0158	0.0288
Echinococcus multilocularis	cpg binding protein	0.0061	0.0251	0.0251
Echinococcus granulosus	glutamate NMDA receptor subunit	0.0287	0.1644	0.3009
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0046	0.0158	0.0158
Brugia malayi	follicle stimulating hormone receptor	0.0046	0.0158	0.124
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0046	0.0158	0.0314
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0046	0.0158	0.0158
Echinococcus multilocularis	neuropeptide receptor A26	0.0046	0.0158	0.0158
Schistosoma mansoni	myosin xvIII	0.0046	0.0158	0.0314
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0046	0.0158	0.0314
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0071	0.0561
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0046	0.0158	0.0158
Echinococcus granulosus	Glutamate receptor ionotropic kainate 2	0.0298	0.1713	0.3136
Echinococcus multilocularis	dro:myosuppressin receptor	0.0046	0.0158	0.0158
Brugia malayi	neuropeptide F receptor	0.0046	0.0158	0.124
Echinococcus granulosus	rhodopsin orphan GPCR	0.0046	0.0158	0.0288
Echinococcus granulosus	glutamate receptor ionotropic kainate 3	0.014	0.074	0.1355
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0158	0.124
Trichomonas vaginalis	penicillin-binding protein, putative	0.0074	0.033	1
Echinococcus multilocularis	Glutamate receptor, ionotropic kainate 2	0.0298	0.1713	0.1713
Schistosoma mansoni	tar DNA-binding protein	0.0061	0.0253	0.0505
Echinococcus multilocularis	receptor type guanylyl cyclase	0.0072	0.0319	0.0319
Loa Loa (eye worm)	hypothetical protein	0.0072	0.0319	0.2513
Schistosoma mansoni	opsin-like receptor	0.0046	0.0158	0.0314
Mycobacterium ulcerans	esterase/lipase LipP	0.0074	0.033	0.1824
Plasmodium falciparum	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0039	0.0116	1
Brugia malayi	F/Y-rich N-terminus family protein	0.0027	0.0042	0.0328
Schistosoma mansoni	hypothetical protein	0.0032	0.0071	0.0142
Echinococcus granulosus	neuropeptide receptor	0.0046	0.0158	0.0288
Echinococcus multilocularis	metabotropic glutamate receptor 5	0.0072	0.0319	0.0319
Brugia malayi	metabotropic GABA-B receptor subtype 2	0.0072	0.0319	0.2513
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0046	0.0158	0.124
Onchocerca volvulus		0.0046	0.0158	0.4777
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0158	0.124
Echinococcus multilocularis	GPCR, family 2	0.0032	0.0071	0.0071
Onchocerca volvulus		0.0046	0.0158	0.4777
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0158	0.124
Loa Loa (eye worm)	glutamate receptor	0.0072	0.0319	0.2513
Loa Loa (eye worm)	hypothetical protein	0.0072	0.0319	0.2513
Onchocerca volvulus	Alhambra homolog	0.0028	0.005	0.152
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0158	0.124
Echinococcus granulosus	metabotropic glutamate receptor 5	0.0072	0.0319	0.0585
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0158	0.124
Echinococcus granulosus	g protein coupled receptor	0.0046	0.0158	0.0288
Echinococcus granulosus	neuropeptide receptor A26	0.0046	0.0158	0.0288
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0046	0.0158	0.0314
Echinococcus granulosus	nmda type glutamate receptor	0.0908	0.5465	1
Onchocerca volvulus		0.0046	0.0158	0.4777
Brugia malayi	beta-lactamase family protein	0.0074	0.033	0.2596
Echinococcus multilocularis	nmda type glutamate receptor	0.0908	0.5465	0.5465
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0094	0.0454	0.0905
Brugia malayi	larval opioid receptor	0.0046	0.0158	0.124
Echinococcus multilocularis	tar DNA binding protein	0.0061	0.0253	0.0253
Leishmania major	extracellular receptor, putative	0.0072	0.0319	0.9507
Echinococcus multilocularis	jumonji domain containing protein	0.0039	0.0118	0.0118
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0158	0.124
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0158	0.124
Trypanosoma cruzi	hypothetical protein, conserved	0.0074	0.033	1
Loa Loa (eye worm)	jmjC domain-containing protein	0.0037	0.0107	0.0841
Echinococcus multilocularis	somatostatin receptor	0.0046	0.0158	0.0158
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0032	0.0071	0.013
Brugia malayi	Serotonin receptor	0.0046	0.0158	0.124
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0074	0.033	0.0807
Brugia malayi	Metabotropic glutamate receptor precursor.	0.0072	0.0319	0.2513
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0122	0.0628	0.125
Brugia malayi	ORL1-like opioid receptor	0.0046	0.0158	0.124
Echinococcus granulosus	rhodopsin orphan GPCR	0.0046	0.0158	0.0288
Schistosoma mansoni	neuropeptide receptor	0.0046	0.0158	0.0314
Schistosoma mansoni	glutamate receptor AMPA	0.0226	0.1271	0.253
Brugia malayi	beta-lactamase	0.0074	0.033	0.2596
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0158	0.124
Echinococcus multilocularis	neuropeptide Y receptor	0.0046	0.0158	0.0158
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0158	0.124
Echinococcus granulosus	glutamate receptor NMDA	0.0538	0.3187	0.5833
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0046	0.0158	0.4777
Mycobacterium tuberculosis	Probable glutamine-binding lipoprotein GlnH (GLNBP)	0.023	0.1291	0.4424
Treponema pallidum	amino acid ABC transporter, periplasmic binding protein (hisJ)	0.023	0.1291	1
Brugia malayi	hypothetical protein	0.0046	0.0158	0.124
Schistosoma mansoni	hypothetical protein	0.0032	0.0071	0.0142
Schistosoma mansoni	biogenic amine receptor	0.0046	0.0158	0.0314
Loa Loa (eye worm)	beta-lactamase	0.0074	0.033	0.2596
Loa Loa (eye worm)	transcription factor SMAD2	0.0118	0.0602	0.4736
Schistosoma mansoni	hypothetical protein	0.0331	0.1914	0.3809
Onchocerca volvulus		0.0072	0.0319	0.968
Echinococcus granulosus	receptor type guanylyl cyclase	0.0072	0.0319	0.0585
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0158	0.124
Brugia malayi	hypothetical protein	0.0046	0.0158	0.124
Plasmodium vivax	hypothetical protein, conserved	0.0074	0.033	1
Echinococcus granulosus	GPCR family 2	0.0032	0.0071	0.013
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0046	0.0158	0.124
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0094	0.0454	0.0905
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0158	0.124
Onchocerca volvulus		0.0046	0.0158	0.4777
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0046	0.0158	0.0314
Schistosoma mansoni	metabotropic glutamate receptor	0.0072	0.0319	0.0636
Onchocerca volvulus		0.0046	0.0158	0.4777
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0023	0.0021	0.0043
Mycobacterium tuberculosis	Probable lipase LipE	0.0074	0.033	0.0807
Loa Loa (eye worm)	melatonin receptor type 1A	0.0046	0.0158	0.124
Echinococcus granulosus	neuropeptide Y receptor	0.0046	0.0158	0.0288
Brugia malayi	Serotonin receptor	0.0046	0.0158	0.124
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0046	0.0158	0.0158
Schistosoma mansoni	hypothetical protein	0.0068	0.0297	0.0591
Schistosoma mansoni	neuropeptide receptor	0.0046	0.0158	0.0314
Trichomonas vaginalis	D-aminoacylase, putative	0.0074	0.033	1
Echinococcus multilocularis	g protein coupled receptor	0.0046	0.0158	0.0158
Brugia malayi	putative neuropeptide receptor NPR1	0.0046	0.0158	0.124
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0094	0.0454	0.0832
Brugia malayi	GnHR receptor homolog	0.0046	0.0158	0.124
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0158	0.124
Onchocerca volvulus		0.0046	0.0158	0.4777
Echinococcus granulosus	glutamate receptor ionotrophic AMPA 3	0.0298	0.1713	0.3136
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0046	0.0158	0.0158
Trichomonas vaginalis	D-aminoacylase, putative	0.0074	0.033	1
Echinococcus multilocularis	Glutamate receptor, ionotropic kainate 3	0.037	0.2154	0.2154
Mycobacterium tuberculosis	Probable hydrolase	0.0074	0.033	0.0807
Brugia malayi	Receptor family ligand binding region containing protein	0.0072	0.0319	0.2513
Echinococcus multilocularis	glutamate receptor 2	0.0158	0.085	0.085
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0158	0.124
Loa Loa (eye worm)	hypothetical protein	0.0068	0.0297	0.2337
Trypanosoma cruzi	hypothetical protein, conserved	0.0074	0.033	1
Echinococcus granulosus	biogenic amine 5HT receptor	0.0046	0.0158	0.0288
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0094	0.0454	0.3576
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0046	0.0158	0.124
Schistosoma mansoni	hypothetical protein	0.0046	0.0158	0.0314
Echinococcus multilocularis	serotonin receptor	0.0046	0.0158	0.0158
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0046	0.0158	0.0314
Onchocerca volvulus		0.0046	0.0158	0.4777
Echinococcus multilocularis	dnaJ subfamily B	0.0819	0.4921	0.4921
Wolbachia endosymbiont of Brugia malayi	exonuclease III	0.0039	0.0116	0.5
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0046	0.0158	0.0158
Echinococcus granulosus	glutamate receptor ionotropic kainate	0.014	0.074	0.1355
Echinococcus multilocularis	neuropeptide s receptor	0.0046	0.0158	0.0158
Mycobacterium tuberculosis	Conserved protein	0.0074	0.033	0.0807
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0046	0.0158	0.0314
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0046	0.0158	0.0314
Brugia malayi	hypothetical protein	0.0046	0.0158	0.124
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0158	0.124
Entamoeba histolytica	hypothetical protein	0.0072	0.0319	1
Schistosoma mansoni	glutamate receptor NMDA	0.0287	0.1644	0.3273
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0046	0.0158	0.0288
Schistosoma mansoni	metabotropic glutamate receptor	0.0072	0.0319	0.0636
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0158	0.124
Echinococcus granulosus	glutamate receptor 2	0.0158	0.085	0.1556
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0158	0.124
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0094	0.0454	0.0905
Schistosoma mansoni	hypothetical protein	0.0046	0.0158	0.0314
Echinococcus multilocularis	Transcription factor, JmjC domain containing protein	0.0092	0.0445	0.0445
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0158	0.124
Schistosoma mansoni	tar DNA-binding protein	0.0061	0.0253	0.0505
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0046	0.0158	0.124
Echinococcus granulosus	geminin	0.0331	0.1914	0.3502
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0046	0.0158	0.0158
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0046	0.0158	0.0158
Brugia malayi	Calcitonin receptor-like protein seb-1	0.01	0.0492	0.3868
Echinococcus multilocularis	tyrosine kinase	0.0072	0.0319	0.0319
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0158	0.124
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0046	0.0158	0.0288
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0158	0.124
Brugia malayi	Bromodomain containing protein	0.0028	0.005	0.0395
Schistosoma mansoni	neuropeptide receptor	0.0046	0.0158	0.0314
Brugia malayi	RNA recognition motif domain containing protein	0.0061	0.0253	0.1995
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0158	0.124
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0046	0.0158	0.0158
Schistosoma mansoni	tyrosine kinase	0.0072	0.0319	0.0636
Schistosoma mansoni	tar DNA-binding protein	0.0061	0.0253	0.0505
Echinococcus multilocularis	glutamate receptor NMDA	0.0538	0.3187	0.3187
Loa Loa (eye worm)	hypothetical protein	0.0028	0.005	0.0395
Loa Loa (eye worm)	TYRA-2 protein	0.0046	0.0158	0.124
Echinococcus multilocularis	glutamate receptor subunit protein glur	0.014	0.074	0.074
Loa Loa (eye worm)	neuropeptide F receptor	0.0046	0.0158	0.124
Schistosoma mansoni	biogenic amine receptor	0.0046	0.0158	0.0314
Echinococcus multilocularis	g protein coupled receptor	0.0046	0.0158	0.0158
Brugia malayi	hypothetical protein	0.0046	0.0158	0.124
Onchocerca volvulus		0.0046	0.0158	0.4777
Loa Loa (eye worm)	receptor family ligand binding region containing protein	0.0072	0.0319	0.2513
Loa Loa (eye worm)	hypothetical protein	0.0072	0.0319	0.2513
Echinococcus multilocularis	nmda type glutamate receptor	0.061	0.363	0.363
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0158	0.124
Leishmania major	hypothetical protein, conserved	0.0074	0.033	1
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0046	0.0158	0.124
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0158	0.124
Echinococcus granulosus	nmda type glutamate receptor	0.061	0.363	0.6643
Brugia malayi	latrophilin 2 splice variant baaae	0.0068	0.0297	0.2337
Loa Loa (eye worm)	metabotropic glutamate receptor 8	0.0072	0.0319	0.2513
Echinococcus multilocularis	glutamate receptor ionotropic kainate	0.014	0.074	0.074
Loa Loa (eye worm)	hypothetical protein	0.0072	0.0319	0.2513
Echinococcus multilocularis	Glutamate receptor, ionotropic kainate 2	0.0298	0.1713	0.1713
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0158	0.124
Loa Loa (eye worm)	hypothetical protein	0.0072	0.0319	0.2513
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0046	0.0158	0.0288
Loa Loa (eye worm)	MH2 domain-containing protein	0.0118	0.0602	0.4736
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0046	0.0158	0.0158
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0074	0.033	0.2596
Echinococcus multilocularis	neuropeptide Y receptor	0.0046	0.0158	0.0158
Brugia malayi	hypothetical protein	0.0046	0.0158	0.124
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0046	0.0158	0.0314
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0158	0.124
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0158	0.124
Echinococcus multilocularis	Ribosomal protein S1, RNA binding domain	0.014	0.074	0.074
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0046	0.0158	0.124
Brugia malayi	metabotropic glutamate receptor type 2	0.0072	0.0319	0.2513
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0158	0.124
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0094	0.0454	0.0454
Echinococcus multilocularis	glutamate (NMDA) receptor subunit	0.0287	0.1644	0.1644
Toxoplasma gondii	exonuclease III APE	0.0039	0.0116	0.1316
Mycobacterium tuberculosis	Probable lipase LipD	0.0074	0.033	0.0807
Schistosoma mansoni	neuropeptide F-like receptor	0.0046	0.0158	0.0314
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0046	0.0158	0.124
Brugia malayi	Dopamine receptor	0.0046	0.0158	0.124
Echinococcus multilocularis	lysine specific demethylase 5A	0.0034	0.0087	0.0087
Schistosoma mansoni	cpg binding protein	0.0061	0.0251	0.05
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0058	0.0231	0.1817
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	0.0039	0.0116	0.0212
Echinococcus granulosus	rhodopsin orphan GPCR	0.0046	0.0158	0.0288
Echinococcus multilocularis	PHD finger protein rhinoceros	0.0028	0.005	0.005
Onchocerca volvulus		0.0072	0.0319	0.968
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0158	0.124
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0046	0.0158	0.0288
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0046	0.0158	0.0288
Echinococcus multilocularis	geminin	0.0331	0.1914	0.1914
Loa Loa (eye worm)	RNA binding protein	0.0061	0.0253	0.1995
Schistosoma mansoni	hypothetical protein	0.014	0.074	0.1473
Echinococcus multilocularis	fmrfamide receptor	0.0046	0.0158	0.0158
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0046	0.0158	0.124
Loa Loa (eye worm)	hypothetical protein	0.0074	0.033	0.2596
Echinococcus granulosus	biogenic amine 5HT receptor	0.0046	0.0158	0.0288
Echinococcus granulosus	g protein coupled receptor	0.0046	0.0158	0.0288
Schistosoma mansoni	amine GPCR	0.0046	0.0158	0.0314
Brugia malayi	G protein-coupled receptor F59B2.13	0.0046	0.0158	0.124
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0032	0.0071	0.0561
Schistosoma mansoni	amine GPCR	0.0046	0.0158	0.0314
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0037	0.0107	0.0213
Schistosoma mansoni	hypothetical protein	0.0046	0.0158	0.0314
Echinococcus granulosus	beta LACTamase domain containing family member	0.0074	0.033	0.0604
Echinococcus granulosus	metabotropic glutamate receptor 2	0.0072	0.0319	0.0585
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0046	0.0158	0.0314
Schistosoma mansoni	jumonji domain containing protein	0.0073	0.0328	0.0653
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0174	0.1369
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0046	0.0158	0.0314
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0158	0.124
Schistosoma mansoni	neuropeptide f receptor 76f	0.0046	0.0158	0.0314
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0158	0.124
Onchocerca volvulus		0.0046	0.0158	0.4777
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0158	0.124
Echinococcus granulosus	allatostatin A receptor	0.0046	0.0158	0.0288
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0046	0.0158	0.0314
Chlamydia trachomatis	arginine ABC transporter substrate-binding protein ArtJ	0.023	0.1291	0.5
Echinococcus multilocularis	glutamate receptor 2	0.0298	0.1713	0.1713
Mycobacterium ulcerans	beta-lactamase	0.0074	0.033	0.1824
Brugia malayi	Latrophilin receptor protein 2	0.0032	0.0071	0.0561
Echinococcus granulosus	lysine specific demethylase 5A	0.0037	0.0107	0.0195
Echinococcus granulosus	neuropeptides capa receptor	0.0046	0.0158	0.0288
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	0.0039	0.0116	0.0116
Echinococcus multilocularis	serotonin receptor	0.0046	0.0158	0.0158
Brugia malayi	sulfakinin receptor protein	0.0046	0.0158	0.124
Echinococcus multilocularis	neuropeptide receptor	0.0046	0.0158	0.0158
Brugia malayi	Guanylyl cyclase protein 23	0.0072	0.0319	0.2513
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.0039	0.0116	0.091
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0046	0.0158	0.0158
Echinococcus granulosus	rhodopsin orphan GPCR	0.0046	0.0158	0.0288
Treponema pallidum	amino acid ABC transporter, periplasmic binding protein	0.023	0.1291	1
Schistosoma mansoni	tyrosine kinase	0.0072	0.0319	0.0636
Loa Loa (eye worm)	hypothetical protein	0.0072	0.0319	0.2513
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0158	0.124
Schistosoma mansoni	growth hormone secretagogue receptor	0.0046	0.0158	0.0314
Echinococcus granulosus	peregrin	0.0028	0.005	0.0092
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0074	0.033	0.0657
Loa Loa (eye worm)	G-protein coupled receptor	0.0046	0.0158	0.124
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0046	0.0158	0.0158
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0158	0.124
Mycobacterium ulcerans	hypothetical protein	0.0074	0.033	0.1824
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0032	0.0071	0.0071
Brugia malayi	putative neuropeptide receptor	0.0046	0.0158	0.124
Brugia malayi	PHD-finger family protein	0.0028	0.005	0.0395
Mycobacterium leprae	Probable lipase LipE	0.0074	0.033	0.5
Echinococcus multilocularis	neuropeptides capa receptor	0.0046	0.0158	0.0158
Loa Loa (eye worm)	hypothetical protein	0.0072	0.0319	0.2513
Trichomonas vaginalis	D-aminoacylase, putative	0.0074	0.033	1
Brugia malayi	jmjC domain containing protein	0.0037	0.0107	0.0841
Echinococcus granulosus	tar DNA binding protein	0.0061	0.0253	0.0464
Brugia malayi	RNA binding protein	0.0061	0.0253	0.1995
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0046	0.0158	0.0314
Brugia malayi	MH2 domain containing protein	0.0118	0.0602	0.4736
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0032	0.0071	0.013
Schistosoma mansoni	glutamate receptor kainate	0.0226	0.1271	0.253
Schistosoma mansoni	bromodomain-containing nuclear protein 1 brd1	0.0028	0.005	0.01
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0074	0.033	0.0807
Echinococcus multilocularis	orexin receptor type 2	0.0046	0.0158	0.0158
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0046	0.0158	0.0158
Echinococcus multilocularis	g-protein coupled receptor	0.0046	0.0158	0.0158
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0158	0.124
Echinococcus granulosus	neuropeptide receptor	0.0046	0.0158	0.0288
Onchocerca volvulus		0.0074	0.033	1
Echinococcus multilocularis	glutamate receptor, ionotrophic, AMPA 3	0.0298	0.1713	0.1713
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0046	0.0158	0.0158
Toxoplasma gondii	ABC1 family protein	0.0074	0.033	0.5623
Loa Loa (eye worm)	TAR-binding protein	0.0061	0.0253	0.1995
Echinococcus multilocularis	glutamate receptor 2	0.0226	0.1271	0.1271
Echinococcus granulosus	Glutamate receptor ionotropic kainate 2	0.0298	0.1713	0.3136
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0046	0.0158	0.0158
Loa Loa (eye worm)	glutamate receptor 1	0.0226	0.1271	1
Mycobacterium tuberculosis	Conserved protein	0.0074	0.033	0.0807
Echinococcus granulosus	dnaJ subfamily B	0.0819	0.4921	0.9005
Loa Loa (eye worm)	G-protein coupled receptor	0.0046	0.0158	0.124
Brugia malayi	hypothetical protein	0.0046	0.0158	0.124
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0046	0.0158	0.0314
Loa Loa (eye worm)	hypothetical protein	0.0072	0.0319	0.2513
Brugia malayi	AKH receptor	0.0046	0.0158	0.124
Schistosoma mansoni	glutamate receptor NMDA	0.0836	0.5024	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0046	0.0158	0.0314
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0046	0.0158	0.124
Schistosoma mansoni	hypothetical protein	0.0046	0.0158	0.0314
Echinococcus multilocularis	Glutamate receptor, ionotropic kainate 2	0.0298	0.1713	0.1713
Echinococcus multilocularis	metabotropic glutamate receptor 2	0.0072	0.0319	0.0319
Schistosoma mansoni	tar DNA-binding protein	0.0061	0.0253	0.0505
Onchocerca volvulus		0.0046	0.0158	0.4777
Brugia malayi	Melatonin receptor type 1A	0.0046	0.0158	0.124
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0158	0.124
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0046	0.0158	0.0158
Trichomonas vaginalis	esterase, putative	0.0074	0.033	1
Schistosoma mansoni	amine GPCR	0.0046	0.0158	0.0314
Schistosoma mansoni	hypothetical protein	0.0331	0.1914	0.3809
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0046	0.0158	0.0314
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.01	0.0492	0.3868
Loa Loa (eye worm)	neuropeptide F receptor	0.0046	0.0158	0.124
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0046	0.0158	0.0314
Echinococcus granulosus	G protein coupled receptor 139	0.0046	0.0158	0.0288
Schistosoma mansoni	opsin-like receptor	0.0046	0.0158	0.0314
Trichomonas vaginalis	penicillin-binding protein, putative	0.0074	0.033	1
Schistosoma mansoni	biogenic amine receptor	0.0046	0.0158	0.0314
Echinococcus granulosus	g protein coupled receptor	0.0046	0.0158	0.0288
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0072	0.0319	0.2513
Echinococcus multilocularis	atrial natriuretic peptide receptor	0.0072	0.0319	0.0319
Echinococcus granulosus	tm gpcr rhodopsin	0.0046	0.0158	0.0288
Echinococcus granulosus	somatostatin receptor	0.0046	0.0158	0.0288
Echinococcus multilocularis	allatostatin A receptor	0.0046	0.0158	0.0158
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0046	0.0158	0.0314
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0072	0.0319	0.2513
Echinococcus granulosus	neuropeptides capa receptor	0.0046	0.0158	0.0288
Onchocerca volvulus		0.0046	0.0158	0.4777
Schistosoma mansoni	adenoreceptor	0.0046	0.0158	0.0314
Echinococcus multilocularis	g protein coupled receptor	0.0046	0.0158	0.0158
Echinococcus granulosus	dro:myosuppressin receptor	0.0046	0.0158	0.0288
Echinococcus granulosus	neuropeptide s receptor	0.0046	0.0158	0.0288
Echinococcus granulosus	tm gpcr rhodopsin	0.0046	0.0158	0.0288
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0046	0.0158	0.0158
Echinococcus granulosus	glutamate receptor 2	0.0298	0.1713	0.3136
Echinococcus multilocularis	NMDA receptor	0.014	0.074	0.074
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0074	0.033	0.2596
Schistosoma mansoni	glutamate receptor kainate	0.0226	0.1271	0.253
Echinococcus granulosus	Glutamate receptor ionotropic kainate 2	0.0298	0.1713	0.3136
Brugia malayi	Dopamine receptor protein 1	0.0046	0.0158	0.124
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0046	0.0158	0.0158
Mycobacterium ulcerans	lipase LipD	0.0074	0.033	0.1824
Echinococcus granulosus	hypothetical protein	0.0046	0.0158	0.0288
Schistosoma mansoni	histamine h1 receptor	0.0046	0.0158	0.0314
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0074	0.033	0.033
Echinococcus granulosus	tm gpcr rhodopsin	0.0046	0.0158	0.0288
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.047	0.2772	1
Loa Loa (eye worm)	metabotropic GABA-B receptor subtype 2	0.0072	0.0319	0.2513
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0158	0.124
Schistosoma mansoni	amine GPCR	0.0046	0.0158	0.0314
Brugia malayi	jmjC domain containing protein	0.0092	0.0445	0.3498
Mycobacterium leprae	conserved hypothetical protein	0.0074	0.033	0.5
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0046	0.0158	0.0288
Echinococcus granulosus	tumor protein p63	0.0335	0.1938	0.3546
Echinococcus granulosus	tyrosine kinase	0.0072	0.0319	0.0585
Schistosoma mansoni	ap endonuclease	0.0039	0.0116	0.023
Brugia malayi	neuropeptide F receptor	0.0046	0.0158	0.124
Echinococcus granulosus	cpg binding protein	0.0061	0.0251	0.046
Echinococcus granulosus	neuropeptide FF receptor 2	0.0046	0.0158	0.0288
Schistosoma mansoni	opsin-like receptor	0.0046	0.0158	0.0314
Schistosoma mansoni	neuropeptide receptor	0.0046	0.0158	0.0314
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0046	0.0158	0.0314
Schistosoma mansoni	hypothetical protein	0.0032	0.0071	0.0142
Schistosoma mansoni	cpg binding protein	0.0058	0.0231	0.046
Schistosoma mansoni	tar DNA-binding protein	0.0061	0.0253	0.0505
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0032	0.0071	0.0071
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0046	0.0158	0.124
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0046	0.0158	0.0314
Schistosoma mansoni	cpg binding protein	0.0061	0.0251	0.05
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0032	0.0071	0.0561
Echinococcus granulosus	rhodopsin orphan GPCR	0.0046	0.0158	0.0288
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0158	0.124
Brugia malayi	hypothetical protein	0.0072	0.0319	0.2513
Loa Loa (eye worm)	hypothetical protein	0.0074	0.033	0.2596
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0046	0.0158	0.0158
Onchocerca volvulus		0.0046	0.0158	0.4777
Trypanosoma cruzi	extracellular receptor, putative	0.0072	0.0319	0.9507
Echinococcus granulosus	atrial natriuretic peptide receptor	0.0072	0.0319	0.0585
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0158	0.124
Echinococcus granulosus	rhodopsin orphan GPCR	0.0046	0.0158	0.0288
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0158	0.124
Onchocerca volvulus		0.0049	0.0178	0.5408
Loa Loa (eye worm)	PHD-finger family protein	0.0028	0.005	0.0395
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0046	0.0158	0.0314
Echinococcus multilocularis	neuropeptides capa receptor	0.0046	0.0158	0.0158
Echinococcus multilocularis	neuropeptide receptor	0.0046	0.0158	0.0158
Brugia malayi	CXXC zinc finger family protein	0.0058	0.0231	0.1817
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0046	0.0158	0.4777
Loa Loa (eye worm)	jmjC domain-containing protein	0.0058	0.0235	0.1847
Giardia lamblia	Endonuclease/Exonuclease/phosphatase	0.0039	0.0116	1
Onchocerca volvulus		0.0046	0.0158	0.4777
Plasmodium vivax	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0039	0.0116	0.2339
Brugia malayi	hypothetical protein	0.0046	0.0158	0.124
Onchocerca volvulus		0.0046	0.0158	0.4777
Brugia malayi	Glutamate receptor 1 precursor	0.0226	0.1271	1
Onchocerca volvulus		0.0046	0.0158	0.4777
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0158	0.124
Brugia malayi	hypothetical protein	0.0046	0.0158	0.124
Schistosoma mansoni	glutamate receptor AMPA	0.0226	0.1271	0.253
Schistosoma mansoni	protein kinase	0.0072	0.0319	0.0636
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0046	0.0158	0.0158
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0046	0.0158	0.0288
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0046	0.0158	0.0158
Mycobacterium tuberculosis	Conserved protein	0.0074	0.033	0.0807
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0158	0.124
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0094	0.0454	0.0832
Loa Loa (eye worm)	hypothetical protein	0.0074	0.033	0.2596
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0046	0.0158	0.0314
Onchocerca volvulus		0.0058	0.0231	0.6999
Onchocerca volvulus		0.0074	0.033	1
Schistosoma mansoni	neuropeptide F-like receptor	0.0046	0.0158	0.0314
Echinococcus multilocularis	G protein coupled receptor 139	0.0046	0.0158	0.0158
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0046	0.0158	0.0288
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0158	0.124
Onchocerca volvulus	Atrial natriuretic peptide receptor 3 homolog	0.0072	0.0319	0.968
Echinococcus granulosus	neuropeptide Y receptor	0.0046	0.0158	0.0288
Echinococcus granulosus	rhodopsin orphan GPCR	0.0046	0.0158	0.0288
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0158	0.124
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0046	0.0158	0.0314
Schistosoma mansoni	hypothetical protein	0.0819	0.4921	0.9794
Echinococcus granulosus	7TM GPCR rhodopsin	0.0046	0.0158	0.0288
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0046	0.0158	0.0314
Mycobacterium ulcerans	glutamine-binding lipoprotein GlnH	0.023	0.1291	1
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0046	0.0158	0.124
Schistosoma mansoni	hypothetical protein	0.0028	0.005	0.01
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0046	0.0158	0.0158

Activities

Activity type	Activity value	Assay description	Source	Reference
Inhibition (functional)	= 0 %	GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 LDH activity, using an LDH reporter assay. Test compounds present at 2uM	ChEMBL.	20485427
Inhibition (functional)	= 0.29 %	ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmGLUT1 that are glucose transport deficient and complemented with the human glucose transporter GLUT1. Activity is measured by DNA content using SYBR green in vitro	ChEMBL.	No reference
Inhibition (functional)	= 0.51 %	ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmGT2 that are glucose transport deficient and complemented with the L. Mexicana glucose transporter 2. Activity is measured by by DNA content using SYBR green in vitro	ChEMBL.	No reference
Inhibition (functional)	= 0.74 %	ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmPfHT that are glucose transport deficient and complemented with the Plasmodium falciparum hexose transporter. Activity is measured by by DNA content using SYBR green in vitro	ChEMBL.	No reference
Inhibition (functional)	= 23 %	GSK_TCMDC: Percent inhibition of human HepG2 cell line. Test compounds present at 10uM.	ChEMBL.	20485427
Inhibition (functional)	= 48 %	GSK_TCMDC: Inhibition of Plasmodium falciparum Dd2 in whole red blood cells, using parasite LDH activity as an index of growth. Test compounds present at 2uM	ChEMBL.	20485427
Inhibition (functional)	= 99 %	GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 in whole red blood cells, using parasite LDH activity as an index of growth. Test compounds present at 2uM	ChEMBL.	20485427
Inhibition frequency index (IFI) (functional)	= 1.54	Inhibition Frequency Index (IFI)	GSK.	20485427
Percent growth inhibition (functional)	= -1 %	Percent inhibition of P. falciparum lactate dehydrogenase activity (at 2 uM)	GSK.	20485427
Percent growth inhibition (functional)	= 23 %	Percent inhibition of HepG2 growth (at 10 uM)	GSK.	20485427
Percent growth inhibition (functional)	= 48 %	Percent inhibition of P. falciparum Dd2 growth (at 2 uM)	GSK.	20485427
Percent growth inhibition (functional)	= 99 %	Percent inhibition of P. falciparum 3D7 growth (at 2 uM)	GSK.	20485427
XC50 (functional)	= 6.37	XC50 determination of P. falciparum 3D7 growth	GSK.	20485427
XC50 (functional)	= 0.42358 uM	GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 in whole erythrocytes, using parasite LDH activity as an index of growth.	ChEMBL.	20485427

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL534552
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Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 591268