Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | Probable cytochrome P450 143 Cyp143 | 0.0187 | 0.0915 | 0.5 |
Mycobacterium tuberculosis | Possible cytochrome P450 135A1 Cyp135A1 | 0.0187 | 0.0915 | 0.5 |
Loa Loa (eye worm) | cytochrome P450 | 0.0187 | 0.0915 | 0.0915 |
Mycobacterium tuberculosis | Probable cytochrome P450 125 Cyp125 | 0.0187 | 0.0915 | 0.5 |
Mycobacterium ulcerans | cytochrome P450 185A4 Cyp185A4 | 0.033 | 0.3985 | 0.338 |
Mycobacterium tuberculosis | Probable cytochrome P450 140 Cyp140 | 0.0187 | 0.0915 | 0.5 |
Echinococcus granulosus | tumor protein p63 | 0.0379 | 0.5032 | 1 |
Mycobacterium leprae | putative cytochrome p450 | 0.0187 | 0.0915 | 0.5 |
Loa Loa (eye worm) | CYP4Cod1 | 0.033 | 0.3985 | 0.3985 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0292 | 0.3173 | 0.3173 |
Trypanosoma brucei | cytochrome P450, putative | 0.033 | 0.3985 | 1 |
Mycobacterium tuberculosis | Probable cytochrome P450 144 Cyp144 | 0.0187 | 0.0915 | 0.5 |
Echinococcus multilocularis | tumor protein p63 | 0.0379 | 0.5032 | 1 |
Schistosoma mansoni | glutaminase | 0.0612 | 1 | 1 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0237 | 0.1986 | 0.1986 |
Mycobacterium tuberculosis | Probable cytochrome P450 139 Cyp139 | 0.0187 | 0.0915 | 0.5 |
Mycobacterium leprae | Conserved hypothetical protein | 0.0187 | 0.0915 | 0.5 |
Brugia malayi | Cytochrome P450 family protein | 0.033 | 0.3985 | 0.338 |
Mycobacterium tuberculosis | Probable cytochrome P450 138 Cyp138 | 0.0187 | 0.0915 | 0.5 |
Mycobacterium tuberculosis | Cytochrome P450 121 Cyp121 | 0.0187 | 0.0915 | 0.5 |
Loa Loa (eye worm) | glutaminase | 0.0612 | 1 | 1 |
Mycobacterium tuberculosis | Probable cytochrome P450 monooxygenase 142 Cyp142 | 0.0187 | 0.0915 | 0.5 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.033 | 0.3985 | 0.3985 |
Onchocerca volvulus | 0.0269 | 0.2685 | 0.5 | |
Mycobacterium tuberculosis | Probable cytochrome P450 136 Cyp136 | 0.0187 | 0.0915 | 0.5 |
Trypanosoma cruzi | cytochrome P450, putative | 0.033 | 0.3985 | 1 |
Mycobacterium tuberculosis | Probable cytochrome P450 124 Cyp124 | 0.0187 | 0.0915 | 0.5 |
Mycobacterium tuberculosis | Probable cytochrome P450 130 Cyp130 | 0.0187 | 0.0915 | 0.5 |
Brugia malayi | Pre-SET motif family protein | 0.0237 | 0.1986 | 0.1179 |
Mycobacterium tuberculosis | Probable cytochrome P450 137 Cyp137 | 0.0187 | 0.0915 | 0.5 |
Leishmania major | cytochrome p450-like protein | 0.033 | 0.3985 | 1 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.033 | 0.3985 | 0.3985 |
Mycobacterium tuberculosis | Possible cytochrome P450 126 Cyp126 | 0.0187 | 0.0915 | 0.5 |
Mycobacterium tuberculosis | Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) | 0.0187 | 0.0915 | 0.5 |
Mycobacterium tuberculosis | Possible cytochrome P450 135B1 Cyp135B1 | 0.0187 | 0.0915 | 0.5 |
Brugia malayi | Cytochrome P450 family protein | 0.0292 | 0.3173 | 0.2485 |
Trypanosoma cruzi | cytochrome P450, putative | 0.033 | 0.3985 | 1 |
Mycobacterium ulcerans | glutaminase | 0.0612 | 1 | 1 |
Brugia malayi | Cytochrome P450 family protein | 0.033 | 0.3985 | 0.338 |
Mycobacterium tuberculosis | Probable cytochrome P450 128 Cyp128 | 0.0187 | 0.0915 | 0.5 |
Brugia malayi | glutaminase DH11.1 | 0.0612 | 1 | 1 |
Mycobacterium tuberculosis | Probable cytochrome P450 123 Cyp123 | 0.0187 | 0.0915 | 0.5 |
Mycobacterium tuberculosis | Probable cytochrome P450 132 Cyp132 | 0.0187 | 0.0915 | 0.5 |
Mycobacterium tuberculosis | Probable cytochrome P450 141 Cyp141 | 0.0187 | 0.0915 | 0.5 |
Trichomonas vaginalis | glutaminase, putative | 0.0612 | 1 | 1 |
Toxoplasma gondii | cytochrome p450 superfamily protein | 0.0187 | 0.0915 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | = 0 | In vitro agonist activity against alpha-2A adrenergic receptor in rat vas deferens | ChEMBL. | 2567783 |
Potency (functional) | 0 | In vitro antagonistic activity against alpha-1 adrenergic receptor in rat anococcygeus; Ag means compound was agonist. | ChEMBL. | 2567783 |
Potency (functional) | = 0.0005 | In vitro antagonistic activity of the compound against alpha-2A adrenergic receptor in rat vas deferens | ChEMBL. | 2567783 |
Potency (functional) | = 0.002 | In vitro agonist activity against alpha-1 adrenergic receptor in rat anococcygeus | ChEMBL. | 2567783 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.