TDR Targets

Basic information

Technical information

TDR Targets ID: 609380
Name: N-(2,5-dimethoxyphenyl)-2-[[3-(4-methoxypheny l)-1,2,4-thiadiazol-5-yl]sulfanyl]acetamide
MW: 417.502 | Formula: C19H19N3O4S2
H donors: 1 H acceptors: 3 LogP: 4.08 Rotable bonds: 9
Rule of 5 violations (Lipinski): 1
SMILES: COc1ccc(cc1)c1nsc(n1)SCC(=O)Nc1cc(OC)ccc1OC
InChi: 1S/C19H19N3O4S2/c1-24-13-6-4-12(5-7-13)18-21-19(28-22-18)27-11-17(23)20-15-10-14(25-2)8-9-16(15)26-3/h4-10H,11H2,1-3H3,(H,20,23)
InChiKey: GXRFBNQSUZRCGD-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

N-(2,5-dimethoxyphenyl)-2-[[3-(4-methoxyphenyl)-1,2,4-thiadiazol-5-yl]thio]acetamide
N-(2,5-dimethoxyphenyl)-2-[[3-(4-methoxyphenyl)-1,2,4-thiadiazol-5-yl]sulfanyl]ethanamide
ZINC03007379

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus granulosus	fetal alzheimer antigen falz	0.0022	0.0256	0.049
Loa Loa (eye worm)	TAR-binding protein	0.0125	0.522	1
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0125	0.522	1
Loa Loa (eye worm)	PHD-finger family protein	0.002	0.0165	0.0317
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0045	0.1375	0.2634
Schistosoma mansoni	tar DNA-binding protein	0.0125	0.522	1
Loa Loa (eye worm)	hypothetical protein	0.0038	0.1006	0.1928
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0045	0.1375	0.2634
Onchocerca volvulus	Protein ultraspiracle homolog	0.0017	0	0.5
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0059	0.2017	0.3865
Loa Loa (eye worm)	hypothetical protein	0.0069	0.254	0.4866
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0045	0.1375	0.2634
Echinococcus granulosus	zinc finger protein	0.0019	0.0115	0.0221
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0035	0.0891	0.1706
Onchocerca volvulus		0.0017	0	0.5
Loa Loa (eye worm)	bromodomain containing protein	0.0017	0.0025	0.0047
Schistosoma mansoni	hypothetical protein	0.002	0.0165	0.0317
Brugia malayi	TAR-binding protein	0.0125	0.522	1
Brugia malayi	Bromodomain containing protein	0.0074	0.2742	0.5254
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0017	0	0.5
Brugia malayi	Bromodomain containing protein	0.0038	0.1003	0.1921
Schistosoma mansoni	acetyl-CoA C-acetyltransferase	0.0022	0.0256	0.049
Onchocerca volvulus	Bile acid receptor homolog	0.0017	0	0.5
Schistosoma mansoni	tar DNA-binding protein	0.0125	0.522	1
Trypanosoma cruzi	cyclic nucleotide phosphodiesterase	0.0224	1	0.5
Echinococcus granulosus	tar DNA binding protein	0.0125	0.522	1
Brugia malayi	RNA recognition motif domain containing protein	0.0125	0.522	1
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0059	0.2017	0.3865
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0045	0.1375	0.2634
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0045	0.1375	0.2634
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0045	0.1375	0.2634
Schistosoma mansoni	tar DNA-binding protein	0.0125	0.522	1
Brugia malayi	PHD-finger family protein	0.0024	0.0368	0.0705
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0035	0.0891	0.1706
Echinococcus multilocularis	zinc finger protein	0.0019	0.0115	0.0221
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0045	0.1375	0.2634
Schistosoma mansoni	tar DNA-binding protein	0.0125	0.522	1
Schistosoma mansoni	zinc finger protein	0.0019	0.0115	0.0221
Brugia malayi	RNA binding protein	0.0125	0.522	1
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0045	0.1375	0.2634
Schistosoma mansoni	tar DNA-binding protein	0.0125	0.522	1
Loa Loa (eye worm)	hypothetical protein	0.004	0.1118	0.2143
Schistosoma mansoni	bromodomain containing protein	0.0062	0.2187	0.419
Echinococcus multilocularis	tar DNA binding protein	0.0125	0.522	1
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0045	0.1375	0.2634
Echinococcus multilocularis	fetal alzheimer antigen, falz	0.0022	0.0256	0.049
Loa Loa (eye worm)	hypothetical protein	0.0042	0.1209	0.2316
Loa Loa (eye worm)	RNA binding protein	0.0125	0.522	1
Trypanosoma brucei	3', 5'-cyclic nucleotide phosphodiesterase, putative	0.0224	1	0.5

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 609380