TDR Targets

Basic information

Technical information

TDR Targets ID: 611615
Name: ethyl 3-[(2-methylbenzoyl)amino]-1-benzofuran -2-carboxylate
MW: 323.343 | Formula: C19H17NO4
H donors: 1 H acceptors: 2 LogP: 4.63 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: CCOC(=O)c1oc2c(c1NC(=O)c1ccccc1C)cccc2
InChi: 1S/C19H17NO4/c1-3-23-19(22)17-16(14-10-6-7-11-15(14)24-17)20-18(21)13-9-5-4-8-12(13)2/h4-11H,3H2,1-2H3,(H,20,21)
InChiKey: WUBBZESAXVQTTR-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

ethyl 3-[(2-methylbenzoyl)amino]benzofuran-2-carboxylate
3-[[(2-methylphenyl)-oxomethyl]amino]-2-benzofurancarboxylic acid ethyl ester
3-[(2-methylbenzoyl)amino]benzofuran-2-carboxylic acid ethyl ester
ethyl 3-[(2-methylphenyl)carbonylamino]-1-benzofuran-2-carboxylate
ZINC00253014

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Brugia malayi	latrophilin 2 splice variant baaae	0.0038	0.075	0.1322
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0019	0.0268	0.0981
Schistosoma mansoni	chromobox protein-related (chromobox 1) (heterochromatin 1)	0.0013	0.0105	0.0069
Schistosoma mansoni	hypothetical protein	0.0124	0.2969	0.2943
Loa Loa (eye worm)	hypothetical protein	0.001	0.0037	0.006
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0019	0.0268	0.0981
Brugia malayi	nuclear receptor NHR-88	0.001	0.0037	0.0065
Leishmania major	aminopeptidase, putative,metallo-peptidase, Clan MF, Family M17	0.0044	0.0923	0.1251
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.001	0.0037	0.0034
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.001	0.0037	0.0034
Echinococcus granulosus	cpg binding protein	0.0029	0.0539	0.0537
Loa Loa (eye worm)	hypothetical protein	0.0055	0.1199	0.2108
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.001	0.0037	0.0065
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.001	0.0037	0.0034
Schistosoma mansoni	hypothetical protein	0.0017	0.023	0.0193
Schistosoma mansoni	ap endonuclease	0.0019	0.0267	0.0231
Onchocerca volvulus		0.0013	0.0105	0.0723
Brugia malayi	photoreceptor-specific nuclear receptor	0.001	0.0037	0.0065
Echinococcus multilocularis	leucyl aminopeptidase	0.0044	0.0923	0.092
Onchocerca volvulus	Heterochromatin protein 1 homolog	0.0043	0.0892	0.9032
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.001	0.0037	0.006
Schistosoma mansoni	chromobox protein	0.0077	0.1763	0.1732
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0019	0.0268	0.0981
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0028	0.0498	0.0873
Echinococcus granulosus	Chromo domain	0.0013	0.0105	0.0102
Schistosoma mansoni	hypothetical protein	0.0017	0.023	0.0193
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0105	0.018
Loa Loa (eye worm)	hypothetical protein	0.0228	0.5677	1
Echinococcus granulosus	GPCR family 2	0.0017	0.023	0.0227
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0017	0.023	0.0227
Brugia malayi	Ubiquitin carboxyl-terminal hydrolase family protein	0.0044	0.0923	0.1626
Brugia malayi	cytosol aminopeptidase	0.0044	0.0923	0.1626
Echinococcus granulosus	leucyl aminopeptidase	0.0044	0.0923	0.092
Brugia malayi	ecdysteroid receptor	0.001	0.0037	0.0065
Trypanosoma brucei	metallo-peptidase, Clan MF, Family M17	0.0044	0.0923	0.1251
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	0.0019	0.0267	0.0264
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0105	0.018
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0053	0.114	0.1915
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.001	0.0037	0.006
Onchocerca volvulus		0.0013	0.0105	0.0723
Leishmania major	cytosolic leucyl aminopeptidase,metallo-peptidase, Clan MF, Family M17	0.0222	0.5511	1
Echinococcus multilocularis	geminin	0.017	0.4162	0.416
Schistosoma mansoni	survival motor neuron protein	0.0047	0.0983	0.095
Leishmania major	aminopeptidase, putative,metallo-peptidase, Clan MF, Family M17	0.0044	0.0923	0.1251
Echinococcus multilocularis	leucyl aminopeptidase	0.0044	0.0923	0.092
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.001	0.0037	0.0065
Loa Loa (eye worm)	hypothetical protein	0.001	0.0037	0.006
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0055	0.1199	0.2108
Echinococcus granulosus	geminin	0.017	0.4162	0.416
Trichomonas vaginalis	conserved hypothetical protein	0.0016	0.0192	0.0526
Schistosoma mansoni	hypothetical protein	0.017	0.4162	0.414
Echinococcus multilocularis	chromobox protein 1	0.0077	0.1763	0.176
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.001	0.0037	0.0065
Trypanosoma brucei	metallo-peptidase, Clan MF, Family M17	0.0044	0.0923	0.1251
Schistosoma mansoni	hypothetical protein	0.0013	0.0105	0.0069
Schistosoma mansoni	hypothetical protein	0.0396	1	1
Loa Loa (eye worm)	aminopeptidase in chromosome III	0.0044	0.0923	0.1621
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.0047	0.0983	0.1732
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0892	0.1567
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0017	0.023	0.0227
Entamoeba histolytica	hypothetical protein	0.0035	0.068	1
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0105	0.018
Trypanosoma brucei	metallo-peptidase, Clan MF, Family M17	0.0222	0.5511	1
Plasmodium vivax	M17 leucyl aminopeptidase, putative	0.0222	0.5511	1
Brugia malayi	Protein cec-1.	0.0013	0.0105	0.0185
Echinococcus granulosus	Mitotic checkpoint protein PRCC C terminal	0.0124	0.2969	0.2967
Chlamydia trachomatis	cytosol aminopeptidase	0.0222	0.5511	0.5
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0017	0.023	0.0227
Echinococcus multilocularis	FTZ F1 alpha	0.001	0.0037	0.0034
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.001	0.0037	0.0065
Brugia malayi	steroid hormone receptor	0.001	0.0037	0.0065
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.001	0.0037	0.006
Onchocerca volvulus		0.0034	0.0652	0.6496
Schistosoma mansoni	thyroid hormone receptor	0.0133	0.3225	0.32
Echinococcus granulosus	ecdysone induced protein 78C	0.001	0.0037	0.0034
Loa Loa (eye worm)	hypothetical protein	0.001	0.0037	0.006
Trichomonas vaginalis	chromobox protein, putative	0.0046	0.0976	0.5254
Echinococcus multilocularis	Chromobox protein 3	0.0013	0.0105	0.0102
Echinococcus multilocularis	chromodomain helicase DNA binding protein 1	0.0013	0.0105	0.0102
Brugia malayi	Steroid receptor seven-up type 2	0.001	0.0037	0.0065
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.001	0.0037	0.006
Schistosoma mansoni	chromobox protein-related (chromobox 1) (heterochromatin 1)	0.0013	0.0105	0.0069
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	0.0019	0.0267	0.0264
Plasmodium vivax	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0019	0.0267	0.0299
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.001	0.0037	0.0065
Loa Loa (eye worm)	hypothetical protein	0.001	0.0037	0.006
Echinococcus multilocularis	Chromo domain	0.0013	0.0105	0.0102
Giardia lamblia	Endonuclease/Exonuclease/phosphatase	0.0019	0.0267	0.5
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.001	0.0037	0.0034
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.001	0.0037	0.0065
Trypanosoma brucei	aminopeptidase, putative	0.0044	0.0923	0.1251
Onchocerca volvulus		0.0013	0.0121	0.0889
Echinococcus multilocularis	survival motor neuron protein 1	0.0228	0.5677	0.5676
Mycobacterium ulcerans	leucyl aminopeptidase	0.0222	0.5511	1
Echinococcus multilocularis	dnaJ subfamily B	0.0396	1	1
Loa Loa (eye worm)	hypothetical protein	0.001	0.0037	0.006
Brugia malayi	Associated with TFs and helicases family protein	0.0013	0.0105	0.0185
Trypanosoma cruzi	metallo-peptidase, Clan MF, Family M17, putative	0.0222	0.5511	1
Echinococcus multilocularis	leucine aminopeptidase protein	0.0222	0.5511	0.551
Schistosoma mansoni	cpg binding protein	0.0028	0.0498	0.0463
Loa Loa (eye worm)	hypothetical protein	0.0017	0.023	0.04
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0019	0.0268	0.0981
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.001	0.0037	0.0065
Onchocerca volvulus		0.0028	0.0498	0.4876
Schistosoma mansoni	PwLAP aminopeptidase (M17 family)	0.0044	0.0923	0.0889
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.001	0.0037	0.0034
Entamoeba histolytica	hypothetical protein	0.0035	0.068	1
Echinococcus granulosus	survival motor neuron protein 1	0.0228	0.5677	0.5676
Trichomonas vaginalis	chromobox protein, putative	0.0077	0.1763	1
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0055	0.1199	0.2112
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0055	0.1199	0.2112
Brugia malayi	hypothetical protein	0.0228	0.5677	1
Entamoeba histolytica	hypothetical protein	0.0035	0.068	1
Schistosoma mansoni	hypothetical protein	0.017	0.4162	0.414
Trichomonas vaginalis	chromobox protein, putative	0.0077	0.1763	1
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0105	0.018
Schistosoma mansoni	chromobox protein	0.0077	0.1763	0.1732
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0035	0.068	0.0677
Brugia malayi	Aminopeptidase ZK353.6 in chromosome III	0.0044	0.0923	0.1626
Brugia malayi	M-phase phosphoprotein, mpp8	0.0013	0.0105	0.0185
Loa Loa (eye worm)	helicase	0.0013	0.0105	0.018
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.001	0.0037	0.0034
Brugia malayi	nuclear hormone receptor	0.001	0.0037	0.0065
Trichomonas vaginalis	ap endonuclease, putative	0.0019	0.0267	0.0976
Echinococcus multilocularis	chromodomain helicase DNA binding protein 4	0.0014	0.0146	0.0143
Echinococcus granulosus	leucyl aminopeptidase	0.0044	0.0923	0.092
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.001	0.0037	0.0065
Brugia malayi	Valyl-tRNA synthetase	0.0013	0.0105	0.0185
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.001	0.0037	0.0034
Brugia malayi	CHD4 protein	0.0014	0.0146	0.0257
Brugia malayi	Aminopeptidase W07G4.4 in chromosome V	0.0044	0.0923	0.1626
Schistosoma mansoni	cpg binding protein	0.0029	0.0539	0.0504
Brugia malayi	exodeoxyribonuclease III family protein	0.0019	0.0267	0.047
Toxoplasma gondii	leucyl aminopeptidase LAP	0.0222	0.5511	1
Trichomonas vaginalis	conserved hypothetical protein	0.003	0.0567	0.2789
Schistosoma mansoni	thyroid hormone receptor	0.0133	0.3225	0.32
Loa Loa (eye worm)	hypothetical protein	0.001	0.0037	0.006
Echinococcus granulosus	chromobox protein 1	0.0077	0.1763	0.176
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0019	0.0268	0.0981
Echinococcus granulosus	ankyrin repeat domain containing protein 17	0.0044	0.0923	0.092
Brugia malayi	hypothetical protein	0.0035	0.068	0.1197
Mycobacterium leprae	Probable cytosol aminopeptidase PepB	0.0222	0.5511	0.5
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0652	0.1144
Schistosoma mansoni	chromodomain helicase DNA binding protein	0.0013	0.0105	0.0069
Loa Loa (eye worm)	hypothetical protein	0.0038	0.075	0.1317
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.001	0.0037	0.0065
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0035	0.068	0.0677
Plasmodium falciparum	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0019	0.0267	0.0299
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0059	0.1303	0.1271
Trichomonas vaginalis	conserved hypothetical protein	0.003	0.0567	0.2789
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0013	0.0121	0.0084
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0017	0.023	0.0227
Wolbachia endosymbiont of Brugia malayi	leucyl aminopeptidase	0.0222	0.5511	1
Brugia malayi	Type III restriction enzyme, res subunit family protein	0.0013	0.0105	0.0185
Loa Loa (eye worm)	hypothetical protein	0.001	0.0037	0.006
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.001	0.0037	0.0065
Trichomonas vaginalis	ap endonuclease, putative	0.0019	0.0267	0.0976
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0105	0.018
Echinococcus granulosus	leucine aminopeptidase protein	0.0222	0.5511	0.551
Brugia malayi	Latrophilin receptor protein 2	0.0017	0.023	0.0404
Schistosoma mansoni	ap endonuclease	0.0019	0.0267	0.0231
Echinococcus granulosus	FTZ F1 alpha	0.001	0.0037	0.0034
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.001	0.0037	0.0065
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0019	0.0268	0.0981
Brugia malayi	chromobox protein homolog 3	0.0043	0.0892	0.1571
Echinococcus granulosus	chromodomain helicase DNA binding protein 4	0.0014	0.0146	0.0143
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0133	0.3225	0.3223
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0105	0.018
Onchocerca volvulus	Heterochromatin protein 1 homolog	0.0046	0.0976	0.9923
Loa Loa (eye worm)	hypothetical protein	0.001	0.0037	0.006
Entamoeba histolytica	hypothetical protein	0.0035	0.068	1
Toxoplasma gondii	exonuclease III APE	0.0019	0.0267	0.0299
Echinococcus multilocularis	chromobox protein 1	0.0077	0.1763	0.176
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0015	0.0181	0.0455
Entamoeba histolytica	exodeoxyribonuclease III, putative	0.0019	0.0267	0.2817
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0105	0.018
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0016	0.0192	0.0526
Brugia malayi	Heterochromatin protein 1	0.0077	0.1763	0.3105
Echinococcus multilocularis	leucyl aminopeptidase	0.0044	0.0923	0.092
Echinococcus multilocularis	ecdysone induced protein 78C	0.001	0.0037	0.0034
Schistosoma mansoni	hypothetical protein	0.0035	0.068	0.0645
Brugia malayi	hypothetical protein	0.0013	0.0105	0.0185
Brugia malayi	SET domain containing protein	0.0013	0.0121	0.0213
Brugia malayi	CXXC zinc finger family protein	0.0028	0.0498	0.0878
Trichomonas vaginalis	conserved hypothetical protein	0.0043	0.0892	0.4746
Trichomonas vaginalis	chromobox protein, putative	0.0046	0.0976	0.5254
Echinococcus granulosus	chromodomain helicase DNA binding protein 1	0.0013	0.0105	0.0102
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.001	0.0037	0.0034
Schistosoma mansoni	chromodomain helicase DNA binding protein	0.0014	0.0146	0.011
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.001	0.0037	0.0034
Schistosoma mansoni	cpg binding protein	0.0029	0.0539	0.0504
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.001	0.0037	0.006
Plasmodium falciparum	M17 leucyl aminopeptidase	0.0222	0.5511	1
Trypanosoma cruzi	cytosolic leucyl aminopeptidase, putative	0.0222	0.5511	1
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.001	0.0037	0.0065
Brugia malayi	Nuclear hormone receptor-like 1	0.001	0.0037	0.0065
Echinococcus multilocularis	cpg binding protein	0.0029	0.0539	0.0537
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.001	0.0037	0.0065
Loa Loa (eye worm)	aminopeptidase in chromosome V	0.0044	0.0923	0.1621
Leishmania major	aminopeptidase, putative,metallo-peptidase, Clan MF, Family M17	0.0044	0.0923	0.1251
Schistosoma mansoni	hypothetical protein	0.0047	0.0983	0.095
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.001	0.0037	0.0034
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0017	0.023	0.04
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0019	0.0268	0.0981
Schistosoma mansoni	chromobox protein	0.0013	0.0105	0.0069
Echinococcus granulosus	chromobox protein 1	0.0077	0.1763	0.176
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.001	0.0037	0.006
Schistosoma mansoni	hypothetical protein	0.0038	0.075	0.0716
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.001	0.0037	0.006
Trypanosoma cruzi	metallo-peptidase, Clan MF, Family M17	0.0044	0.0923	0.1251
Schistosoma mansoni	chromobox protein	0.0013	0.0105	0.0069
Schistosoma mansoni	leucine aminopeptidase	0.0044	0.0923	0.0889
Loa Loa (eye worm)	CHromoDomain protein family member	0.0014	0.0146	0.0253
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.001	0.0037	0.0034
Echinococcus granulosus	chromobox protein 2	0.0013	0.0105	0.0102
Echinococcus multilocularis	Mitotic checkpoint protein PRCC, C terminal	0.0124	0.2969	0.2967
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.001	0.0037	0.0034
Treponema pallidum	exodeoxyribonuclease (exoA)	0.0019	0.0267	0.5
Onchocerca volvulus		0.0047	0.0983	1
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.0019	0.0267	0.0466
Schistosoma mansoni	hypothetical protein	0.0017	0.023	0.0193
Mycobacterium tuberculosis	Probable aminopeptidase PepB	0.0222	0.5511	1
Loa Loa (eye worm)	heterochromatin protein 1	0.0077	0.1763	0.3102
Echinococcus multilocularis	chromobox protein 2	0.0013	0.0105	0.0102
Echinococcus granulosus	Chromobox protein 3	0.0013	0.0105	0.0102
Schistosoma mansoni	transcription factor LCR-F1	0.0035	0.068	0.0645
Trichomonas vaginalis	conserved hypothetical protein	0.0043	0.0892	0.4746
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0019	0.0268	0.0981
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.001	0.0037	0.0034
Schistosoma mansoni	hypothetical protein	0.0017	0.023	0.0193
Loa Loa (eye worm)	steroid hormone receptor	0.001	0.0037	0.006
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0017	0.023	0.0404
Echinococcus multilocularis	GPCR, family 2	0.0017	0.023	0.0227
Trypanosoma cruzi	metallo-peptidase, Clan MF, Family M17	0.0044	0.0923	0.1251

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

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Detailed information for compound 611615