TDR Targets

Basic information

Technical information

TDR Targets ID: 620768
Name: methyl 2-[3-(3,4-dimethoxyphenyl)-2-oxochrome n-7-yl]oxypropanoate
MW: 384.379 | Formula: C21H20O7
H donors: 0 H acceptors: 2 LogP: 3.78 Rotable bonds: 7
Rule of 5 violations (Lipinski): 1
SMILES: COC(=O)C(Oc1ccc2c(c1)oc(=O)c(c2)c1ccc(c(c1)OC)OC)C
InChi: 1S/C21H20O7/c1-12(20(22)26-4)27-15-7-5-14-9-16(21(23)28-18(14)11-15)13-6-8-17(24-2)19(10-13)25-3/h5-12H,1-4H3
InChiKey: PAIGCABXKKIXCP-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

methyl 2-[3-(3,4-dimethoxyphenyl)-2-oxo-chromen-7-yl]oxypropanoate
2-[[3-(3,4-dimethoxyphenyl)-2-oxo-7-chromenyl]oxy]propanoic acid methyl ester
2-[3-(3,4-dimethoxyphenyl)-2-keto-chromen-7-yl]oxypropionic acid methyl ester

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	hypothetical protein	0.0034	0.053	0.1034
Giardia lamblia	Prolyl-tRNA synthetase	0.0034	0.053	1
Trypanosoma cruzi	prolyl-tRNA synthetase, putative	0.0039	0.0649	1
Mycobacterium ulcerans	sugar transporter	0.0016	0.0147	0.2954
Mycobacterium ulcerans	lysyl-tRNA synthetase	0.0025	0.0345	1
Trypanosoma cruzi	hexose transporter, putative	0.0035	0.0554	0.8107
Trichomonas vaginalis	lysyl-tRNA synthetase, putative	0.0025	0.0345	0.0961
Trypanosoma cruzi	hexose transporter, putative	0.0035	0.0554	0.8107
Schistosoma mansoni	protein kinase	0.0034	0.0544	0.08
Trichomonas vaginalis	lysyl-tRNA synthetase, putative	0.0022	0.0279	0.0641
Echinococcus granulosus	tumor protein p63	0.0327	0.6816	1
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0147	0.0287
Schistosoma mansoni	glucose transport protein	0.0112	0.221	0.415
Plasmodium vivax	lysine--tRNA ligase, putative	0.0025	0.0345	0.0201
Brugia malayi	Smad1	0.0016	0.0154	0.0301
Brugia malayi	TAR-binding protein	0.0248	0.5119	1
Schistosoma mansoni	lysyl-tRNA synthetase	0.0025	0.0345	0.0399
Echinococcus multilocularis	mothers against decapentaplegic 5	0.0016	0.0154	0.0011
Trypanosoma cruzi	prolyl-tRNA synthetase, putative	0.0039	0.0649	1
Brugia malayi	Calcium/calmodulin-dependent protein kinase type II alpha chain	0.0034	0.0544	0.1063
Trichomonas vaginalis	conserved hypothetical protein	0.0035	0.0554	0.1973
Leishmania major	prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative	0.0039	0.0649	1
Trichomonas vaginalis	sugar transporter, putative	0.0035	0.0554	0.1973
Brugia malayi	Sugar transporter family protein	0.0112	0.221	0.4317
Schistosoma mansoni	protein kinase	0.0034	0.0544	0.08
Plasmodium vivax	calcium-dependent protein kinase 1, putative	0.0034	0.0545	0.0404
Plasmodium falciparum	calcium-dependent protein kinase 1	0.0034	0.0545	0.0404
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0031	0.0465	0.0908
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0248	0.5119	1
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0112	0.221	0.3094
Plasmodium falciparum	protein kinase 7	0.0317	0.6593	0.6542
Toxoplasma gondii	calcium-dependent protein kinase CDPK2A	0.0034	0.0545	0.0617
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0112	0.221	0.3094
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0112	0.221	0.3094
Trypanosoma cruzi	lysyl-tRNA synthetase, putative	0.0025	0.0345	0.395
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0147	0.0287
Schistosoma mansoni	tar DNA-binding protein	0.0248	0.5119	1
Echinococcus granulosus	glutamyl tRNA synthetase cytoplasmic	0.0034	0.053	0.0574
Loa Loa (eye worm)	MH2 domain-containing protein	0.0016	0.0154	0.0301
Schistosoma mansoni	Smad4	0.0016	0.0154	0.0015
Trypanosoma cruzi	hexose transporter, putative	0.0035	0.0554	0.8107
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0147	0.0287
Echinococcus granulosus	GPCR family 2	0.0031	0.0465	0.0477
Trypanosoma brucei	lysyl-tRNA synthetase, putative	0.0025	0.0345	0.395
Brugia malayi	major facilitator superfamily protein	0.0016	0.0147	0.0287
Mycobacterium ulcerans	sugar-transport integral membrane protein SugI	0.0016	0.0147	0.2954
Plasmodium falciparum	hexose transporter	0.0112	0.221	0.2094
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0544	0.1063
Trichomonas vaginalis	CAMK family protein kinase	0.0034	0.0544	0.1927
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0034	0.0544	0.0596
Plasmodium falciparum	lysine--tRNA ligase	0.0025	0.0345	0.0201
Schistosoma mansoni	tar DNA-binding protein	0.0248	0.5119	1
Schistosoma mansoni	hypothetical protein	0.0031	0.0465	0.0639
Mycobacterium ulcerans	integral membrane transport protein	0.0016	0.0147	0.2954
Loa Loa (eye worm)	major facilitator superfamily transporter	0.0016	0.0147	0.0287
Loa Loa (eye worm)	RNA binding protein	0.0248	0.5119	1
Trichomonas vaginalis	glucose transporter, putative	0.0035	0.0554	0.1973
Trypanosoma brucei	glucose transporter, putative	0.0035	0.0554	0.8107
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0031	0.0465	0.0908
Brugia malayi	major facilitator superfamily protein	0.0016	0.0147	0.0287
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0147	0.0287
Brugia malayi	latrophilin 2 splice variant baaae	0.0066	0.1226	0.2394
Schistosoma mansoni	cellular tumor antigen P53	0.0048	0.0835	0.1384
Brugia malayi	MH2 domain containing protein	0.0016	0.0154	0.0301
Toxoplasma gondii	cell-cycle-associated protein kinase MAPK, putative	0.0181	0.3689	0.5495
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0147	0.0287
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0345	0.0674
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0112	0.221	0.3094
Brugia malayi	hypothetical protein	0.0016	0.0147	0.0287
Chlamydia trachomatis	lysine--tRNA ligase	0.0025	0.0345	1
Plasmodium falciparum	calcium-dependent protein kinase 2	0.0034	0.0545	0.0404
Trypanosoma brucei	glucose transporter, putative	0.0035	0.0554	0.8107
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0147	0.0287
Toxoplasma gondii	facilitative glucose transporter GT1	0.0112	0.221	0.3201
Schistosoma mansoni	tar DNA-binding protein	0.0248	0.5119	1
Brugia malayi	Major Facilitator Superfamily protein	0.0016	0.0147	0.0287
Toxoplasma gondii	calcium-dependent protein kinase CDPK2B	0.0034	0.0545	0.0617
Plasmodium vivax	CDK-related protein kinase 6, putative	0.0476	1	1
Leishmania major	protein kinase, putative	0.0034	0.0544	0.7919
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0147	0.0287
Brugia malayi	MH2 domain containing protein	0.0237	0.4873	0.9518
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0112	0.221	0.3094
Echinococcus multilocularis	General substrate transporter	0.0096	0.1873	0.2588
Echinococcus multilocularis	glutamyl tRNA synthetase cytoplasmic	0.0034	0.053	0.0574
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0147	0.0287
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0147	0.0287
Brugia malayi	bifunctional aminoacyl-tRNA synthetase	0.0034	0.053	0.1034
Schistosoma mansoni	glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs)	0.0034	0.053	0.077
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0031	0.0465	0.0477
Loa Loa (eye worm)	hypothetical protein	0.0034	0.053	0.1034
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0147	0.0287
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0147	0.0287
Plasmodium vivax	calcium-dependent protein kinase 3, putative	0.0034	0.0545	0.0404
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0034	0.0544	0.0596
Schistosoma mansoni	glucose transport protein	0.0112	0.221	0.415
Mycobacterium leprae	Probable prolyl tRNA synthetase ProS	0.0034	0.053	1
Echinococcus multilocularis	lysyl tRNA synthetase	0.0025	0.0345	0.0297
Echinococcus multilocularis	TGF beta signal transducer SmadC	0.0016	0.0154	0.0011
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0112	0.221	0.3094
Loa Loa (eye worm)	MH2 domain-containing protein	0.0237	0.4873	0.9518
Brugia malayi	Sugar transporter family protein	0.0016	0.0147	0.0287
Plasmodium falciparum	calcium-dependent protein kinase 5	0.0034	0.0545	0.0404
Schistosoma mansoni	glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs)	0.0034	0.053	0.077
Schistosoma mansoni	protein kinase	0.0034	0.0544	0.08
Schistosoma mansoni	smad1 5 8 and	0.0016	0.0154	0.0015
Leishmania major	glucose transporter, lmgt2	0.0035	0.0554	0.8107
Plasmodium falciparum	proline--tRNA ligase	0.0039	0.0649	0.051
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0035	0.0554	0.8107
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0034	0.0544	0.0596
Treponema pallidum	prolyl-tRNA synthetase	0.0012	0.0064	0.5
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0147	0.0287
Trypanosoma brucei	calcium/calmodulin-dependent protein kinase, putative	0.0034	0.0544	0.7919
Echinococcus granulosus	lysyl tRNA synthetase	0.0025	0.0345	0.0297
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0031	0.0465	0.0477
Brugia malayi	Cam kinase protein 1	0.0034	0.0544	0.1063
Schistosoma mansoni	hypothetical protein	0.0112	0.221	0.415
Mycobacterium tuberculosis	Lysyl-tRNA synthetase 2 LysX	0.0021	0.0264	1
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0035	0.0554	0.8107
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0147	0.0287
Trypanosoma brucei	glucose transporter, putative	0.0035	0.0554	0.8107
Loa Loa (eye worm)	CAMK/CAMK2 protein kinase	0.0034	0.0544	0.1063
Echinococcus multilocularis	smad	0.0016	0.0154	0.0011
Trichomonas vaginalis	conserved hypothetical protein	0.0112	0.221	1
Brugia malayi	hypothetical protein	0.0016	0.0147	0.0287
Schistosoma mansoni	glucose transport protein	0.0112	0.221	0.415
Trypanosoma brucei	bifunctional aminoacyl-tRNA synthetase, putative	0.0039	0.0649	1
Leishmania major	glucose transporter/membrane transporter D2, putative	0.0035	0.0554	0.8107
Schistosoma mansoni	smad	0.0016	0.0154	0.0015
Echinococcus multilocularis	Smad4	0.0016	0.0154	0.0011
Trypanosoma brucei	glucose transporter, putative	0.0035	0.0554	0.8107
Schistosoma mansoni	tar DNA-binding protein	0.0248	0.5119	1
Plasmodium vivax	mitogen-activated protein kinase 2, putative	0.0181	0.3689	0.3595
Trichomonas vaginalis	glucose transporter, putative	0.0035	0.0554	0.1973
Plasmodium vivax	calcium-dependent protein kinase 4, putative	0.0034	0.0545	0.0404
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type 1	0.0034	0.0544	0.0596
Loa Loa (eye worm)	major facilitator superfamily transporter	0.0016	0.0147	0.0287
Echinococcus multilocularis	tar DNA binding protein	0.0248	0.5119	0.7456
Plasmodium falciparum	calcium-dependent protein kinase 3	0.0034	0.0545	0.0404
Mycobacterium ulcerans	lysyl-tRNA synthetase	0.0025	0.0345	1
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0394	0.0771
Onchocerca volvulus		0.0048	0.0835	1
Brugia malayi	Major Facilitator Superfamily protein	0.0016	0.0147	0.0287
Brugia malayi	Sugar transporter family protein	0.0016	0.0147	0.0287
Schistosoma mansoni	TGF-beta signal transducer Smad2	0.0016	0.0154	0.0015
Loa Loa (eye worm)	hypothetical protein	0.0097	0.1881	0.3675
Schistosoma mansoni	serine/threonine protein kinase	0.0034	0.0544	0.08
Echinococcus granulosus	TGF beta signal transducer SmadC	0.0016	0.0154	0.0011
Toxoplasma gondii	lysine-tRNA ligase	0.0025	0.0345	0.0308
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0112	0.221	0.3094
Loa Loa (eye worm)	bifunctional aminoacyl-tRNA synthetase	0.0014	0.0105	0.0205
Plasmodium falciparum	mitogen-activated protein kinase 2	0.0181	0.3689	0.3595
Brugia malayi	RNA recognition motif domain containing protein	0.0248	0.5119	1
Mycobacterium leprae	Possible lysyl-tRNA synthetase 2 LysX	0.0025	0.0345	0.3046
Schistosoma mansoni	smad1 5 8 and	0.0016	0.0154	0.0015
Loa Loa (eye worm)	calcium/calmodulin-dependent protein kinase ID	0.0034	0.0544	0.1063
Trypanosoma brucei	glucose transporter, putative	0.0035	0.0554	0.8107
Echinococcus granulosus	General substrate transporter	0.0096	0.1873	0.2588
Schistosoma mansoni	hypothetical protein	0.0031	0.0465	0.0639
Trypanosoma brucei	glucose transporter, putative	0.0035	0.0554	0.8107
Wolbachia endosymbiont of Brugia malayi	major facilitator superfamily permease	0.0016	0.0147	0.5
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0031	0.0465	0.0477
Echinococcus granulosus	mothers against decapentaplegic 5	0.0016	0.0154	0.0011
Plasmodium falciparum	calcium-dependent protein kinase 4	0.0034	0.0545	0.0404
Loa Loa (eye worm)	TAR-binding protein	0.0248	0.5119	1
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0147	0.0287
Echinococcus multilocularis	calcium dependent protein kinase	0.0032	0.0499	0.0528
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0147	0.0287
Leishmania major	prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative	0.0039	0.0649	1
Echinococcus multilocularis	tumor protein p63	0.0327	0.6816	1
Echinococcus granulosus	Smad4	0.0016	0.0154	0.0011
Schistosoma mansoni	smad1 5 8 and	0.0016	0.0154	0.0015
Schistosoma mansoni	hypothetical protein	0.0066	0.1226	0.2169
Trypanosoma cruzi	hexose transporter	0.0035	0.0554	0.8107
Brugia malayi	Latrophilin receptor protein 2	0.0031	0.0465	0.0908
Leishmania major	lysyl-tRNA synthetase, putative	0.0025	0.0345	0.395
Plasmodium vivax	proline--tRNA ligase, putative	0.0039	0.0649	0.051
Loa Loa (eye worm)	transcription factor SMAD2	0.0237	0.4873	0.9518
Echinococcus granulosus	tar DNA binding protein	0.0248	0.5119	0.7456
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0031	0.0465	0.0477
Entamoeba histolytica	prolyl-tRNA synthetase, putative	0.0034	0.053	0.9253
Trichomonas vaginalis	sugar transporter, putative	0.0035	0.0554	0.1973
Brugia malayi	Major Facilitator Superfamily protein	0.0016	0.0147	0.0287
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0835	0.1631
Toxoplasma gondii	prolyl-tRNA synthetase (ProRS)	0.0039	0.0649	0.0779
Mycobacterium tuberculosis	Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase)	0.0021	0.0264	1
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0465	0.0908
Plasmodium vivax	hexose transporter	0.0112	0.221	0.2094
Brugia malayi	Bifunctional aminoacyl-tRNA synthetase	0.0034	0.053	0.1034
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0035	0.0554	0.8107
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0034	0.0544	0.0596
Echinococcus multilocularis	solute carrier family 2, facilitated glucose	0.0112	0.221	0.3094
Brugia malayi	hypothetical protein	0.0016	0.0147	0.0287
Giardia lamblia	Lysyl-tRNA synthetase	0.0025	0.0345	0.5182
Entamoeba histolytica	protein kinase, putative	0.0034	0.0544	1
Trypanosoma brucei	glucose transporter 1E	0.0035	0.0554	0.8107
Trichomonas vaginalis	sugar transporter, putative	0.0035	0.0554	0.1973
Schistosoma mansoni	lysyl-tRNA synthetase	0.0025	0.0345	0.0399
Trypanosoma cruzi	hexose transporter, putative	0.0019	0.0216	0.1383
Plasmodium vivax	calcium-dependent protein kinase, putative	0.0034	0.0545	0.0404
Brugia malayi	MH1 domain containing protein	0.0016	0.0154	0.0301
Entamoeba histolytica	protein kinase, putative	0.0034	0.0544	1
Schistosoma mansoni	hypothetical protein	0.0031	0.0465	0.0639
Echinococcus granulosus	calcium dependent protein kinase	0.0032	0.0499	0.0528
Trypanosoma brucei	glucose transporter 2A	0.0035	0.0554	0.8107
Loa Loa (eye worm)	Smad1	0.0016	0.0154	0.0301
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0034	0.0544	0.0596
Loa Loa (eye worm)	sugar transporter	0.0016	0.0147	0.0287
Echinococcus multilocularis	GPCR, family 2	0.0031	0.0465	0.0477
Mycobacterium ulcerans	fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT	0.0016	0.0147	0.2954
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0034	0.0544	0.0596
Schistosoma mansoni	tar DNA-binding protein	0.0248	0.5119	1
Toxoplasma gondii	calcium-dependent protein kinase CDPK3	0.0034	0.0545	0.0617
Schistosoma mansoni	hypothetical protein	0.0031	0.0465	0.0639
Brugia malayi	lysyl-tRNA synthetase	0.0025	0.0345	0.0674
Loa Loa (eye worm)	sugar transporter	0.0112	0.221	0.4317
Echinococcus granulosus	smad	0.0016	0.0154	0.0011
Loa Loa (eye worm)	hypothetical protein	0.0066	0.1226	0.2394
Brugia malayi	MH1 domain containing protein	0.0016	0.0154	0.0301
Brugia malayi	RNA binding protein	0.0248	0.5119	1
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0097	0.1881	0.3675
Toxoplasma gondii	protein kinase, putative	0.0317	0.6593	1
Trypanosoma brucei	glucose transporter, putative	0.0035	0.0554	0.8107
Trichomonas vaginalis	prolyl-tRNA synthetase, putative	0.0034	0.053	0.1855
Trypanosoma brucei	glucose transporter, putative	0.0035	0.0554	0.8107
Trichomonas vaginalis	conserved hypothetical protein	0.0035	0.0554	0.1973
Leishmania major	glucose transporter, lmgt1	0.0035	0.0554	0.8107
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0097	0.1881	0.3675
Brugia malayi	MH2 domain containing protein	0.0016	0.0154	0.0301
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0034	0.0544	0.0596
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0097	0.1881	0.3675
Loa Loa (eye worm)	MH1 domain-containing protein	0.0016	0.0154	0.0301
Leishmania major	glucose transporter, lmgt3	0.0035	0.0554	0.8107

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 620768