TDR Targets

Basic information

Technical information

TDR Targets ID: 622143
Name: N-[4-(4-cyanophenyl)-1,3-thiazol-2-yl]-1,3-be nzothiazole-6-carboxamide
MW: 362.428 | Formula: C18H10N4OS2
H donors: 1 H acceptors: 4 LogP: 3.96 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: N#Cc1ccc(cc1)c1csc(n1)NC(=O)c1ccc2c(c1)scn2
InChi: 1S/C18H10N4OS2/c19-8-11-1-3-12(4-2-11)15-9-24-18(21-15)22-17(23)13-5-6-14-16(7-13)25-10-20-14/h1-7,9-10H,(H,21,22,23)
InChiKey: DNFVCXURCDERHZ-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

N-[4-(4-cyanophenyl)thiazol-2-yl]-1,3-benzothiazole-6-carboxamide
N-[4-(4-cyanophenyl)-2-thiazolyl]-1,3-benzothiazole-6-carboxamide
Oprea1_402919
ZINC04088410

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Entamoeba histolytica	phosphatidylinositol 3-kinase 1, putative	0.0337	0.0121	0.0137
Schistosoma mansoni	phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K	0.0363	0.0133	0.0331
Schistosoma mansoni	ataxia telangiectasia mutated (atm)-related	0.1628	0.0705	0.9868
Toxoplasma gondii	phosphatidylinositol 3- and 4-kinase	0.0363	0.0133	0.0338
Leishmania major	phosphatidylinositol 3-kinase, putative	0.1602	0.0693	0.1916
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.1645	0.0713	1
Trypanosoma cruzi	phosphatidylinositol 4-kinase alpha, putative	0.0363	0.0133	0.0383
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0502	0.0196	0.2749
Onchocerca volvulus		0.0319	0.0113	0.5
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0591	0.0236	0.2077
Leishmania major	target of rapamycin (TOR) kinase 2, putative	0.1628	0.0705	0.1948
Trypanosoma cruzi	phosphatidylinositol kinase related protein, putative	0.0331	0.0119	0.0342
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1611	0.0697	0.9875
Brugia malayi	phosphatidylinositol 4-kinase, catalytic, alpha polypeptide	0.0363	0.0133	0.1868
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0417	0.0158	0.0755
Trypanosoma brucei	phosphatidylinositol 4-kinase, putative	0.0319	0.0113	0.1607
Echinococcus granulosus	phosphatidylinositol 3 and 4 kinase	0.1645	0.0713	0.0606
Trypanosoma brucei	phosphatidylinositol 4-kinase alpha, putative	0.0363	0.0133	0.1889
Trichomonas vaginalis	PIKK family atypical protein kinase	0.162	0.0701	0.994
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1618	0.07	0.9925
Trichomonas vaginalis	phosphatidylinositol 3-kinase catalytic subunit gamma, putative	0.0655	0.0265	0.2571
Trypanosoma cruzi	phosphatidylinositol kinase related protein, putative	0.0922	0.0386	0.111
Leishmania major	hypothetical protein, unknown function	0.0319	0.0113	0.0313
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0922	0.0386	0.4607
Trypanosoma brucei	phosphatidylinositol 3-kinase catalytic subunit, putative	0.0319	0.0113	0.1607
Echinococcus granulosus	serine:threonine protein kinase SMG1	0.0909	0.038	0.027
Echinococcus multilocularis	FKBP12 rapamycin complex associated protein	0.1628	0.0705	0.0598
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1612	0.0698	0.988
Trichomonas vaginalis	phosphatidylinositol 3-kinase class, putative	0.0363	0.0133	0.0336
Trichomonas vaginalis	phosphatidylinositol kinase, putative	0.0417	0.0158	0.0755
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0918	0.0384	0.4581
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1602	0.0693	0.9804
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1618	0.07	0.9925
Echinococcus granulosus	phosphatidylinositol 4 kinase alpha	0.0363	0.0133	0.002
Trichomonas vaginalis	conserved hypothetical protein	0.1012	0.0426	0.5293
Trichomonas vaginalis	phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative	0.0571	0.0227	0.1929
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1602	0.0693	0.9804
Loa Loa (eye worm)	hypothetical protein	0.0693	0.0282	0.4007
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1618	0.07	0.9925
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0925	0.0387	0.4631
Trichomonas vaginalis	phopsphatidylinositol 3-kinase, drosophila, putative	0.0655	0.0265	0.2571
Onchocerca volvulus		0.0319	0.0113	0.5
Entamoeba histolytica	phosphatidylinositol-4,5-bisphosphate 3-kinase, putative	0.0363	0.0133	0.0336
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0922	0.0386	0.5413
Trypanosoma cruzi	phosphatidylinositol 3-related kinase, putative	0.1645	0.0713	0.2051
Trichomonas vaginalis	phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative	0.0417	0.0158	0.0755
Trypanosoma brucei	phosphatidylinositol 3-kinase, putative	0.1602	0.0693	0.9836
Trichomonas vaginalis	phosphatidylinositol kinase, putative	0.0363	0.0133	0.0336
Trypanosoma cruzi	hypothetical protein, conserved	0.7758	0.3474	1
Echinococcus multilocularis	DNA dependent protein kinase catalytic subunit	2.2203	1	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0925	0.0387	0.4631
Leishmania major	phosphatidylinositol kinase, putative	0.0319	0.0113	0.0313
Trypanosoma brucei	phosphatidylinositol 3-kinase, putative	0.0417	0.0158	0.2241
Echinococcus multilocularis	phosphatidylinositol 4 phosphate 3 kinase C2	0.0502	0.0196	0.0084
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor2	0.1628	0.0705	0.2028
Trichomonas vaginalis	phosphatidylinositol 3-kinase class, putative	0.0417	0.0158	0.0755
Entamoeba histolytica	hypothetical protein	0.0922	0.0386	0.4607
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0417	0.0158	0.0755
Trichomonas vaginalis	PIKK family atypical protein kinase	0.161	0.0697	0.9865
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1602	0.0693	0.9804
Toxoplasma gondii	target of rapamycin (TOR), putative	0.1618	0.07	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.161	0.0697	0.9865
Entamoeba histolytica	Phosphatidylinositol 3- and 4-kinase family	0.0918	0.0384	0.4581
Trichomonas vaginalis	PIKK family atypical protein kinase	0.161	0.0697	0.9865
Loa Loa (eye worm)	phosphatidylinositol 3	0.0099	0.0014	0.0198
Schistosoma mansoni	ataxia telangiectasia mutated (atm)	0.0922	0.0386	0.4546
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor1	0.1628	0.0705	0.2028
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0327	0.0117	0.006
Toxoplasma gondii	non-specific serine/threonine protein kinase	0.1012	0.0426	0.5334
Trypanosoma cruzi	phosphatidylinositol 3-related kinase, putative	0.1645	0.0713	0.2051
Trichomonas vaginalis	PIKK family atypical protein kinase	0.161	0.0697	0.9865
Trichomonas vaginalis	conserved hypothetical protein	0.0693	0.0282	0.2859
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0447	0.0171	0.0978
Trichomonas vaginalis	PIKK family atypical protein kinase	0.161	0.0697	0.9864
Trypanosoma cruzi	phosphatidylinositol 3-kinase, putative	0.0319	0.0113	0.0326
Toxoplasma gondii	phosphatidylinositol 3- and 4-kinase	0.0363	0.0133	0.0338
Loa Loa (eye worm)	hypothetical protein	0.0154	0.0039	0.055
Leishmania major	target of rapamycin (TOR) kinase 1, putative	0.1628	0.0705	0.1948
Loa Loa (eye worm)	hypothetical protein	0.0603	0.0242	0.3431
Loa Loa (eye worm)	hypothetical protein	0.0909	0.038	0.5393
Trypanosoma cruzi	phosphatidylinositol 3-kinase vps34-like	0.0417	0.0158	0.0454
Loa Loa (eye worm)	phosphatidylinositol 3	0.0319	0.0113	0.1607
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0319	0.0113	0.159
Schistosoma mansoni	fkbp-rapamycin associated protein	0.0909	0.038	0.4452
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1628	0.0705	1
Trypanosoma brucei	target of rapamycin kinase 3, putative	0.162	0.0701	0.995
Trichomonas vaginalis	conserved hypothetical protein	0.0591	0.0236	0.2077
Leishmania major	phosphatidylinositol 3-kinase, putative	0.0363	0.0133	0.0368
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0655	0.0265	0.3724
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1618	0.07	0.9925
Echinococcus multilocularis	serine:threonine protein kinase SMG1	0.0909	0.038	0.027
Trichomonas vaginalis	phosphatidylinositol 3-kinase class, putative	0.0571	0.0227	0.1929
Trypanosoma cruzi	phosphatidylinositol 3-kinase 2, putative	0.0655	0.0265	0.0764
Leishmania major	phosphatidylinositol 3-related kinase, putative	0.1611	0.0697	0.1927
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1618	0.07	0.9925
Trypanosoma cruzi	phosphatidylinositol 4-kinase, putative	0.0319	0.0113	0.0326
Giardia lamblia	Phosphoinositide-3-kinase, class 3	0.0374	0.0138	0.0419
Echinococcus granulosus	FKBP12 rapamycin complex associated protein	0.1628	0.0705	0.0598
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.06	0.0241	0.2152
Trypanosoma brucei	phosphatidylinositol 3-kinase tor, putative	0.0334	0.012	0.1708
Brugia malayi	FAT domain containing protein	0.0693	0.0282	0.3962
Echinococcus granulosus	phosphatidylinositol 45 bisphosphate 3 kinase	0.0803	0.0332	0.0221
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1618	0.07	0.9925
Plasmodium vivax	phosphatidylinositol 3-kinase, putative	0.0363	0.0133	1
Echinococcus granulosus	serine protein kinase ATM	0.0922	0.0386	0.0276
Brugia malayi	Cytochrome P450 family protein	0.0143	0.0034	0.0479
Trypanosoma cruzi	phosphatidylinositol kinase related protein, putative	0.0603	0.0242	0.0696
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0319	0.0113	0.159
Echinococcus multilocularis	phosphatidylinositol 4,5 bisphosphate 3 kinase	0.0803	0.0332	0.0221
Echinococcus multilocularis	phosphatidylinositol 3 and 4 kinase	0.1645	0.0713	0.0606
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0927	0.0388	0.4646
Trypanosoma brucei	phosphatidylinositol 4-kinase, putative	0.1628	0.0705	1
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.1628	0.0705	0.9889
Echinococcus granulosus	phosphatidylinositol 4 phosphate 3 kinase C2	0.0502	0.0196	0.0084
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0417	0.0158	0.2216
Leishmania major	phosphatidylinositol kinase related protein, putative	0.0331	0.0119	0.0329
Loa Loa (eye worm)	phosphatidylinositol 3	0.0319	0.0113	0.1607
Trichomonas vaginalis	PIKK family atypical protein kinase	0.162	0.0701	0.994
Entamoeba histolytica	protein kinase rad3, putative	0.0909	0.038	0.4511
Trichomonas vaginalis	PIKK family atypical protein kinase	0.162	0.0701	0.994
Trichomonas vaginalis	PIKK family atypical protein kinase	0.162	0.0701	0.994
Schistosoma mansoni	phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K	0.0803	0.0332	0.3652
Entamoeba histolytica	FKBP-rapamycin associated protein (FRAP), putative	0.1628	0.0705	1
Trypanosoma cruzi	target of rapamycin kinase 3	0.162	0.0701	0.2018
Brugia malayi	phosphoinositide 3'-hydroxykinase p110-alpha subunit, putative	0.0148	0.0036	0.0506
Loa Loa (eye worm)	phosphatidylinositol 3	0.1611	0.0697	0.9895
Leishmania major	phosphatidylinositol 4-kinase, putative	0.0319	0.0113	0.0313
Leishmania major	target of rapamycin kinase (TOR) kinase 3	0.162	0.0701	0.1938
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1618	0.07	0.9925
Trichomonas vaginalis	PIKK family atypical protein kinase	0.161	0.0697	0.9864
Echinococcus multilocularis	Zinc finger, PHD finger	0.0363	0.0133	0.002
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0909	0.038	0.4511
Trypanosoma brucei	Phosphatidylinositol 3-kinase tor1	0.1628	0.0705	1
Trypanosoma cruzi	phosphatidylinositol 4-kinase, putative	0.0319	0.0113	0.0326
Trichomonas vaginalis	phosphatidylinositol 4-kinase, putative	0.0363	0.0133	0.0336
Loa Loa (eye worm)	hypothetical protein	0.0319	0.0113	0.1607
Entamoeba histolytica	phosphatidylinositol3-kinaseTor2, putative	0.1628	0.0705	1
Trypanosoma cruzi	phosphatidylinositol 4-kinase alpha, putative	0.0363	0.0133	0.0383
Entamoeba histolytica	phosphatidylinositol 4-kinase, putative	0.0363	0.0133	0.0336
Entamoeba histolytica	hypothetical protein	0.06	0.0241	0.2152
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0655	0.0265	0.2571
Trypanosoma brucei	phosphatidylinositol kinase related protein, putative	0.0922	0.0386	0.5474
Schistosoma mansoni	hypothetical protein	0.0693	0.0282	0.2821
Loa Loa (eye worm)	phosphatidylinositol 3	0.0319	0.0113	0.1607
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0935	0.0392	0.4707
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1628	0.0705	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1628	0.0705	1
Schistosoma mansoni	phosphatidylinositol 4-kinase	0.0363	0.0133	0.0331
Loa Loa (eye worm)	phosphatidylinositol 3	0.0748	0.0307	0.4362
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0925	0.0387	0.4631
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1029	0.0434	0.5429
Loa Loa (eye worm)	phosphatidylinositol 3	0.0319	0.0113	0.1607
Giardia lamblia	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	0.0516	0.0203	0.151
Trichomonas vaginalis	PIKK family atypical protein kinase	0.161	0.0697	0.9864
Plasmodium falciparum	phosphatidylinositol 3-kinase	0.0363	0.0133	1
Leishmania major	hypothetical protein, conserved	0.8077	0.3618	1
Trypanosoma cruzi	phosphatidylinositol kinase, putative	0.0319	0.0113	0.0326
Loa Loa (eye worm)	phosphatidylinositol 4-kinase type 3 alpha isoform 1	0.0363	0.0133	0.1889
Echinococcus multilocularis	phosphatidylinositol 4 kinase alpha	0.0363	0.0133	0.002
Mycobacterium leprae	conserved hypothetical protein	0.0319	0.0113	0.5
Giardia lamblia	GTOR	0.1628	0.0705	1
Trypanosoma brucei	FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative	0.102	0.043	0.61
Echinococcus granulosus	PIK kinase FAT and Armadillo domain containing protein	0.0693	0.0282	0.0171
Loa Loa (eye worm)	phosphatidylinositol kinase	0.0319	0.0113	0.1607
Trichomonas vaginalis	phosphatidylinositol kinase, putative	0.0655	0.0265	0.2571
Schistosoma mansoni	phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K	0.0417	0.0158	0.0745
Loa Loa (eye worm)	hypothetical protein	0.0502	0.0196	0.278
Toxoplasma gondii	FATC domain-containing protein	0.0922	0.0386	0.4642
Leishmania major	phosphatidylinositol 4-kinase alpha, putative	0.0363	0.0133	0.0368
Trypanosoma cruzi	phosphatidylinositol 3-kinase 2, putative	0.0655	0.0265	0.0764
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0909	0.038	0.5334
Trichomonas vaginalis	PIKK family atypical protein kinase	0.162	0.0701	0.994
Echinococcus granulosus	phosphatidylinositol 3 kinase catalytic subunit	0.0363	0.0133	0.002
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1602	0.0693	0.9804
Trypanosoma cruzi	phosphatidylinositol 3-kinase, putative	0.0909	0.038	0.1094
Echinococcus multilocularis	serine protein kinase ATM	0.0922	0.0386	0.0276
Loa Loa (eye worm)	hypothetical protein	0.1012	0.0426	0.605
Loa Loa (eye worm)	cytochrome P450 family protein	0.0143	0.0034	0.0484
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1612	0.0698	0.988
Mycobacterium ulcerans	cytochrome P450 185A4 Cyp185A4	0.0068	0	0.5
Loa Loa (eye worm)	phosphatidylinositol 3	0.1628	0.0705	1
Trypanosoma cruzi	phosphatidylinositol 3-kinase, putative	0.0099	0.0014	0.004
Echinococcus multilocularis	PIK kinase, FAT and Armadillo domain containing protein	0.0693	0.0282	0.0171
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0319	0.0113	0.5
Trypanosoma brucei	phosphatidylinositol 3-related kinase, putative	0.1611	0.0697	0.9895
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0319	0.0113	0.159
Schistosoma mansoni	phosphatidylinositol 3-and 4-kinase	0.1645	0.0713	1

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 622143