TDR Targets

Basic information

Technical information

TDR Targets ID: 624108
Name: ethyl 1-[3-(3,4-dimethylphenyl)sulfonyl-6-met hoxyquinolin-4-yl]piperidine-3-carboxylate
MW: 482.592 | Formula: C26H30N2O5S
H donors: 0 H acceptors: 4 LogP: 4.52 Rotable bonds: 7
Rule of 5 violations (Lipinski): 1
SMILES: CCOC(=O)C1CCCN(C1)c1c2cc(OC)ccc2ncc1S(=O)(=O)c1ccc(c(c1)C)C
InChi: 1S/C26H30N2O5S/c1-5-33-26(29)19-7-6-12-28(16-19)25-22-14-20(32-4)9-11-23(22)27-15-24(25)34(30,31)21-10-8-17(2)18(3)13-21/h8-11,13-15,19H,5-7,12,16H2,1-4H3
InChiKey: CJAUPBMMZFUOFS-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

ethyl 1-[3-(3,4-dimethylphenyl)sulfonyl-6-methoxy-4-quinolyl]piperidine-3-carboxylate
1-[3-(3,4-dimethylphenyl)sulfonyl-6-methoxy-4-quinolyl]-3-piperidinecarboxylic acid ethyl ester
1-[3-(3,4-dimethylphenyl)sulfonyl-6-methoxy-4-quinolyl]nipecotic acid ethyl ester
ethyl 1-[3-(3,4-dimethylphenyl)sulfonyl-6-methoxy-quinolin-4-yl]piperidine-3-carboxylate

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.005	0.0993	0.1146
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0045	0.0864	0.1362
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0045	0.0864	0.0985
Brugia malayi	MH2 domain containing protein	0.0017	0.0077	0.0121
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0045	0.0864	0.0985
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0025	0.0321	0.0196
Trichomonas vaginalis	importin beta-1, putative	0.0023	0.026	0.0135
Mycobacterium ulcerans	3-ketoacyl-ACP reductase	0.0025	0.0321	0.0196
Mycobacterium ulcerans	oxidoreductase	0.0025	0.0321	0.0196
Wolbachia endosymbiont of Brugia malayi	enoyl-ACP reductase	0.0376	1	1
Mycobacterium ulcerans	3-ketoacyl-ACP reductase	0.0025	0.0321	0.0196
Mycobacterium ulcerans	3-oxoacyl-ACP reductase	0.0025	0.0321	0.0196
Toxoplasma gondii	short chain dehydrogenase family protein, putative	0.0025	0.0321	0.0196
Schistosoma mansoni	chromobox protein	0.0077	0.1753	0.2097
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0221	0.5738	0.7082
Echinococcus granulosus	geminin	0.0165	0.4177	0.5128
Brugia malayi	Heterochromatin protein 1	0.0077	0.1753	0.2764
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0045	0.0864	0.0985
Mycobacterium ulcerans	short chain dehydrogenase	0.0025	0.0321	0.0196
Toxoplasma gondii	enoyl-acyl carrier reductase ENR	0.0376	1	1
Trichomonas vaginalis	chromobox protein, putative	0.0047	0.0906	0.0789
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0025	0.0321	0.0506
Schistosoma mansoni	hypothetical protein	0.005	0.0993	0.1146
Echinococcus multilocularis	3 oxoacyl acyl carrier protein reductase	0.0025	0.0321	0.0306
Brugia malayi	follicle stimulating hormone receptor	0.0228	0.5928	0.9343
Echinococcus granulosus	GPCR family 2	0.005	0.0993	0.1146
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0045	0.0864	0.0985
Echinococcus multilocularis	geminin	0.0165	0.4177	0.5128
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0045	0.0864	0.0985
Brugia malayi	chromobox protein homolog 3	0.0043	0.0815	0.1285
Loa Loa (eye worm)	GTP-binding nuclear protein RAN/TC4	0.0021	0.0201	0.0156
Trypanosoma brucei	GTP-binding nuclear protein rtb2, putative	0.0021	0.0201	0.2453
Brugia malayi	Pre-SET motif family protein	0.0032	0.0496	0.0782
Trichomonas vaginalis	chromobox protein, putative	0.0077	0.1753	0.1647
Brugia malayi	hypothetical protein	0.004	0.0721	0.1136
Brugia malayi	Importin beta-1 subunit	0.0029	0.041	0.0646
Loa Loa (eye worm)	hypothetical protein	0.0107	0.2587	0.3141
Trypanosoma cruzi	beta-ketoacyl-ACP reductase	0.0025	0.0321	0.6464
Trypanosoma cruzi	oxidoreductase-like protein, putative	0.0029	0.0427	1
Echinococcus granulosus	chromobox protein 1	0.0077	0.1753	0.2097
Plasmodium falciparum	importin beta, putative	0.0029	0.041	0.0286
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0029	0.0427	0.0304
Plasmodium vivax	GTP-binding nuclear protein RAN/TC4, putative	0.0021	0.0201	0.0075
Mycobacterium ulcerans	short chain dehydrogenase	0.0025	0.0321	0.0196
Mycobacterium ulcerans	3-ketoacyl-ACP reductase	0.0025	0.0321	0.0196
Leishmania major	dehydrogenase/oxidoreductase-like protein	0.0025	0.0321	0.6464
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0045	0.0864	0.0985
Schistosoma mansoni	hypothetical protein	0.004	0.0721	0.0806
Brugia malayi	MH2 domain containing protein	0.0243	0.6344	1
Toxoplasma gondii	3-ketoacyl-(acyl-carrier-protein) reductase	0.0025	0.0321	0.0196
Mycobacterium ulcerans	short chain dehydrogenase	0.0029	0.0427	0.0304
Loa Loa (eye worm)	nucleolar RNA-associated protein alpha	0.0306	0.8071	1
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0025	0.0321	0.0196
Toxoplasma gondii	HEAT repeat-containing protein	0.0029	0.041	0.0286
Mycobacterium ulcerans	short chain dehydrogenase	0.0025	0.0321	0.0196
Toxoplasma gondii	2,4-dienoyl CoA reductase 2, peroxisomal family protein	0.0029	0.0427	0.0304
Schistosoma mansoni	ap endonuclease	0.0018	0.0127	0.0064
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0045	0.0864	0.0985
Schistosoma mansoni	3-oxoacyl-[ACP] reductase	0.0025	0.0321	0.0306
Mycobacterium tuberculosis	NADH-dependent enoyl-[acyl-carrier-protein] reductase InhA (NADH-dependent enoyl-ACP reductase)	0.0376	1	1
Brugia malayi	Smad1	0.0017	0.0077	0.0121
Mycobacterium leprae	NADH-DEPENDENT ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE INHA (NADH-DEPENDENT ENOYL-ACP REDUCTASE)	0.0376	1	1
Plasmodium vivax	enoyl-acyl carrier protein reductase	0.0376	1	1
Echinococcus multilocularis	GPCR, family 2	0.005	0.0993	0.1146
Trichomonas vaginalis	hypothetical protein	0.0376	1	1
Schistosoma mansoni	chromobox protein	0.0077	0.1753	0.2097
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0032	0.0496	0.0525
Schistosoma mansoni	hypothetical protein	0.0165	0.4177	0.5128
Schistosoma mansoni	hypothetical protein	0.0107	0.2587	0.3141
Loa Loa (eye worm)	oxidoreductase	0.0025	0.0321	0.0306
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0557	0.06
Onchocerca volvulus	Heterochromatin protein 1 homolog	0.0047	0.0906	0.0934
Leishmania major	dehydrogenase/oxidoreductase-like protein	0.0025	0.0321	0.6464
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0029	0.0427	0.0304
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0045	0.0864	0.0985
Schistosoma mansoni	ran	0.0021	0.0201	0.0156
Onchocerca volvulus		0.0034	0.0557	0.0376
Loa Loa (eye worm)	latrophilin receptor protein 2	0.005	0.0993	0.1146
Echinococcus multilocularis	chromobox protein 1	0.0077	0.1753	0.2097
Mycobacterium ulcerans	enoyl-(acyl carrier protein) reductase	0.0376	1	1
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0228	0.5928	0.7319
Plasmodium vivax	3-oxoacyl-[acyl-carrier-protein] reductase, putative	0.0025	0.0321	0.0196
Echinococcus multilocularis	snurportin 1	0.0306	0.8071	1
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0157	0.3962	0.4859
Mycobacterium ulcerans	3-oxoacyl-ACP reductase	0.0025	0.0321	0.0196
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	0.0018	0.0127	0.0064
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.005	0.0993	0.1564
Entamoeba histolytica	hypothetical protein	0.004	0.0721	1
Mycobacterium ulcerans	short chain dehydrogenase	0.0025	0.0321	0.0196
Mycobacterium ulcerans	short chain dehydrogenase	0.0025	0.0321	0.0196
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0032	0.0496	0.0525
Brugia malayi	Pre-SET motif family protein	0.0221	0.5738	0.9045
Trypanosoma cruzi	importin beta-1 subunit, putative	0.0023	0.026	0.443
Trypanosoma cruzi	beta-ketoacyl-ACP reductase	0.0025	0.0321	0.6464
Leishmania major	oxidoreductase-like protein	0.0029	0.0427	1
Mycobacterium ulcerans	short chain dehydrogenase	0.0025	0.0321	0.0196
Leishmania major	GTP-binding protein, putative	0.0021	0.0201	0.2453
Trypanosoma cruzi	GTP-binding nuclear protein rtb2, putative	0.0021	0.0201	0.2453
Trichomonas vaginalis	ran, putative	0.0021	0.0201	0.0075
Plasmodium vivax	SET domain protein, putative	0.0032	0.0496	0.0373
Brugia malayi	GTP-binding nuclear protein RAN/TC4	0.0021	0.0201	0.0317
Schistosoma mansoni	hypothetical protein	0.0165	0.4177	0.5128
Loa Loa (eye worm)	hypothetical protein	0.005	0.0993	0.1146
Mycobacterium tuberculosis	Probable 3-oxoacyl-[acyl-carrier protein] reductase FabG2 (3-ketoacyl-acyl carrier protein reductase)	0.0025	0.0321	0.0196
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0025	0.0321	0.0196
Echinococcus multilocularis	chromobox protein 1	0.0077	0.1753	0.2097
Echinococcus granulosus	histone lysine methyltransferase setb	0.0032	0.0496	0.0525
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0321	0.0306
Trichomonas vaginalis	set domain proteins, putative	0.0252	0.6584	0.654
Mycobacterium ulcerans	20-beta-hydroxysteroid dehydrogenase FabG3	0.0025	0.0321	0.0196
Wolbachia endosymbiont of Brugia malayi	Short-chain alcohol dehydrogenase family enzyme	0.0025	0.0321	0.0196
Schistosoma mansoni	ran	0.0021	0.0201	0.0156
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.004	0.0721	0.0806
Trypanosoma brucei	oxidoreductase-like protein	0.0029	0.0427	1
Loa Loa (eye worm)	retinol dehydrogenase 12	0.0025	0.0321	0.0306
Entamoeba histolytica	hypothetical protein	0.004	0.0721	1
Loa Loa (eye worm)	hypothetical protein	0.0157	0.3962	0.4859
Mycobacterium tuberculosis	Possible oxidoreductase	0.0025	0.0321	0.0196
Brugia malayi	MH1 domain containing protein	0.0017	0.0077	0.0121
Schistosoma mansoni	hypothetical protein	0.005	0.0993	0.1146
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.004	0.0721	0.0806
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0025	0.0321	0.0196
Onchocerca volvulus		0.0029	0.0427	0.0169
Mycobacterium tuberculosis	Possible oxidoreductase	0.0025	0.0321	0.0196
Trichomonas vaginalis	chromobox protein, putative	0.0077	0.1753	0.1647
Plasmodium falciparum	3-oxoacyl-[acyl-carrier-protein] reductase	0.0025	0.0321	0.0196
Schistosoma mansoni	importin beta-1	0.0029	0.041	0.0417
Mycobacterium ulcerans	short chain dehydrogenase	0.0025	0.0321	0.0196
Mycobacterium ulcerans	short chain dehydrogenase	0.0025	0.0321	0.0196
Echinococcus granulosus	snurportin 1	0.0306	0.8071	1
Loa Loa (eye worm)	hypothetical protein	0.0029	0.041	0.0417
Leishmania major	importin beta-1 subunit, putative	0.0023	0.026	0.443
Trypanosoma cruzi	GTP-binding nuclear protein rtb2, putative	0.0021	0.0201	0.2453
Leishmania major	pteridine reductase 1	0.0029	0.0427	1
Brugia malayi	Latrophilin receptor protein 2	0.005	0.0993	0.1564
Entamoeba histolytica	3-oxoacyl-(acyl-carrier protein) reductase, putative	0.0025	0.0321	0.3268
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.0018	0.0127	0.0064
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0023	0.026	0.0135
Mycobacterium tuberculosis	Probable dehydrogenase/reductase	0.0025	0.0321	0.0196
Trichomonas vaginalis	conserved hypothetical protein	0.0043	0.0815	0.0697
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0023	0.026	0.0135
Echinococcus multilocularis	GTP binding nuclear protein Ran	0.0021	0.0201	0.0156
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	0.0018	0.0127	0.0064
Mycobacterium tuberculosis	Probable oxidoreductase	0.0029	0.0427	0.0304
Mycobacterium tuberculosis	Probable short-chain type dehydrogenase/reductase	0.0025	0.0321	0.0196
Trichomonas vaginalis	chromobox protein, putative	0.0047	0.0906	0.0789
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0496	0.0525
Schistosoma mansoni	hypothetical protein	0.0306	0.8071	1
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0032	0.0496	0.0525
Trypanosoma brucei	beta-ketoacyl-ACP reductase	0.0025	0.0321	0.6464
Entamoeba histolytica	hypothetical protein	0.004	0.0721	1
Giardia lamblia	GTP-binding nuclear protein RAN/TC4	0.0021	0.0201	1
Mycobacterium ulcerans	short chain dehydrogenase	0.0025	0.0321	0.0196
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.0031	0.0464	0.0484
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0032	0.0496	0.0525
Onchocerca volvulus		0.0252	0.6584	1
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0157	0.3962	0.6244
Brugia malayi	MH1 domain containing protein	0.0017	0.0077	0.0121
Trypanosoma brucei	importin beta-1 subunit, putative	0.0029	0.041	0.9423
Brugia malayi	latrophilin 2 splice variant baaae	0.0107	0.2587	0.4078
Brugia malayi	exodeoxyribonuclease III family protein	0.0018	0.0127	0.0201
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0157	0.3962	0.6244
Schistosoma mansoni	dihydropteridine reductase	0.0025	0.0321	0.0306
Echinococcus granulosus	GTP binding nuclear protein Ran	0.0021	0.0201	0.0156
Echinococcus granulosus	importin subunit beta 1	0.0029	0.041	0.0417
Schistosoma mansoni	hypothetical protein	0.005	0.0993	0.1146
Plasmodium vivax	importin-beta 2, putative	0.0029	0.041	0.0286
Loa Loa (eye worm)	transcription factor SMAD2	0.0243	0.6344	0.784
Mycobacterium ulcerans	short chain dehydrogenase	0.0025	0.0321	0.0196
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0815	0.0924
Echinococcus granulosus	3 oxoacyl acyl carrier protein reductase	0.0025	0.0321	0.0306
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.005	0.0993	0.1146
Mycobacterium tuberculosis	Probable short-chain type dehydrogenase/reductase	0.0025	0.0321	0.0196
Onchocerca volvulus	Heterochromatin protein 1 homolog	0.0043	0.0815	0.0788
Plasmodium falciparum	GTP-binding nuclear protein RAN/TC4	0.0021	0.0201	0.0075
Mycobacterium ulcerans	3-ketoacyl-ACP reductase	0.0025	0.0321	0.0196
Mycobacterium ulcerans	3-alpha-hydroxysteroid dehydrogenase	0.0029	0.0427	0.0304
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0025	0.0321	0.0196
Mycobacterium ulcerans	3-ketoacyl-ACP reductase	0.0025	0.0321	0.0196
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0044	0.0846	0.0962
Loa Loa (eye worm)	heterochromatin protein 1	0.0077	0.1753	0.2097
Leishmania major	3-oxoacyl-ACP reductase, putative	0.0025	0.0321	0.6464
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0025	0.0321	0.0506
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.0032	0.0496	0.0525
Loa Loa (eye worm)	3-hydroxyacyl-CoA dehydrogenase type II	0.0025	0.0321	0.0306
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.0032	0.0496	0.0373
Mycobacterium tuberculosis	Possible 20-beta-hydroxysteroid dehydrogenase FabG3 (cortisone reductase) ((R)-20-hydroxysteroid dehydrogenase)	0.0025	0.0321	0.0196
Schistosoma mansoni	transcription factor LCR-F1	0.004	0.0721	0.0806
Echinococcus multilocularis	importin subunit beta 1	0.0029	0.041	0.0417
Mycobacterium ulcerans	short chain dehydrogenase	0.0025	0.0321	0.0196
Echinococcus granulosus	chromobox protein 1	0.0077	0.1753	0.2097
Trichomonas vaginalis	conserved hypothetical protein	0.0043	0.0815	0.0697
Entamoeba histolytica	Ran family GTPase	0.0021	0.0201	0.124
Schistosoma mansoni	ap endonuclease	0.0018	0.0127	0.0064
Onchocerca volvulus		0.0044	0.0846	0.0837
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.005	0.0993	0.1146
Toxoplasma gondii	GTP-binding nuclear protein ran/tc4	0.0021	0.0201	0.0075
Schistosoma mansoni	hypothetical protein	0.005	0.0993	0.1146
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0025	0.0321	0.0196
Trypanosoma brucei	importin beta-1 subunit, putative	0.0029	0.041	0.9423
Trypanosoma brucei	pteridine reductase 1	0.0025	0.0321	0.6464
Brugia malayi	RNA, U transporter 1	0.0081	0.187	0.2947
Entamoeba histolytica	hypothetical protein	0.004	0.0721	1
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.005	0.0993	0.1146
Entamoeba histolytica	hypothetical protein	0.0023	0.026	0.224
Mycobacterium tuberculosis	Probable short-chain type dehydrogenase/reductase	0.0025	0.0321	0.0196
Trichomonas vaginalis	conserved hypothetical protein	0.0031	0.0466	0.0343
Brugia malayi	MH2 domain containing protein	0.0017	0.0077	0.0121
Plasmodium falciparum	enoyl-acyl carrier reductase	0.0376	1	1
Loa Loa (eye worm)	MH2 domain-containing protein	0.0243	0.6344	0.784
Trichomonas vaginalis	conserved hypothetical protein	0.0031	0.0466	0.0343
Treponema pallidum	exodeoxyribonuclease (exoA)	0.0018	0.0127	0.5

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 624108