TDR Targets

Basic information

Technical information

TDR Targets ID: 625569
Name: 5-[(4-ethylpiperazin-1-yl)-(3-fluorophenyl)me thyl]-[1,3]thiazolo[2,3-e][1,2,4]triazol-6-ol
MW: 361.437 | Formula: C17H20FN5OS
H donors: 1 H acceptors: 3 LogP: 2.67 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: CCN1CCN(CC1)C(c1sc2n(c1O)ncn2)c1cccc(c1)F
InChi: 1S/C17H20FN5OS/c1-2-21-6-8-22(9-7-21)14(12-4-3-5-13(18)10-12)15-16(24)23-17(25-15)19-11-20-23/h3-5,10-11,14,24H,2,6-9H2,1H3
InChiKey: RUPVYMQJJNOVBW-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

5-[(4-ethylpiperazin-1-yl)-(3-fluorophenyl)methyl]thiazolo[2,3-e][1,2,4]triazol-6-ol
5-[(4-ethyl-1-piperazinyl)-(3-fluorophenyl)methyl]-6-thiazolo[2,3-e][1,2,4]triazolol

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0043	0.1004	0.0953
Echinococcus multilocularis	GPCR, family 2	0.0016	0.0182	0.0126
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0282	0.0118
Brugia malayi	latrophilin 2 splice variant baaae	0.0034	0.0735	0.0578
Brugia malayi	Eukaryotic-type carbonic anhydrase family protein	0.0162	0.4546	0.4453
Brugia malayi	inosine-5'-monophosphate dehydrogenase	0.0057	0.1404	0.1258
Mycobacterium ulcerans	lipase LipD	0.0043	0.1004	0.1076
Leishmania major	carbonic anhydrase-like protein	0.0345	1	1
Loa Loa (eye worm)	RecQ helicase	0.0019	0.0282	0.0118
Plasmodium falciparum	inosine-5'-monophosphate dehydrogenase	0.0129	0.3549	0.7661
Schistosoma mansoni	DNA helicase recq1	0.0019	0.0282	0.0282
Echinococcus granulosus	beta LACTamase domain containing family member	0.0043	0.1004	0.0953
Echinococcus multilocularis	carbonic anhydrase	0.0162	0.4546	0.4515
Schistosoma mansoni	glutaminase	0.0276	0.7955	0.7955
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0016	0.0182	0.0016
Leishmania major	inosine-5-monophosphate dehydrogenase	0.0129	0.3549	0.3439
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0043	0.1004	0.1076
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0036	0.0792	0.0739
Mycobacterium tuberculosis	Probable inosine-5'-monophosphate dehydrogenase GuaB3 (imp dehydrogenase) (inosinic acid dehydrogenase) (inosinate dehydrogenase	0.0072	0.1851	0.1926
Loa Loa (eye worm)	hypothetical protein	0.0043	0.1004	0.0852
Brugia malayi	ATP-dependent DNA helicase, RecQ family protein	0.0019	0.0282	0.0118
Plasmodium falciparum	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0023	0.0384	0.024
Trypanosoma cruzi	ATP-dependent DEAD/H DNA helicase recQ, putative	0.0019	0.0282	0.0118
Plasmodium vivax	inosine-5'-monophosphate dehydrogenase, putative	0.0129	0.3549	1
Brugia malayi	inosine-5'-monophosphate dehydrogenase family protein	0.0129	0.3549	0.3439
Mycobacterium ulcerans	inosine 5-monophosphate dehydrogenase	0.0057	0.1404	0.1589
Brugia malayi	inosine-5'-monophosphate dehydrogenase	0.0057	0.1404	0.1258
Leishmania major	hypothetical protein, conserved	0.0026	0.0487	0.0326
Trypanosoma brucei	carbonic anhydrase-like protein	0.0345	1	1
Mycobacterium tuberculosis	Conserved protein	0.0043	0.1004	0.0814
Mycobacterium tuberculosis	Probable lipase LipD	0.0043	0.1004	0.0814
Brugia malayi	Putative carbonic anhydrase 5 precursor	0.0345	1	1
Mycobacterium tuberculosis	Probable esterase LipL	0.0043	0.1004	0.0814
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease, putative	0.0023	0.0384	0.0221
Entamoeba histolytica	recQ family helicase, putative	0.0019	0.0282	0.3565
Loa Loa (eye worm)	eukaryotic-type carbonic anhydrase	0.0345	1	1
Schistosoma mansoni	ap endonuclease	0.0023	0.0384	0.0384
Trypanosoma cruzi	inosine-5'-monophosphate dehydrogenase, putative	0.0129	0.3549	0.3439
Trypanosoma brucei	PAB1-binding protein , putative	0.0026	0.0487	0.0326
Plasmodium falciparum	carbonic anhydrase	0.0162	0.4546	1
Mycobacterium ulcerans	glutaminase	0.0276	0.7955	1
Brugia malayi	hypothetical protein	0.0036	0.0792	0.0636
Trypanosoma brucei	inosine-5'-monophosphate dehydrogenase	0.0129	0.3549	0.3439
Trichomonas vaginalis	penicillin-binding protein, putative	0.0043	0.1004	0.0941
Plasmodium vivax	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0023	0.0384	0.1083
Echinococcus multilocularis	carbonic anhydrase II	0.0345	1	1
Schistosoma mansoni	hypothetical protein	0.0034	0.0735	0.0735
Trypanosoma brucei	GMP reductase	0.0129	0.3549	0.3439
Brugia malayi	beta-lactamase family protein	0.0043	0.1004	0.0852
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0735	0.0578
Loa Loa (eye worm)	carbonic anhydrase 3	0.0345	1	1
Entamoeba histolytica	hypothetical protein	0.0036	0.0792	1
Schistosoma mansoni	carbonic anhydrase-related	0.0162	0.4546	0.4546
Schistosoma mansoni	carbonic anhydrase	0.0162	0.4546	0.4546
Trichomonas vaginalis	D-aminoacylase, putative	0.0043	0.1004	0.0941
Trypanosoma cruzi	GMP reductase	0.0129	0.3549	0.3439
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0016	0.0182	0.0016
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0182	0.0016
Loa Loa (eye worm)	hypothetical protein	0.005	0.1211	0.1062
Leishmania major	guanosine monophosphate reductase	0.0129	0.3549	0.3439
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.0023	0.0384	0.0221
Toxoplasma gondii	IMP dehydrogenas	0.0129	0.3549	0.7806
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0055	0.1356	0.1306
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0055	0.1356	0.1356
Mycobacterium leprae	Probable inosine-5'-monophosphate dehydrogenase GuaB2 (IMP dehydrogenase) (IMPDH) (IMPD)	0.0129	0.3549	1
Loa Loa (eye worm)	hypothetical protein	0.0043	0.1004	0.0852
Toxoplasma gondii	LsmAD domain-containing protein	0.0026	0.0487	0.1072
Schistosoma mansoni	hypothetical protein	0.0162	0.4546	0.4546
Mycobacterium ulcerans	beta-lactamase	0.0043	0.1004	0.1076
Loa Loa (eye worm)	hypothetical protein	0.0162	0.4546	0.4453
Trypanosoma cruzi	hypothetical protein, conserved	0.0043	0.1004	0.0852
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0055	0.1356	0.1306
Echinococcus granulosus	carbonic anhydrase II	0.0345	1	1
Brugia malayi	Latrophilin receptor protein 2	0.0016	0.0182	0.0016
Schistosoma mansoni	hypothetical protein	0.0016	0.0182	0.0182
Plasmodium falciparum	ataxin-2 like protein, putative	0.0026	0.0487	0.0481
Wolbachia endosymbiont of Brugia malayi	IMP dehydrogenase	0.0129	0.3549	1
Trypanosoma cruzi	hypothetical protein, conserved	0.0043	0.1004	0.0852
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0278	0.7999	1
Trypanosoma cruzi	PAB1-binding protein , putative	0.0026	0.0487	0.0326
Loa Loa (eye worm)	hypothetical protein	0.0162	0.4546	0.4453
Schistosoma mansoni	ap endonuclease	0.0023	0.0384	0.0384
Entamoeba histolytica	exodeoxyribonuclease III, putative	0.0023	0.0384	0.4854
Loa Loa (eye worm)	hypothetical protein	0.0043	0.1004	0.0852
Loa Loa (eye worm)	MH2 domain-containing protein	0.0121	0.3309	0.3195
Schistosoma mansoni	hypothetical protein	0.0016	0.0182	0.0182
Brugia malayi	beta-lactamase	0.0043	0.1004	0.0852
Schistosoma mansoni	survival motor neuron protein	0.0057	0.1412	0.1412
Trichomonas vaginalis	esterase, putative	0.0043	0.1004	0.0941
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.0057	0.1412	0.1266
Echinococcus multilocularis	survival motor neuron protein 1	0.028	0.8069	0.8058
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0043	0.1004	0.0814
Loa Loa (eye worm)	hypothetical protein	0.0043	0.1004	0.0852
Mycobacterium tuberculosis	Probable lipase LipE	0.0043	0.1004	0.0814
Loa Loa (eye worm)	cytochrome P450 family protein	0.0025	0.0467	0.0305
Mycobacterium ulcerans	esterase/lipase LipP	0.0043	0.1004	0.1076
Echinococcus granulosus	inosine 5' monophosphate dehydrogenase 2	0.0129	0.3549	0.3512
Brugia malayi	hypothetical protein	0.0026	0.0487	0.0326
Giardia lamblia	Endonuclease/Exonuclease/phosphatase	0.0023	0.0384	1
Brugia malayi	exodeoxyribonuclease III family protein	0.0023	0.0384	0.0221
Echinococcus multilocularis	ATP dependent DNA helicase Q5	0.0019	0.0282	0.0227
Brugia malayi	Bloom's syndrome protein homolog	0.0019	0.0282	0.0118
Trichomonas vaginalis	glutaminase, putative	0.0276	0.7955	1
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0016	0.0182	0.0126
Mycobacterium leprae	PROBABLE INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE GUAB1(IMP DEHYDROGENASE) (IMPDH) (IMPD)	0.0057	0.1404	0.157
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0055	0.1356	0.1209
Loa Loa (eye worm)	hypothetical protein	0.028	0.8069	0.8036
Echinococcus multilocularis	ATP dependent DNA helicase Q1	0.0019	0.0282	0.0227
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease	0.0023	0.0384	0.0221
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0055	0.1356	0.1356
Loa Loa (eye worm)	hypothetical protein	0.0043	0.1004	0.0852
Trypanosoma cruzi	GMP reductase	0.0129	0.3549	0.3439
Onchocerca volvulus		0.0057	0.1412	1
Mycobacterium ulcerans	exodeoxyribonuclease III protein XthA	0.0023	0.0384	0.028
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0016	0.0182	0.0126
Echinococcus multilocularis	carbonic anhydrase	0.0162	0.4546	0.4515
Leishmania major	apurinic/apyrimidinic endonuclease-redox protein	0.0023	0.0384	0.0221
Brugia malayi	Carbonic anhydrase like protein 2 precursor	0.0162	0.4546	0.4453
Plasmodium vivax	ataxin-2 like protein, putative	0.0026	0.0487	0.1374
Plasmodium vivax	hypothetical protein, conserved	0.0043	0.1004	0.2831
Echinococcus granulosus	bloom syndrome protein	0.0019	0.0282	0.0227
Trypanosoma brucei	ATP-dependent DEAD/H DNA helicase recQ, putative	0.0019	0.0282	0.0118
Trypanosoma cruzi	inosine-5'-monophosphate dehydrogenase, putative	0.0129	0.3549	0.3439
Loa Loa (eye worm)	IMP dehydrogenase 1	0.0129	0.3549	0.3439
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.005	0.1211	0.1062
Loa Loa (eye worm)	glutaminase 2	0.0276	0.7955	0.792
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0043	0.1004	0.1004
Plasmodium falciparum	ataxin-2 like protein, putative	0.0026	0.0487	0.0481
Toxoplasma gondii	ATP-dependent DNA helicase, RecQ family protein	0.0019	0.0282	0.0621
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0036	0.0792	0.0739
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0055	0.1356	0.1306
Entamoeba histolytica	hypothetical protein	0.0036	0.0792	1
Schistosoma mansoni	carbonic anhydrase II (carbonate dehydratase II)	0.0345	1	1
Schistosoma mansoni	transcription factor LCR-F1	0.0036	0.0792	0.0792
Trypanosoma cruzi	carbonic anhydrase-like protein, putative	0.0345	1	1
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0043	0.1004	0.0814
Schistosoma mansoni	hypothetical protein	0.0036	0.0792	0.0792
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	0.0023	0.0384	0.033
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0043	0.1004	0.0852
Brugia malayi	glutaminase DH11.1	0.0276	0.7955	0.792
Leishmania major	ATP-dependent DEAD/H DNA helicase recQ, putative	0.0019	0.0282	0.0118
Trichomonas vaginalis	D-aminoacylase, putative	0.0043	0.1004	0.0941
Mycobacterium tuberculosis	Conserved protein	0.0043	0.1004	0.0814
Schistosoma mansoni	carbonic anhydrase-related	0.0162	0.4546	0.4546
Brugia malayi	Carbonic anhydrase like protein 2 precursor	0.0162	0.4546	0.4453
Brugia malayi	Calcitonin receptor-like protein seb-1	0.005	0.1211	0.1062
Entamoeba histolytica	hypothetical protein	0.0036	0.0792	1
Schistosoma mansoni	inosine-5-monophosphate dehydrogenase	0.0129	0.3549	0.3549
Trichomonas vaginalis	ap endonuclease, putative	0.0023	0.0384	0.0133
Trichomonas vaginalis	ap endonuclease, putative	0.0023	0.0384	0.0133
Schistosoma mansoni	hypothetical protein	0.0016	0.0182	0.0182
Brugia malayi	beta-lactamase family protein	0.0043	0.1004	0.0852
Brugia malayi	hypothetical protein	0.028	0.8069	0.8036
Schistosoma mansoni	hypothetical protein	0.0016	0.0182	0.0182
Trypanosoma cruzi	carbonic anhydrase-like protein, putative	0.0345	1	1
Brugia malayi	Eukaryotic-type carbonic anhydrase family protein	0.0162	0.4546	0.4453
Schistosoma mansoni	carbonic anhydrase II (carbonate dehydratase II)	0.0345	1	1
Entamoeba histolytica	hypothetical protein	0.0036	0.0792	1
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0055	0.1356	0.1356
Echinococcus granulosus	ATP dependent DNA helicase Q1	0.0019	0.0282	0.0227
Onchocerca volvulus	Putative GMP reductase	0.0057	0.1404	0.9801
Mycobacterium leprae	Probable inosine-5'-monophosphate dehydrogenase GuaB3 (IMP dehydrogenase 2) (inosinic acid dehydrogenase) (inosinate dehydrogena	0.0072	0.1851	0.3328
Loa Loa (eye worm)	hypothetical protein	0.0043	0.1004	0.0852
Brugia malayi	MH2 domain containing protein	0.0121	0.3309	0.3195
Loa Loa (eye worm)	hypothetical protein	0.0162	0.4546	0.4453
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0055	0.1356	0.1209
Echinococcus granulosus	survival motor neuron protein 1	0.028	0.8069	0.8058
Echinococcus granulosus	carbonic anhydrase	0.0162	0.4546	0.4515
Mycobacterium tuberculosis	Probable inosine-5'-monophosphate dehydrogenase GuaB2 (imp dehydrogenase) (inosinic acid dehydrogenase) (inosinate dehydrogenase	0.0129	0.3549	0.4155
Leishmania major	hypothetical protein, conserved	0.0043	0.1004	0.0852
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0043	0.1004	0.0814
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	0.0023	0.0384	0.033
Schistosoma mansoni	hypothetical protein	0.0012	0.0057	0.0057
Loa Loa (eye worm)	eukaryotic-type carbonic anhydrase	0.0162	0.4546	0.4453
Loa Loa (eye worm)	beta-lactamase	0.0043	0.1004	0.0852
Trypanosoma cruzi	inosine-5'-monophosphate dehydrogenase, putative	0.0129	0.3549	0.3439
Brugia malayi	ATP-dependent DNA helicase, RecQ family protein	0.0019	0.0282	0.0118
Toxoplasma gondii	exonuclease III APE	0.0023	0.0384	0.0846
Echinococcus multilocularis	bloom syndrome protein	0.0019	0.0282	0.0227
Loa Loa (eye worm)	glutaminase	0.0276	0.7955	0.792
Mycobacterium ulcerans	inosine 5-monophosphate dehydrogenase	0.0129	0.3549	0.4342
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0043	0.1004	0.0852
Brugia malayi	Cytochrome P450 family protein	0.0025	0.0467	0.0305
Trypanosoma brucei	apurinic/apyrimidinic endonuclease, putative	0.0023	0.0384	0.0221
Echinococcus granulosus	ATP dependent DNA helicase Q5	0.0019	0.0282	0.0227
Toxoplasma gondii	ATP-dependent DNA helicase, RecQ family protein	0.0019	0.0282	0.0621
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.005	0.1211	0.1062
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0487	0.0326
Mycobacterium tuberculosis	Probable hydrolase	0.0043	0.1004	0.0814
Schistosoma mansoni	hypothetical protein	0.0057	0.1412	0.1412
Echinococcus multilocularis	carbonic anhydrase	0.0162	0.4546	0.4515
Trichomonas vaginalis	penicillin-binding protein, putative	0.0043	0.1004	0.0941
Trypanosoma cruzi	PAB1-binding protein , putative	0.0026	0.0487	0.0326
Trichomonas vaginalis	D-aminoacylase, putative	0.0043	0.1004	0.0941
Brugia malayi	GMP reductase	0.0057	0.1404	0.1258
Mycobacterium ulcerans	hypothetical protein	0.0043	0.1004	0.1076
Brugia malayi	hypothetical protein	0.0017	0.0211	0.0045
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0016	0.0182	0.0126
Echinococcus multilocularis	inosine 5' monophosphate dehydrogenase 2	0.0129	0.3549	0.3512
Loa Loa (eye worm)	ATP-dependent DNA helicase	0.0019	0.0282	0.0118
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0055	0.1356	0.1306
Schistosoma mansoni	carbonic anhydrase-related	0.0162	0.4546	0.4546
Schistosoma mansoni	DNA helicase recq5	0.0019	0.0282	0.0282
Mycobacterium ulcerans	inosine 5'-monophosphate dehydrogenase	0.0129	0.3549	0.4342
Echinococcus granulosus	carbonic anhydrase	0.0162	0.4546	0.4515
Brugia malayi	Eukaryotic-type carbonic anhydrase family protein	0.0162	0.4546	0.4453
Loa Loa (eye worm)	transcription factor SMAD2	0.0121	0.3309	0.3195
Toxoplasma gondii	ABC1 family protein	0.0043	0.1004	0.221
Treponema pallidum	exodeoxyribonuclease (exoA)	0.0023	0.0384	0.5
Toxoplasma gondii	hypothetical protein	0.0162	0.4546	1
Echinococcus granulosus	GPCR family 2	0.0016	0.0182	0.0126
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0016	0.0182	0.0126
Trypanosoma brucei	hypothetical protein, conserved	0.0043	0.1004	0.0852
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0043	0.1004	0.1004
Loa Loa (eye worm)	GMP reductase	0.0057	0.1404	0.1258
Mycobacterium tuberculosis	Conserved protein	0.0043	0.1004	0.0814
Echinococcus granulosus	carbonic anhydrase	0.0162	0.4546	0.4515

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 625569