Detailed information for compound 631267

Basic information

Technical information
  • TDR Targets ID: 631267
  • Name: 1-[3-(2-chlorophenoxy)propoxy]-4-methoxybenze ne
  • MW: 292.757 | Formula: C16H17ClO3
  • H donors: 0 H acceptors: 0 LogP: 4.52 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1)OCCCOc1ccccc1Cl
  • InChi: 1S/C16H17ClO3/c1-18-13-7-9-14(10-8-13)19-11-4-12-20-16-6-3-2-5-15(16)17/h2-3,5-10H,4,11-12H2,1H3
  • InChiKey: BOKDGCFYZWUODT-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 1-[3-(2-chlorophenoxy)propoxy]-4-methoxy-benzene
  • ZINC02904352

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) T-complex protein 1 0.0026 0.0588 0.0588
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0083 0.2485 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.1773 0.2577
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.1773 0.2577
Onchocerca volvulus 0.0016 0.0253 0.0582
Brugia malayi Probable ClpP-like protease 0.0083 0.2485 0.4385
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0063 0.1823 1
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0036 0.0929 0.4867
Trichomonas vaginalis CMGC family protein kinase 0.005 0.1369 0.2316
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0041 0.1071 0.1512
Treponema pallidum hypothetical protein 0.0037 0.094 0.1503
Trichomonas vaginalis importin beta-1, putative 0.0023 0.0493 0.075
Trichomonas vaginalis Clan MA, family M48, Ste24 endopeptidase-like metallopeptidase 0.0011 0.008 0.0012
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0253 0.032
Entamoeba histolytica cysteine proteinase, putative 0.0016 0.0253 0.032
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0421 0.0311
Loa Loa (eye worm) hypothetical protein 0.0011 0.0074 0.0074
Echinococcus granulosus mitogen activated protein kinase 0.005 0.1369 0.1369
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.1773 0.2577
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0253 0.032
Toxoplasma gondii CAAX amino terminal protease family protein 0.0037 0.094 0.3081
Plasmodium vivax protease, putative 0.0037 0.094 0.3081
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0083 0.2485 1
Echinococcus granulosus GTP binding nuclear protein Ran 0.0021 0.0421 0.0421
Toxoplasma gondii t-complex protein beta subunit 0.0026 0.0588 0.1501
Brugia malayi serine/threonine-protein kinase plk-2 0.0103 0.3145 0.5551
Toxoplasma gondii hypothetical protein 0.0029 0.0667 0.1857
Entamoeba histolytica Ran family GTPase 0.0021 0.0421 0.0621
Brugia malayi T-complex protein 1, beta subunit 0.0026 0.0588 0.1037
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.005 0.1369 0.1369
Onchocerca volvulus 0.0085 0.2558 0.8088
Echinococcus multilocularis geminin 0.0164 0.5186 0.5186
Entamoeba histolytica cysteine proteinase, putative 0.0016 0.0253 0.032
Echinococcus granulosus geminin 0.0164 0.5186 0.5186
Plasmodium falciparum T-complex protein 1 subunit beta 0.0026 0.0588 0.1501
Trypanosoma brucei protein kinase, putative 0.005 0.1369 0.1808
Brugia malayi Cathepsin L-like precursor 0.0016 0.0253 0.0446
Leishmania major CAAX prenyl protease 2, putative,peptidase with unknown catalytic mechanism (family U48) 0.0178 0.5666 1
Loa Loa (eye worm) MH2 domain-containing protein 0.0127 0.3945 0.3945
Trypanosoma cruzi CAAX prenyl protease 1, putative 0.0066 0.1904 0.3051
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0091 0.2756 0.2756
Brugia malayi Cathepsin L-like precursor 0.0016 0.0253 0.0446
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0016 0.0253 0.032
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0016 0.0253 0.0253
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0021 0.0421 0.0754
Brugia malayi MH2 domain containing protein 0.0127 0.3945 0.6963
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0253 0.032
Schistosoma mansoni hypothetical protein 0.0308 1 1
Plasmodium falciparum protease, putative 0.0037 0.094 0.3081
Mycobacterium tuberculosis Probable integral membrane protein 0.0037 0.094 0.4934
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0253 0.032
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0253 0.032
Loa Loa (eye worm) hypothetical protein 0.0029 0.0675 0.0675
Echinococcus granulosus mitogen activated protein kinase 3 0.005 0.1369 0.1369
Trichomonas vaginalis CMGC family protein kinase 0.005 0.1369 0.2316
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0436 0.0648
Brugia malayi RNA, U transporter 1 0.0082 0.2452 0.4328
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.005 0.1369 0.2062
Leishmania major T-complex protein 1, beta subunit, putative 0.0026 0.0588 0.0619
Brugia malayi Cathepsin L-like precursor 0.0016 0.0253 0.0446
Brugia malayi Papain family cysteine protease containing protein 0.0016 0.0253 0.0446
Echinococcus multilocularis cysteine protease 0.0016 0.0253 0.0253
Loa Loa (eye worm) peptidase family M48 containing protein 0.0066 0.1904 0.1904
Echinococcus multilocularis caax prenyl protease 1 0.0066 0.1904 0.1904
Entamoeba histolytica CAAX amino terminal protease family 0.0037 0.094 0.155
Giardia lamblia Kinase, CMGC MAPK 0.005 0.1369 0.1808
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0253 0.032
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.005 0.1369 0.2062
Trichomonas vaginalis CAMK family protein kinase 0.0051 0.1419 0.2405
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0063 0.1823 0.7248
Brugia malayi MAP kinase sur-1 0.005 0.1369 0.2416
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0253 0.032
Echinococcus granulosus chaperonin containing TCP1 subunit 2 beta 0.0026 0.0588 0.0588
Brugia malayi Cathepsin L-like precursor 0.0011 0.0074 0.013
Schistosoma mansoni farnesylated-protein converting enzyme 1 (M48 family) 0.0066 0.1904 0.1904
Loa Loa (eye worm) hypothetical protein 0.0091 0.2756 0.2756
Loa Loa (eye worm) hypothetical protein 0.0011 0.0074 0.0074
Mycobacterium ulcerans integral membrane protein 0.0037 0.094 0.3577
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0253 0.032
Plasmodium vivax importin-beta 2, putative 0.0029 0.0675 0.1894
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0021 0.0421 0.0421
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0059 0.1681 0.1681
Trypanosoma brucei metallo- peptidase, Clan M- Family M48 0.0066 0.1904 0.2828
Onchocerca volvulus 0.0016 0.0253 0.0582
Trypanosoma cruzi major cysteine proteinase, putative 0.0048 0.1332 0.1993
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0253 0.032
Brugia malayi Importin beta-1 subunit 0.0029 0.0675 0.1192
Brugia malayi Peptidase family M48 containing protein 0.0066 0.1904 0.3361
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0083 0.2485 1
Echinococcus multilocularis peptidase Clp (S14 family) 0.0054 0.1529 0.1529
Trypanosoma cruzi polo-like protein kinase, putative 0.0103 0.3145 0.5343
Brugia malayi T-complex protein 1, beta subunit 0.0026 0.0588 0.1037
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0036 0.0929 0.3528
Schistosoma mansoni kinase 0.0052 0.1464 0.1464
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0083 0.2485 1
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0041 0.1071 0.1783
Brugia malayi Cathepsin L-like precursor 0.0016 0.0253 0.0446
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.1773 0.2577
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0253 0.032
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.1773 0.2577
Entamoeba histolytica T-complex protein 1 beta subunit, putative 0.0026 0.0588 0.0919
Loa Loa (eye worm) hypothetical protein 0.0091 0.2756 0.2756
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0493 0.075
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0063 0.1823 0.1823
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0421 0.0311
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0021 0.0421 0.0754
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0041 0.1071 0.1512
Brugia malayi Inositol-1 0.0041 0.1071 0.189
Plasmodium vivax T-complex protein 1 subunit beta, putative 0.0026 0.0588 0.1501
Entamoeba histolytica CAAX prenyl protease, putative 0.0066 0.1904 0.3273
Toxoplasma gondii hypothetical protein 0.0037 0.094 0.3081
Loa Loa (eye worm) hypothetical protein 0.0016 0.0253 0.0253
Entamoeba histolytica CAAX prenyl protease family 0.0178 0.5666 1
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.005 0.1369 0.2062
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0041 0.1071 0.4121
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0253 0.032
Trichomonas vaginalis CAMK family protein kinase 0.0051 0.1419 0.2405
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0675 0.0485
Mycobacterium ulcerans hypothetical protein 0.0037 0.094 0.3577
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0041 0.1071 0.3667
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.008 0.0012
Trichomonas vaginalis CAMK family protein kinase 0.0103 0.3145 0.5492
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0054 0.1529 0.8314
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.005 0.1369 0.5002
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0054 0.1529 0.6026
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0253 0.032
Entamoeba histolytica CAAX amino terminal protease family 0.0037 0.094 0.155
Trichomonas vaginalis CAMK family protein kinase 0.0103 0.3145 0.5492
Echinococcus multilocularis chaperonin containing TCP1, subunit 2 (beta) 0.0026 0.0588 0.0588
Echinococcus multilocularis importin subunit beta 1 0.0029 0.0675 0.0675
Schistosoma mansoni serine/threonine protein kinase 0.005 0.1369 0.1369
Trypanosoma brucei CAAX amino terminal protease, putative 0.0178 0.5666 1
Schistosoma mansoni serine/threonine protein kinase 0.0103 0.3145 0.3145
Brugia malayi CAAX amino terminal protease family protein 0.0178 0.5666 1
Trypanosoma cruzi cysteine peptidase, putative 0.0062 0.1773 0.2808
Echinococcus granulosus cathepsin l1 0.0011 0.0074 0.0074
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.1773 0.2577
Echinococcus granulosus peptidase Clp S14 family 0.0054 0.1529 0.1529
Trypanosoma brucei polo-like protein kinase 0.0103 0.3145 0.5194
Loa Loa (eye worm) hypothetical protein 0.0083 0.2485 0.2485
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0253 0.032
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb 0.0026 0.0588 0.0588
Toxoplasma gondii HEAT repeat-containing protein 0.0029 0.0675 0.1894
Echinococcus granulosus CAAX prenyl protease 2 0.0178 0.5666 0.5666
Brugia malayi cathepsin L-like precursor 0.0011 0.0074 0.013
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0054 0.1529 0.8314
Giardia lamblia TCP-1 chaperonin subunit beta 0.0026 0.0588 0.0318
Trypanosoma cruzi importin beta-1 subunit, putative 0.0023 0.0493 0.0444
Schistosoma mansoni importin beta-1 0.0029 0.0675 0.0675
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0029 0.0667 0.1857
Loa Loa (eye worm) hypothetical protein 0.0011 0.0074 0.0074
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0083 0.2485 1
Loa Loa (eye worm) ctsf protein 0.0016 0.0253 0.0253
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0253 0.032
Echinococcus multilocularis cathepsin L cysteine protease 0.0016 0.0253 0.0253
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0091 0.2756 0.2756
Loa Loa (eye worm) hypothetical protein 0.0178 0.5666 0.5666
Entamoeba histolytica serine/threonine protein kinase, putative 0.0103 0.3145 0.5492
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0063 0.1823 0.3218
Trichomonas vaginalis CAMK family protein kinase 0.0103 0.3145 0.5492
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0103 0.3145 0.3145
Echinococcus multilocularis snurportin 1 0.0308 1 1
Brugia malayi Trypsin family protein 0.0091 0.2756 0.4865
Mycobacterium tuberculosis Conserved hypothetical protein 0.0037 0.094 0.4934
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0103 0.3145 0.3145
Leishmania major importin beta-1 subunit, putative 0.0023 0.0493 0.0444
Entamoeba histolytica cysteine protease, putative 0.0016 0.0253 0.032
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0308 1 1
Onchocerca volvulus 0.0016 0.0253 0.0582
Trichomonas vaginalis Clan U, family U48, CaaX prenyl peptidase 2-like 0.0178 0.5666 1
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0083 0.2485 1
Echinococcus granulosus cathepsin l cysteine peptidase 0.0016 0.0253 0.0253
Trypanosoma cruzi peptidase with unknown catalytic mechanism (family U48) 0.0178 0.5666 1
Mycobacterium ulcerans hypothetical protein 0.0037 0.094 0.3577
Trypanosoma cruzi CAAX prenyl protease 2, putative 0.0178 0.5666 1
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.005 0.1369 0.1808
Schistosoma mansoni cathepsin F (C01 family) 0.0011 0.0074 0.0074
Schistosoma mansoni family U48 unassigned peptidase (U48 family) 0.0178 0.5666 0.5666
Trypanosoma cruzi cruzipain precursor, putative 0.0062 0.1773 0.2808
Onchocerca volvulus 0.0016 0.0253 0.0582
Onchocerca volvulus Cathepsin F homolog 0.0016 0.0253 0.0582
Onchocerca volvulus 0.0016 0.0253 0.0582
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0016 0.0253 0.0253
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb 0.0026 0.0588 0.0588
Trypanosoma brucei T-complex protein 1, beta subunit, putative 0.0026 0.0588 0.0318
Echinococcus granulosus cathepsin L cysteine proteinase 0.0016 0.0253 0.0253
Echinococcus multilocularis mitogen activated protein kinase 0.005 0.1369 0.1369
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0029 0.0667 0.1857
Trichomonas vaginalis CMGC family protein kinase 0.005 0.1369 0.2316
Schistosoma mansoni ran 0.0021 0.0421 0.0421
Brugia malayi Cathepsin L-like cysteine proteinase 0.0011 0.0074 0.013
Loa Loa (eye worm) cysteine protease 0.0016 0.0253 0.0253
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0253 0.032
Schistosoma mansoni cathepsin F (C01 family) 0.0016 0.0253 0.0253
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0253 0.032
Toxoplasma gondii CAAX metallo endopeptidase 0.0066 0.1904 0.74
Mycobacterium tuberculosis Probable conserved integral membrane protein 0.0037 0.094 0.4934
Trypanosoma cruzi cysteine peptidase, putative 0.0062 0.1773 0.2808
Mycobacterium tuberculosis Probable conserved integral membrane protein 0.0037 0.094 0.4934
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0253 0.032
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0253 0.032
Giardia lamblia Kinase, PLK 0.0103 0.3145 0.5194
Schistosoma mansoni hypothetical protein 0.0164 0.5186 0.5186
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0041 0.1071 0.1783
Schistosoma mansoni ran 0.0021 0.0421 0.0421
Toxoplasma gondii hypothetical protein 0.0037 0.094 0.3081
Onchocerca volvulus 0.0091 0.2756 0.8735
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0253 0.032
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0083 0.2485 1
Trypanosoma cruzi metallo- peptidase, Clan M- Family M48 0.0066 0.1904 0.3051
Trichomonas vaginalis CAMK family protein kinase 0.0103 0.3145 0.5492
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0021 0.0421 0.0743
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0103 0.3145 0.5343
Loa Loa (eye worm) transcription factor SMAD2 0.0127 0.3945 0.3945
Trichomonas vaginalis inositol monophosphatase, putative 0.0041 0.1071 0.1783
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0083 0.2485 0.2485
Schistosoma mansoni cathepsin F (C01 family) 0.0016 0.0253 0.0253
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0016 0.0253 0.032
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0041 0.1071 0.4121
Loa Loa (eye worm) fibroinase 0.0016 0.0253 0.0253
Giardia lamblia Hypothetical protein 0.0178 0.5666 1
Brugia malayi Cathepsin L-like precursor 0.0016 0.0253 0.0446
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0083 0.2485 1
Schistosoma mansoni peptidase Clp (S14 family) 0.0083 0.2485 0.2485
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0083 0.2485 1
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.005 0.1369 0.2062
Onchocerca volvulus Cathepsin L homolog 0.0016 0.0253 0.0582
Trichomonas vaginalis ran, putative 0.0021 0.0421 0.0621
Onchocerca volvulus Serine\/threonine kinase homolog 0.0103 0.3145 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0253 0.032
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.1773 0.2577
Echinococcus multilocularis cathepsin L cysteine protease 0.0016 0.0253 0.0253
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 0.0029 0.0667 0.244
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0103 0.3145 0.3145
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0021 0.0421 0.0421
Leishmania major cathepsin L-like protease 0.0062 0.1773 0.2808
Trichomonas vaginalis chaperonin, putative 0.0026 0.0588 0.0919
Trichomonas vaginalis CAMK family protein kinase 0.0103 0.3145 0.5492
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.1773 0.2577
Onchocerca volvulus 0.0016 0.0253 0.0582
Echinococcus granulosus importin subunit beta 1 0.0029 0.0675 0.0675
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0041 0.1071 0.124
Trichomonas vaginalis Clan MA, family M48, Ste24 endopeptidase-like metallopeptidase 0.0066 0.1904 0.3273
Echinococcus multilocularis mitogen activated protein kinase 3 0.005 0.1369 0.1369
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0041 0.1071 0.1512
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb 0.0026 0.0588 0.0588
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0253 0.032
Trichomonas vaginalis CMGC family protein kinase 0.005 0.1369 0.2316
Echinococcus multilocularis CAAX prenyl protease 2 0.0178 0.5666 0.5666
Onchocerca volvulus 0.0016 0.0253 0.0582
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0021 0.0421 0.0754
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0083 0.2485 1
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0675 0.0485
Trypanosoma cruzi T-complex protein 1, beta subunit, putative 0.0026 0.0588 0.0619
Schistosoma mansoni hypothetical protein 0.0164 0.5186 0.5186
Schistosoma mansoni family U48 unassigned peptidase (U48 family) 0.0178 0.5666 0.5666
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0436 0.0648
Echinococcus granulosus caax prenyl protease 1 0.0066 0.1904 0.1904
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0083 0.2485 0.2485
Echinococcus multilocularis cysteine protease 0.0016 0.0253 0.0253
Trichomonas vaginalis CAMK family protein kinase 0.0103 0.3145 0.5492
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0253 0.032
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0056 0.1594 0.2478
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0016 0.0253 0.0253
Echinococcus multilocularis inositol monophosphatase 1 0.0041 0.1071 0.1071
Brugia malayi Cathepsin L-like precursor 0.0011 0.0074 0.013
Echinococcus granulosus cathepsin l1 0.0016 0.0253 0.0253
Trichomonas vaginalis CAMK family protein kinase 0.0103 0.3145 0.5492
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0063 0.1823 0.1823
Leishmania major cathepsin L-like protease 0.0062 0.1773 0.2808
Schistosoma mansoni inositol monophosphatase 0.0041 0.1071 0.1071
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.1773 0.2577
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.1773 0.2577
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.005 0.1369 0.2062
Trichomonas vaginalis chaperonin-60kD, ch60, putative 0.0026 0.0588 0.0919
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0063 0.1823 0.2901
Leishmania major GTP-binding protein, putative 0.0021 0.0421 0.0311
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0083 0.2485 1
Trypanosoma cruzi polo-like protein kinase, putative 0.0103 0.3145 0.5343
Leishmania major CAAX prenyl protease 1, putative,metallo-peptidase, Clan M-, Family M48 0.0066 0.1904 0.3051
Echinococcus granulosus inositol monophosphatase 1 0.0041 0.1071 0.1071
Loa Loa (eye worm) inositol-1 0.0041 0.1071 0.1071
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0063 0.1823 0.7248
Leishmania major cathepsin L-like protease 0.0062 0.1773 0.2808
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0253 0.032
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.005 0.1369 0.2062
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0493 0.075
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0063 0.1823 0.1823
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.1773 0.2577
Trypanosoma cruzi cysteine peptidase, putative 0.0062 0.1773 0.2808
Onchocerca volvulus Cathepsin L homolog 0.0016 0.0253 0.0582
Plasmodium falciparum importin beta, putative 0.0029 0.0675 0.1894
Brugia malayi Cathepsin L-like precursor 0.0016 0.0253 0.0446
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0016 0.0253 0.0253
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0041 0.1071 0.1783
Entamoeba histolytica hypothetical protein 0.0023 0.0493 0.075
Schistosoma mansoni inositol monophosphatase 0.0041 0.1071 0.1071
Trichomonas vaginalis Clan MA, family M48, Ste24 endopeptidase-like metallopeptidase 0.0066 0.1904 0.3273

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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