TDR Targets

Basic information

Technical information

TDR Targets ID: 646941
Name: 5-(3,4-dichlorophenyl)-N-(4-ethoxyphenyl)fura n-2-carboxamide
MW: 376.233 | Formula: C19H15Cl2NO3
H donors: 1 H acceptors: 1 LogP: 5.41 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: CCOc1ccc(cc1)NC(=O)c1ccc(o1)c1ccc(c(c1)Cl)Cl
InChi: 1S/C19H15Cl2NO3/c1-2-24-14-6-4-13(5-7-14)22-19(23)18-10-9-17(25-18)12-3-8-15(20)16(21)11-12/h3-11H,2H2,1H3,(H,22,23)
InChiKey: AEDBYXCCDIQFGA-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

5-(3,4-dichlorophenyl)-N-(4-ethoxyphenyl)-2-furancarboxamide
5-(3,4-dichlorophenyl)-N-(4-ethoxyphenyl)-2-furamide
ZINC01411729

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trypanosoma cruzi	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0043	0.0073	0.3273
Echinococcus multilocularis	tumor protein p63	0.0345	0.0901	0.0862
Mycobacterium ulcerans	ATP-dependent Clp protease proteolytic subunit	0.008	0.0173	0.0138
Leishmania major	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0043	0.0073	0.3273
Chlamydia trachomatis	ATP-dependent Clp protease proteolytic subunit	0.008	0.0173	0.5
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0079	0.017	0.1302
Echinococcus granulosus	beta LACTamase domain containing family member	0.0079	0.017	0.0132
Plasmodium vivax	SET domain protein, putative	0.0032	0.0042	0.1138
Chlamydia trachomatis	ATP-dependent Clp protease proteolytic subunit	0.008	0.0173	0.5
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0079	0.017	0.0134
Trypanosoma cruzi	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0043	0.0073	0.3273
Loa Loa (eye worm)	hypothetical protein	0.0079	0.017	0.1132
Mycobacterium tuberculosis	Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2)	0.0052	0.0098	0.0052
Schistosoma mansoni	cellular tumor antigen P53	0.0051	0.0093	0.0051
Echinococcus multilocularis	survival motor neuron protein 1	0.0494	0.1309	0.1273
Echinococcus granulosus	ATP dependent Clp protease proteolytic subunit	0.008	0.0173	0.0135
Plasmodium vivax	ATP-dependent Clp protease proteolytic subunit, putative	0.0028	0.003	0.0328
Mycobacterium tuberculosis	Probable lipase LipD	0.0079	0.017	0.0151
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.0032	0.0042	0.1138
Toxoplasma gondii	hypothetical protein	0.0028	0.003	0.0328
Brugia malayi	Inositol-1	0.0043	0.0073	0.0555
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0079	0.017	0.0151
Toxoplasma gondii	ABC1 family protein	0.0079	0.017	0.9801
Mycobacterium leprae	Probable lipase LipE	0.0079	0.017	0.0192
Loa Loa (eye worm)	hypothetical protein	0.0079	0.017	0.1132
Trichomonas vaginalis	esterase, putative	0.0079	0.017	0.1699
Onchocerca volvulus		0.0101	0.0231	0.3115
Echinococcus granulosus	survival motor neuron protein 1	0.0494	0.1309	0.1276
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0079	0.017	0.0129
Echinococcus multilocularis	inositol monophosphatase 1	0.0043	0.0073	0.0031
Leishmania major	hypothetical protein, conserved	0.0079	0.017	1
Brugia malayi	Pre-SET motif family protein	0.0223	0.0564	0.4309
Plasmodium falciparum	ATP-dependent Clp protease proteolytic subunit	0.0028	0.003	0.0328
Trichomonas vaginalis	D-aminoacylase, putative	0.0079	0.017	0.1699
Brugia malayi	Probable ClpP-like protease	0.008	0.0173	0.1324
Mycobacterium ulcerans	lipase LipD	0.0079	0.017	0.0134
Mycobacterium tuberculosis	Probable esterase LipL	0.0079	0.017	0.0151
Brugia malayi	beta-lactamase	0.0079	0.017	0.1302
Trichomonas vaginalis	D-aminoacylase, putative	0.0079	0.017	0.1699
Mycobacterium ulcerans	hypothetical protein	0.0079	0.017	0.0134
Plasmodium vivax	ATP-dependent Clp protease proteolytic subunit, putative	0.008	0.0173	1
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.0101	0.0231	0.1763
Schistosoma mansoni	survival motor neuron protein	0.0101	0.0231	0.019
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0079	0.017	0.1132
Schistosoma mansoni	microtubule-associated protein tau	0.3666	1	1
Wolbachia endosymbiont of Brugia malayi	ATP-dependent Clp protease proteolytic subunit	0.008	0.0173	1
Brugia malayi	Pre-SET motif family protein	0.0032	0.0042	0.032
Echinococcus granulosus	histone lysine methyltransferase setb	0.0032	0.0042	0.0003
Mycobacterium tuberculosis	Transcriptional regulatory repressor protein (TetR-family) EthR	0.2705	0.7367	1
Onchocerca volvulus		0.0079	0.017	0.2119
Loa Loa (eye worm)	hypothetical protein	0.0079	0.017	0.1132
Mycobacterium ulcerans	beta-lactamase	0.0079	0.017	0.0134
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0079	0.017	0.0151
Trypanosoma brucei	hypothetical protein, conserved	0.0079	0.017	1
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0093	0.0529
Mycobacterium leprae	conserved hypothetical protein	0.0079	0.017	0.0192
Loa Loa (eye worm)	hypothetical protein	0.0494	0.1309	1
Onchocerca volvulus		0.0051	0.0093	0.0841
Loa Loa (eye worm)	hypothetical protein	0.0079	0.017	0.1132
Trichomonas vaginalis	set domain proteins, putative	0.0253	0.0648	1
Loa Loa (eye worm)	hypothetical protein	0.0079	0.017	0.1132
Trypanosoma brucei	inositol-1(or 4)-monophosphatase 1, putative	0.0043	0.0073	0.3273
Toxoplasma gondii	inositol(myo)-1(or 4)-monophosphatase 2, putative	0.0043	0.0073	0.3208
Toxoplasma gondii	ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein	0.008	0.0173	1
Mycobacterium ulcerans	transcriptional regulator	0.2705	0.7367	1
Mycobacterium tuberculosis	Probable lipase LipE	0.0079	0.017	0.0151
Brugia malayi	beta-lactamase family protein	0.0079	0.017	0.1302
Trichomonas vaginalis	D-aminoacylase, putative	0.0079	0.017	0.1699
Echinococcus multilocularis	ATP dependent Clp protease proteolytic subunit	0.008	0.0173	0.0132
Trypanosoma cruzi	hypothetical protein, conserved	0.0079	0.017	1
Echinococcus granulosus	inositol monophosphatase 1	0.0043	0.0073	0.0034
Trichomonas vaginalis	penicillin-binding protein, putative	0.0079	0.017	0.1699
Trichomonas vaginalis	penicillin-binding protein, putative	0.0079	0.017	0.1699
Echinococcus multilocularis	peptidase Clp (S14 family)	0.0052	0.0098	0.0056
Plasmodium vivax	hypothetical protein, conserved	0.0079	0.017	0.9801
Schistosoma mansoni	hypothetical protein	0.0101	0.0231	0.019
Loa Loa (eye worm)	hypothetical protein	0.0079	0.017	0.1132
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0223	0.0564	0.4198
Trypanosoma cruzi	hypothetical protein, conserved	0.0079	0.017	1
Loa Loa (eye worm)	inositol-1	0.0043	0.0073	0.0371
Echinococcus granulosus	peptidase Clp S14 family	0.0052	0.0098	0.006
Brugia malayi	hypothetical protein	0.0494	0.1309	1
Mycobacterium ulcerans	ATP-dependent Clp protease proteolytic subunit	0.008	0.0173	0.0138
Schistosoma mansoni	inositol monophosphatase	0.0043	0.0073	0.0031
Plasmodium falciparum	ATP-dependent Clp protease proteolytic subunit	0.008	0.0173	1
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0079	0.017	0.0151
Onchocerca volvulus		0.0079	0.017	0.2119
Mycobacterium leprae	PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP)	0.0052	0.0098	0.0093
Mycobacterium leprae	PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2)	0.008	0.0173	0.0196
Mycobacterium ulcerans	TetR family transcriptional regulator	0.2705	0.7367	1
Mycobacterium tuberculosis	Probable hydrolase	0.0079	0.017	0.0151
Mycobacterium leprae	Probable transcriptional regulatory repressor protein (TetR-family) EthR	0.2705	0.7367	1
Mycobacterium tuberculosis	Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP)	0.0052	0.0098	0.0052
Treponema pallidum	ATP-dependent Clp protease proteolytic subunit	0.008	0.0173	1
Toxoplasma gondii	ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein	0.008	0.0173	1
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0079	0.017	0.0129
Loa Loa (eye worm)	beta-lactamase	0.0079	0.017	0.1132
Entamoeba histolytica	myo-inositol monophosphatase, putative	0.0043	0.0073	0.5
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0079	0.017	0.0129
Mycobacterium tuberculosis	Conserved protein	0.0079	0.017	0.0151
Loa Loa (eye worm)	hypothetical protein	0.008	0.0173	0.1155
Brugia malayi	beta-lactamase family protein	0.0079	0.017	0.1302
Mycobacterium tuberculosis	Conserved protein	0.0079	0.017	0.0151
Brugia malayi	hypothetical protein	0.0026	0.0025	0.0191
Mycobacterium ulcerans	esterase/lipase LipP	0.0079	0.017	0.0134
Echinococcus multilocularis	atpase aaa+ type core atpase aaa type core	0.0829	0.2225	0.2192
Echinococcus multilocularis	microtubule associated protein 2	0.3666	1	1
Onchocerca volvulus		0.0079	0.017	0.2119
Mycobacterium ulcerans	AcrR family transcriptional regulator	0.2705	0.7367	1
Onchocerca volvulus		0.0253	0.0648	1
Mycobacterium leprae	possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ).	0.0039	0.006	0.0041
Schistosoma mansoni	peptidase Clp (S14 family)	0.008	0.0173	0.0132
Mycobacterium tuberculosis	Conserved protein	0.0079	0.017	0.0151
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0042	0.0131
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0504	0.1335	0.1744
Echinococcus granulosus	tumor protein p63	0.0345	0.0901	0.0865
Schistosoma mansoni	inositol monophosphatase	0.0043	0.0073	0.0031

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 646941