TDR Targets

Basic information

Technical information

TDR Targets ID: 649763
Name: (5Z)-5-[(3-hydroxyphenyl)methylidene]-1-(4-me thylphenyl)-1,3-diazinane-2,4,6-trione
MW: 322.315 | Formula: C18H14N2O4
H donors: 2 H acceptors: 4 LogP: 2.71 Rotable bonds: 2
Rule of 5 violations (Lipinski): 1
SMILES: Cc1ccc(cc1)N1C(=O)NC(=O)C(=Cc2cccc(c2)O)C1=O
InChi: 1S/C18H14N2O4/c1-11-5-7-13(8-6-11)20-17(23)15(16(22)19-18(20)24)10-12-3-2-4-14(21)9-12/h2-10,21H,1H3,(H,19,22,24)/b15-10-
InChiKey: OMNOSRRMISICIS-GDNBJRDFSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

(5Z)-5-[(3-hydroxyphenyl)methylene]-1-(4-methylphenyl)hexahydropyrimidine-2,4,6-trione
(5Z)-5-(3-hydroxybenzylidene)-1-(4-methylphenyl)barbituric acid
ZINC05043675

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Leishmania major	glucose transporter, lmgt1	0.0065	0.1055	1
Trypanosoma cruzi	hexose transporter, putative	0.0065	0.1055	1
Trichomonas vaginalis	sugar transporter, putative	0.0029	0.0333	0.0461
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0209	0.3993	1
Plasmodium vivax	CDK-related protein kinase 6, putative	0.0448	0.8886	1
Brugia malayi	nicotinic acetylcholine receptor alpha subunit, putative	0.0193	0.3672	0.5162
Schistosoma mansoni	nAChR subunit	0.0193	0.3672	0.9151
Leishmania major	flap endonuclease-1 (FEN-1), putative	0.0028	0.0315	0.1186
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0193	0.3672	0.5162
Brugia malayi	Major Facilitator Superfamily protein	0.0029	0.0333	0.0341
Plasmodium vivax	calcium-dependent protein kinase 3, putative	0.0032	0.0395	0.0207
Trichomonas vaginalis	conserved hypothetical protein	0.0029	0.0333	0.0461
Trichomonas vaginalis	sugar transporter, putative	0.0029	0.0333	0.0461
Brugia malayi	nicotinic acetylcholine receptor beta-1 chain precursor	0.0193	0.3672	0.5162
Trypanosoma cruzi	hexose transporter, putative	0.0029	0.0333	0.14
Loa Loa (eye worm)	LGC-31 protein	0.0193	0.3672	0.3672
Echinococcus multilocularis	solute carrier family 2, facilitated glucose	0.0209	0.3993	1
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0209	0.3993	1
Echinococcus multilocularis	synaptic vesicle 2 protein	0.0029	0.0333	0.0311
Schistosoma mansoni	tar DNA-binding protein	0.0068	0.1133	0.2427
Brugia malayi	Cation transporter family protein	0.0193	0.3672	0.5162
Schistosoma mansoni	glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs)	0.0032	0.0381	0.0438
Plasmodium vivax	calcium-dependent protein kinase 1, putative	0.0032	0.0395	0.0207
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0333	0.0333
Schistosoma mansoni	nAChR subunit	0.0089	0.1551	0.3535
Chlamydia trachomatis	lysine--tRNA ligase	0.0024	0.0216	0.5
Loa Loa (eye worm)	hypothetical protein	0.0104	0.1856	0.1856
Loa Loa (eye worm)	ACC-1 protein	0.0193	0.3672	0.3672
Schistosoma mansoni	sugar transporter	0.0029	0.0333	0.0311
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0039	0.0537	0.085
Schistosoma mansoni	protein kinase	0.0032	0.0395	0.0474
Trichomonas vaginalis	sugar transporter, putative	0.0029	0.0333	0.0461
Brugia malayi	bifunctional aminoacyl-tRNA synthetase	0.0032	0.0381	0.041
Trichomonas vaginalis	sugar transporter, putative	0.0029	0.0333	0.0461
Echinococcus granulosus	glycine receptor subunit alpha 1	0.0193	0.3672	0.9151
Loa Loa (eye worm)	glutamate-gated chloride channel alpha3A subunit	0.0193	0.3672	0.3672
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0209	0.3993	1
Echinococcus granulosus	nicotinic acetylcholine receptor a11 subunit	0.0193	0.3672	0.9151
Toxoplasma gondii	sugar transporter ST1	0.0029	0.0333	0.0209
Echinococcus multilocularis	nAChR subunit	0.0193	0.3672	0.9151
Giardia lamblia	Flap structure-specific endonuclease	0.0028	0.0315	0.601
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0333	0.0333
Loa Loa (eye worm)	CAMK/CAMK2 protein kinase	0.0032	0.0395	0.0395
Trichomonas vaginalis	conserved hypothetical protein	0.0029	0.0333	0.0461
Loa Loa (eye worm)	hypothetical protein	0.0089	0.1551	0.1551
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0209	0.3993	1
Trichomonas vaginalis	flap endonuclease-1, putative	0.0028	0.0315	0.0414
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0104	0.1856	0.2539
Trichomonas vaginalis	sugar transporter, putative	0.0029	0.0333	0.0461
Entamoeba histolytica	hypothetical protein	0.0104	0.1856	1
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0068	0.1133	0.1133
Brugia malayi	hypothetical protein	0.0039	0.0537	0.0635
Echinococcus granulosus	acetylcholine receptor subunit beta 1	0.0193	0.3672	0.9151
Echinococcus multilocularis	glutamyl tRNA synthetase cytoplasmic	0.0032	0.0381	0.0438
Onchocerca volvulus		0.0193	0.3672	1
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0065	0.1055	1
Echinococcus multilocularis	Cys loop ligand gated ion channel subunit	0.0089	0.1551	0.3535
Trypanosoma brucei	flap endonuclease-1 (FEN-1), putative	0.0028	0.0315	0.1186
Loa Loa (eye worm)	hypothetical protein	0.0089	0.1551	0.1551
Entamoeba histolytica	hypothetical protein	0.0039	0.0537	0.1958
Leishmania major	prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative	0.0037	0.0489	0.325
Echinococcus multilocularis	General substrate transporter	0.0179	0.3394	0.8415
Loa Loa (eye worm)	hypothetical protein	0.0193	0.3672	0.3672
Echinococcus granulosus	nicotinic acetylcholine receptor subunit alpha 8	0.0193	0.3672	0.9151
Schistosoma mansoni	glucose transport protein	0.0209	0.3993	1
Echinococcus multilocularis	solute carrier family 22	0.0029	0.0333	0.0311
Trypanosoma cruzi	flap endonuclease-1 (FEN-1), putative	0.0028	0.0315	0.1186
Loa Loa (eye worm)	hypothetical protein	0.0268	0.5206	0.5206
Schistosoma mansoni	nAChR subunit (ShAR1-alpha-like)	0.0193	0.3672	0.9151
Trichomonas vaginalis	sugar transporter, putative	0.0029	0.0333	0.0461
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0193	0.3672	0.5162
Trichomonas vaginalis	sugar transporter, putative	0.0029	0.0333	0.0461
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0381	0.0381
Plasmodium falciparum	ataxin-2 like protein, putative	0.0028	0.0297	0.0093
Brugia malayi	glutamate-gated chloride channel alpha3A subunit, putative	0.0089	0.1551	0.2099
Brugia malayi	Cam kinase protein 1	0.0032	0.0395	0.0429
Schistosoma mansoni	protein kinase	0.0032	0.0395	0.0474
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0193	0.3672	0.5162
Plasmodium vivax	mitogen-activated protein kinase 2, putative	0.0171	0.3219	0.3464
Loa Loa (eye worm)	major facilitator superfamily transporter	0.0029	0.0333	0.0333
Plasmodium falciparum	calcium-dependent protein kinase 2	0.0032	0.0395	0.0207
Schistosoma mansoni	sugar transporter	0.0029	0.0333	0.0311
Trichomonas vaginalis	sugar transporter, putative	0.0029	0.0333	0.0461
Brugia malayi	Acetylcholine receptor protein, alpha-like chain 1 precursor	0.0089	0.1551	0.2099
Trypanosoma brucei	bifunctional aminoacyl-tRNA synthetase, putative	0.0037	0.0489	0.325
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0297	0.0297
Brugia malayi	hypothetical protein	0.0029	0.0333	0.0341
Toxoplasma gondii	facilitative glucose transporter GT1	0.0209	0.3993	0.6732
Brugia malayi	Sugar transporter family protein	0.0029	0.0333	0.0341
Plasmodium falciparum	hexose transporter	0.0209	0.3993	0.4356
Mycobacterium tuberculosis	Probable dicarboxylic acid transport integral membrane protein KgtP (dicarboxylate transporter)	0.0029	0.0333	1
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0032	0.0395	0.0474
Trypanosoma cruzi	glucose transporter, putative	0.0029	0.0333	0.14
Loa Loa (eye worm)	acetylcholine receptor alpha subunit	0.0193	0.3672	0.3672
Onchocerca volvulus		0.0089	0.1551	0.3647
Echinococcus granulosus	General substrate transporter	0.0179	0.3394	0.8415
Trypanosoma brucei	myo-inositol/proton symporter (MIT)	0.0029	0.0333	0.14
Echinococcus granulosus	Cys loop ligand gated ion channel subunit	0.0193	0.3672	0.9151
Echinococcus granulosus	solute carrier family 22	0.0029	0.0333	0.0311
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0209	0.3993	1
Trichomonas vaginalis	sugar transporter, putative	0.0029	0.0333	0.0461
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0333	0.0333
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.0193	0.3672	0.9151
Echinococcus granulosus	flap endonuclease 1	0.0028	0.0315	0.0264
Onchocerca volvulus		0.0193	0.3672	1
Trichomonas vaginalis	sugar transporter, putative	0.0029	0.0333	0.0461
Leishmania major	protein kinase, putative	0.0032	0.0395	0.2132
Trypanosoma brucei	glucose transporter, putative	0.0065	0.1055	1
Loa Loa (eye worm)	hypothetical protein	0.0193	0.3672	0.3672
Trichomonas vaginalis	glucose transporter, putative	0.0029	0.0333	0.0461
Echinococcus granulosus	Sugar transporter ERD6 protein	0.0029	0.0333	0.0311
Loa Loa (eye worm)	hypothetical protein	0.0104	0.1856	0.1856
Trypanosoma cruzi	prolyl-tRNA synthetase, putative	0.0037	0.0489	0.325
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0089	0.1551	0.2099
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0193	0.3672	0.5162
Echinococcus multilocularis	Cys loop ligand gated ion channel subunit	0.0193	0.3672	0.9151
Echinococcus multilocularis	nicotinic acetylcholine receptor a11 subunit	0.0193	0.3672	0.9151
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0193	0.3672	0.9151
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0193	0.3672	0.5162
Brugia malayi	Major Facilitator Superfamily protein	0.0029	0.0333	0.0341
Brugia malayi	acetylcholine receptor alpha subunit precursor, putative	0.0193	0.3672	0.5162
Echinococcus multilocularis	nicotinic acetylcholine receptor alpha subunit	0.0193	0.3672	0.9151
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0333	0.0333
Echinococcus multilocularis	glycine receptor subunit beta	0.0193	0.3672	0.9151
Entamoeba histolytica	protein kinase, putative	0.0032	0.0395	0.1091
Loa Loa (eye worm)	nicotinic acetylcholine receptor non-alpha subunit	0.0193	0.3672	0.3672
Trypanosoma brucei	glucose transporter, putative	0.0065	0.1055	1
Trichomonas vaginalis	conserved hypothetical protein	0.0029	0.0333	0.0461
Mycobacterium ulcerans	integral membrane transport protein	0.0029	0.0333	1
Loa Loa (eye worm)	hypothetical protein	0.0104	0.1856	0.1856
Giardia lamblia	Prolyl-tRNA synthetase	0.0032	0.0381	1
Brugia malayi	major facilitator superfamily protein	0.0029	0.0333	0.0341
Echinococcus multilocularis	nAChR subunit	0.0104	0.1856	0.4342
Echinococcus granulosus	calcium dependent protein kinase	0.003	0.0354	0.0366
Brugia malayi	acetylcholine receptor protein, alpha-like chain, putative	0.0193	0.3672	0.5162
Schistosoma mansoni	nAChR subunit	0.0193	0.3672	0.9151
Echinococcus granulosus	glycine receptor subunit beta	0.0193	0.3672	0.9151
Brugia malayi	TAR-binding protein	0.0068	0.1133	0.1495
Brugia malayi	hypothetical protein	0.0029	0.0333	0.0341
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0381	0.0381
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0193	0.3672	0.5162
Toxoplasma gondii	cell-cycle-associated protein kinase MAPK, putative	0.0171	0.3219	0.5352
Schistosoma mansoni	tar DNA-binding protein	0.0068	0.1133	0.2427
Trypanosoma cruzi	hexose transporter, putative	0.0065	0.1055	1
Plasmodium falciparum	calcium-dependent protein kinase 3	0.0032	0.0395	0.0207
Plasmodium vivax	proline--tRNA ligase, putative	0.0037	0.0489	0.0315
Brugia malayi	Major Facilitator Superfamily protein	0.0029	0.0333	0.0341
Loa Loa (eye worm)	hypothetical protein	0.0193	0.3672	0.3672
Schistosoma mansoni	sugar transporter	0.0029	0.0333	0.0311
Brugia malayi	Sugar transporter family protein	0.0209	0.3993	0.5625
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0089	0.1551	0.2099
Echinococcus granulosus	glycine receptor subunit beta	0.0193	0.3672	0.9151
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0193	0.3672	0.5162
Echinococcus multilocularis	Sugar transporter ERD6 protein	0.0029	0.0333	0.0311
Echinococcus granulosus	glycine receptor subunit alpha 1	0.0193	0.3672	0.9151
Leishmania major	glucose transporter, lmgt3	0.0065	0.1055	1
Loa Loa (eye worm)	hypothetical protein	0.0089	0.1551	0.1551
Loa Loa (eye worm)	hypothetical protein	0.0089	0.1551	0.1551
Trichomonas vaginalis	sugar transporter, putative	0.0029	0.0333	0.0461
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0032	0.0395	0.0474
Loa Loa (eye worm)	hypothetical protein	0.0089	0.1551	0.1551
Loa Loa (eye worm)	hypothetical protein	0.0104	0.1856	0.1856
Entamoeba histolytica	hypothetical protein	0.0039	0.0537	0.1958
Onchocerca volvulus		0.0193	0.3672	1
Trichomonas vaginalis	prolyl-tRNA synthetase, putative	0.0032	0.0381	0.0586
Onchocerca volvulus		0.0104	0.1856	0.456
Brugia malayi	hypothetical protein	0.0089	0.1551	0.2099
Plasmodium falciparum	calcium-dependent protein kinase 5	0.0032	0.0395	0.0207
Toxoplasma gondii	calcium-dependent protein kinase CDPK3	0.0032	0.0395	0.032
Schistosoma mansoni	nAChR subunit	0.0193	0.3672	0.9151
Brugia malayi	Bifunctional aminoacyl-tRNA synthetase	0.0032	0.0381	0.041
Echinococcus granulosus	nAChR subunit	0.0193	0.3672	0.9151
Schistosoma mansoni	hypothetical protein	0.0039	0.0537	0.085
Brugia malayi	hypothetical protein	0.0089	0.1551	0.2099
Schistosoma mansoni	protein kinase	0.0032	0.0395	0.0474
Brugia malayi	Cytochrome P450 family protein	0.0028	0.0312	0.031
Trichomonas vaginalis	glucose transporter, putative	0.0065	0.1055	0.2343
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0333	0.0333
Entamoeba histolytica	protein kinase, putative	0.0032	0.0395	0.1091
Loa Loa (eye worm)	hypothetical protein	0.0104	0.1856	0.1856
Loa Loa (eye worm)	sugar transporter	0.0029	0.0333	0.0333
Echinococcus multilocularis	solute carrier family 22	0.0029	0.0333	0.0311
Toxoplasma gondii	flap structure-specific endonuclease 1, putative	0.0028	0.0315	0.0177
Loa Loa (eye worm)	calcium/calmodulin-dependent protein kinase ID	0.0032	0.0395	0.0395
Loa Loa (eye worm)	hypothetical protein	0.0193	0.3672	0.3672
Trypanosoma brucei	glucose transporter, putative	0.0065	0.1055	1
Trichomonas vaginalis	sugar transporter, putative	0.0029	0.0333	0.0461
Echinococcus granulosus	solute carrier family 22	0.0029	0.0333	0.0311
Echinococcus multilocularis	flap endonuclease 1	0.0028	0.0315	0.0264
Trichomonas vaginalis	sugar transporter, putative	0.0029	0.0333	0.0461
Loa Loa (eye worm)	hypothetical protein	0.0104	0.1856	0.1856
Loa Loa (eye worm)	hypothetical protein	0.0104	0.1856	0.1856
Plasmodium vivax	ataxin-2 like protein, putative	0.0028	0.0297	0.0093
Brugia malayi	Neuronal acetylcholine receptor protein, alpha-2 chain precursor	0.0089	0.1551	0.2099
Echinococcus multilocularis	glycine receptor subunit beta	0.0193	0.3672	0.9151
Loa Loa (eye worm)	cytochrome P450 family protein	0.0028	0.0312	0.0312
Trichomonas vaginalis	CAMK family protein kinase	0.0032	0.0395	0.0621
Loa Loa (eye worm)	hypothetical protein	0.0193	0.3672	0.3672
Toxoplasma gondii	sugar transporter ST2	0.0029	0.0333	0.0209
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0193	0.3672	0.5162
Loa Loa (eye worm)	hypothetical protein	0.0104	0.1856	0.1856
Trypanosoma cruzi	PAB1-binding protein , putative	0.0028	0.0297	0.0964
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0039	0.0537	0.085
Echinococcus granulosus	Cys loop ligand gated ion channel subunit	0.0089	0.1551	0.3535
Loa Loa (eye worm)	hypothetical protein	0.0193	0.3672	0.3672
Brugia malayi	excitatory GABA receptor EXP-1A	0.0193	0.3672	0.5162
Trichomonas vaginalis	conserved hypothetical protein	0.0209	0.3993	1
Trichomonas vaginalis	sugar transporter, putative	0.0029	0.0333	0.0461
Brugia malayi	hypothetical protein	0.0029	0.0333	0.0341
Plasmodium falciparum	major facilitator superfamily domain-containing protein, putative	0.0029	0.0333	0.0136
Loa Loa (eye worm)	hypothetical protein	0.0193	0.3672	0.3672
Trypanosoma cruzi	PAB1-binding protein , putative	0.0028	0.0297	0.0964
Echinococcus granulosus	tar DNA binding protein	0.0068	0.1133	0.2427
Loa Loa (eye worm)	hypothetical protein	0.0089	0.1551	0.1551
Schistosoma mansoni	acetylcholine receptor-related	0.0089	0.1551	0.3535
Trypanosoma brucei	glucose transporter 1E	0.0065	0.1055	1
Trypanosoma brucei	glucose transporter, putative	0.0065	0.1055	1
Trypanosoma brucei	glucose transporter, putative	0.0065	0.1055	1
Echinococcus multilocularis	tar DNA binding protein	0.0068	0.1133	0.2427
Toxoplasma gondii	transporter, major facilitator family protein	0.0029	0.0333	0.0209
Brugia malayi	Cation transporter family protein	0.0193	0.3672	0.5162
Loa Loa (eye worm)	flap endonuclease-1	0.0028	0.0315	0.0315
Loa Loa (eye worm)	hypothetical protein	0.0026	0.026	0.026
Plasmodium vivax	calcium-dependent protein kinase, putative	0.0032	0.0395	0.0207
Mycobacterium leprae	Probable prolyl tRNA synthetase ProS	0.0032	0.0381	1
Entamoeba histolytica	Flap nuclease, putative	0.0028	0.0315	0.0607
Echinococcus granulosus	nicotinic acetylcholine receptor alpha subunit	0.0193	0.3672	0.9151
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0333	0.0333
Brugia malayi	Sugar transporter family protein	0.0029	0.0333	0.0341
Loa Loa (eye worm)	acetylcholine receptor protein	0.0089	0.1551	0.1551
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0395	0.0395
Loa Loa (eye worm)	hypothetical protein	0.0193	0.3672	0.3672
Loa Loa (eye worm)	hypothetical protein	0.0089	0.1551	0.1551
Schistosoma mansoni	nAChR subunit	0.0193	0.3672	0.9151
Toxoplasma gondii	protein kinase, putative	0.0298	0.5826	1
Mycobacterium tuberculosis	Probable conserved integral membrane transport protein	0.0029	0.0333	1
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0193	0.3672	0.5162
Echinococcus multilocularis	nicotinic acetylcholine receptor subunit alpha 8	0.0193	0.3672	0.9151
Brugia malayi	RNA binding protein	0.0068	0.1133	0.1495
Trypanosoma brucei	calcium/calmodulin-dependent protein kinase, putative	0.0032	0.0395	0.2132
Loa Loa (eye worm)	hypothetical protein	0.0089	0.1551	0.1551
Trypanosoma cruzi	sugar transporter, putative	0.0029	0.0333	0.14
Loa Loa (eye worm)	glutamate-gated chloride channel alpha3A subunit	0.0089	0.1551	0.1551
Loa Loa (eye worm)	excitatory GABA receptor EXP-1A	0.0193	0.3672	0.3672
Brugia malayi	hypothetical protein	0.0089	0.1551	0.2099
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0209	0.3993	1
Onchocerca volvulus		0.0104	0.1856	0.456
Echinococcus multilocularis	nicotinic acetylcholine receptor subunit type	0.0089	0.1551	0.3535
Echinococcus multilocularis	solute carrier family 22	0.0029	0.0333	0.0311
Trichomonas vaginalis	sugar transporter, putative	0.0065	0.1055	0.2343
Schistosoma mansoni	neurotransmitter gated ion channel	0.0104	0.1856	0.4342
Trichomonas vaginalis	sugar transporter, putative	0.0029	0.0333	0.0461
Leishmania major	hypothetical protein, conserved	0.0028	0.0297	0.0964
Onchocerca volvulus		0.0089	0.1551	0.3647
Trichomonas vaginalis	sugar transporter, putative	0.0029	0.0333	0.0461
Trichomonas vaginalis	sugar transporter, putative	0.0029	0.0333	0.0461
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0209	0.3993	1
Trichomonas vaginalis	sugar transporter, putative	0.0029	0.0333	0.0461
Trichomonas vaginalis	sugar transporter, putative	0.0065	0.1055	0.2343
Mycobacterium ulcerans	sugar transporter	0.0029	0.0333	1
Loa Loa (eye worm)	major facilitator superfamily transporter	0.0029	0.0333	0.0333
Trypanosoma brucei	glucose transporter, putative	0.0065	0.1055	1
Trichomonas vaginalis	sugar transporter, putative	0.0029	0.0333	0.0461
Echinococcus multilocularis	solute carrier family 22	0.0029	0.0333	0.0311
Trichomonas vaginalis	myo-inositol transporter, putative	0.0029	0.0333	0.0461
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0333	0.0333
Brugia malayi	hypothetical protein	0.0089	0.1551	0.2099
Schistosoma mansoni	serine/threonine protein kinase	0.0032	0.0395	0.0474
Echinococcus granulosus	neuronal acetylcholine receptor subunit alpha 4	0.0193	0.3672	0.9151
Trichomonas vaginalis	sugar transporter, putative	0.0029	0.0333	0.0461
Loa Loa (eye worm)	hypothetical protein	0.0193	0.3672	0.3672
Toxoplasma gondii	calcium-dependent protein kinase CDPK2B	0.0032	0.0395	0.032
Loa Loa (eye worm)	hypothetical protein	0.0089	0.1551	0.1551
Brugia malayi	lysyl-tRNA synthetase	0.0024	0.0216	0.0171
Brugia malayi	RNA recognition motif domain containing protein	0.0068	0.1133	0.1495
Trichomonas vaginalis	sugar transporter, putative	0.0029	0.0333	0.0461
Brugia malayi	gamma-aminobutyric-acid receptor beta subunit precursor	0.0357	0.7022	1
Trichomonas vaginalis	sugar transporter, putative	0.0029	0.0333	0.0461
Loa Loa (eye worm)	hypothetical protein	0.0193	0.3672	0.3672
Echinococcus granulosus	glutamyl tRNA synthetase cytoplasmic	0.0032	0.0381	0.0438
Schistosoma mansoni	glucose transporter	0.0029	0.0333	0.0311
Loa Loa (eye worm)	sugar transporter	0.0209	0.3993	0.3993
Trichomonas vaginalis	sugar transporter, putative	0.0029	0.0333	0.0461
Loa Loa (eye worm)	hypothetical protein	0.0089	0.1551	0.1551
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type 1	0.0032	0.0395	0.0474
Mycobacterium leprae	Possible lysyl-tRNA synthetase 2 LysX	0.0024	0.0216	0.3046
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0032	0.0395	0.0474
Trichomonas vaginalis	sugar transporter, putative	0.0029	0.0333	0.0461
Trypanosoma brucei	glucose transporter, putative	0.0065	0.1055	1
Echinococcus multilocularis	acetylcholine receptor subunit beta 1	0.0193	0.3672	0.9151
Brugia malayi	glutamate-gated chloride channel alpha3A subunit, putative	0.0104	0.1856	0.2539
Toxoplasma gondii	calcium-dependent protein kinase CDPK2A	0.0032	0.0395	0.032
Echinococcus granulosus	nicotinic acetylcholine receptor beta 1 subunit	0.0193	0.3672	0.9151
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0333	0.0333
Schistosoma mansoni	neurotransmitter gated ion channel	0.0089	0.1551	0.3535
Trichomonas vaginalis	sugar transporter, putative	0.0029	0.0333	0.0461
Loa Loa (eye worm)	hypothetical protein	0.0357	0.7022	0.7022
Loa Loa (eye worm)	nicotinic acetylcholine receptor alpha subunit	0.0193	0.3672	0.3672
Loa Loa (eye worm)	ACC-1 protein	0.0193	0.3672	0.3672
Loa Loa (eye worm)	hypothetical protein	0.0193	0.3672	0.3672
Trichomonas vaginalis	conserved hypothetical protein	0.0065	0.1055	0.2343
Giardia lamblia	Hexose transporter	0.0029	0.0333	0.7094
Loa Loa (eye worm)	neuronal acetylcholine receptor protein	0.0089	0.1551	0.1551
Trichomonas vaginalis	glucose transporter, putative	0.0065	0.1055	0.2343
Plasmodium falciparum	ataxin-2 like protein, putative	0.0028	0.0297	0.0093
Loa Loa (eye worm)	hypothetical protein	0.0089	0.1551	0.1551
Schistosoma mansoni	sugar transporter	0.0029	0.0333	0.0311
Onchocerca volvulus		0.0193	0.3672	1
Toxoplasma gondii	sugar transporter ST3	0.0029	0.0333	0.0209
Entamoeba histolytica	prolyl-tRNA synthetase, putative	0.0032	0.0381	0.101
Schistosoma mansoni	nAChR subunit (ShAR1-beta-like)	0.0193	0.3672	0.9151
Plasmodium vivax	calcium-dependent protein kinase 4, putative	0.0032	0.0395	0.0207
Plasmodium vivax	sugar transporter, putative	0.0029	0.0333	0.0136
Brugia malayi	Flap endonuclease-1	0.0028	0.0315	0.0315
Schistosoma mansoni	nicotinic acetylcholine receptor alpha	0.0104	0.1856	0.4342
Plasmodium falciparum	mitogen-activated protein kinase 2	0.0171	0.3219	0.3464
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0333	0.0333
Schistosoma mansoni	nAChR subunit	0.0193	0.3672	0.9151
Echinococcus granulosus	nicotinic acetylcholine receptor subunit type	0.0193	0.3672	0.9151
Echinococcus multilocularis	calcium dependent protein kinase	0.003	0.0354	0.0366
Echinococcus granulosus	nAChR subunit	0.0104	0.1856	0.4342
Brugia malayi	acetylcholine receptor, alpha-type subunit unc-38 precursor	0.0193	0.3672	0.5162
Leishmania major	prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative	0.0037	0.0489	0.325
Trichomonas vaginalis	conserved hypothetical protein	0.0029	0.0333	0.0461
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0032	0.0395	0.0474
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0032	0.0395	0.0474
Leishmania major	glucose transporter/membrane transporter D2, putative	0.0065	0.1055	1
Brugia malayi	Calcium/calmodulin-dependent protein kinase type II alpha chain	0.0032	0.0395	0.0429
Giardia lamblia	Sugar-proton symporter	0.0029	0.0333	0.7094
Trichomonas vaginalis	sugar transporter, putative	0.0029	0.0333	0.0461
Schistosoma mansoni	glucose transport protein	0.0209	0.3993	1
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0104	0.1856	0.4342
Loa Loa (eye worm)	hypothetical protein	0.0193	0.3672	0.3672
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0333	0.0333
Leishmania major	glucose transporter, lmgt2	0.0065	0.1055	1
Trichomonas vaginalis	sugar transporter, putative	0.0029	0.0333	0.0461
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0193	0.3672	0.9151
Trypanosoma brucei	glucose transporter, putative	0.0065	0.1055	1
Schistosoma mansoni	acetylcholine receptor subunit beta	0.0089	0.1551	0.3535
Plasmodium falciparum	protein kinase 6	0.0448	0.8886	1
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0032	0.0395	0.0474
Plasmodium falciparum	flap endonuclease 1	0.0028	0.0315	0.0115
Entamoeba histolytica	hypothetical protein	0.0039	0.0537	0.1958
Toxoplasma gondii	prolyl-tRNA synthetase (ProRS)	0.0037	0.0489	0.0486
Schistosoma mansoni	glucose transport protein	0.0209	0.3993	1
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0333	0.0333
Trypanosoma cruzi	hexose transporter, putative	0.0065	0.1055	1
Schistosoma mansoni	nAChR subunit (ShAR1-beta2-like)	0.0193	0.3672	0.9151
Schistosoma mansoni	hypothetical protein	0.0209	0.3993	1
Schistosoma mansoni	glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs)	0.0032	0.0381	0.0438
Onchocerca volvulus	Putative nachr subunit	0.0193	0.3672	1
Trichomonas vaginalis	conserved hypothetical protein	0.0029	0.0333	0.0461
Loa Loa (eye worm)	hypothetical protein	0.0193	0.3672	0.3672
Echinococcus granulosus	glycine receptor subunit alpha 1	0.0193	0.3672	0.9151
Trichomonas vaginalis	sugar transporter, putative	0.0029	0.0333	0.0461
Trypanosoma cruzi	hexose transporter, putative	0.0035	0.0456	0.2867
Trypanosoma brucei	sugar transporter, putative	0.0029	0.0333	0.14
Echinococcus multilocularis	gamma aminobutyric acid receptor subunit	0.0089	0.1551	0.3535
Echinococcus multilocularis	nicotinic acetylcholine receptor beta 1 subunit	0.0193	0.3672	0.9151
Mycobacterium ulcerans	sugar-transport integral membrane protein SugI	0.0029	0.0333	1
Leishmania major	hypothetical protein, conserved	0.0029	0.0333	0.14
Trypanosoma cruzi	prolyl-tRNA synthetase, putative	0.0037	0.0489	0.325
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0333	0.0333
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0089	0.1551	0.2099
Plasmodium vivax	hexose transporter	0.0209	0.3993	0.4356
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0333	0.0333
Brugia malayi	major facilitator superfamily protein	0.0029	0.0333	0.0341
Echinococcus granulosus	gamma aminobutyric acid receptor subunit	0.0089	0.1551	0.3535
Loa Loa (eye worm)	hypothetical protein	0.0089	0.1551	0.1551
Trypanosoma cruzi	hexose transporter	0.0065	0.1055	1
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0216	0.0216
Schistosoma mansoni	transcription factor LCR-F1	0.0039	0.0537	0.085
Trichomonas vaginalis	sugar transport protein, putative	0.0029	0.0333	0.0461
Trypanosoma brucei	glucose transporter 2A	0.0065	0.1055	1
Schistosoma mansoni	nuclear transcription factor X-box binding 1 (nfx1)	0.0029	0.0333	0.0311
Echinococcus granulosus	synaptic vesicle 2 protein	0.0029	0.0333	0.0311
Trichomonas vaginalis	sugar transporter, putative	0.0029	0.0333	0.0461
Loa Loa (eye worm)	hypothetical protein	0.0089	0.1551	0.1551
Echinococcus granulosus	solute carrier family 22	0.0029	0.0333	0.0311
Trichomonas vaginalis	conserved hypothetical protein	0.0065	0.1055	0.2343
Plasmodium falciparum	protein kinase 7	0.0298	0.5826	0.6471
Loa Loa (eye worm)	ligand-Gated ion Channel family member	0.0193	0.3672	0.3672
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0065	0.1055	1
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0032	0.0395	0.0474
Echinococcus granulosus	solute carrier family 22	0.0029	0.0333	0.0311
Loa Loa (eye worm)	RNA binding protein	0.0068	0.1133	0.1133
Onchocerca volvulus		0.0193	0.3672	1
Schistosoma mansoni	nAChR subunit	0.0089	0.1551	0.3535
Loa Loa (eye worm)	hypothetical protein	0.0089	0.1551	0.1551
Loa Loa (eye worm)	hypothetical protein	0.0193	0.3672	0.3672
Plasmodium falciparum	calcium-dependent protein kinase 4	0.0032	0.0395	0.0207
Plasmodium falciparum	proline--tRNA ligase	0.0037	0.0489	0.0315
Loa Loa (eye worm)	hypothetical protein	0.0193	0.3672	0.3672
Plasmodium vivax	flap endonuclease 1, putative	0.0028	0.0315	0.0115
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0104	0.1856	0.2539
Trypanosoma brucei	PAB1-binding protein , putative	0.0028	0.0297	0.0964
Trichomonas vaginalis	lysyl-tRNA synthetase, putative	0.0024	0.0216	0.0155
Onchocerca volvulus		0.0193	0.3672	1
Trichomonas vaginalis	sugar transporter, putative	0.0065	0.1055	0.2343
Brugia malayi	hypothetical protein	0.0089	0.1551	0.2099
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0333	0.0333
Trichomonas vaginalis	sugar transporter, putative	0.0029	0.0333	0.0461
Brugia malayi	Hypothetical glycine receptor like protein T20B12.9 in chromosome III	0.0193	0.3672	0.5162
Echinococcus multilocularis	neuronal acetylcholine receptor subunit alpha 4	0.0193	0.3672	0.9151
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.0193	0.3672	0.9151
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.0193	0.3672	0.9151
Loa Loa (eye worm)	hypothetical protein	0.0193	0.3672	0.3672
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0333	0.0333
Mycobacterium ulcerans	fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT	0.0029	0.0333	1
Toxoplasma gondii	LsmAD domain-containing protein	0.0028	0.0297	0.0144
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0065	0.1055	1
Loa Loa (eye worm)	TAR-binding protein	0.0068	0.1133	0.1133
Schistosoma mansoni	neurotransmitter gated ion channel	0.0089	0.1551	0.3535
Schistosoma mansoni	flap endonuclease-1	0.0026	0.0259	0.0116
Brugia malayi	Hypothetical glycine receptor like protein T20B12.9 in chromosome III	0.0104	0.1856	0.2539
Brugia malayi	hypothetical protein	0.0028	0.0297	0.0288
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0193	0.3672	0.9151
Trichomonas vaginalis	sugar transporter, putative	0.0029	0.0333	0.0461
Schistosoma mansoni	tar DNA-binding protein	0.0068	0.1133	0.2427
Loa Loa (eye worm)	hypothetical protein	0.0089	0.1551	0.1551
Schistosoma mansoni	nAChR subunit	0.0193	0.3672	0.9151
Plasmodium falciparum	calcium-dependent protein kinase 1	0.0032	0.0395	0.0207
Schistosoma mansoni	tar DNA-binding protein	0.0068	0.1133	0.2427
Onchocerca volvulus		0.0089	0.1551	0.3647
Schistosoma mansoni	nAChR subunit	0.0193	0.3672	0.9151
Wolbachia endosymbiont of Brugia malayi	major facilitator superfamily permease	0.0029	0.0333	0.5
Loa Loa (eye worm)	hypothetical protein	0.0193	0.3672	0.3672
Trichomonas vaginalis	sugar transporter, putative	0.0029	0.0333	0.0461
Loa Loa (eye worm)	GABA receptor subunit	0.0104	0.1856	0.1856
Trichomonas vaginalis	sugar transporter, putative	0.0029	0.0333	0.0461
Trichomonas vaginalis	sugar transporter, putative	0.0029	0.0333	0.0461
Leishmania major	myo-inositol/proton symporter (MIT)	0.0029	0.0333	0.14
Brugia malayi	Cation transporter family protein	0.0193	0.3672	0.5162
Schistosoma mansoni	tar DNA-binding protein	0.0068	0.1133	0.2427
Trichomonas vaginalis	sugar transporter, putative	0.0029	0.0333	0.0461
Entamoeba histolytica	hypothetical protein	0.0039	0.0537	0.1958

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 649763