Detailed information for compound 650284

Basic information

Technical information
  • TDR Targets ID: 650284
  • Name: (E)-2,3-di(phenyl)-N-prop-2-enylprop-2-enamid e
  • MW: 263.334 | Formula: C18H17NO
  • H donors: 1 H acceptors: 1 LogP: 3.9 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: C=CCNC(=O)C(=Cc1ccccc1)c1ccccc1
  • InChi: 1S/C18H17NO/c1-2-13-19-18(20)17(16-11-7-4-8-12-16)14-15-9-5-3-6-10-15/h2-12,14H,1,13H2,(H,19,20)/b17-14+
  • InChiKey: ZHTHNCIAYRZCBY-SAPNQHFASA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • (E)-N-allyl-2,3-di(phenyl)prop-2-enamide
  • (E)-N-allyl-2,3-di(phenyl)acrylamide
  • (E)-2,3-di(phenyl)-N-prop-2-enyl-prop-2-enamide
  • ZINC02980840

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus cpg binding protein 0.0029 0.035 0.0471
Echinococcus granulosus neuroligin 0.0072 0.1108 0.1497
Loa Loa (eye worm) hypothetical protein 0.0011 0.0028 0.0034
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0029 0.0347 0.047
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.003 0.037 0.4742
Loa Loa (eye worm) hypothetical protein 0.0362 0.6233 0.8438
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0072 0.1108 0.15
Treponema pallidum fructose-bisphosphate aldolase 0.0575 1 0.5
Brugia malayi Carboxylesterase family protein 0.0427 0.7386 1
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0209 0.3525 0.4771
Loa Loa (eye worm) hypothetical protein 0.005 0.0716 0.0966
Onchocerca volvulus Alhambra homolog 0.0029 0.0347 0.0258
Echinococcus multilocularis calmodulin 0.0024 0.025 0.0335
Plasmodium falciparum phd finger protein, putative 0.0029 0.0347 1
Echinococcus granulosus jumonji domain containing protein 0.0041 0.0549 0.074
Echinococcus multilocularis lysine specific demethylase 5A 0.0035 0.0456 0.0614
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0347 0.4447
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0281 0.4799 1
Echinococcus multilocularis calmodulin 0.0024 0.025 0.0335
Schistosoma mansoni acetylcholinesterase 0.0072 0.1108 0.15
Echinococcus granulosus lysine specific demethylase 5A 0.0037 0.0484 0.0652
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0575 1 1
Echinococcus granulosus dnaJ subfamily B 0.0395 0.6824 0.9238
Echinococcus multilocularis calmodulin 0.0024 0.025 0.0335
Loa Loa (eye worm) hypothetical protein 0.0072 0.1108 0.1497
Trypanosoma brucei calmodulin 0.0024 0.025 0.0401
Leishmania major C-8 sterol isomerase-like protein 0.0362 0.6233 1
Toxoplasma gondii histone lysine methyltransferase SET1 0.0054 0.0781 1
Loa Loa (eye worm) PHD-finger family protein 0.0029 0.0347 0.0467
Plasmodium falciparum calmodulin 0.0024 0.025 0.6935
Onchocerca volvulus 0.0072 0.1108 0.2268
Trypanosoma brucei calmodulin 0.0024 0.025 0.0401
Echinococcus granulosus carboxylesterase 5A 0.0427 0.7386 1
Echinococcus granulosus calmodulin 0.0024 0.025 0.0335
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.037 0.0498
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0281 0.4799 1
Trypanosoma brucei calmodulin 0.0024 0.025 0.0401
Plasmodium vivax SET domain protein, putative 0.003 0.037 1
Loa Loa (eye worm) hypothetical protein 0.0185 0.3103 0.4199
Brugia malayi jmjC domain containing protein 0.0037 0.0484 0.0655
Schistosoma mansoni jumonji/arid domain-containing protein 0.0037 0.0484 0.0655
Brugia malayi Carboxylesterase family protein 0.0072 0.1108 0.15
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0029 0.034 0.0457
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0575 1 1
Echinococcus multilocularis calmodulin 0.0024 0.025 0.0335
Echinococcus granulosus calmodulin 0.0024 0.025 0.0335
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0095 0.1521 0.2056
Schistosoma mansoni gliotactin 0.0072 0.1108 0.15
Schistosoma mansoni cpg binding protein 0.0029 0.035 0.0474
Toxoplasma gondii calmodulin, putative 0.0024 0.025 0.3202
Trypanosoma brucei C-8 sterol isomerase, putative 0.0362 0.6233 1
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.0072 0.1108 0.1497
Loa Loa (eye worm) MH2 domain-containing protein 0.0115 0.1872 0.2532
Schistosoma mansoni cpg binding protein 0.0028 0.0322 0.0436
Onchocerca volvulus 0.0028 0.0322 0.0192
Echinococcus granulosus calmodulin 0.0024 0.025 0.0335
Echinococcus multilocularis PHD finger protein rhinoceros 0.0029 0.0347 0.0467
Trichomonas vaginalis set domain proteins, putative 0.0237 0.4034 0.3881
Loa Loa (eye worm) carboxylesterase 0.0072 0.1108 0.1497
Schistosoma mansoni hypothetical protein 0.0029 0.0347 0.047
Brugia malayi CXXC zinc finger family protein 0.0028 0.0322 0.0436
Echinococcus multilocularis BC026374 protein (S09 family) 0.0072 0.1108 0.1497
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0072 0.1108 0.15
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.037 0.0501
Trichomonas vaginalis spcc417.12 protein, putative 0.0072 0.1108 0.088
Schistosoma mansoni BC026374 protein (S09 family) 0.0072 0.1108 0.15
Echinococcus multilocularis carboxylesterase 5A 0.0427 0.7386 1
Loa Loa (eye worm) hypothetical protein 0.0072 0.1108 0.1497
Loa Loa (eye worm) hypothetical protein 0.0072 0.1108 0.1497
Trichomonas vaginalis carboxylesterase domain containing protein, putative 0.0072 0.1108 0.088
Brugia malayi PHD-finger family protein 0.0029 0.0347 0.047
Loa Loa (eye worm) hypothetical protein 0.003 0.037 0.0498
Brugia malayi jmjC domain containing protein 0.0095 0.1521 0.2059
Loa Loa (eye worm) acetylcholinesterase 1 0.0427 0.7386 1
Onchocerca volvulus 0.0072 0.1108 0.2268
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.003 0.037 0.0501
Echinococcus multilocularis dnaJ subfamily B 0.0395 0.6824 0.9238
Brugia malayi Carboxylesterase family protein 0.0072 0.1108 0.15
Onchocerca volvulus 0.0237 0.4034 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0575 1 1
Echinococcus multilocularis CalModulin family member (cmd 1) 0.0024 0.025 0.0335
Schistosoma mansoni calmodulin 0.0024 0.025 0.0339
Echinococcus granulosus BC026374 protein S09 family 0.0072 0.1108 0.1497
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0575 1 1
Trypanosoma cruzi C-8 sterol isomerase, putative 0.0362 0.6233 1
Echinococcus multilocularis jumonji domain containing protein 0.0041 0.0549 0.074
Brugia malayi Bromodomain containing protein 0.0029 0.0347 0.047
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0095 0.1521 0.2056
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0322 0.0433
Echinococcus multilocularis neuroligin 0.0072 0.1108 0.1497
Brugia malayi MH2 domain containing protein 0.0115 0.1872 0.2535
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0011 0.0026 0.0031
Echinococcus multilocularis calmodulin 0.0024 0.025 0.0335
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.003 0.037 0.0498
Loa Loa (eye worm) hypothetical protein 0.0072 0.1108 0.1497
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0072 0.1108 0.15
Brugia malayi Carboxylesterase family protein 0.0072 0.1108 0.15
Onchocerca volvulus 0.003 0.037 0.0319
Brugia malayi F/Y-rich N-terminus family protein 0.0019 0.0169 0.0229
Brugia malayi ERG2 and Sigma1 receptor like protein 0.0362 0.6233 0.8439
Giardia lamblia PHD finger protein 15 0.0029 0.0347 0.01
Loa Loa (eye worm) carboxylesterase 0.0427 0.7386 1
Onchocerca volvulus 0.0072 0.1108 0.2268
Brugia malayi Pre-SET motif family protein 0.003 0.037 0.0501
Giardia lamblia Fructose-bisphosphate aldolase 0.0575 1 1
Loa Loa (eye worm) jmjC domain-containing protein 0.0037 0.0484 0.0652
Echinococcus granulosus CalModulin family member cmd 1 0.0024 0.025 0.0335
Brugia malayi Carboxylesterase family protein 0.0427 0.7386 1
Loa Loa (eye worm) jmjC domain-containing protein 0.006 0.0897 0.1211
Echinococcus granulosus acetylcholinesterase 0.0427 0.7386 1
Echinococcus granulosus calmodulin 0.0024 0.025 0.0334
Loa Loa (eye worm) carboxylesterase 0.0072 0.1108 0.1497
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0347 0.4447
Schistosoma mansoni mixed-lineage leukemia protein mll 0.006 0.0892 0.1208
Schistosoma mansoni neuroligin 3 (S09 family) 0.0072 0.1108 0.15
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0575 1 1
Echinococcus multilocularis calmodulin 0.0024 0.025 0.0334
Brugia malayi hypothetical protein 0.0072 0.1108 0.15
Loa Loa (eye worm) hypothetical protein 0.0427 0.7386 1
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0011 0.0026 0.0031
Brugia malayi PHD-finger family protein 0.0011 0.0028 0.0038
Schistosoma mansoni hypothetical protein 0.0395 0.6824 0.9238
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0575 1 1
Echinococcus multilocularis acetylcholinesterase 0.0427 0.7386 1
Echinococcus granulosus peregrin 0.0029 0.0347 0.0467
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0575 1 1
Loa Loa (eye worm) hypothetical protein 0.0427 0.7386 1
Echinococcus granulosus PHD finger protein rhinoceros 0.0029 0.0347 0.0467
Brugia malayi Carboxylesterase family protein 0.0072 0.1108 0.15
Echinococcus granulosus family S9 non peptidase ue S09 family 0.0072 0.1108 0.1497
Loa Loa (eye worm) hypothetical protein 0.0029 0.0347 0.0467
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0427 0.7386 1
Schistosoma mansoni jumonji domain containing protein 0.0076 0.1174 0.1589
Schistosoma mansoni jumonji/arid domain-containing protein 0.0037 0.0484 0.0655
Loa Loa (eye worm) transcription factor SMAD2 0.0115 0.1872 0.2532
Echinococcus granulosus para nitrobenzyl esterase 0.0072 0.1108 0.1497
Echinococcus granulosus histone lysine methyltransferase setb 0.003 0.037 0.0498
Plasmodium vivax hypothetical protein, conserved 0.0029 0.0347 0.9322
Echinococcus multilocularis cpg binding protein 0.0029 0.035 0.0471
Echinococcus multilocularis acetylcholinesterase 0.0427 0.7386 1
Echinococcus multilocularis peregrin 0.0029 0.0347 0.0467
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.037 0.0501
Loa Loa (eye worm) hypothetical protein 0.0072 0.1108 0.1497
Onchocerca volvulus Calmodulin homolog 0.0024 0.025 0.0001
Onchocerca volvulus 0.0072 0.1108 0.2268
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0281 0.4799 0.5
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0575 1 1
Plasmodium vivax calmodulin, putative 0.0024 0.025 0.6465
Schistosoma mansoni cpg binding protein 0.0029 0.035 0.0474
Echinococcus multilocularis para nitrobenzyl esterase 0.0072 0.1108 0.1497
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0575 1 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.037 0.0501
Brugia malayi Pre-SET motif family protein 0.0209 0.3525 0.4772
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0018 0.0141 0.0191
Brugia malayi calmodulin 0.0024 0.025 0.0339
Echinococcus granulosus acetylcholinesterase 0.0427 0.7386 1
Trypanosoma brucei calmodulin 0.0024 0.025 0.0401
Onchocerca volvulus 0.0072 0.1108 0.2268
Loa Loa (eye worm) hypothetical protein 0.0024 0.025 0.0335
Loa Loa (eye worm) hypothetical protein 0.0072 0.1108 0.1497
Loa Loa (eye worm) hypothetical protein 0.0072 0.1108 0.1497

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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