Detailed information for compound 656114

Basic information

Technical information
  • TDR Targets ID: 656114
  • Name: 3-(2-nitrophenyl)-2-[4-(4-nitrophenyl)-1,3-th iazol-2-yl]prop-2-enenitrile
  • MW: 378.361 | Formula: C18H10N4O4S
  • H donors: 0 H acceptors: 6 LogP: 4.09 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: N#CC(=Cc1ccccc1[N+](=O)[O-])c1scc(n1)c1ccc(cc1)[N+](=O)[O-]
  • InChi: 1S/C18H10N4O4S/c19-10-14(9-13-3-1-2-4-17(13)22(25)26)18-20-16(11-27-18)12-5-7-15(8-6-12)21(23)24/h1-9,11H/b14-9+
  • InChiKey: CPFKIUXPWNRFIM-NTEUORMPSA-N  


Substructure search Similarity search

Network

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Synonyms

  • (E)-3-(2-nitrophenyl)-2-[4-(4-nitrophenyl)-1,3-thiazol-2-yl]prop-2-enenitrile
  • (E)-3-(2-nitrophenyl)-2-[4-(4-nitrophenyl)thiazol-2-yl]prop-2-enenitrile
  • 3-(2-nitrophenyl)-2-[4-(4-nitrophenyl)thiazol-2-yl]prop-2-enenitrile
  • (E)-3-(2-nitrophenyl)-2-[4-(4-nitrophenyl)-2-thiazolyl]prop-2-enenitrile
  • 3-(2-nitrophenyl)-2-[4-(4-nitrophenyl)-2-thiazolyl]prop-2-enenitrile
  • (E)-3-(2-nitrophenyl)-2-[4-(4-nitrophenyl)thiazol-2-yl]acrylonitrile
  • 3-(2-nitrophenyl)-2-[4-(4-nitrophenyl)thiazol-2-yl]acrylonitrile
  • 3-(2-Nitro-phenyl)-2-[4-(4-nitro-phenyl)-thiazol-2-yl]-acrylonitrile
  • BAS 00873900
  • ZINC04853680

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.4095 1 1
Entamoeba histolytica cysteine protease, putative 0.0972 0.2339 0.5554
Echinococcus multilocularis cathepsin l cysteine peptidase 0.1736 0.4212 0.43
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.2066 0.5022 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0452 0.1062 0.2116
Giardia lamblia Cathepsin L precursor 0.0452 0.1062 0.2116
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0452 0.1062 0.2116
Giardia lamblia Cathepsin B precursor 0.0452 0.1062 0.2116
Loa Loa (eye worm) hypothetical protein 0.0452 0.1062 0.1085
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0452 0.1062 0.2116
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0023 0.0011 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1736 0.4212 0.8386
Echinococcus granulosus cathepsin L cysteine proteinase 0.1736 0.4212 0.43
Brugia malayi Cathepsin L-like precursor 0.1736 0.4212 0.43
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0452 0.1062 0.2116
Loa Loa (eye worm) papain family cysteine protease containing protein 0.1736 0.4212 0.43
Entamoeba histolytica cysteine protease, putative 0.0972 0.2339 0.5554
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.004 0.0041
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0011 0.0011
Entamoeba histolytica cysteine proteinase, putative 0.1736 0.4212 1
Entamoeba histolytica acyl-coA synthetase, putative 0.0023 0.0011 0.0025
Trichomonas vaginalis conserved hypothetical protein 0.0452 0.1062 0.2116
Trichomonas vaginalis conserved hypothetical protein 0.0452 0.1062 0.2116
Schistosoma mansoni hypothetical protein 0.0035 0.004 0.0041
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.052 0.1231 0.1256
Trypanosoma cruzi cysteine peptidase, putative 0.4095 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0972 0.2339 0.4658
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0452 0.1062 0.1085
Entamoeba histolytica cysteine proteinase, putative 0.0972 0.2339 0.5554
Onchocerca volvulus 0.1736 0.4212 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1736 0.4212 0.8386
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.004 0.0041
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0972 0.2339 0.2388
Brugia malayi Cathepsin L-like precursor 0.052 0.1231 0.1256
Entamoeba histolytica cysteine protease, putative 0.0972 0.2339 0.5554
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1215 0.2935 0.5844
Loa Loa (eye worm) hypothetical protein 0.0452 0.1062 0.1085
Loa Loa (eye worm) hypothetical protein 0.0452 0.1062 0.1085
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0452 0.1062 0.1085
Giardia lamblia Cathepsin B precursor 0.0452 0.1062 0.2116
Entamoeba histolytica cysteine proteinase 2 0.0972 0.2339 0.5554
Plasmodium vivax vivapain-3 0.0972 0.2339 0.4054
Plasmodium falciparum cysteine proteinase falcipain 2a 0.1736 0.4212 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1736 0.4212 0.8386
Brugia malayi cathepsin Z-like cysteine proteinase 0.0452 0.1062 0.1085
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.4012 0.9796 1
Giardia lamblia Cysteine protease 0.0452 0.1062 0.2116
Brugia malayi cathepsin L-like precursor 0.1215 0.2935 0.2996
Echinococcus multilocularis tumor protein p63 0.033 0.0763 0.0779
Onchocerca volvulus Cathepsin F homolog 0.1736 0.4212 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.4095 1 1
Echinococcus multilocularis cathepsin L cysteine protease 0.1736 0.4212 0.43
Brugia malayi Cathepsin L-like precursor 0.1736 0.4212 0.43
Plasmodium vivax vivapain-2 0.1736 0.4212 1
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0023 0.0011 0.5
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.4012 0.9796 1
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0452 0.1062 0.2523
Entamoeba histolytica cysteine protease, putative 0.0972 0.2339 0.5554
Giardia lamblia Cathepsin L precursor 0.0452 0.1062 0.2116
Entamoeba histolytica cysteine protease, putative 0.0972 0.2339 0.5554
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.4095 1 1
Giardia lamblia Cysteine protease 0.0452 0.1062 0.2116
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.4095 1 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0011 1
Echinococcus granulosus cathepsin l1 0.1215 0.2935 0.2996
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0452 0.1062 0.2116
Loa Loa (eye worm) cathepsin B 0.2066 0.5022 0.5127
Loa Loa (eye worm) hypothetical protein 0.0048 0.0072 0.0074
Echinococcus granulosus cathepsin l cysteine peptidase 0.1736 0.4212 0.43
Echinococcus multilocularis cathepsin b 0.4012 0.9796 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1736 0.4212 0.8386
Brugia malayi Papain family cysteine protease containing protein 0.1736 0.4212 0.43
Echinococcus multilocularis cathepsin b 0.4012 0.9796 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.4095 1 1
Brugia malayi Cathepsin L-like cysteine proteinase 0.1215 0.2935 0.2996
Schistosoma mansoni cathepsin B (C01 family) 0.0452 0.1062 0.1085
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0452 0.1062 0.2116
Entamoeba histolytica hypothetical protein 0.0035 0.004 0.0095
Trypanosoma cruzi cysteine peptidase, putative 0.0972 0.2339 0.2339
Brugia malayi cathepsin L precursor 0.0452 0.1062 0.1085
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0452 0.1062 0.1085
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.4012 0.9796 0.9796
Brugia malayi Cathepsin L-like precursor 0.1736 0.4212 0.43
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1736 0.4212 0.8386
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0452 0.1062 0.2116
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0011 0.0011
Entamoeba histolytica cysteine protease, putative 0.0972 0.2339 0.5554
Plasmodium vivax unspecified product 0.0972 0.2339 0.4054
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0972 0.2339 0.2339
Giardia lamblia Cysteine protease 0.0452 0.1062 0.2116
Giardia lamblia Cathepsin B precursor 0.2066 0.5022 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1736 0.4212 0.8386
Leishmania major cysteine peptidase A (CPA) 0.1736 0.4212 0.4212
Onchocerca volvulus 0.0048 0.0072 0.0147
Loa Loa (eye worm) hypothetical protein 0.0452 0.1062 0.1085
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0452 0.1062 0.1085
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1736 0.4212 0.8386
Trypanosoma cruzi cysteine proteinase, putative 0.0972 0.2339 0.2339
Onchocerca volvulus 0.1736 0.4212 1
Loa Loa (eye worm) hypothetical protein 0.1215 0.2935 0.2996
Entamoeba histolytica cysteine protease, putative 0.0972 0.2339 0.5554
Loa Loa (eye worm) hypothetical protein 0.0452 0.1062 0.1085
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1736 0.4212 0.8386
Echinococcus granulosus cathepsin L 0.0972 0.2339 0.2388
Loa Loa (eye worm) hypothetical protein 0.0023 0.0011 0.0011
Trichomonas vaginalis Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase 0.0452 0.1062 0.2116
Loa Loa (eye worm) hypothetical protein 0.4012 0.9796 1
Brugia malayi Cathepsin L-like precursor 0.1215 0.2935 0.2996
Giardia lamblia Cysteine protease 0.0452 0.1062 0.2116
Giardia lamblia Cathepsin B precursor 0.2066 0.5022 1
Entamoeba histolytica cysteine protease, putative 0.0452 0.1062 0.2523
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0011 0.0011
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0452 0.1062 0.2116
Leishmania major cathepsin L-like protease 0.1736 0.4212 0.4212
Entamoeba histolytica cysteine proteinase, putative 0.1736 0.4212 1
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.2066 0.5022 0.5022
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1736 0.4212 0.8386
Mycobacterium ulcerans hypothetical protein 0.0023 0.0011 1
Brugia malayi cathepsin F-like cysteine proteinase 0.052 0.1231 0.1256
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0452 0.1062 0.1085
Brugia malayi cathepsin B-like cysteine proteinase 0.4012 0.9796 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0452 0.1062 0.2116
Echinococcus multilocularis cathepsin l cysteine peptidase 0.1736 0.4212 0.43
Onchocerca volvulus Cathepsin L homolog 0.0452 0.1062 0.2504
Entamoeba histolytica cysteine proteinase, putative 0.1215 0.2935 0.6969
Trypanosoma cruzi cysteine protease, putative 0.0972 0.2339 0.2339
Trichomonas vaginalis Clan CA, family C1, cathepsin L or H-like cysteine peptidase 0.0452 0.1062 0.2116
Onchocerca volvulus 0.0452 0.1062 0.2504
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0452 0.1062 0.2116
Entamoeba histolytica cysteine protease, putative 0.0972 0.2339 0.5554
Trypanosoma cruzi cysteine peptidase, putative 0.4095 1 1
Brugia malayi Cathepsin L-like precursor 0.1736 0.4212 0.43
Loa Loa (eye worm) hypothetical protein 0.0023 0.0011 0.0011
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0011 0.0011
Entamoeba histolytica hypothetical protein 0.0035 0.004 0.0095
Plasmodium falciparum cysteine proteinase falcipain 1 0.0972 0.2339 0.4054
Entamoeba histolytica cysteine protease, putative 0.0452 0.1062 0.2523
Loa Loa (eye worm) hypothetical protein 0.1736 0.4212 0.43
Entamoeba histolytica cysteine proteinase, putative 0.0972 0.2339 0.5554
Loa Loa (eye worm) hypothetical protein 0.0452 0.1062 0.1085
Giardia lamblia Cathepsin B precursor 0.0452 0.1062 0.2116
Loa Loa (eye worm) hypothetical protein 0.052 0.1231 0.1256
Trypanosoma cruzi cruzipain precursor, putative 0.4095 1 1
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0452 0.1062 0.1085
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0011 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1215 0.2935 0.5844
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0452 0.1062 0.1085
Echinococcus granulosus cathepsin b 0.4012 0.9796 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0972 0.2339 0.4658
Giardia lamblia Cathepsin L-like protease 0.0452 0.1062 0.2116
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1736 0.4212 0.8386
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0972 0.2339 0.2339
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1736 0.4212 0.8386
Entamoeba histolytica cysteine protease, putative 0.0972 0.2339 0.5554
Brugia malayi cathepsin Z-like cysteine proteinase 0.0452 0.1062 0.1085
Leishmania major cathepsin L-like protease 0.4095 1 1
Schistosoma mansoni cathepsin s 0.052 0.1231 0.1256
Entamoeba histolytica cysteine protease, putative 0.0972 0.2339 0.5554
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.3574 0.8723 0.8723
Onchocerca volvulus 0.1736 0.4212 1
Entamoeba histolytica hypothetical protein 0.0452 0.1062 0.2523
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.1736 0.4212 0.8386
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1736 0.4212 0.8386
Onchocerca volvulus 0.1736 0.4212 1
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0011 0.0011
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.4095 1 1
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0023 0.0011 1
Loa Loa (eye worm) cysteine protease 0.1736 0.4212 0.43
Plasmodium vivax vivapain-1 0.0972 0.2339 0.4054
Schistosoma mansoni cathepsin S (C01 family) 0.0452 0.1062 0.1085
Giardia lamblia Cathepsin L precursor 0.0452 0.1062 0.2116
Schistosoma mansoni cathepsin C 0.0452 0.1062 0.1085
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0452 0.1062 0.1085
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.4095 1 1
Giardia lamblia Cathepsin L precursor 0.0452 0.1062 0.2116
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0452 0.1062 0.2116
Plasmodium falciparum cysteine proteinase falcipain 3 0.1736 0.4212 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1736 0.4212 0.8386
Entamoeba histolytica cysteine proteinase, putative 0.0972 0.2339 0.5554
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1736 0.4212 0.8386
Loa Loa (eye worm) hypothetical protein 0.052 0.1231 0.1256
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1736 0.4212 0.8386
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0452 0.1062 0.1085
Schistosoma mansoni cathepsin F (C01 family) 0.1736 0.4212 0.43
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0452 0.1062 0.1085
Brugia malayi Papain family cysteine protease containing protein 0.0452 0.1062 0.1085
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0023 0.0011 1
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.004 0.0041
Entamoeba histolytica cysteine protease, putative 0.0972 0.2339 0.5554
Echinococcus multilocularis cysteine protease 0.1736 0.4212 0.43
Leishmania major cathepsin L-like protease 0.1736 0.4212 0.4212
Entamoeba histolytica cysteine protease, putative 0.0452 0.1062 0.2523
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0023 0.0011 1
Giardia lamblia Cathepsin B precursor 0.0452 0.1062 0.2116
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.1736 0.4212 0.43
Loa Loa (eye worm) papain family cysteine protease containing protein 0.052 0.1231 0.1256
Onchocerca volvulus 0.1736 0.4212 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.4095 1 1
Echinococcus granulosus cysteine protease 0.0972 0.2339 0.2388
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0023 0.0011 1
Echinococcus granulosus cathepsin b 0.4012 0.9796 1
Entamoeba histolytica cysteine protease, putative 0.0452 0.1062 0.2523
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1736 0.4212 0.8386
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0023 0.0011 1
Toxoplasma gondii cathepsin B 0.2066 0.5022 1
Giardia lamblia Cathepsin B precursor 0.2066 0.5022 1
Echinococcus granulosus tumor protein p63 0.033 0.0763 0.0779
Trypanosoma cruzi cysteine peptidase, putative 0.4095 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1736 0.4212 0.8386
Trypanosoma cruzi cysteine peptidase, putative 0.1736 0.4212 0.4212
Trypanosoma cruzi cysteine peptidase, putative 0.052 0.1231 0.1231
Giardia lamblia Cathepsin L precursor 0.0452 0.1062 0.2116
Brugia malayi Papain family cysteine protease containing protein 0.0452 0.1062 0.1085
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1736 0.4212 0.8386
Plasmodium falciparum cysteine proteinase falcipain 2b 0.1736 0.4212 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.1736 0.4212 0.8386
Echinococcus granulosus cathepsin L 0.0452 0.1062 0.1085
Onchocerca volvulus 0.1736 0.4212 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0452 0.1062 0.2116
Echinococcus granulosus cathepsin L cysteine protease 0.0972 0.2339 0.2388
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.0011 0.0025
Schistosoma mansoni cathepsin F (C01 family) 0.1736 0.4212 0.43
Schistosoma mansoni cathepsin F (C01 family) 0.1215 0.2935 0.2996
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.4095 1 1
Trypanosoma cruzi cysteine proteinase, putative 0.0972 0.2339 0.2339
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0452 0.1062 0.2523
Giardia lamblia Hypothetical protein 0.0452 0.1062 0.2116
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0972 0.2339 0.2388
Entamoeba histolytica hypothetical protein 0.0035 0.004 0.0095
Entamoeba histolytica cysteine proteinase 1, putative 0.0972 0.2339 0.5554
Echinococcus multilocularis cathepsin L 0.0972 0.2339 0.2388
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0972 0.2339 0.2339
Entamoeba histolytica cysteine protease, putative 0.0972 0.2339 0.5554
Entamoeba histolytica hypothetical protein 0.0035 0.004 0.0095
Giardia lamblia Encystation-specific protease 0.0452 0.1062 0.2116
Giardia lamblia Cathepsin L precursor 0.0452 0.1062 0.2116
Loa Loa (eye worm) hypothetical protein 0.052 0.1231 0.1256
Trypanosoma cruzi cruzipain precursor, putative 0.052 0.1231 0.1231
Leishmania major cathepsin L-like protease 0.4095 1 1
Leishmania major cathepsin L-like protease 0.1736 0.4212 0.4212
Leishmania major cathepsin L-like protease 0.1736 0.4212 0.4212
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0452 0.1062 0.1085
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.4095 1 1
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.0011 0.0025
Plasmodium vivax vivapain-2 0.1736 0.4212 1
Brugia malayi Cathepsin L-like precursor 0.1736 0.4212 0.43
Brugia malayi Papain family cysteine protease containing protein 0.0452 0.1062 0.1085
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.4012 0.9796 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0452 0.1062 0.2116
Loa Loa (eye worm) hypothetical protein 0.1215 0.2935 0.2996
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0452 0.1062 0.2116
Brugia malayi Papain family cysteine protease containing protein 0.0972 0.2339 0.2388
Entamoeba histolytica cysteine proteinase, putative 0.0972 0.2339 0.5554
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.4012 0.9796 1
Onchocerca volvulus Cathepsin L homolog 0.1736 0.4212 1
Brugia malayi Cathepsin L-like precursor 0.1736 0.4212 0.43
Brugia malayi cathepsin F-like cysteine proteinase 0.0452 0.1062 0.1085
Brugia malayi hypothetical protein 0.0035 0.004 0.0041
Entamoeba histolytica cysteine protease, putative 0.1736 0.4212 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1736 0.4212 0.8386
Onchocerca volvulus 0.1736 0.4212 1
Toxoplasma gondii cathepsin CPL 0.1736 0.4212 0.7953
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.2066 0.5022 0.5022
Giardia lamblia Hypothetical protein 0.0452 0.1062 0.2116
Trichomonas vaginalis Clan CA, family C1, cathepsin H-like cysteine peptidase 0.0452 0.1062 0.2116
Echinococcus multilocularis cysteine protease 0.1736 0.4212 0.43
Trypanosoma brucei cysteine peptidase C (CPC) 0.2066 0.5022 0.5022
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0452 0.1062 0.2116
Leishmania major cathepsin L-like protease 0.1736 0.4212 0.4212
Plasmodium vivax unspecified product 0.052 0.1231 0.0534
Trypanosoma cruzi major cysteine proteinase, putative 0.2811 0.6851 0.6851
Schistosoma mansoni cellular tumor antigen P53 0.0048 0.0072 0.0074
Loa Loa (eye worm) hypothetical protein 0.0023 0.0011 0.0011
Entamoeba histolytica cysteine protease, putative 0.0452 0.1062 0.2523
Trypanosoma cruzi major cysteine proteinase, putative 0.0452 0.1062 0.1062
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0011 1
Loa Loa (eye worm) ctsf protein 0.1736 0.4212 0.43
Giardia lamblia Cathepsin L-like protease 0.0452 0.1062 0.2116
Brugia malayi cathepsin L-like cysteine proteinase 0.0452 0.1062 0.1085
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1736 0.4212 0.8386
Echinococcus multilocularis cathepsin L cysteine protease 0.1736 0.4212 0.43
Giardia lamblia Cathepsin B-like cysteine proteinase 3 precursor 0.0452 0.1062 0.2116
Entamoeba histolytica cysteine protease, putative 0.0452 0.1062 0.2523
Loa Loa (eye worm) hypothetical protein 0.1215 0.2935 0.2996
Brugia malayi Cathepsin L-like precursor 0.1215 0.2935 0.2996
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0011 0.0011
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.4095 1 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.2066 0.5022 0.5127
Echinococcus granulosus cathepsin l1 0.1736 0.4212 0.43
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1736 0.4212 0.8386
Loa Loa (eye worm) fibroinase 0.1736 0.4212 0.43
Onchocerca volvulus Cathepsin L homolog 0.1736 0.4212 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1736 0.4212 0.8386
Giardia lamblia Cathepsin B precursor 0.0452 0.1062 0.2116
Echinococcus multilocularis cathepsin L 0.0452 0.1062 0.1085
Onchocerca volvulus 0.1215 0.2935 0.6961
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0972 0.2339 0.2388
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0023 0.0011 0.5
Brugia malayi fibroinase precursor 0.0452 0.1062 0.1085
Trichomonas vaginalis Clan CA, family C1, cathepsin F-like cysteine peptidase 0.0452 0.1062 0.2116
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0452 0.1062 0.1085
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0452 0.1062 0.1085
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0452 0.1062 0.2116
Brugia malayi Papain family cysteine protease containing protein 0.0972 0.2339 0.2388
Entamoeba histolytica cysteine protease, putative 0.0972 0.2339 0.5554
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1736 0.4212 0.8386

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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