Detailed information for compound 660258

Basic information

Technical information
  • TDR Targets ID: 660258
  • Name: N-tert-butyl-4-iodo-N-(phenylmethyl)benzamide
  • MW: 393.262 | Formula: C18H20INO
  • H donors: 0 H acceptors: 1 LogP: 4.51 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: Ic1ccc(cc1)C(=O)N(C(C)(C)C)Cc1ccccc1
  • InChi: 1S/C18H20INO/c1-18(2,3)20(13-14-7-5-4-6-8-14)17(21)15-9-11-16(19)12-10-15/h4-12H,13H2,1-3H3
  • InChiKey: LAEIARBTSVSEFO-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

  • N-(benzyl)-N-tert-butyl-4-iodo-benzamide
  • ZINC04913476

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.01 0.2471 0.4646
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0013 0.0082 0.0082
Entamoeba histolytica hypothetical protein 0.0011 0.0038 0.0144
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0038 0.0766 0.1204
Trypanosoma brucei unspecified product 0.002 0.0275 0.1643
Brugia malayi Pre-SET motif family protein 0.0205 0.5313 1
Entamoeba histolytica cysteine proteinase, putative 0.0019 0.0247 0.0931
Echinococcus multilocularis chromodomain helicase DNA binding protein 1 0.0011 0.0038 0.0038
Plasmodium vivax hypothetical protein, conserved 0.0011 0.0038 0.0692
Leishmania major cathepsin L-like protease 0.0071 0.1676 1
Echinococcus granulosus Chromobox protein 3 0.0011 0.0038 0.0038
Trichomonas vaginalis chromobox protein, putative 0.0011 0.0038 0.0063
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0013 0.0082 0.0082
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0071 0.1676 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0275 0.1643
Trichomonas vaginalis hypothetical protein 0.0011 0.0038 0.0063
Echinococcus granulosus cpg binding protein 0.003 0.0549 0.0549
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0038 0.0063
Entamoeba histolytica cysteine protease, putative 0.0019 0.0247 0.0931
Toxoplasma gondii histone lysine methyltransferase SET1 0.0054 0.1221 1
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.003 0.0552 0.4346
Loa Loa (eye worm) CHromoDomain protein family member 0.0013 0.0082 0.0145
Brugia malayi Cathepsin L-like precursor 0.0019 0.0247 0.0464
Loa Loa (eye worm) hypothetical protein 0.0011 0.0038 0.0063
Echinococcus granulosus cathepsin l1 0.0012 0.0078 0.0078
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0012 0.0078 0.0129
Plasmodium vivax vivapain-2 0.0019 0.0247 0.4466
Schistosoma mansoni cathepsin F (C01 family) 0.0012 0.0078 0.0184
Plasmodium falciparum cysteine proteinase falcipain 3 0.0019 0.0247 1
Echinococcus multilocularis cysteine protease 0.0019 0.0247 0.0247
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.0247 0.0405
Onchocerca volvulus 0.0028 0.0505 0.0773
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0275 0.1643
Entamoeba histolytica hypothetical protein 0.0011 0.0038 0.0144
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0247 0.0405
Echinococcus granulosus dna polymerase kappa 0.002 0.0275 0.0275
Brugia malayi Valyl-tRNA synthetase 0.0011 0.0038 0.0072
Leishmania major DNA polymerase kappa, putative 0.002 0.0275 0.0201
Brugia malayi Cathepsin L-like precursor 0.0019 0.0247 0.0464
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.0552 0.0552
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0046 0.1003 0.1003
Loa Loa (eye worm) hypothetical protein 0.0147 0.3736 0.7029
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0275 0.1643
Echinococcus multilocularis Chromo domain 0.0011 0.0038 0.0038
Loa Loa (eye worm) fibroinase 0.0019 0.0247 0.0456
Onchocerca volvulus 0.0019 0.0247 0.0345
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0012 0.0078 0.0129
Echinococcus granulosus dna polymerase eta 0.002 0.0275 0.0275
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0038 0.0063
Entamoeba histolytica glycogen phosphorylase, putative 0.0107 0.2648 1
Trichomonas vaginalis Heterochromatin protein, putative 0.0011 0.0038 0.0063
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0552 0.1295
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0071 0.1676 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0071 0.1676 1
Trichomonas vaginalis DNA polymerase eta, putative 0.002 0.0275 0.0453
Echinococcus granulosus chromodomain helicase DNA binding protein 1 0.0011 0.0038 0.0038
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0131 0.0216
Echinococcus multilocularis glycogen phosphorylase 0.0107 0.2648 0.2648
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0147 0.3736 0.7029
Loa Loa (eye worm) latrophilin receptor protein 2 0.0046 0.1003 0.1881
Brugia malayi Cathepsin L-like precursor 0.0019 0.0247 0.0464
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0061 0.1394 0.327
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0046 0.1003 0.1003
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.002 0.0275 0.051
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0275 0.1643
Brugia malayi Papain family cysteine protease containing protein 0.0019 0.0247 0.0464
Echinococcus granulosus Glycosyl transferase family 35 0.0107 0.2648 0.2648
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0011 0.0038 0.1549
Schistosoma mansoni cathepsin F (C01 family) 0.0019 0.0247 0.0578
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.002 0.0275 0.0275
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.0247 0.0405
Schistosoma mansoni cpg binding protein 0.0028 0.0505 0.1185
Entamoeba histolytica cysteine proteinase, putative 0.0019 0.0247 0.0931
Loa Loa (eye worm) MH2 domain-containing protein 0.0117 0.2927 0.5504
Loa Loa (eye worm) hypothetical protein 0.0011 0.0038 0.0063
Trichomonas vaginalis glycogen phosphorylase, putative 0.0107 0.2648 0.4355
Onchocerca volvulus 0.003 0.0544 0.0837
Onchocerca volvulus 0.0019 0.0247 0.0345
Loa Loa (eye worm) hypothetical protein 0.003 0.0552 0.1031
Loa Loa (eye worm) hypothetical protein 0.0011 0.0038 0.0063
Schistosoma mansoni chromobox protein 0.0011 0.0038 0.009
Trichomonas vaginalis chromobox protein, putative 0.0041 0.0844 0.1388
Echinococcus granulosus glycogen phosphorylase 0.0107 0.2648 0.2648
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0071 0.1676 1
Trypanosoma cruzi cysteine peptidase, putative 0.0071 0.1676 1
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0205 0.5313 1
Entamoeba histolytica hypothetical protein 0.0011 0.0038 0.0144
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0013 0.0082 0.0192
Trichomonas vaginalis set domain proteins, putative 0.0233 0.6081 1
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0275 0.1643
Echinococcus multilocularis chromobox protein 2 0.0011 0.0038 0.0038
Brugia malayi CXXC zinc finger family protein 0.0028 0.0505 0.0951
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0011 0.0038 0.0144
Schistosoma mansoni terminal deoxycytidyl transferase 0.002 0.0275 0.0646
Mycobacterium ulcerans glycogen phosphorylase GlgP 0.0046 0.0996 1
Trichomonas vaginalis chromobox protein, putative 0.0067 0.1572 0.2585
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0019 0.0247 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.0247 0.0405
Trypanosoma cruzi cruzipain precursor, putative 0.0071 0.1676 1
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.001 0.0005 0.0005
Trichomonas vaginalis chromobox protein, putative 0.0041 0.0844 0.1388
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0011 0.0038 0.009
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0275 0.1643
Trichomonas vaginalis chromobox protein, putative 0.0011 0.0038 0.0063
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0071 0.1676 1
Echinococcus multilocularis Chromobox protein 3 0.0011 0.0038 0.0038
Loa Loa (eye worm) cysteine protease 0.0019 0.0247 0.0456
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0275 0.1643
Brugia malayi SET domain containing protein 0.0013 0.0084 0.0159
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0046 0.1003 0.1003
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0011 0.0038 0.0144
Echinococcus multilocularis cpg binding protein 0.003 0.0549 0.0549
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0017 0.0212 0.0349
Brugia malayi hypothetical protein 0.0011 0.0038 0.0072
Trypanosoma brucei unspecified product 0.0014 0.0109 0.0648
Chlamydia trachomatis glycogen phosphorylase 0.0107 0.2648 0.5
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0466 0.0766
Echinococcus multilocularis glycogen phosphorylase 0.0107 0.2648 0.2648
Echinococcus granulosus Chromo domain 0.0011 0.0038 0.0038
Onchocerca volvulus Cathepsin L homolog 0.0019 0.0247 0.0345
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0011 0.0038 0.0063
Loa Loa (eye worm) hypothetical protein 0.0038 0.0766 0.1434
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0275 0.1643
Loa Loa (eye worm) hypothetical protein 0.002 0.0275 0.051
Echinococcus granulosus cathepsin l cysteine peptidase 0.0019 0.0247 0.0247
Echinococcus granulosus cathepsin L cysteine proteinase 0.0019 0.0247 0.0247
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0247 0.0405
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.002 0.0275 0.0275
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0109 0.0648
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0071 0.1676 1
Onchocerca volvulus 0.0019 0.0247 0.0345
Echinococcus multilocularis Glycosyl transferase, family 35 0.0107 0.2648 0.2648
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0247 0.0405
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0505 0.0943
Plasmodium vivax heterochromatin protein 1, putative 0.0011 0.0038 0.0692
Echinococcus granulosus chromobox protein 1 0.0067 0.1572 0.1572
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0247 0.0405
Loa Loa (eye worm) hypothetical protein 0.0011 0.0038 0.0063
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0019 0.0247 0.0456
Schistosoma mansoni cellular tumor antigen P53 0.0055 0.124 0.2908
Schistosoma mansoni glycogen phosphorylase 0.0107 0.2648 0.6211
Entamoeba histolytica cysteine proteinase, putative 0.0012 0.0078 0.0296
Echinococcus granulosus GPCR family 2 0.0046 0.1003 0.1003
Loa Loa (eye worm) hypothetical protein 0.0011 0.0038 0.0063
Onchocerca volvulus 0.0019 0.0247 0.0345
Echinococcus granulosus geminin 0.0166 0.4264 0.4264
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0019 0.0247 0.0405
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0275 0.1643
Echinococcus multilocularis dna polymerase eta 0.002 0.0275 0.0275
Echinococcus granulosus chromobox protein 1 0.0067 0.1572 0.1572
Trichomonas vaginalis glycogen phosphorylase, putative 0.0107 0.2648 0.4355
Trichomonas vaginalis chromobox protein, putative 0.0067 0.1572 0.2585
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0109 0.0648
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0275 0.1643
Schistosoma mansoni cpg binding protein 0.003 0.0549 0.1287
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0038 0.0063
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0247 0.0405
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0019 0.0247 0.0405
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.0247 0.0405
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0119 0.0195
Plasmodium vivax vivapain-2 0.0019 0.0247 0.4466
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0147 0.3736 0.7032
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0247 0.0405
Schistosoma mansoni chromobox protein 0.0067 0.1572 0.3687
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0017 0.0212 0.0349
Brugia malayi F/Y-rich N-terminus family protein 0.001 0.0002 0.0003
Loa Loa (eye worm) hypothetical protein 0.0011 0.0038 0.0063
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0275 0.1643
Plasmodium falciparum heterochromatin protein 1 0.0011 0.0038 0.1549
Brugia malayi chromobox protein homolog 3 0.0038 0.0766 0.1442
Schistosoma mansoni hypothetical protein 0.0166 0.4264 1
Leishmania major DNA polymerase eta, putative 0.002 0.0275 0.0201
Loa Loa (eye worm) hypothetical protein 0.0011 0.0038 0.0063
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0071 0.1676 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0247 0.0456
Entamoeba histolytica glycogen phosphorylase, putative 0.0046 0.0996 0.3762
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0014 0.0131 0.0216
Schistosoma mansoni hypothetical protein 0.0046 0.1003 0.2353
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.0247 0.0405
Brugia malayi Cathepsin L-like precursor 0.0019 0.0247 0.0464
Echinococcus granulosus cathepsin l1 0.0019 0.0247 0.0247
Entamoeba histolytica glycogen phosphorylase, putative 0.0107 0.2648 1
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0065 0.1507 0.8997
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0038 0.0063
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0017 0.0212 0.0349
Onchocerca volvulus 0.0012 0.0078 0.0067
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0275 0.1643
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0011 0.0038 0.0063
Schistosoma mansoni hypothetical protein 0.0046 0.1003 0.2353
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0552 0.1295
Echinococcus multilocularis geminin 0.0166 0.4264 0.4264
Plasmodium falciparum chromodomain-helicase-DNA-binding protein 1 homolog, putative 0.0011 0.0038 0.1549
Echinococcus multilocularis chromobox protein 1 0.0067 0.1572 0.1572
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0011 0.0038 0.0063
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.001 0.0005 0.0005
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0041 0.0844 0.1334
Echinococcus multilocularis cysteine protease 0.0019 0.0247 0.0247
Schistosoma mansoni glycogen phosphorylase 0.0107 0.2648 0.6211
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0275 0.1643
Loa Loa (eye worm) helicase 0.0011 0.0038 0.0063
Brugia malayi Cathepsin L-like precursor 0.0019 0.0247 0.0464
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0046 0.1003 0.1888
Brugia malayi carbohydrate phosphorylase 0.0107 0.2648 0.4984
Loa Loa (eye worm) hypothetical protein 0.0046 0.1003 0.1881
Brugia malayi Calcitonin receptor-like protein seb-1 0.0147 0.3736 0.7032
Loa Loa (eye worm) ctsf protein 0.0019 0.0247 0.0456
Loa Loa (eye worm) hypothetical protein 0.0012 0.0078 0.0139
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0071 0.1676 1
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0019 0.0247 0.0456
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0011 0.0038 0.0144
Onchocerca volvulus 0.0019 0.0247 0.0345
Brugia malayi Latrophilin receptor protein 2 0.0046 0.1003 0.1888
Trypanosoma cruzi DNA polymerase eta, putative 0.002 0.0275 0.1643
Schistosoma mansoni chromobox protein 0.0011 0.0038 0.009
Plasmodium vivax SET domain protein, putative 0.003 0.0552 1
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0017 0.0212 0.0349
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0038 0.0063
Trichomonas vaginalis chromobox protein, putative 0.0011 0.0038 0.0063
Brugia malayi Pre-SET motif family protein 0.003 0.0552 0.1039
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.0247 0.0405
Trypanosoma cruzi cysteine peptidase, putative 0.0019 0.0247 0.1472
Onchocerca volvulus 0.0055 0.124 0.1989
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0017 0.0212 0.0349
Toxoplasma gondii cathepsin CPL 0.0019 0.0247 0.1762
Loa Loa (eye worm) heterochromatin protein 1 0.0067 0.1572 0.2952
Entamoeba histolytica deoxycytidyl transferase, putative 0.002 0.0275 0.104
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0275 0.0518
Brugia malayi MH2 domain containing protein 0.0117 0.2927 0.5508
Schistosoma mansoni DNA polymerase eta 0.002 0.0275 0.0646
Brugia malayi CHD4 protein 0.0013 0.0082 0.0154
Brugia malayi Associated with TFs and helicases family protein 0.0011 0.0038 0.0072
Schistosoma mansoni cpg binding protein 0.003 0.0549 0.1287
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.003 0.0552 0.0552
Onchocerca volvulus 0.0019 0.0247 0.0345
Leishmania major cathepsin L-like protease 0.0071 0.1676 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0017 0.0212 0.0349
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0041 0.0852 0.1999
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0247 0.0405
Brugia malayi Heterochromatin protein 1 0.0067 0.1572 0.2958
Brugia malayi Cathepsin L-like precursor 0.0012 0.0078 0.0148
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0046 0.1003 0.1003
Echinococcus granulosus chromobox protein 2 0.0011 0.0038 0.0038
Schistosoma mansoni hypothetical protein 0.0166 0.4264 1
Schistosoma mansoni hypothetical protein 0.01 0.2471 0.5796
Brugia malayi Protein cec-1. 0.0011 0.0038 0.0072
Brugia malayi latrophilin 2 splice variant baaae 0.01 0.2471 0.4651
Plasmodium vivax hypothetical protein, conserved 0.0011 0.0038 0.0692
Onchocerca volvulus 0.0233 0.6081 1
Mycobacterium tuberculosis Probable glycogen phosphorylase GlgP 0.0046 0.0996 1
Echinococcus multilocularis GPCR, family 2 0.0046 0.1003 0.1003
Echinococcus multilocularis tumor protein p63 0.0377 1 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.0247 0.0405
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0247 0.0405
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.0247 0.0405
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0017 0.0212 0.0349
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0275 0.1643
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0019 0.0247 1
Schistosoma mansoni hypothetical protein 0.0011 0.0038 0.009
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0109 0.0648
Brugia malayi Type III restriction enzyme, res subunit family protein 0.0011 0.0038 0.0072
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0275 0.1643
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0275 0.1643
Loa Loa (eye worm) hypothetical protein 0.0012 0.0078 0.0139
Echinococcus multilocularis dna polymerase kappa 0.002 0.0275 0.0275
Echinococcus granulosus glycogen phosphorylase 0.0107 0.2648 0.2648
Schistosoma mansoni cathepsin F (C01 family) 0.0019 0.0247 0.0578
Trypanosoma brucei DNA polymerase eta, putative 0.002 0.0275 0.1643
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0275 0.0518
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.002 0.0275 0.0453
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0019 0.0247 0.0247
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0038 0.0063
Giardia lamblia Glycogen phosphorylase 0.0107 0.2648 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0247 0.0405
Echinococcus multilocularis chromobox protein 1 0.0067 0.1572 0.1572
Entamoeba histolytica glycogenphosphorylase, putative 0.0046 0.0996 0.3762
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0247 0.0405
Onchocerca volvulus 0.0011 0.0038 0.000000055262
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0506 0.0506
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0466 0.0766
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.0247 0.0405
Schistosoma mansoni hypothetical protein 0.0046 0.1003 0.2353
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0017 0.0212 0.0349
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0766 0.126
Trypanosoma brucei unspecified product 0.0014 0.0109 0.0648
Loa Loa (eye worm) hypothetical protein 0.0055 0.124 0.2327
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0038 0.0063
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0011 0.0038 0.009
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0038 0.0063
Loa Loa (eye worm) glycogen phosphorylase 0.0107 0.2648 0.498
Onchocerca volvulus Cathepsin F homolog 0.0019 0.0247 0.0345
Brugia malayi Cathepsin L-like precursor 0.0012 0.0078 0.0148
Onchocerca volvulus Cathepsin L homolog 0.0019 0.0247 0.0345
Entamoeba histolytica glycogen phosphorylase, putative 0.0046 0.0996 0.3762
Brugia malayi Cathepsin L-like precursor 0.0019 0.0247 0.0464
Trypanosoma cruzi cysteine peptidase, putative 0.0071 0.1676 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0247 0.0405
Brugia malayi Cathepsin L-like cysteine proteinase 0.0012 0.0078 0.0148
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0071 0.1676 1
Leishmania major cathepsin L-like protease 0.0071 0.1676 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0071 0.1676 1
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0766 0.126
Schistosoma mansoni hypothetical protein 0.0046 0.1003 0.2353
Schistosoma mansoni glycogen phosphorylase 0.0046 0.0996 0.2337
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0552 0.1295
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0011 0.0038 0.009
Schistosoma mansoni chromobox protein 0.0067 0.1572 0.3687
Echinococcus multilocularis cathepsin L cysteine protease 0.0019 0.0247 0.0247
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0247 0.0405
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.002 0.0275 0.0646
Onchocerca volvulus 0.0041 0.0852 0.1347
Brugia malayi cathepsin L-like precursor 0.0012 0.0078 0.0148
Echinococcus multilocularis cathepsin L cysteine protease 0.0019 0.0247 0.0247
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0247 0.0405
Brugia malayi M-phase phosphoprotein, mpp8 0.0011 0.0038 0.0072
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.002 0.0275 0.0201
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0275 0.1643
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0247 0.0405
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0019 0.0247 0.0247
Loa Loa (eye worm) hypothetical protein 0.003 0.0544 0.1016
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0071 0.1676 1
Onchocerca volvulus 0.0019 0.0247 0.0345
Loa Loa (eye worm) hypothetical protein 0.0012 0.0078 0.0139
Trypanosoma cruzi major cysteine proteinase, putative 0.0056 0.1261 0.7525
Echinococcus granulosus histone lysine methyltransferase setb 0.003 0.0552 0.0552
Onchocerca volvulus Glycogen phosphorylase homolog 0.0107 0.2648 0.4319
Loa Loa (eye worm) transcription factor SMAD2 0.0117 0.2927 0.5504
Trypanosoma cruzi cysteine peptidase, putative 0.0071 0.1676 1

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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