Detailed information for compound 662110

Basic information

Technical information
  • TDR Targets ID: 662110
  • Name: (3,6-dichloro-1-benzothiophen-2-yl)-[4-(4-met hoxyphenyl)piperazin-1-yl]methanone
  • MW: 421.34 | Formula: C20H18Cl2N2O2S
  • H donors: 0 H acceptors: 1 LogP: 5.55 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1)N1CCN(CC1)C(=O)c1sc2c(c1Cl)ccc(c2)Cl
  • InChi: 1S/C20H18Cl2N2O2S/c1-26-15-5-3-14(4-6-15)23-8-10-24(11-9-23)20(25)19-18(22)16-7-2-13(21)12-17(16)27-19/h2-7,12H,8-11H2,1H3
  • InChiKey: WYMQFJKSBIBNQA-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • (3,6-dichlorobenzothiophen-2-yl)-[4-(4-methoxyphenyl)piperazin-1-yl]methanone
  • (3,6-dichloro-2-benzothiophenyl)-[4-(4-methoxyphenyl)-1-piperazinyl]methanone
  • Oprea1_478812
  • STOCK2S-95590
  • Oprea1_546465

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Leishmania major glucose transporter, lmgt2 0.0033 0.0237 0.037
Leishmania major eukaryotic initiation factor 4a, putative 0.0024 0.0063 0.0053
Mycobacterium ulcerans Type I modular polyketide synthase 0.0076 0.1052 0.1014
Schistosoma mansoni hypothetical protein 0.0108 0.1667 0.5345
Plasmodium falciparum DNA gyrase subunit B 0.0541 1 1
Toxoplasma gondii DNA topoisomerase 2, putative 0.0182 0.3089 0.5181
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0033 0.0229 0.0567
Chlamydia trachomatis DNA gyrase subunit A 0.0329 0.5909 0.5886
Echinococcus multilocularis DNA topoisomerase 2 alpha 0.0182 0.3089 1
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0038 0.0319 0.0479
Brugia malayi GRF zinc finger family protein 0.0045 0.0463 0.1405
Trypanosoma brucei glucose transporter, putative 0.0033 0.0237 0.0329
Echinococcus multilocularis rho GTPase activating protein 20 0.0045 0.0463 0.1339
Mycobacterium leprae Probable DNA topoisomerase I TopA (omega-protein) (relaxing enzyme) (untwisting enzyme) (swivelase) (type I DNA topoisomerase) ( 0.0045 0.0463 0.1609
Entamoeba histolytica DNA topoisomerase III, putative 0.0045 0.0463 0.1339
Trichomonas vaginalis sugar transporter, putative 0.0033 0.0237 0.0768
Trypanosoma brucei DNA topoisomerase ii 0.0309 0.5529 1
Plasmodium falciparum calcium-dependent protein kinase 2 0.0033 0.0229 0.0173
Toxoplasma gondii DNA topoisomerase domain-containing protein 0.0045 0.0463 0.0694
Schistosoma mansoni glucose transport protein 0.0108 0.1667 0.5345
Trichomonas vaginalis DEAD box ATP-dependent RNA helicase, putative 0.0024 0.0063 0.0203
Loa Loa (eye worm) hypothetical protein 0.0034 0.025 0.0637
Trypanosoma brucei THT1 - hexose transporter, putative 0.0033 0.0237 0.0329
Loa Loa (eye worm) hypothetical protein 0.0032 0.0216 0.0525
Trypanosoma brucei DNA topoisomerase III, putative 0.0045 0.0463 0.0742
Onchocerca volvulus Putative DNA topoisomerase 2, mitochondrial 0.0182 0.3089 1
Toxoplasma gondii type I fatty acid synthase, putative 0.0081 0.1143 0.1855
Wolbachia endosymbiont of Brugia malayi DNA gyrase, topoisomerase II, B subunit, GyrB 0.0541 1 1
Plasmodium vivax DNA topoisomerase 3, putative 0.0045 0.0463 0.0408
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0024 0.0057 0.0018
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.0309 0.5529 1
Loa Loa (eye worm) hypothetical protein 0.0103 0.1565 0.4973
Trichomonas vaginalis CAMK family protein kinase 0.0033 0.0229 0.0741
Giardia lamblia Translation initiation factor eIF-4A, putative 0.0024 0.0063 0.0108
Toxoplasma gondii eukaryotic initiation factor-4A, putative 0.0024 0.0063 0.001
Loa Loa (eye worm) acyl carrier protein 0.0035 0.0265 0.0685
Toxoplasma gondii facilitative glucose transporter GT1 0.0108 0.1667 0.2751
Trypanosoma brucei Eukaryotic initiation factor 4A-1 0.0024 0.0063 0.001
Echinococcus granulosus DNA topoisomerase 3 beta 1 0.0045 0.0463 0.1339
Mycobacterium ulcerans multifunctional mycocerosic acid synthase membrane-associated Mas 0.0081 0.1143 0.1105
Trypanosoma brucei DNA topoisomerase II alpha, putative 0.0137 0.2221 0.3954
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.0174 0.2943 0.2902
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0033 0.0229 0.0567
Mycobacterium tuberculosis DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) 0.0541 1 1
Loa Loa (eye worm) hypothetical protein 0.0042 0.0411 0.1168
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0038 0.0319 0.052
Plasmodium vivax calcium-dependent protein kinase, putative 0.0033 0.0229 0.0173
Brugia malayi DNA gyrase/topoisomerase IV, A subunit family protein 0.0182 0.3089 1
Giardia lamblia Lysyl-tRNA synthetase 0.0024 0.0057 0.0088
Loa Loa (eye worm) hypothetical protein 0.0024 0.0063 0.0018
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0076 0.1052 0.1022
Loa Loa (eye worm) DNA topoisomerase III beta-1 0.0045 0.0463 0.1339
Mycobacterium ulcerans polyketide synthase Pks9 0.005 0.0558 0.0518
Giardia lamblia DNA topoisomerase III 0.0045 0.0463 0.1606
Onchocerca volvulus DNA topoisomerase 2 homolog 0.0182 0.3089 1
Onchocerca volvulus DNA topoisomerase 2 homolog 0.0182 0.3089 1
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0108 0.1667 0.5309
Wolbachia endosymbiont of Brugia malayi DNA gyrase subunit A 0.0329 0.5909 0.571
Trypanosoma brucei glucose transporter 2A 0.0033 0.0237 0.0329
Echinococcus multilocularis eukaryotic initiation factor 4A 0.0024 0.0063 0.0018
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.0032 0.0216 0.0642
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.0032 0.0216 0.07
Brugia malayi eukaryotic initiation factor 4A 0.0024 0.0063 0.0095
Onchocerca volvulus 0.0071 0.0956 0.2953
Loa Loa (eye worm) DNA topoisomerase III 0.0045 0.0463 0.1339
Trypanosoma brucei glucose transporter 1E 0.0033 0.0237 0.0329
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.0032 0.0216 0.0525
Mycobacterium tuberculosis DNA gyrase (subunit A) GyrA (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) 0.0329 0.5909 0.5895
Mycobacterium tuberculosis Polyketide synthetase MbtD (polyketide synthase) 0.0023 0.0043 0.0009
Chlamydia trachomatis DNA gyrase subunit A 0.0034 0.025 0.0194
Plasmodium vivax DNA gyrase subunit B, putative 0.0541 1 1
Trichomonas vaginalis DNA topoisomerase II, putative 0.0182 0.3089 1
Trypanosoma brucei glucose transporter, putative 0.0033 0.0237 0.0329
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0033 0.0229 0.0567
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0237 0.0768
Mycobacterium tuberculosis Probable membrane bound polyketide synthase Pks6 0.0113 0.1773 0.1745
Brugia malayi DNA topoisomerase II, alpha isozyme 0.0182 0.3089 1
Loa Loa (eye worm) hypothetical protein 0.0103 0.1565 0.4973
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0038 0.0319 0.052
Giardia lamblia Prolyl-tRNA synthetase 0.0032 0.0216 0.0683
Mycobacterium tuberculosis Polyketide synthase Pks13 0.0113 0.1773 0.1745
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA 0.0076 0.1052 0.3917
Echinococcus granulosus eukaryotic initiation factor 4A III 0.0024 0.0063 0.0018
Mycobacterium tuberculosis Probable polyketide synthase Pks7 0.0081 0.1143 0.1113
Toxoplasma gondii DNA gyrase/topoisomerase IV, A subunit domain-containing protein 0.0329 0.5909 1
Plasmodium falciparum calcium-dependent protein kinase 4 0.0033 0.0229 0.0173
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0032 0.0216 0.0597
Entamoeba histolytica protein kinase, putative 0.0033 0.0229 0.0567
Schistosoma mansoni protein kinase 0.0033 0.0229 0.064
Trypanosoma cruzi hexose transporter 0.0033 0.0237 0.0329
Mycobacterium tuberculosis Probable polyketide synthase Pks9 0.0043 0.0423 0.0391
Plasmodium falciparum DNA topoisomerase 3, putative 0.0045 0.0463 0.0408
Treponema pallidum DNA gyrase, subunit B (gyrB) 0.0541 1 1
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0033 0.0229 0.0173
Brugia malayi DNA topoisomerase III 0.0045 0.0463 0.1405
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0024 0.0057 0.0014
Loa Loa (eye worm) hypothetical protein 0.0032 0.0216 0.0525
Mycobacterium leprae Probable polyketide synthase Pks1 0.0081 0.1143 0.4272
Plasmodium falciparum calcium-dependent protein kinase 1 0.0033 0.0229 0.0173
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.0038 0.0319 0.0479
Trypanosoma cruzi hexose transporter, putative 0.0033 0.0237 0.0329
Brugia malayi Beta-ketoacyl synthase, N-terminal domain containing protein 0.0076 0.1052 0.3334
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0033 0.0229 0.0173
Plasmodium vivax DNA topoisomerase II, putative 0.0182 0.3089 0.3049
Echinococcus granulosus eukaryotic initiation factor 4A 0.0024 0.0063 0.0018
Chlamydia trachomatis DNA topoisomerase I 0.0045 0.0463 0.0408
Loa Loa (eye worm) TOPoisomerase family member 0.0182 0.3089 1
Mycobacterium ulcerans polyketide synthase 0.0076 0.1052 0.1014
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0033 0.0229 0.0295
Mycobacterium tuberculosis Polyketide synthase Pks12 0.0081 0.1143 0.1113
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0081 0.1143 0.1105
Mycobacterium ulcerans thioesterase TesA 0.0063 0.0809 0.077
Trichomonas vaginalis sugar transporter, putative 0.0033 0.0237 0.0768
Mycobacterium ulcerans polyketide synthase 0.0081 0.1143 0.1105
Mycobacterium tuberculosis Probable polyketide synthase Pks8 0.0062 0.0787 0.0755
Plasmodium vivax hexose transporter 0.0108 0.1667 0.1619
Echinococcus multilocularis DNA topoisomerase 3 beta 1 0.0045 0.0463 0.1339
Schistosoma mansoni protein kinase 0.0033 0.0229 0.064
Loa Loa (eye worm) hypothetical protein 0.0034 0.025 0.0637
Trypanosoma brucei glucose transporter, putative 0.0033 0.0237 0.0329
Trypanosoma brucei DNA topoisomerase II beta, putative 0.0137 0.2221 0.3954
Trypanosoma cruzi DNA topoisomerase II, putative 0.0137 0.2221 0.3954
Plasmodium vivax proline--tRNA ligase, putative 0.0038 0.0319 0.0264
Trypanosoma cruzi hexose transporter, putative 0.0033 0.0237 0.0329
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0034 0.0109
Schistosoma mansoni glucose transport protein 0.0108 0.1667 0.5345
Leishmania major DNA topoisomerase III, putative 0.0045 0.0463 0.0781
Leishmania major glucose transporter/membrane transporter D2, putative 0.0033 0.0237 0.037
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0033 0.0229 0.0567
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsB 0.0061 0.0767 0.0728
Trichomonas vaginalis glucose transporter, putative 0.0033 0.0237 0.0768
Trypanosoma brucei DNA topoisomerase III, putative 0.0045 0.0463 0.0742
Mycobacterium leprae Polyketide synthase Pks13 0.0113 0.1773 0.6742
Onchocerca volvulus Fatty acid synthase homolog 0.0137 0.2222 0.7135
Mycobacterium ulcerans DNA gyrase subunit B 0.0541 1 1
Plasmodium vivax CDK-related protein kinase 6, putative 0.0458 0.8389 0.838
Trypanosoma cruzi DNA topoisomerase II, putative 0.0137 0.2221 0.3954
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0033 0.0229 0.064
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0033 0.0229 0.0567
Leishmania major glucose transporter, lmgt1 0.0033 0.0237 0.037
Plasmodium falciparum DNA topoisomerase 2 0.0182 0.3089 0.3049
Plasmodium falciparum eukaryotic initiation factor 4A 0.0024 0.0063 0.0006
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.0174 0.2943 0.4931
Trichomonas vaginalis conserved hypothetical protein 0.0108 0.1667 0.5395
Leishmania major mitochondrial DNA topoisomerase II 0.0309 0.5529 1
Chlamydia trachomatis DNA gyrase subunit B 0.0414 0.756 0.7546
Schistosoma mansoni DEAD box ATP-dependent RNA helicase 0.0024 0.0063 0.0095
Trypanosoma brucei THT1 - hexose transporter, putative 0.0033 0.0237 0.0329
Leishmania major eukaryotic initiation factor 4a, putative 0.0024 0.0063 0.0053
Schistosoma mansoni prokaryotic DNA topoisomerase 0.0045 0.0463 0.1405
Brugia malayi Probable DNA topoisomerase II 0.0182 0.3089 1
Mycobacterium tuberculosis Probable fatty acid synthase Fas (fatty acid synthetase) 0.0024 0.0052 0.0019
Loa Loa (eye worm) hypothetical protein 0.0033 0.0229 0.0567
Mycobacterium ulcerans DNA gyrase subunit A 0.0329 0.5909 0.5892
Mycobacterium leprae PROBABLE THIOESTERASE TESA 0.0063 0.0809 0.2965
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0108 0.1667 0.5309
Echinococcus granulosus calcium dependent protein kinase 0.0031 0.019 0.0438
Brugia malayi DNA topoisomerase III beta-1 0.0045 0.0463 0.1405
Loa Loa (eye worm) hypothetical protein 0.0026 0.01 0.014
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0076 0.1052 0.1022
Loa Loa (eye worm) sugar transporter 0.0108 0.1667 0.5309
Onchocerca volvulus 0.0045 0.0463 0.1323
Brugia malayi Sugar transporter family protein 0.0108 0.1667 0.5345
Leishmania major glucose transporter, lmgt3 0.0033 0.0237 0.037
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0033 0.0229 0.0295
Trypanosoma cruzi DNA topoisomerase IA, putative 0.0045 0.0463 0.0742
Plasmodium vivax DNA gyrase subunit A, putative 0.0329 0.5909 0.5886
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsE 0.005 0.0558 0.0518
Toxoplasma gondii DNA topoisomerase family protein 0.0045 0.0463 0.0694
Trypanosoma brucei glucose transporter, putative 0.0033 0.0237 0.0329
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0032 0.0216 0.0597
Schistosoma mansoni prokaryotic DNA topoisomerase 0.0045 0.0463 0.1405
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0033 0.0229 0.0567
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0108 0.1667 0.5309
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0108 0.1667 0.5309
Plasmodium falciparum DNA gyrase subunit A 0.0329 0.5909 0.5886
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0108 0.1667 0.5309
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0024 0.0057 0.0185
Loa Loa (eye worm) fatty acid synthase 0.0075 0.1033 0.3218
Plasmodium falciparum protein kinase 6 0.0458 0.8389 0.838
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein 0.0144 0.2357 0.7605
Echinococcus multilocularis eukaryotic initiation factor 4A III 0.0024 0.0063 0.0018
Trypanosoma brucei glucose transporter, putative 0.0033 0.0237 0.0329
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.0032 0.0216 0.0597
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.0032 0.0216 0.0525
Trypanosoma cruzi Eukaryotic initiation factor 4A-1 0.0024 0.0063 0.001
Trypanosoma brucei glucose transporter, putative 0.0033 0.0237 0.0329
Toxoplasma gondii beta-ketoacyl synthase, N-terminal domain-containing protein 0.0049 0.054 0.0825
Mycobacterium ulcerans thioesterase 0.0063 0.0809 0.077
Trypanosoma cruzi DNA topoisomerase III, putative 0.0045 0.0463 0.0742
Leishmania major DNA topoisomerase ii 0.0137 0.2221 0.398
Toxoplasma gondii type I fatty acid synthase, putative 0.0054 0.0632 0.0983
Plasmodium falciparum protein kinase 7 0.0305 0.5449 0.5423
Leishmania major lysyl-tRNA synthetase, putative 0.0024 0.0057 0.0043
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.0309 0.5529 1
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD 0.0076 0.1052 0.3917
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC 0.0081 0.1143 0.4272
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0108 0.1667 0.5309
Toxoplasma gondii protein kinase, putative 0.0305 0.5449 0.9214
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0032 0.0216 0.0597
Plasmodium falciparum calcium-dependent protein kinase 3 0.0033 0.0229 0.0173
Entamoeba histolytica DNA topoisomerase III, putative 0.0045 0.0463 0.1339
Trypanosoma cruzi Eukaryotic initiation factor 4A-1 0.0024 0.0063 0.001
Entamoeba histolytica protein kinase, putative 0.0033 0.0229 0.0567
Echinococcus granulosus DNA topoisomerase 2 alpha 0.0182 0.3089 1
Schistosoma mansoni glucose transport protein 0.0108 0.1667 0.5345
Schistosoma mansoni DNA topoisomerase II 0.0182 0.3089 1
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB 0.0061 0.0767 0.2801
Echinococcus granulosus General substrate transporter 0.0093 0.1375 0.4348
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0076 0.1052 0.1014
Mycobacterium ulcerans Type I modular polyketide synthase 0.0076 0.1052 0.1014
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0076 0.1052 0.1022
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0071 0.0956 0.2966
Schistosoma mansoni serine/threonine protein kinase 0.0033 0.0229 0.064
Entamoeba histolytica DNA topoisomerase II, putative 0.0182 0.3089 1
Mycobacterium tuberculosis Probable cold-shock DeaD-box protein A homolog DeaD (ATP-dependent RNA helicase dead homolog) 0.0024 0.0063 0.0029
Mycobacterium ulcerans DNA topoisomerase I 0.0045 0.0463 0.0422
Plasmodium vivax RNA helicase-1, putative 0.0024 0.0063 0.0006
Treponema pallidum DNA topoisomerase I (topA) 0.0045 0.0463 0.0403
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0033 0.0229 0.0567
Plasmodium falciparum hexose transporter 0.0108 0.1667 0.1619
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0108 0.1667 0.5309
Mycobacterium tuberculosis Probable polyketide synthase Pks1 0.0054 0.0642 0.061
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0024 0.0057 0.0014
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.0032 0.0216 0.0525
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSE 0.005 0.0558 0.1983
Plasmodium falciparum mitogen-activated protein kinase 2 0.0174 0.2943 0.2902
Schistosoma mansoni protein kinase 0.0033 0.0229 0.064
Leishmania major protein kinase, putative 0.0033 0.0229 0.0356
Echinococcus multilocularis calcium dependent protein kinase 0.0031 0.019 0.0438
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0061 0.0767 0.0728
Loa Loa (eye worm) hypothetical protein 0.0127 0.2043 0.6551
Plasmodium falciparum calcium-dependent protein kinase 5 0.0033 0.0229 0.0173
Onchocerca volvulus 0.0132 0.2132 0.6836
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0275 0.4873 0.823
Giardia lamblia DNA topoisomerase II 0.0162 0.2708 1
Trypanosoma cruzi DNA topoisomerase IA, putative 0.0045 0.0463 0.0742
Trichomonas vaginalis prokaryotic DNA topoisomerase, putative 0.0045 0.0463 0.1499
Mycobacterium tuberculosis Probable multifunctional mycocerosic acid synthase membrane-associated Mas 0.0081 0.1143 0.1113
Trichomonas vaginalis glucose transporter, putative 0.0033 0.0237 0.0768
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0038 0.0331 0.0468
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0038 0.0319 0.0479
Schistosoma mansoni DEAD box ATP-dependent RNA helicase 0.0024 0.0063 0.0095
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0033 0.0229 0.0567
Brugia malayi lysyl-tRNA synthetase 0.0024 0.0057 0.0077
Mycobacterium leprae Probable DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (Type II DNA topoisomerase) 0.0127 0.2034 0.7765
Trichomonas vaginalis DEAD box ATP-dependent RNA helicase, putative 0.0024 0.0063 0.0203
Entamoeba histolytica DEAD/DEAH box helicase, putative 0.0024 0.0063 0.0018
Brugia malayi Cam kinase protein 1 0.0033 0.0229 0.064
Mycobacterium tuberculosis Polyketide synthetase MbtC (polyketide synthase) 0.0026 0.0096 0.0062
Giardia lamblia DNA topoisomerase III 0.0045 0.0463 0.1606
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0033 0.0229 0.0173
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0043 0.003
Mycobacterium ulcerans fatty acid synthase Fas 0.0024 0.0052 0.001
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0033 0.0229 0.0314
Trypanosoma brucei glucose transporter, putative 0.0033 0.0237 0.0329
Mycobacterium ulcerans polyketide synthase Pks13 0.0113 0.1773 0.1738
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0071 0.0956 0.0926
Trichomonas vaginalis sugar transporter, putative 0.0033 0.0237 0.0768
Mycobacterium tuberculosis Probable polyketide synthase Pks15 0.0031 0.0184 0.0151
Trichomonas vaginalis prokaryotic DNA topoisomerase, putative 0.0045 0.0463 0.1499
Trypanosoma cruzi DNA topoisomerase III, putative 0.0045 0.0463 0.0742
Echinococcus granulosus DNA topoisomerase 3 alpha 0.0045 0.0463 0.1339
Brugia malayi AMP-binding enzyme family protein 0.0071 0.0956 0.302
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0033 0.0229 0.0567
Mycobacterium ulcerans Type I modular polyketide synthase 0.0076 0.1052 0.1014
Mycobacterium tuberculosis Probable thioesterase TesA 0.0063 0.0809 0.0778
Trypanosoma brucei DNA topoisomerase IA, putative 0.0045 0.0463 0.0742
Treponema pallidum DNA gyrase, subunit A (gyrA) 0.0329 0.5909 0.5883
Mycobacterium leprae Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas 0.0081 0.1143 0.4272
Echinococcus multilocularis General substrate transporter 0.0093 0.1375 0.4348
Trypanosoma brucei glucose transporter, putative 0.0033 0.0237 0.0329
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.0038 0.0319 0.0448
Leishmania major DNA topoisomerase III, putative 0.0045 0.0463 0.0781
Leishmania major DNA topoisomerase 1A 0.0045 0.0463 0.0781
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0237 0.0768
Trypanosoma cruzi hexose transporter, putative 0.0033 0.0237 0.0329
Trypanosoma brucei THT1 - hexose transporter, putative 0.0033 0.0237 0.0329
Mycobacterium tuberculosis Polyketide synthase Pks2 0.0074 0.1007 0.0977
Schistosoma mansoni lysyl-tRNA synthetase 0.0024 0.0057 0.0077
Mycobacterium tuberculosis Probable polyketide synthase Pks5 0.0074 0.1007 0.0977
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0033 0.0229 0.0567
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0033 0.0229 0.0295
Mycobacterium leprae Probable DNA gyrase (subunit A) GyrA (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (Type II DNA topoisomerase) 0.0157 0.2605 1
Plasmodium falciparum proline--tRNA ligase 0.0038 0.0319 0.0264
Trichomonas vaginalis DEAD box ATP-dependent RNA helicase, putative 0.0024 0.0063 0.0203
Trypanosoma cruzi DNA topoisomerase III, putative 0.0045 0.0463 0.0742
Schistosoma mansoni lysyl-tRNA synthetase 0.0024 0.0057 0.0077
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0108 0.1667 0.5309

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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