Detailed information for compound 66531

Basic information

Technical information
  • TDR Targets ID: 66531
  • Name: 2-[4-[(4,5,7-trifluoro-1,3-benzothiazol-2-yl) methyl]phenyl]acetic acid
  • MW: 337.316 | Formula: C16H10F3NO2S
  • H donors: 1 H acceptors: 3 LogP: 4.1 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: OC(=O)Cc1ccc(cc1)Cc1sc2c(n1)c(F)c(cc2F)F
  • InChi: 1S/C16H10F3NO2S/c17-10-7-11(18)16-15(14(10)19)20-12(23-16)5-8-1-3-9(4-2-8)6-13(21)22/h1-4,7H,5-6H2,(H,21,22)
  • InChiKey: FWVKJCTVGOMXEI-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-[4-[(4,5,7-trifluoro-1,3-benzothiazol-2-yl)methyl]phenyl]ethanoic acid

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Sus scrofa Aldose reductase Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Loa Loa (eye worm) oxidoreductase Get druggable targets OG5_126583 All targets in OG5_126583
Candida albicans Aldose reductase Get druggable targets OG5_126583 All targets in OG5_126583
Leishmania donovani prostaglandin f synthase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Brugia malayi oxidoreductase, aldo/keto reductase family protein Get druggable targets OG5_126583 All targets in OG5_126583
Brugia malayi oxidoreductase, aldo/keto reductase family protein Get druggable targets OG5_126583 All targets in OG5_126583
Leishmania major aldehyde reductase, putative,oxidoreductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus granulosus aldo keto reductase Get druggable targets OG5_126583 All targets in OG5_126583
Trichomonas vaginalis aldo-keto reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus multilocularis aldo keto reductase Get druggable targets OG5_126583 All targets in OG5_126583
Trypanosoma congolense aldo-keto reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Leishmania braziliensis prostaglandin f synthase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Trichomonas vaginalis aldo-keto reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus granulosus hypothetical protein Get druggable targets OG5_126583 All targets in OG5_126583
Candida albicans similar to mammalian aldo/keto reductases Get druggable targets OG5_126583 All targets in OG5_126583
Trichomonas vaginalis aldo-keto reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus multilocularis aldehyde reductase Get druggable targets OG5_126583 All targets in OG5_126583
Leishmania major aldo-keto reductase-like protein Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus multilocularis aldo keto reductase Get druggable targets OG5_126583 All targets in OG5_126583
Candida albicans similar to mammalian aldo/keto reductases Get druggable targets OG5_126583 All targets in OG5_126583
Entamoeba histolytica aldose reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Trichomonas vaginalis dihydrodiol dehydrogenase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Schistosoma mansoni aldo-keto reductase Get druggable targets OG5_126583 All targets in OG5_126583
Brugia malayi oxidoreductase, aldo/keto reductase family protein Get druggable targets OG5_126583 All targets in OG5_126583
Schistosoma mansoni aldo-keto reductase Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus multilocularis aldo keto reductase family 1, member B4 Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus granulosus aldo keto reductase family 1 member B4 Get druggable targets OG5_126583 All targets in OG5_126583
Entamoeba histolytica aldose reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Mycobacterium tuberculosis Probable oxidoreductase Get druggable targets OG5_126583 All targets in OG5_126583
Trichomonas vaginalis aldo-keto reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126583 All targets in OG5_126583
Leishmania infantum prostaglandin f2-alpha synthase/D-arabinose dehydrogenase Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus multilocularis aldo keto reductase family 1, member B4 Get druggable targets OG5_126583 All targets in OG5_126583
Schistosoma japonicum IPR001395,Aldo/keto reductase,domain-containing Get druggable targets OG5_126583 All targets in OG5_126583
Onchocerca volvulus Get druggable targets OG5_126583 All targets in OG5_126583
Leishmania braziliensis aldo-keto reductase-like protein Get druggable targets OG5_126583 All targets in OG5_126583
Toxoplasma gondii aldose reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Loa Loa (eye worm) oxidoreductase Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus granulosus aldo keto reductase Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus multilocularis aldo keto reductase family 1, member B4 Get druggable targets OG5_126583 All targets in OG5_126583
Onchocerca volvulus Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus granulosus aldo keto reductase family 1 member B4 Get druggable targets OG5_126583 All targets in OG5_126583
Trichomonas vaginalis dihydrodiol dehydrogenase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Trichomonas vaginalis dihydrodiol dehydrogenase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus multilocularis aldo keto reductase family 1, member B4 Get druggable targets OG5_126583 All targets in OG5_126583
Candida albicans see also nonallelic CaP19.2244 Get druggable targets OG5_126583 All targets in OG5_126583
Trichomonas vaginalis aldo/keto reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Leishmania donovani prostaglandin f2-alpha synthase Get druggable targets OG5_126583 All targets in OG5_126583
Leishmania braziliensis aldehyde reductase, putative,oxidoreductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus granulosus aldo keto reductase family 1 member B4 Get druggable targets OG5_126583 All targets in OG5_126583
Trichomonas vaginalis aldo-keto reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus granulosus aldo keto reductase family 1 member B4 Get druggable targets OG5_126583 All targets in OG5_126583
Trichomonas vaginalis aldo/keto reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Candida albicans see also nonallelic CaP19.2244 Get druggable targets OG5_126583 All targets in OG5_126583
Loa Loa (eye worm) oxidoreductase Get druggable targets OG5_126583 All targets in OG5_126583
Leishmania donovani aldehyde reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Leishmania braziliensis prostaglandin f2-alpha synthase/D-arabinose dehydrogenase Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus multilocularis aldo keto reductase family 1, member B4 Get druggable targets OG5_126583 All targets in OG5_126583
Onchocerca volvulus Get druggable targets OG5_126583 All targets in OG5_126583
Trichomonas vaginalis aldo-keto reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Trypanosoma brucei gambiense aldo-keto reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Onchocerca volvulus Get druggable targets OG5_126583 All targets in OG5_126583
Candida albicans similar to mammalian aldo/keto reductases Get druggable targets OG5_126583 All targets in OG5_126583
Leishmania mexicana prostaglandin f2-alpha synthase Get druggable targets OG5_126583 All targets in OG5_126583
Leishmania major prostaglandin f2-alpha synthase/D-arabinose dehydrogenase Get druggable targets OG5_126583 All targets in OG5_126583
Leishmania infantum aldehyde reductase, putative,oxidoreductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Trichomonas vaginalis aldo-keto reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus multilocularis aldo keto reductase Get druggable targets OG5_126583 All targets in OG5_126583
Leishmania mexicana aldehyde reductase, putative,oxidoreductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus granulosus aldo keto reductase family 1 member B4 Get druggable targets OG5_126583 All targets in OG5_126583
Giardia lamblia Aldose reductase Get druggable targets OG5_126583 All targets in OG5_126583
Loa Loa (eye worm) oxidoreductase Get druggable targets OG5_126583 All targets in OG5_126583
Candida albicans Aldose reductase Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus granulosus aldo keto reductase family 1 member B4 Get druggable targets OG5_126583 All targets in OG5_126583
Trichomonas vaginalis aldo-keto reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Giardia lamblia Aldose reductase Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus granulosus aldehyde reductase Get druggable targets OG5_126583 All targets in OG5_126583
Trypanosoma congolense prostaglandin f synthase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Leishmania mexicana prostaglandin f synthase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus multilocularis aldo keto reductase family 1, member B4 Get druggable targets OG5_126583 All targets in OG5_126583
Leishmania mexicana aldo-keto reductase-like protein Get druggable targets OG5_126583 All targets in OG5_126583
Leishmania donovani aldo-keto reductase-like protein Get druggable targets OG5_126583 All targets in OG5_126583
Schistosoma japonicum ko:K00011 aldehyde reductase [EC1.1.1.21], putative Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus multilocularis aldo keto reductase family 1, member B4 Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus multilocularis aldo keto reductase Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus granulosus aldo keto reductase family 1 member B4 Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus granulosus aldo keto reductase family 1 member B4 Get druggable targets OG5_126583 All targets in OG5_126583
Neospora caninum Oxidoreductase, aldo/keto reductase family, related Get druggable targets OG5_126583 All targets in OG5_126583
Leishmania infantum aldo-keto reductase-like protein Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus multilocularis aldo keto reductase family 1, member B4 Get druggable targets OG5_126583 All targets in OG5_126583
Brugia malayi oxidoreductase, aldo/keto reductase family protein Get druggable targets OG5_126583 All targets in OG5_126583
Trypanosoma brucei aldo-keto reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Trypanosoma cruzi aldo/keto reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus multilocularis aldo keto reductase family 1, member B4 Get druggable targets OG5_126583 All targets in OG5_126583
Onchocerca volvulus Get druggable targets OG5_126583 All targets in OG5_126583
Trypanosoma brucei prostaglandin f synthase Get druggable targets OG5_126583 All targets in OG5_126583
Trypanosoma cruzi aldo-keto reductase Get druggable targets OG5_126583 All targets in OG5_126583
Trichomonas vaginalis aldo-keto reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Leishmania infantum prostaglandin f synthase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Mycobacterium leprae Conserved hypothetical protein Get druggable targets OG5_126583 All targets in OG5_126583
Entamoeba histolytica aldose reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Mycobacterium leprae PROBABLE OXIDOREDUCTASE Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus granulosus aldo keto reductase family 1 member B4 Get druggable targets OG5_126583 All targets in OG5_126583
Trichomonas vaginalis aldo-keto reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus granulosus aldo keto reductase Get druggable targets OG5_126583 All targets in OG5_126583
Trichomonas vaginalis aldo-keto reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus multilocularis aldo keto reductase family 1, member B4 Get druggable targets OG5_126583 All targets in OG5_126583
Mycobacterium ulcerans oxidoreductase Get druggable targets OG5_126583 All targets in OG5_126583
Loa Loa (eye worm) oxidoreductase Get druggable targets OG5_126583 All targets in OG5_126583
Trypanosoma brucei gambiense prostaglandin f synthase. putative Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus multilocularis aldo keto reductase family 1, member B4 Get druggable targets OG5_126583 All targets in OG5_126583
Leishmania major prostaglandin f synthase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Trichomonas vaginalis aldo/keto reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Onchocerca volvulus Get druggable targets OG5_126583 All targets in OG5_126583
Schistosoma mansoni pol-related Get druggable targets OG5_126583 All targets in OG5_126583
Candida albicans similar to mammalian aldo/keto reductases Get druggable targets OG5_126583 All targets in OG5_126583
Trichomonas vaginalis aldo-keto reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Onchocerca volvulus Aldose reductase   316 aa 313 aa 37.7 %
Mycobacterium ulcerans hypothetical protein Aldose reductase   316 aa 321 aa 25.5 %
Onchocerca volvulus Multiple coagulation factor deficiency protein 2 homolog Aldose reductase   316 aa 320 aa 41.6 %
Candida albicans aryl alcohol dehydrogenase Aldose reductase   316 aa 335 aa 19.7 %
Neospora caninum aldo/keto reductase family oxidoreductase, putative Aldose reductase   316 aa 288 aa 23.3 %
Candida albicans D-arabinose dehydrogenase, NADP-dependent Aldose reductase   316 aa 278 aa 34.9 %
Candida albicans aryl alcohol dehydrogenase Aldose reductase   316 aa 324 aa 18.5 %
Candida albicans see also nonallelic CaP19.6816 Aldose reductase   316 aa 279 aa 30.1 %
Candida albicans similar to putative aryl alcohol dehydrogenase family Aldose reductase   316 aa 313 aa 20.1 %
Candida albicans aryl alcohol dehydrogenase Aldose reductase   316 aa 324 aa 18.5 %
Toxoplasma gondii aldo/keto reductase family oxidoreductase Aldose reductase   316 aa 293 aa 26.6 %
Candida albicans putative aryl alcohol dehydrogenase Aldose reductase   316 aa 321 aa 20.2 %
Candida albicans aryl alcohol dehydrogenase Aldose reductase   316 aa 335 aa 19.7 %
Mycobacterium tuberculosis Conserved protein Aldose reductase   316 aa 322 aa 26.1 %
Onchocerca volvulus Aldose reductase   316 aa 321 aa 40.5 %
Trypanosoma cruzi aldo/keto reductase, putative Aldose reductase   316 aa 306 aa 28.8 %
Candida albicans D-arabinose dehydrogenase, NADP-dependent Aldose reductase   316 aa 278 aa 34.9 %
Candida albicans see also nonallelic CaP19.6816 Aldose reductase   316 aa 279 aa 30.1 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus aldo keto reductase 0.0038 0.0506 0.1649
Loa Loa (eye worm) tyrosinase 1 0.0409 1 1
Brugia malayi hypothetical protein 0.0022 0.008 0.008
Trypanosoma cruzi aldo/keto reductase, putative 0.0038 0.0506 1
Onchocerca volvulus Peroxidasin homolog 0.0086 0.174 0.1673
Echinococcus granulosus Polycystic kidney disease protein 0.0022 0.008 0.0261
Loa Loa (eye worm) oxidoreductase 0.0038 0.0506 0.0506
Echinococcus multilocularis aldo keto reductase 0.0038 0.0506 0.1596
Trichomonas vaginalis aldo-keto reductase, putative 0.0038 0.0506 0.8453
Loa Loa (eye worm) hypothetical protein 0.0086 0.174 0.174
Echinococcus multilocularis aldo keto reductase 0.0038 0.0506 0.1596
Trichomonas vaginalis aldo-keto reductase, putative 0.0038 0.0506 0.8453
Trichomonas vaginalis aldo-keto reductase, putative 0.0038 0.0506 0.8453
Loa Loa (eye worm) hypothetical protein 0.0086 0.174 0.174
Echinococcus granulosus RUN 0.0022 0.008 0.0261
Schistosoma mansoni pol-related 0.0038 0.0506 0.0506
Mycobacterium ulcerans oxidoreductase 0.0038 0.0506 1
Loa Loa (eye worm) blistered cuticle protein 3 0.0086 0.174 0.174
Trypanosoma brucei prostaglandin f synthase 0.0038 0.0506 1
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0038 0.0506 0.0506
Trichomonas vaginalis aldo-keto reductase, putative 0.0038 0.0506 0.8453
Giardia lamblia Histone acetyltransferase GCN5 0.0038 0.051 1
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0038 0.0506 0.1649
Onchocerca volvulus 0.0409 1 1
Onchocerca volvulus 0.0038 0.0506 0.043
Loa Loa (eye worm) hypothetical protein 0.0038 0.0506 0.0506
Schistosoma mansoni peroxidasin 0.0086 0.174 0.174
Brugia malayi hypothetical protein 0.0022 0.008 0.008
Plasmodium falciparum histone acetyltransferase GCN5 0.0038 0.051 1
Onchocerca volvulus 0.0038 0.0506 0.043
Trichomonas vaginalis aldo-keto reductase, putative 0.0038 0.0506 0.8453
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0018 0 0.5
Onchocerca volvulus 0.0038 0.0506 0.043
Loa Loa (eye worm) hypothetical protein 0.0409 1 1
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0038 0.0506 0.1596
Echinococcus multilocularis lipoxygenase domain containing protein 0.0022 0.008 0.0252
Onchocerca volvulus 0.0038 0.0506 0.043
Brugia malayi Animal haem peroxidase family protein 0.0086 0.174 0.174
Echinococcus multilocularis aldo keto reductase 0.0038 0.0506 0.1596
Loa Loa (eye worm) animal heme peroxidase 0.0086 0.174 0.174
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0038 0.0506 0.8453
Trypanosoma brucei aldo-keto reductase, putative 0.0038 0.0506 1
Loa Loa (eye worm) ShTK domain-containing protein 0.0409 1 1
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0038 0.0506 0.1596
Loa Loa (eye worm) hypothetical protein 0.0086 0.174 0.174
Loa Loa (eye worm) hypothetical protein 0.0086 0.174 0.174
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0038 0.0506 0.1596
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0038 0.0506 0.1649
Onchocerca volvulus 0.0409 1 1
Onchocerca volvulus Peroxidase homolog 0.0086 0.174 0.1673
Echinococcus multilocularis lipoxygenase domain containing protein 0.0022 0.008 0.0252
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0038 0.0506 0.1596
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0038 0.0506 0.1649
Loa Loa (eye worm) hypothetical protein 0.0086 0.174 0.174
Mycobacterium leprae PROBABLE OXIDOREDUCTASE 0.0038 0.0506 1
Loa Loa (eye worm) hypothetical protein 0.0022 0.008 0.008
Trichomonas vaginalis aldo-keto reductase, putative 0.0038 0.0506 0.8453
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0038 0.0506 0.1649
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0042 0.0599 1
Loa Loa (eye worm) oxidoreductase 0.0038 0.0506 0.0506
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0038 0.0506 0.1596
Trichomonas vaginalis aldo-keto reductase, putative 0.0038 0.0506 0.8453
Leishmania major prostaglandin f2-alpha synthase/D-arabinose dehydrogenase 0.0038 0.0506 1
Echinococcus granulosus peroxidasin 0.0086 0.174 0.5665
Echinococcus granulosus lipoxygenase domain containing protein 0.0022 0.008 0.0261
Loa Loa (eye worm) doublecortin family protein 0.0022 0.008 0.008
Echinococcus multilocularis RUN 0.0022 0.008 0.0252
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0038 0.0506 0.1596
Schistosoma mansoni aldo-keto reductase 0.0038 0.0506 0.0506
Loa Loa (eye worm) oxidoreductase 0.0038 0.0506 0.0506
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0038 0.0506 0.1596
Loa Loa (eye worm) hypothetical protein 0.0086 0.174 0.174
Leishmania major aldo-keto reductase-like protein 0.0038 0.0506 1
Trichomonas vaginalis aldo-keto reductase, putative 0.0038 0.0506 0.8453
Echinococcus granulosus aldo keto reductase 0.0038 0.0506 0.1649
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0038 0.0506 0.1596
Onchocerca volvulus Peroxidasin homolog 0.0086 0.174 0.1673
Trichomonas vaginalis aldo/keto reductase, putative 0.0038 0.0506 0.8453
Toxoplasma gondii aldose reductase, putative 0.0038 0.0506 0.8453
Loa Loa (eye worm) hypothetical protein 0.0086 0.174 0.174
Echinococcus granulosus histone acetyltransferase KAT2B 0.0042 0.0599 0.1951
Loa Loa (eye worm) animal heme peroxidase 0.0086 0.174 0.174
Mycobacterium tuberculosis Probable oxidoreductase 0.0038 0.0506 1
Loa Loa (eye worm) hypothetical protein 0.0409 1 1
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0142 0.3173 0.3173
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0038 0.0506 0.1596
Loa Loa (eye worm) hypothetical protein 0.0086 0.174 0.174
Treponema pallidum exodeoxyribonuclease (exoA) 0.0018 0 0.5
Schistosoma mansoni aldo-keto reductase 0.0038 0.0506 0.0506
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0042 0.0599 1
Trichomonas vaginalis aldo/keto reductase, putative 0.0038 0.0506 0.8453
Brugia malayi hypothetical protein 0.0086 0.174 0.174
Brugia malayi Animal haem peroxidase family protein 0.0086 0.174 0.174
Brugia malayi Animal haem peroxidase family protein 0.0086 0.174 0.174
Brugia malayi Hypothetical tyrosinase-like protein F21C3.2 in chromosome I 0.0409 1 1
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0038 0.0506 0.1649
Entamoeba histolytica acetyltransferase, GNAT family 0.0038 0.051 1
Schistosoma mansoni polycystin 1-related 0.0022 0.008 0.008
Echinococcus granulosus aldo keto reductase 0.0038 0.0506 0.1649
Trichomonas vaginalis aldo-keto reductase, putative 0.0038 0.0506 0.8453
Trichomonas vaginalis aldo-keto reductase, putative 0.0038 0.0506 0.8453
Schistosoma mansoni tyrosinase precursor 0.0409 1 1
Brugia malayi Animal haem peroxidase family protein 0.0086 0.174 0.174
Loa Loa (eye worm) hypothetical protein 0.0086 0.174 0.174
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0129 0.2836 0.8938
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0038 0.0506 0.8453
Echinococcus granulosus histone acetyltransferase KAT2B 0.0138 0.3071 1
Onchocerca volvulus 0.0086 0.174 0.1673
Trichomonas vaginalis bromodomain-containing protein, putative 0.0042 0.0599 1
Schistosoma mansoni peroxidasin 0.0086 0.174 0.174
Loa Loa (eye worm) animal heme peroxidase 0.0086 0.174 0.174
Brugia malayi Doublecortin family protein 0.0022 0.008 0.008
Trichomonas vaginalis aldo/keto reductase, putative 0.0038 0.0506 0.8453
Loa Loa (eye worm) acetyltransferase 0.0142 0.3173 0.3173
Schistosoma mansoni lipoxygenase 0.0129 0.2836 0.2836
Onchocerca volvulus 0.0086 0.174 0.1673
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0042 0.0599 1
Loa Loa (eye worm) hypothetical protein 0.0086 0.174 0.174
Leishmania major prostaglandin f synthase, putative 0.0038 0.0506 1
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0038 0.0506 0.1596
Entamoeba histolytica aldose reductase, putative 0.0038 0.0506 0.9934
Onchocerca volvulus 0.0038 0.0506 0.043
Loa Loa (eye worm) hypothetical protein 0.0022 0.008 0.008
Loa Loa (eye worm) hypothetical protein 0.0086 0.174 0.174
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0038 0.0506 0.1649
Trichomonas vaginalis aldo-keto reductase, putative 0.0038 0.0506 0.8453
Trypanosoma cruzi aldo-keto reductase 0.0038 0.0506 1
Echinococcus multilocularis peroxidasin 0.0086 0.174 0.5483
Entamoeba histolytica aldose reductase, putative 0.0038 0.0506 0.9934
Echinococcus multilocularis aldehyde reductase 0.0027 0.0223 0.0702
Loa Loa (eye worm) oxidoreductase 0.0038 0.0506 0.0506
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0042 0.0599 1
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0038 0.0506 0.1649
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0038 0.0506 0.0506
Brugia malayi Hypothetical tyrosinase-like protein C02C2.1 in chromosome III 0.0409 1 1
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0038 0.0506 0.1649
Giardia lamblia Aldose reductase 0.0038 0.0506 0.9934
Schistosoma mansoni tyrosinase precursor 0.0409 1 1
Echinococcus granulosus lipoxygenase domain containing protein 0.0022 0.008 0.0261
Brugia malayi Hypothetical tyrosinase-like protein C02C2.1 in chromosome III 0.0409 1 1
Brugia malayi Animal haem peroxidase family protein 0.0086 0.174 0.174
Echinococcus multilocularis Polycystic kidney disease protein 0.0022 0.008 0.0252
Onchocerca volvulus 0.0409 1 1
Brugia malayi Common central domain of tyrosinase family protein 0.0409 1 1
Entamoeba histolytica aldose reductase, putative 0.0038 0.0506 0.9934
Trichomonas vaginalis aldo-keto reductase, putative 0.0038 0.0506 0.8453
Schistosoma mansoni rab6-interacting 0.0022 0.008 0.008
Loa Loa (eye worm) animal heme peroxidase 0.0086 0.174 0.174
Loa Loa (eye worm) oxidoreductase 0.0038 0.0506 0.0506
Schistosoma mansoni hypothetical protein 0.0022 0.008 0.008
Brugia malayi Blistered cuticle protein 3 0.0086 0.174 0.174
Onchocerca volvulus Dual oxidase homolog 0.0086 0.174 0.1673
Brugia malayi Hypothetical tyrosinase-like protein C02C2.1 in chromosome III 0.0409 1 1
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0038 0.0506 0.0506
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0129 0.2836 0.9236
Loa Loa (eye worm) hypothetical protein 0.0086 0.174 0.174
Leishmania major aldehyde reductase, putative,oxidoreductase, putative 0.0038 0.0506 1
Loa Loa (eye worm) ShTK domain-containing protein 0.0409 1 1
Loa Loa (eye worm) hypothetical protein 0.0086 0.174 0.174
Loa Loa (eye worm) hypothetical protein 0.0086 0.174 0.174
Onchocerca volvulus 0.0038 0.0506 0.043
Brugia malayi Peroxidasin 0.0086 0.174 0.174
Onchocerca volvulus 0.0086 0.174 0.1673
Onchocerca volvulus 0.0409 1 1
Echinococcus granulosus hypothetical protein 0.0038 0.0506 0.1649
Brugia malayi acetyltransferase, GNAT family protein 0.0142 0.3173 0.3173
Plasmodium falciparum LCCL domain-containing protein 0.0022 0.008 0.1571
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0038 0.0506 0.0506
Echinococcus granulosus aldehyde reductase 0.0027 0.0223 0.0725
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0142 0.3173 1
Onchocerca volvulus Chorion peroxidase homolog 0.0086 0.174 0.1673
Echinococcus multilocularis aldo keto reductase 0.0038 0.0506 0.1596
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0038 0.0506 0.1649
Giardia lamblia Aldose reductase 0.0038 0.0506 0.9934
Plasmodium vivax multidomain scavenger receptor, putative 0.0022 0.008 0.1337
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0038 0.0506 0.8453
Schistosoma mansoni lipoxygenase 0.009 0.184 0.184
Onchocerca volvulus Peroxidase homolog 0.0086 0.174 0.1673
Schistosoma mansoni loxhd1 0.0022 0.008 0.008
Schistosoma mansoni rab6-interacting 0.0022 0.008 0.008
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0038 0.0506 0.1596

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 38 nM Inhibitory concentration against porcine lens aldose reductase (AR) with DL-glyceraldehyde as the substrate ChEMBL. No reference
IC50 (binding) = 38 nM Inhibitory concentration against porcine lens aldose reductase (AR) with DL-glyceraldehyde as the substrate ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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