TDR Targets

Basic information

Technical information

TDR Targets ID: 666873
Name: 4-chloro-3-[(3,4-dimethylphenyl)sulfamoyl]-N- (2-nitrophenyl)benzamide
MW: 459.903 | Formula: C21H18ClN3O5S
H donors: 2 H acceptors: 5 LogP: 5.02 Rotable bonds: 7
Rule of 5 violations (Lipinski): 1
SMILES: Clc1ccc(cc1S(=O)(=O)Nc1ccc(c(c1)C)C)C(=O)Nc1ccccc1[N+](=O)[O-]
InChi: 1S/C21H18ClN3O5S/c1-13-7-9-16(11-14(13)2)24-31(29,30)20-12-15(8-10-17(20)22)21(26)23-18-5-3-4-6-19(18)25(27)28/h3-12,24H,1-2H3,(H,23,26)
InChiKey: YNHAPUOUZOLUKT-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0308	0.8513	1
Plasmodium falciparum	glutathione reductase	0.0093	0.2291	1
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0143	0.3732	0.3707
Plasmodium vivax	thioredoxin reductase, putative	0.0093	0.2291	1
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0357	0.0419
Echinococcus multilocularis	lamin	0.0027	0.0357	0.032
Schistosoma mansoni	ap endonuclease	0.0021	0.0185	0.0147
Giardia lamblia	PHD finger protein 15	0.0028	0.0414	0.0975
Echinococcus multilocularis	musashi	0.0027	0.0357	0.032
Trypanosoma brucei	dihydrolipoamide dehydrogenase, point mutation	0.0032	0.0525	0.1954
Brugia malayi	Intermediate filament tail domain containing protein	0.0027	0.0357	0.0419
Schistosoma mansoni	lamin	0.0027	0.0357	0.032
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0143	0.3732	0.3707
Loa Loa (eye worm)	thioredoxin reductase	0.0093	0.2291	0.2691
Chlamydia trachomatis	dihydrolipoyl dehydrogenase	0.0032	0.0525	0.5
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0032	0.0525	0.1954
Echinococcus granulosus	Transcription factor JmjC domain containing protein	0.0093	0.2292	0.2262
Plasmodium vivax	dihydrolipoyl dehydrogenase, apicoplast, putative	0.0032	0.0525	0.2158
Loa Loa (eye worm)	CMGC/MAPK/ERK1 protein kinase	0.0101	0.2526	0.2967
Loa Loa (eye worm)	intermediate filament protein	0.0027	0.0357	0.0419
Treponema pallidum	NADH oxidase	0.0032	0.0525	1
Echinococcus granulosus	jumonji domain containing protein	0.004	0.0737	0.0701
Loa Loa (eye worm)	tyrosyl-DNA phosphodiesterase	0.0065	0.1471	0.1728
Echinococcus granulosus	PHD finger protein rhinoceros	0.0028	0.0414	0.0376
Leishmania major	2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein	0.0032	0.0525	0.1954
Trypanosoma cruzi	mitogen activated protein kinase 2, putative	0.0101	0.2526	1
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0143	0.3732	0.4383
Echinococcus multilocularis	thioredoxin glutathione reductase	0.0094	0.2307	0.2277
Schistosoma mansoni	hypothetical protein	0.0359	1	1
Mycobacterium ulcerans	glutaminase	0.0264	0.7249	1
Echinococcus granulosus	transcription factor Dp 1	0.0038	0.0678	0.0642
Echinococcus multilocularis	Transcription factor, JmjC domain containing protein	0.0093	0.2292	0.2262
Brugia malayi	Tyrosyl-DNA phosphodiesterase family protein	0.0065	0.1471	0.1728
Trypanosoma brucei	dihydrolipoyl dehydrogenase	0.0032	0.0525	0.1954
Entamoeba histolytica	hypothetical protein	0.0072	0.1682	1
Echinococcus multilocularis	tyrosyl DNA phosphodiesterase 1	0.0065	0.1471	0.1438
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0143	0.3732	0.3707
Plasmodium vivax	dihydrolipoyl dehydrogenase, mitochondrial, putative	0.0032	0.0525	0.2158
Mycobacterium tuberculosis	NADPH-dependent mycothiol reductase Mtr	0.0093	0.2291	0.3518
Loa Loa (eye worm)	hypothetical protein	0.0097	0.2412	0.2833
Echinococcus granulosus	mitogen activated protein kinase	0.0101	0.2526	0.2497
Mycobacterium ulcerans	flavoprotein disulfide reductase	0.0032	0.0525	0.048
Brugia malayi	Bromodomain containing protein	0.0028	0.0414	0.0486
Loa Loa (eye worm)	isocitrate dehydrogenase	0.0016	0.0039	0.0045
Schistosoma mansoni	bromodomain-containing nuclear protein 1 brd1	0.0028	0.0414	0.0376
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0143	0.3732	0.3707
Brugia malayi	alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase	0.0024	0.0276	0.0324
Loa Loa (eye worm)	hypothetical protein	0.0049	0.1003	0.1179
Loa Loa (eye worm)	MH2 domain-containing protein	0.012	0.3067	0.3603
Plasmodium falciparum	glutathione reductase	0.0032	0.0525	0.2158
Mycobacterium tuberculosis	Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot	0.0032	0.0525	0.0759
Entamoeba histolytica	hypothetical protein	0.0072	0.1682	1
Plasmodium falciparum	thioredoxin reductase	0.0093	0.2291	1
Plasmodium vivax	glutathione reductase, putative	0.0093	0.2291	1
Trichomonas vaginalis	CMGC family protein kinase	0.0101	0.2526	0.3314
Brugia malayi	jmjC domain containing protein	0.0034	0.0587	0.069
Mycobacterium ulcerans	dihydrolipoamide dehydrogenase	0.0032	0.0525	0.048
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0097	0.2412	0.2383
Brugia malayi	Thioredoxin reductase	0.0093	0.2291	0.2691
Leishmania major	tyrosyl-DNA phosphodiesterase 1	0.0065	0.1471	0.5757
Loa Loa (eye worm)	jmjC domain-containing protein	0.0059	0.1293	0.1518
Leishmania major	mitogen activated protein kinase, putative,map kinase, putative	0.0101	0.2526	1
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	0.0021	0.0185	0.0147
Schistosoma mansoni	ap endonuclease	0.0021	0.0185	0.0147
Leishmania major	trypanothione reductase	0.0093	0.2291	0.9054
Mycobacterium tuberculosis	Probable oxidoreductase	0.0236	0.6442	1
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0097	0.2412	0.2383
Mycobacterium tuberculosis	Probable reductase	0.0213	0.5754	0.8925
Trypanosoma cruzi	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.0065	0.1471	0.5757
Trypanosoma cruzi	dihydrolipoyl dehydrogenase, putative	0.0032	0.0525	0.1954
Entamoeba histolytica	tyrosyl-DNA phosphodiesterase, putative	0.0065	0.1471	0.8587
Toxoplasma gondii	pyruvate dehydrogenase complex subunit PDH-E3II	0.0032	0.0525	0.1954
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0143	0.3732	0.3707
Giardia lamblia	Kinase, CMGC MAPK	0.0101	0.2526	1
Trypanosoma cruzi	dihydrolipoyl dehydrogenase, putative	0.0032	0.0525	0.1954
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	0.0021	0.0185	0.0147
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0414	0.0486
Schistosoma mansoni	hypothetical protein	0.0072	0.1682	0.165
Trichomonas vaginalis	CMGC family protein kinase	0.0101	0.2526	0.3314
Loa Loa (eye worm)	jmjC domain-containing protein	0.0034	0.0587	0.069
Trypanosoma brucei	protein kinase, putative	0.0101	0.2526	1
Brugia malayi	Isocitrate dehydrogenase	0.0016	0.0039	0.0045
Schistosoma mansoni	jumonji domain containing protein	0.0074	0.1736	0.1704
Echinococcus multilocularis	lamin dm0	0.0027	0.0357	0.032
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	0.0101	0.2526	1
Brugia malayi	Latrophilin receptor protein 2	0.0097	0.2412	0.2833
Trypanosoma cruzi	trypanothione reductase, putative	0.0032	0.0525	0.1954
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0027	0.0357	0.0419
Mycobacterium ulcerans	dihydrolipoamide dehydrogenase, LpdB	0.0032	0.0525	0.048
Wolbachia endosymbiont of Brugia malayi	dihydrolipoamide dehydrogenase E3 component	0.0032	0.0525	1
Brugia malayi	glutaminase DH11.1	0.0264	0.7249	0.8515
Trypanosoma brucei	dihydrolipoamide dehydrogenase	0.0032	0.0525	0.1954
Echinococcus granulosus	lamin dm0	0.0027	0.0357	0.032
Schistosoma mansoni	hypothetical protein	0.0097	0.2412	0.2383
Echinococcus multilocularis	mitogen activated protein kinase 3	0.0101	0.2526	0.2497
Schistosoma mansoni	transcription factor LCR-F1	0.0072	0.1682	0.165
Trypanosoma brucei	apurinic/apyrimidinic endonuclease, putative	0.0021	0.0185	0.059
Schistosoma mansoni	hypothetical protein	0.0097	0.2412	0.2383
Schistosoma mansoni	hypothetical protein	0.0097	0.2412	0.2383
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.0021	0.0185	0.0218
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease, putative	0.0021	0.0185	0.059
Brugia malayi	exodeoxyribonuclease III family protein	0.0021	0.0185	0.0218
Brugia malayi	dihydrolipoyl dehydrogenase, mitochondrial precursor, putative	0.0032	0.0525	0.0616
Leishmania major	acetoin dehydrogenase e3 component-like protein	0.0032	0.0525	0.1954
Schistosoma mansoni	dihydrolipoamide dehydrogenase	0.0032	0.0525	0.0488
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0143	0.3732	0.4383
Echinococcus granulosus	peregrin	0.0028	0.0414	0.0376
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0034	0.0587	0.0551
Trypanosoma cruzi	trypanothione reductase, putative	0.0093	0.2291	0.9054
Trypanosoma cruzi	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.0065	0.1471	0.5757
Brugia malayi	isocitrate dehydrogenase	0.0016	0.0039	0.0045
Trypanosoma brucei	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.0065	0.1471	0.5757
Trichomonas vaginalis	CMGC family protein kinase	0.0101	0.2526	0.3314
Loa Loa (eye worm)	glutaminase	0.0264	0.7249	0.8515
Onchocerca volvulus	Alhambra homolog	0.0028	0.0414	1
Brugia malayi	PHD-finger family protein	0.0028	0.0414	0.0486
Echinococcus granulosus	intermediate filament protein	0.0027	0.0357	0.032
Mycobacterium tuberculosis	Probable membrane NADH dehydrogenase NdhA	0.0213	0.5754	0.8925
Schistosoma mansoni	intermediate filament proteins	0.0027	0.0357	0.032
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	0.0101	0.2526	1
Echinococcus multilocularis	peregrin	0.0028	0.0414	0.0376
Brugia malayi	hypothetical protein	0.0072	0.1682	0.1976
Schistosoma mansoni	lamin	0.0027	0.0357	0.032
Mycobacterium tuberculosis	Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras	0.0236	0.6442	1
Echinococcus multilocularis	mitogen activated protein kinase	0.0101	0.2526	0.2497
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0308	0.8513	1
Loa Loa (eye worm)	transcription factor SMAD2	0.012	0.3067	0.3603
Schistosoma mansoni	hypothetical protein	0.021	0.5689	0.5673
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0097	0.2412	0.2833
Plasmodium vivax	hypothetical protein, conserved	0.0028	0.0414	0.1665
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0097	0.2412	0.2383
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0308	0.8513	1
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0143	0.3732	0.3707
Wolbachia endosymbiont of Brugia malayi	dihydrolipoamide dehydrogenase E3 component	0.0032	0.0525	1
Toxoplasma gondii	exonuclease III APE	0.0021	0.0185	0.059
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0032	0.0525	0.1954
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0032	0.0525	0.1954
Leishmania major	apurinic/apyrimidinic endonuclease-redox protein	0.0021	0.0185	0.059
Trichomonas vaginalis	glutathione reductase, putative	0.0032	0.0525	0.048
Toxoplasma gondii	CMGC kinase, MAPK family (ERK) MAPK-1	0.0101	0.2526	1
Toxoplasma gondii	thioredoxin reductase	0.0093	0.2291	0.9054
Plasmodium falciparum	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0021	0.0185	0.0651
Echinococcus multilocularis	jumonji domain containing protein	0.004	0.0737	0.0701
Brugia malayi	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein	0.0024	0.0276	0.0324
Toxoplasma gondii	PHD-finger domain-containing protein	0.0028	0.0414	0.1507
Schistosoma mansoni	glutaminase	0.0264	0.7249	0.7238
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0343	0.0403
Schistosoma mansoni	tyrosyl-DNA phosphodiesterase	0.0065	0.1471	0.1438
Echinococcus multilocularis	PHD finger protein rhinoceros	0.0028	0.0414	0.0376
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0143	0.3732	0.3707
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0072	0.1682	0.165
Schistosoma mansoni	hypothetical protein	0.0097	0.2412	0.2383
Plasmodium falciparum	thioredoxin reductase	0.0032	0.0525	0.2158
Schistosoma mansoni	serine/threonine protein kinase	0.0101	0.2526	0.2497
Brugia malayi	MH2 domain containing protein	0.012	0.3067	0.3603
Plasmodium falciparum	dihydrolipoyl dehydrogenase, apicoplast	0.0032	0.0525	0.2158
Mycobacterium tuberculosis	Probable NADH dehydrogenase Ndh	0.0213	0.5754	0.8925
Toxoplasma gondii	NADPH-glutathione reductase	0.0032	0.0525	0.1954
Echinococcus multilocularis	geminin	0.0359	1	1
Schistosoma mansoni	hypothetical protein	0.0028	0.0414	0.0376
Echinococcus multilocularis	lysine specific demethylase 5A	0.0034	0.0587	0.0551
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0032	0.0525	0.1954
Echinococcus granulosus	lamin	0.0027	0.0357	0.032
Entamoeba histolytica	hypothetical protein	0.0072	0.1682	1
Loa Loa (eye worm)	hypothetical protein	0.0308	0.8513	1
Trypanosoma cruzi	mitogen activated protein kinase 4, putative	0.0101	0.2526	1
Loa Loa (eye worm)	glutathione reductase	0.0093	0.2291	0.2691
Echinococcus granulosus	GPCR family 2	0.0097	0.2412	0.2383
Plasmodium falciparum	phd finger protein, putative	0.0028	0.0414	0.1665
Toxoplasma gondii	PHD-finger domain-containing protein	0.0028	0.0414	0.1507
Trichomonas vaginalis	CMGC family protein kinase	0.0101	0.2526	0.3314
Trichomonas vaginalis	mercuric reductase, putative	0.0032	0.0525	0.048
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0032	0.0525	0.1954
Echinococcus granulosus	tyrosyl DNA phosphodiesterase 1	0.0065	0.1471	0.1438
Echinococcus granulosus	thioredoxin glutathione reductase	0.0094	0.2307	0.2277
Brugia malayi	intermediate filament protein	0.0027	0.0357	0.0419
Brugia malayi	glutathione reductase	0.0093	0.2291	0.2691
Entamoeba histolytica	hypothetical protein	0.0072	0.1682	1
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0032	0.0525	0.1954
Loa Loa (eye worm)	hypothetical protein	0.021	0.5689	0.6683
Mycobacterium tuberculosis	Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB	0.0213	0.5754	0.8925
Trypanosoma brucei	trypanothione reductase	0.0093	0.2291	0.9054
Giardia lamblia	NADH oxidase lateral transfer candidate	0.0032	0.0525	0.145
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease	0.0021	0.0185	0.059
Plasmodium vivax	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0021	0.0185	0.0651
Mycobacterium tuberculosis	NAD(P)H quinone reductase LpdA	0.0236	0.6442	1
Leishmania major	dihydrolipoamide dehydrogenase, putative	0.0032	0.0525	0.1954
Leishmania major	dihydrolipoamide dehydrogenase, putative	0.0032	0.0525	0.1954
Echinococcus multilocularis	GPCR, family 2	0.0097	0.2412	0.2383
Trypanosoma brucei	dihydrolipoamide dehydrogenase	0.0032	0.0525	0.1954
Loa Loa (eye worm)	glutaminase 2	0.0264	0.7249	0.8515
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0097	0.2412	0.2833
Echinococcus multilocularis	dihydrolipoamide dehydrogenase	0.0032	0.0525	0.0488
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0097	0.2412	0.2383
Echinococcus granulosus	mitogen activated protein kinase 3	0.0101	0.2526	0.2497
Echinococcus granulosus	dihydrolipoamide dehydrogenase	0.0032	0.0525	0.0488
Plasmodium falciparum	dihydrolipoyl dehydrogenase, mitochondrial	0.0032	0.0525	0.2158
Brugia malayi	latrophilin 2 splice variant baaae	0.021	0.5689	0.6683
Mycobacterium tuberculosis	Putative ferredoxin reductase	0.0213	0.5754	0.8925
Mycobacterium tuberculosis	Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI)	0.0021	0.0185	0.0229
Schistosoma mansoni	hypothetical protein	0.0359	1	1
Echinococcus granulosus	lysine specific demethylase 5A	0.0034	0.0587	0.0551
Trichomonas vaginalis	glutaminase, putative	0.0264	0.7249	1
Mycobacterium tuberculosis	Probable dehydrogenase	0.0213	0.5754	0.8925
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0072	0.1682	0.165
Loa Loa (eye worm)	PHD-finger family protein	0.0028	0.0414	0.0486
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0034	0.0587	0.0551
Echinococcus multilocularis	transcription factor Dp 1	0.0038	0.0678	0.0642
Mycobacterium leprae	DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE	0.0236	0.6442	1
Trypanosoma brucei	mitogen activated protein kinase 4, putative	0.0101	0.2526	1
Brugia malayi	MAP kinase sur-1	0.0101	0.2526	0.2967
Brugia malayi	jmjC domain containing protein	0.0093	0.2292	0.2692
Leishmania major	mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440	0.0101	0.2526	1

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 666873