TDR Targets

Basic information

Technical information

TDR Targets ID: 679112
Name: 1-[1-(2-chlorophenyl)-2,5-dioxopyrrolidin-3-y l]piperidine-4-carboxamide
MW: 335.785 | Formula: C16H18ClN3O3
H donors: 1 H acceptors: 3 LogP: 0.87 Rotable bonds: 3
Rule of 5 violations (Lipinski): 1
SMILES: NC(=O)C1CCN(CC1)C1CC(=O)N(C1=O)c1ccccc1Cl
InChi: 1S/C16H18ClN3O3/c17-11-3-1-2-4-12(11)20-14(21)9-13(16(20)23)19-7-5-10(6-8-19)15(18)22/h1-4,10,13H,5-9H2,(H2,18,22)
InChiKey: KLIVEUSSOHBTCR-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

1-[1-(2-chlorophenyl)-2,5-dioxo-pyrrolidin-3-yl]piperidine-4-carboxamide
1-[1-(2-chlorophenyl)-2,5-dioxo-3-pyrrolidinyl]-4-piperidinecarboxamide
1-[1-(2-chlorophenyl)-2,5-diketo-pyrrolidin-3-yl]isonipecotamide
STOCK3S-46879
BAS 05590815

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Chlamydia trachomatis	SWIB complex protein	0.0256	0.7226	0.5
Echinococcus multilocularis	Upstream activation factor subunit UAF30	0.0256	0.7226	0.7226
Echinococcus multilocularis	ring and YY1 binding protein	0.0091	0.2369	0.2369
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0134	0.3632	0.4283
Brugia malayi	brahma associated protein 60 kDa	0.0256	0.7226	1
Loa Loa (eye worm)	nucleolar RNA-associated protein alpha	0.0298	0.8479	1
Echinococcus multilocularis	importin subunit beta 1	0.0028	0.0511	0.0511
Plasmodium falciparum	ataxin-2 like protein, putative	0.0025	0.0419	0.0266
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	0.0019	0.0234	0.0234
Echinococcus granulosus	SWI:SNF matrix associated	0.0256	0.7226	0.7226
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0134	0.3632	0.3632
Trichomonas vaginalis	glucosylceramidase, putative	0.0164	0.4527	0.614
Trypanosoma brucei	apurinic/apyrimidinic endonuclease, putative	0.0019	0.0234	0.0986
Trichomonas vaginalis	glucosylceramidase, putative	0.0173	0.4788	0.6513
Brugia malayi	Zn-finger in Ran binding protein and others containing protein	0.0091	0.2369	0.3279
Echinococcus granulosus	Upstream activation factor subunit UAF30	0.0256	0.7226	0.7226
Trichomonas vaginalis	glucosylceramidase, putative	0.025	0.7064	0.9767
Mycobacterium tuberculosis	Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI)	0.0019	0.0234	1
Treponema pallidum	exodeoxyribonuclease (exoA)	0.0019	0.0234	0.5
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.0019	0.0234	0.0275
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0134	0.3632	0.4283
Trypanosoma cruzi	hypothetical protein, conserved	0.0091	0.2369	1
Trichomonas vaginalis	glucosylceramidase, putative	0.0164	0.4527	0.614
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0023	0.0355	0.0174
Trypanosoma cruzi	cytochrome P450, putative	0.0019	0.0258	0.1088
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0134	0.3632	0.3632
Trypanosoma cruzi	WLM domain containing protein, putative	0.0091	0.2369	1
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0134	0.3632	0.3632
Echinococcus multilocularis	Nuclear pore complex protein Nup153	0.0091	0.2369	0.2369
Echinococcus granulosus	ring and YY1 binding protein	0.0091	0.2369	0.2369
Trichomonas vaginalis	glucosylceramidase, putative	0.0164	0.4527	0.614
Echinococcus granulosus	snurportin 1	0.0298	0.8479	0.8479
Chlamydia trachomatis	DNA topoisomerase I	0.0256	0.7226	0.5
Echinococcus multilocularis	Zinc finger, RanBP2 type	0.0091	0.2369	0.2369
Trypanosoma brucei	hypothetical protein, conserved	0.0091	0.2369	1
Plasmodium vivax	SWIB/MDM2 domain-containing protein, putative	0.0256	0.7226	1
Echinococcus multilocularis	SWI:SNF matrix associated	0.0256	0.7226	0.7226
Plasmodium vivax	importin-beta 2, putative	0.0028	0.0511	0.0397
Trichomonas vaginalis	glucosylceramidase, putative	0.0164	0.4527	0.614
Plasmodium falciparum	importin beta, putative	0.0028	0.0511	0.0397
Echinococcus granulosus	Ataxin 2 N terminaldomain containing protein	0.0011	0.0016	0.0016
Brugia malayi	Cytochrome P450 family protein	0.0049	0.1123	0.1554
Echinococcus multilocularis	tumor protein p63	0.035	1	1
Toxoplasma gondii	LsmAD domain-containing protein	0.0025	0.0419	0.058
Echinococcus multilocularis	GTP binding nuclear protein Ran	0.0021	0.0294	0.0294
Toxoplasma gondii	SWIB/MDM2 domain-containing protein	0.0256	0.7226	1
Leishmania major	hypothetical protein, conserved	0.0091	0.2369	1
Trypanosoma cruzi	mitochondrial RNA binding complex 1 subunit, putative	0.0091	0.2369	1
Trypanosoma cruzi	Zn-finger in Ran binding protein and others, putative	0.0091	0.2369	1
Trypanosoma cruzi	WLM domain containing protein, putative	0.0091	0.2369	1
Brugia malayi	Importin beta-1 subunit	0.0028	0.0511	0.0707
Loa Loa (eye worm)	GTP-binding nuclear protein RAN/TC4	0.0021	0.0294	0.0346
Entamoeba histolytica	Ran family GTPase	0.0021	0.0294	0.4938
Trypanosoma brucei	importin beta-1 subunit, putative	0.0028	0.0511	0.2157
Trichomonas vaginalis	glucosylceramidase, putative	0.025	0.7064	0.9767
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0511	0.0603
Plasmodium vivax	GTP-binding nuclear protein RAN/TC4, putative	0.0021	0.0294	0.0086
Mycobacterium leprae	putative cytochrome p450	0.0011	0	0.5
Loa Loa (eye worm)	cytochrome P450 family protein	0.0049	0.1123	0.1324
Loa Loa (eye worm)	hypothetical protein	0.0091	0.2369	0.2794
Trypanosoma brucei	Zn-finger in Ran binding protein and others/FYVE zinc finger, putative	0.0091	0.2369	1
Echinococcus multilocularis	snurportin 1	0.0298	0.8479	0.8479
Mycobacterium ulcerans	cytochrome P450 185A4 Cyp185A4	0.0019	0.0258	1
Onchocerca volvulus	Glucosylceramidase homolog	0.0164	0.4527	0.5523
Trypanosoma brucei	importin beta-1 subunit, putative	0.0028	0.0511	0.2157
Schistosoma mansoni	hypothetical protein	0.0256	0.7226	0.8522
Plasmodium falciparum	zinc finger Ran-binding domain-containing protein 2, putative	0.0091	0.2369	0.3054
Brugia malayi	exodeoxyribonuclease III family protein	0.0019	0.0234	0.0323
Echinococcus granulosus	Nuclear pore complex protein Nup153	0.0091	0.2369	0.2369
Schistosoma mansoni	hypothetical protein	0.0167	0.4607	0.5433
Trichomonas vaginalis	glucosylceramidase, putative	0.025	0.7064	0.9767
Echinococcus granulosus	zinc finger protein Ran binding	0.0091	0.2369	0.2369
Toxoplasma gondii	exonuclease III APE	0.0019	0.0234	0.0323
Trichomonas vaginalis	glucosylceramidase, putative	0.025	0.7064	0.9767
Brugia malayi	Zn-finger in Ran binding protein and others containing protein	0.0091	0.2369	0.3279
Loa Loa (eye worm)	brahma associated protein	0.0256	0.7226	0.8522
Brugia malayi	SWIB/MDM2 domain containing protein	0.0256	0.7226	1
Leishmania major	hypothetical protein, conserved	0.0091	0.2369	1
Brugia malayi	hypothetical protein	0.0025	0.0419	0.058
Loa Loa (eye worm)	hypothetical protein	0.0091	0.2369	0.2794
Plasmodium falciparum	GTP-binding nuclear protein RAN/TC4	0.0021	0.0294	0.0086
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease, putative	0.0019	0.0234	0.0986
Echinococcus granulosus	GTP binding nuclear protein Ran	0.0021	0.0294	0.0294
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	0.0019	0.0234	0.0234
Onchocerca volvulus		0.0091	0.2369	0.1944
Echinococcus multilocularis	zinc finger protein Ran binding	0.0091	0.2369	0.2369
Loa Loa (eye worm)	O-glycosyl hydrolase family 30 protein	0.025	0.7064	0.833
Brugia malayi	hypothetical protein	0.0016	0.016	0.0221
Toxoplasma gondii	ran binding protein	0.0091	0.2369	0.3279
Trypanosoma brucei	GTP-binding nuclear protein rtb2, putative	0.0021	0.0294	0.124
Mycobacterium ulcerans	exodeoxyribonuclease III protein XthA	0.0019	0.0234	0.9061
Trypanosoma cruzi	mitochondrial RNA binding complex 1 subunit, putative	0.0091	0.2369	1
Plasmodium falciparum	SWIB/MDM2 domain-containing protein	0.0256	0.7226	1
Schistosoma mansoni	ap endonuclease	0.0019	0.0234	0.0275
Schistosoma mansoni	hypothetical protein	0.0256	0.7226	0.8522
Brugia malayi	Zn-finger in Ran binding protein and others containing protein	0.0091	0.2369	0.3279
Leishmania major	hypothetical protein, conserved	0.0091	0.2369	1
Brugia malayi	Cytochrome P450 family protein	0.0019	0.0258	0.0357
Echinococcus granulosus	geminin	0.0167	0.4607	0.4607
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0134	0.3632	0.3632
Brugia malayi	RNA, U transporter 1	0.0079	0.203	0.2809
Loa Loa (eye worm)	CYP4Cod1	0.0019	0.0258	0.0304
Echinococcus granulosus	Zinc finger RanBP2 type	0.0091	0.2369	0.2369
Loa Loa (eye worm)	hypothetical protein	0.0091	0.2369	0.2794
Schistosoma mansoni	hypothetical protein	0.0298	0.8479	1
Leishmania major	hypothetical protein, conserved	0.0091	0.2369	1
Loa Loa (eye worm)	hypothetical protein	0.0051	0.1197	0.1412
Onchocerca volvulus		0.0091	0.2369	0.1944
Trypanosoma cruzi	hypothetical protein, conserved	0.0091	0.2369	1
Wolbachia endosymbiont of Brugia malayi	exonuclease III	0.0019	0.0234	0.5
Brugia malayi	Cytochrome P450 family protein	0.0019	0.0258	0.0357
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0023	0.0355	0.0174
Toxoplasma gondii	HEAT repeat-containing protein	0.0028	0.0511	0.0707
Loa Loa (eye worm)	SWIB/MDM2 domain-containing protein	0.0256	0.7226	0.8522
Echinococcus multilocularis	SWI:SNF matrix associated	0.0256	0.7226	0.7226
Leishmania major	hypothetical protein, conserved	0.0091	0.2369	1
Toxoplasma gondii	DNA topoisomerase domain-containing protein	0.0256	0.7226	1
Leishmania major	hypothetical protein, conserved	0.0025	0.0419	0.177
Schistosoma mansoni	zinc finger protein	0.0091	0.2369	0.2794
Trypanosoma cruzi	GTP-binding nuclear protein rtb2, putative	0.0021	0.0294	0.124
Schistosoma mansoni	ran	0.0021	0.0294	0.0346
Loa Loa (eye worm)	cytochrome P450 family protein	0.0019	0.0258	0.0304
Mycobacterium leprae	Conserved hypothetical protein	0.0011	0	0.5
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease	0.0019	0.0234	0.0986
Echinococcus multilocularis	Ataxin 2, N terminal,domain containing protein	0.0011	0.0016	0.0016
Toxoplasma gondii	GTP-binding nuclear protein ran/tc4	0.0021	0.0294	0.0406
Onchocerca volvulus		0.0256	0.7226	1
Brugia malayi	brahma associated protein 60 kDa	0.0256	0.7226	1
Loa Loa (eye worm)	hypothetical protein	0.0091	0.2369	0.2794
Loa Loa (eye worm)	hypothetical protein	0.0091	0.2369	0.2794
Trichomonas vaginalis	ran, putative	0.0021	0.0294	0.0086
Schistosoma mansoni	hypothetical protein	0.0167	0.4607	0.5433
Echinococcus multilocularis	SWI:SNF matrix associated	0.0256	0.7226	0.7226
Brugia malayi	GTP-binding nuclear protein RAN/TC4	0.0021	0.0294	0.0406
Schistosoma mansoni	cellular tumor antigen P53	0.0051	0.1197	0.1412
Schistosoma mansoni	TRABID protein (C64 family)	0.0091	0.2369	0.2794
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0134	0.3632	0.4283
Trypanosoma cruzi	GTP-binding nuclear protein rtb2, putative	0.0021	0.0294	0.124
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0419	0.0495
Schistosoma mansoni	ran	0.0021	0.0294	0.0346
Leishmania major	importin beta-1 subunit, putative	0.0023	0.0355	0.15
Plasmodium falciparum	ataxin-2 like protein, putative	0.0025	0.0419	0.0266
Schistosoma mansoni	hypothetical protein	0.0256	0.7226	0.8522
Trypanosoma brucei	PAB1-binding protein , putative	0.0025	0.0419	0.177
Trypanosoma brucei	mitochondrial RNA binding complex 1 subunit	0.0091	0.2369	1
Echinococcus granulosus	importin subunit beta 1	0.0028	0.0511	0.0511
Onchocerca volvulus		0.0091	0.2369	0.1944
Brugia malayi	Zn-finger in Ran binding protein and others containing protein	0.0091	0.2369	0.3279
Plasmodium vivax	hypothetical protein, conserved	0.0256	0.7226	1
Brugia malayi	YY1-associated factor 2	0.0091	0.2369	0.3279
Trichomonas vaginalis	glucosylceramidase, putative	0.0173	0.4788	0.6513
Schistosoma mansoni	brg-1 associated factor	0.0256	0.7226	0.8522
Trypanosoma cruzi	cytochrome P450, putative	0.0019	0.0258	0.1088
Leishmania major	GTP-binding protein, putative	0.0021	0.0294	0.124
Onchocerca volvulus	Ubiquitin thioesterase ZRANB1 homolog	0.0091	0.2369	0.1944
Trichomonas vaginalis	conserved hypothetical protein	0.0256	0.7226	1
Schistosoma mansoni	ap endonuclease	0.0019	0.0234	0.0275
Schistosoma mansoni	fusion	0.0091	0.2369	0.2794
Echinococcus multilocularis	geminin	0.0167	0.4607	0.4607
Plasmodium falciparum	SWIB/MDM2 domain-containing protein	0.0256	0.7226	1
Trypanosoma cruzi	PAB1-binding protein , putative	0.0025	0.0419	0.177
Giardia lamblia	GTP-binding nuclear protein RAN/TC4	0.0021	0.0294	1
Trypanosoma brucei	cytochrome P450, putative	0.0019	0.0258	0.1088
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0134	0.3632	0.5026
Leishmania major	apurinic/apyrimidinic endonuclease-redox protein	0.0019	0.0234	0.0986
Trypanosoma cruzi	PAB1-binding protein , putative	0.0025	0.0419	0.177
Onchocerca volvulus		0.0091	0.2369	0.1944
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0134	0.3632	0.4283
Leishmania major	cytochrome p450-like protein	0.0019	0.0258	0.1088
Trypanosoma cruzi	Zn-finger in Ran binding protein and others, putative	0.0091	0.2369	1
Trichomonas vaginalis	glucosylceramidase, putative	0.025	0.7064	0.9767
Trichomonas vaginalis	glucosylceramidase, putative	0.025	0.7064	0.9767
Trypanosoma cruzi	hypothetical protein, conserved	0.0091	0.2369	1
Trypanosoma brucei	hypothetical protein, conserved	0.0091	0.2369	1
Schistosoma mansoni	hypothetical protein	0.0011	0.0016	0.0019
Schistosoma mansoni	hypothetical protein	0.0091	0.2369	0.2794
Trypanosoma cruzi	Zn-finger in Ran binding protein and others/FYVE zinc finger, putative	0.0091	0.2369	1
Trichomonas vaginalis	importin beta-1, putative	0.0023	0.0355	0.0174
Schistosoma mansoni	RNA binding protein	0.0091	0.2369	0.2794
Trichomonas vaginalis	glucosylceramidase, putative	0.0164	0.4527	0.614
Toxoplasma gondii	Zn-finger in Ran binding protein and others domain-containing protein	0.0091	0.2369	0.3279
Trichomonas vaginalis	glucosylceramidase, putative	0.0164	0.4527	0.614
Plasmodium vivax	ataxin-2 like protein, putative	0.0025	0.0419	0.0266
Trichomonas vaginalis	glucosylceramidase, putative	0.0164	0.4527	0.614
Trypanosoma cruzi	importin beta-1 subunit, putative	0.0023	0.0355	0.15
Schistosoma mansoni	importin beta-1	0.0028	0.0511	0.0603
Loa Loa (eye worm)	cytochrome P450 family protein	0.0019	0.0258	0.0304
Brugia malayi	O-Glycosyl hydrolase family 30 protein	0.025	0.7064	0.9775
Entamoeba histolytica	hypothetical protein	0.0023	0.0355	1

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 679112