TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 455.952 | Formula: C25H27ClFN3O2
H donors: 1 H acceptors: 2 LogP: 4.35 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: CCn1c(C)cc(c(c1=O)C(c1ccccc1Cl)N1CCN(CC1)c1ccccc1F)O
InChi: 1S/C25H27ClFN3O2/c1-3-30-17(2)16-22(31)23(25(30)32)24(18-8-4-5-9-19(18)26)29-14-12-28(13-15-29)21-11-7-6-10-20(21)27/h4-11,16,24,31H,3,12-15H2,1-2H3
InChiKey: MXRLNSQOKBQYIG-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	6-phosphofructokinase	0.0124	0.1974	0.2675
Echinococcus granulosus	tyrosyl DNA phosphodiesterase 1	0.0075	0.0949	0.1099
Schistosoma mansoni	lipoxygenase	0.0128	0.206	0.2791
Loa Loa (eye worm)	phosphofructokinase	0.0124	0.1974	0.1974
Trypanosoma brucei	ATP-dependent 6-phosphofructokinase, glycosomal	0.0124	0.1974	0.2878
Chlamydia trachomatis	fructose-6-phosphate phosphotransferase	0.0034	0.0069	0.5
Schistosoma mansoni	hypothetical protein	0.038	0.7349	1
Schistosoma mansoni	aldehyde dehydrogenase	0.007	0.0847	0.1138
Trypanosoma cruzi	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.0075	0.0949	0.1306
Schistosoma mansoni	aldehyde dehydrogenase	0.007	0.0847	0.1138
Echinococcus granulosus	lysine specific demethylase 5A	0.0042	0.0239	0.0266
Trichomonas vaginalis	CAMK family protein kinase	0.0055	0.0523	0.0873
Trichomonas vaginalis	CAMK family protein kinase	0.0055	0.0523	0.0873
Loa Loa (eye worm)	hypothetical protein	0.0506	1	1
Leishmania major	ATP-dependent phosphofructokinase	0.0124	0.1974	0.2878
Trichomonas vaginalis	glucosylceramidase, putative	0.0184	0.3237	0.6095
Trichomonas vaginalis	glucosylceramidase, putative	0.0184	0.3237	0.6095
Loa Loa (eye worm)	hypothetical protein	0.0171	0.2951	0.2951
Echinococcus granulosus	PHD finger protein rhinoceros	0.0034	0.0087	0.0088
Echinococcus multilocularis	Protein lozenge	0.0063	0.0698	0.0805
Toxoplasma gondii	PHD-finger domain-containing protein	0.0034	0.0087	0.0225
Echinococcus granulosus	muscleblind protein	0.0171	0.2951	0.3446
Loa Loa (eye worm)	6-phosphofructokinase	0.0124	0.1974	0.1974
Mycobacterium tuberculosis	Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase)	0.0124	0.1974	0.608
Schistosoma mansoni	gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2	0.0168	0.2903	0.3941
Giardia lamblia	Histone acetyltransferase GCN5	0.0045	0.0318	0.1521
Schistosoma mansoni	hypothetical protein	0.0034	0.0087	0.0102
Schistosoma mansoni	kinesin eg-5	0.0057	0.0557	0.0742
Trichomonas vaginalis	glucosylceramidase, putative	0.0194	0.3446	0.6496
Entamoeba histolytica	phosphofructokinase, putative	0.0124	0.1974	1
Trichomonas vaginalis	glucosylceramidase, putative	0.0184	0.3237	0.6095
Echinococcus multilocularis	gcn5proteinral control of amino acid synthesis	0.0168	0.2903	0.339
Loa Loa (eye worm)	hypothetical protein	0.0171	0.2951	0.2951
Brugia malayi	6-phosphofructokinase	0.0124	0.1974	0.1965
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0035	0.0098	0.0101
Echinococcus multilocularis	GPCR, family 2	0.0035	0.0097	0.01
Leishmania major	protein kinase, putative,polo-like protein kinase, putative	0.0111	0.1706	0.2466
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0012	0.0012
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0103	0.1521	0.177
Onchocerca volvulus	Alhambra homolog	0.0034	0.0087	0.0075
Echinococcus multilocularis	Transcription factor, JmjC domain containing protein	0.0113	0.1731	0.2016
Brugia malayi	jmjC domain containing protein	0.0042	0.0239	0.0227
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0103	0.1521	0.2057
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0182	0.3184	1
Loa Loa (eye worm)	tyrosyl-DNA phosphodiesterase	0.0075	0.0949	0.0949
Schistosoma mansoni	serine/threonine protein kinase	0.0111	0.1706	0.2308
Echinococcus granulosus	geminin	0.0181	0.3166	0.3698
Schistosoma mansoni	hypothetical protein	0.0075	0.0947	0.1275
Echinococcus granulosus	histone acetyltransferase KAT2B	0.0049	0.0405	0.0461
Plasmodium vivax	hypothetical protein, conserved	0.0034	0.0087	0.0359
Echinococcus granulosus	6 phosphofructokinase	0.0124	0.1974	0.2301
Treponema pallidum	diphosphate--fructose-6-phosphate 1-phosphotransferase	0.0124	0.1974	1
Echinococcus granulosus	GPCR family 2	0.0035	0.0097	0.01
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0031	0.0012	0.0012
Schistosoma mansoni	tyrosyl-DNA phosphodiesterase	0.0075	0.0949	0.1278
Trypanosoma cruzi	mitochondrial DNA polymerase beta, putative	0.0345	0.6616	1
Onchocerca volvulus	Serine\/threonine kinase homolog	0.0111	0.1706	0.1696
Mycobacterium tuberculosis	Probable aldehyde dehydrogenase	0.007	0.0847	0.2426
Leishmania major	tyrosyl-DNA phosphodiesterase 1	0.0075	0.0949	0.1306
Echinococcus multilocularis	PHD finger protein rhinoceros	0.0034	0.0087	0.0088
Trichomonas vaginalis	glucosylceramidase, putative	0.0281	0.5267	1
Trypanosoma cruzi	DNA polymerase beta thumb, putative	0.0048	0.0384	0.0439
Loa Loa (eye worm)	6-phosphofructokinase	0.0124	0.1974	0.1974
Echinococcus multilocularis	kinesin family 1	0.0436	0.8542	1
Echinococcus granulosus	NADP dependent isocitrate dehydrogenase	0.0035	0.0098	0.0101
Trypanosoma cruzi	DNA polymerase beta thumb, putative	0.0048	0.0384	0.0439
Leishmania major	mitochondrial DNA polymerase beta	0.0345	0.6616	1
Onchocerca volvulus		0.0506	1	1
Schistosoma mansoni	lipoxygenase	0.009	0.1249	0.1686
Brugia malayi	Kinesin motor domain containing protein	0.0057	0.0557	0.0545
Schistosoma mansoni	hypothetical protein	0.0035	0.0097	0.0116
Entamoeba histolytica	acetyltransferase, GNAT family	0.0045	0.0318	0.1307
Schistosoma mansoni	hypothetical protein	0.0181	0.3166	0.4298
Trichomonas vaginalis	CAMK family protein kinase	0.0111	0.1706	0.3148
Toxoplasma gondii	histone lysine acetyltransferase GCN5-A	0.0049	0.0405	0.4316
Trichomonas vaginalis	phosphofructokinase, putative	0.0124	0.1974	0.3665
Brugia malayi	acetyltransferase, GNAT family protein	0.0168	0.2903	0.2895
Loa Loa (eye worm)	hypothetical protein	0.0506	1	1
Trichomonas vaginalis	CAMK family protein kinase	0.0111	0.1706	0.3148
Onchocerca volvulus		0.0172	0.2993	0.2984
Trichomonas vaginalis	glucosylceramidase, putative	0.0184	0.3237	0.6095
Trichomonas vaginalis	CAMK family protein kinase	0.0111	0.1706	0.3148
Loa Loa (eye worm)	hypothetical protein	0.0172	0.2993	0.2993
Echinococcus granulosus	kinesin family 1	0.0436	0.8542	1
Loa Loa (eye worm)	acetyltransferase	0.0168	0.2903	0.2903
Trypanosoma brucei	polo-like protein kinase	0.0111	0.1706	0.2466
Schistosoma mansoni	6-phosphofructokinase	0.0124	0.1974	0.2675
Plasmodium vivax	isocitrate dehydrogenase [NADP], mitochondrial, putative	0.0035	0.0098	0.0589
Trichomonas vaginalis	glucosylceramidase, putative	0.0184	0.3237	0.6095
Trypanosoma brucei	mitochondrial DNA polymerase beta	0.0345	0.6616	1
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	0.007	0.0847	0.0979
Loa Loa (eye worm)	isocitrate dehydrogenase	0.0035	0.0098	0.0098
Trichomonas vaginalis	glucosylceramidase, putative	0.0281	0.5267	1
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.0048	0.0384	0.0439
Trichomonas vaginalis	CAMK family protein kinase	0.0111	0.1706	0.3148
Trichomonas vaginalis	cat eye syndrome critical region protein 2, cscr2, putative	0.0049	0.0405	0.0646
Trichomonas vaginalis	glucosylceramidase, putative	0.0194	0.3446	0.6496
Echinococcus multilocularis	6 phosphofructokinase	0.0124	0.1974	0.2301
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.0163	0.2796	0.414
Loa Loa (eye worm)	jmjC domain-containing protein	0.0071	0.0856	0.0856
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0035	0.0097	0.01
Schistosoma mansoni	bromodomain-containing nuclear protein 1 brd1	0.0034	0.0087	0.0102
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0087	0.0087
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0035	0.0097	0.0085
Schistosoma mansoni	jumonji domain containing protein	0.0089	0.1245	0.168
Echinococcus multilocularis	transcription factor Dp 1	0.0044	0.0282	0.0316
Trypanosoma brucei	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.0075	0.0949	0.1306
Echinococcus multilocularis	isocitrate dehydrogenase	0.0035	0.0098	0.0101
Trichomonas vaginalis	glucosylceramidase, putative	0.0184	0.3237	0.6095
Giardia lamblia	PHD finger protein 15	0.0034	0.0087	0.0107
Leishmania major	mitochondrial DNA polymerase beta-PAK, putative	0.0163	0.2796	0.414
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0049	0.0405	0.0646
Plasmodium vivax	histone acetyltransferase GCN5, putative	0.0049	0.0405	0.689
Brugia malayi	Isocitrate dehydrogenase	0.0035	0.0098	0.0086
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0035	0.0097	0.01
Trichomonas vaginalis	CAMK family protein kinase	0.0111	0.1706	0.3148
Loa Loa (eye worm)	O-glycosyl hydrolase family 30 protein	0.0281	0.5267	0.5267
Trypanosoma cruzi	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.0075	0.0949	0.1306
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0042	0.0239	0.031
Toxoplasma gondii	isocitrate dehydrogenase	0.0035	0.0098	0.0369
Echinococcus multilocularis	muscleblind protein	0.0171	0.2951	0.3446
Loa Loa (eye worm)	PLK/PLK1 protein kinase	0.0111	0.1706	0.1706
Trypanosoma brucei	DNA polymerase beta thumb, putative	0.0048	0.0384	0.0439
Echinococcus granulosus	Transcription factor JmjC domain containing protein	0.0113	0.1731	0.2016
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0103	0.1521	0.177
Brugia malayi	latrophilin 2 splice variant baaae	0.0075	0.0947	0.0936
Brugia malayi	Muscleblind-like protein	0.0171	0.2951	0.2943
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0103	0.1521	0.1521
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0603	0.0603
Loa Loa (eye worm)	kinesin-like protein KLP2	0.0057	0.0557	0.0557
Echinococcus granulosus	jumonji domain containing protein	0.0048	0.037	0.042
Entamoeba histolytica	phosphofructokinase, putative	0.0124	0.1974	1
Onchocerca volvulus	Glucosylceramidase homolog	0.0184	0.3237	0.3229
Schistosoma mansoni	kinase	0.0057	0.0554	0.0739
Loa Loa (eye worm)	transcription factor SMAD2	0.0139	0.2279	0.2279
Echinococcus granulosus	serine:threonine protein kinase PLK1	0.0111	0.1706	0.1986
Plasmodium falciparum	phd finger protein, putative	0.0034	0.0087	0.0359
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0035	0.0098	0.0101
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0035	0.0098	0.0101
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0103	0.1521	0.177
Echinococcus multilocularis	tyrosyl DNA phosphodiesterase 1	0.0075	0.0949	0.1099
Toxoplasma gondii	hypothetical protein	0.0056	0.0534	0.5975
Trichomonas vaginalis	glucosylceramidase, putative	0.0281	0.5267	1
Loa Loa (eye worm)	hypothetical protein	0.0075	0.0947	0.0947
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.011	0.168	0.168
Trichomonas vaginalis	phosphofructokinase, putative	0.0124	0.1974	0.3665
Echinococcus granulosus	arachidonate 5 lipoxygenase	0.0128	0.206	0.2401
Loa Loa (eye worm)	jmjC domain-containing protein	0.0042	0.0239	0.0239
Brugia malayi	Bromodomain containing protein	0.0038	0.0174	0.0162
Schistosoma mansoni	hypothetical protein	0.0035	0.0097	0.0116
Giardia lamblia	Kinesin-5	0.0057	0.0557	0.2977
Echinococcus multilocularis	isocitrate dehydrogenase 2 (NADP+)	0.0035	0.0098	0.0101
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0035	0.0097	0.0097
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0103	0.1521	0.2057
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.0059	0.0607	0.0781
Echinococcus granulosus	peregrin	0.0038	0.0174	0.019
Trichomonas vaginalis	CAMK family protein kinase	0.0111	0.1706	0.3148
Trichomonas vaginalis	glucosylceramidase, putative	0.0281	0.5267	1
Entamoeba histolytica	serine/threonine protein kinase, putative	0.0111	0.1706	0.859
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0042	0.0239	0.031
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0035	0.0097	0.01
Trypanosoma cruzi	ATP-dependent 6-phosphofructokinase, glycosomal	0.0124	0.1974	0.2878
Mycobacterium ulcerans	6-phosphofructokinase	0.0124	0.1974	0.4824
Schistosoma mansoni	hypothetical protein	0.0035	0.0097	0.0116
Echinococcus multilocularis	geminin	0.0181	0.3166	0.3698
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0103	0.1521	0.1511
Entamoeba histolytica	tyrosyl-DNA phosphodiesterase, putative	0.0075	0.0949	0.4619
Echinococcus multilocularis	serine:threonine protein kinase PLK1	0.0111	0.1706	0.1986
Brugia malayi	serine/threonine-protein kinase plk-2	0.0111	0.1706	0.1696
Trichomonas vaginalis	glucosylceramidase, putative	0.0281	0.5267	1
Trichomonas vaginalis	glucosylceramidase, putative	0.0184	0.3237	0.6095
Trypanosoma brucei	mitochondrial DNA polymerase beta-PAK	0.0163	0.2796	0.414
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0103	0.1521	0.177
Leishmania major	aldehyde dehydrogenase, mitochondrial precursor	0.007	0.0847	0.1149
Trichomonas vaginalis	glucosylceramidase, putative	0.0281	0.5267	1
Plasmodium falciparum	histone acetyltransferase GCN5	0.0045	0.0318	0.511
Mycobacterium ulcerans	hypothetical protein	0.0182	0.3184	1
Toxoplasma gondii	isocitrate dehydrogenase	0.0035	0.0098	0.0369
Brugia malayi	isocitrate dehydrogenase	0.0035	0.0098	0.0086
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0103	0.1521	0.2057
Echinococcus multilocularis	arachidonate 5 lipoxygenase	0.0128	0.206	0.2401
Plasmodium vivax	kinesin-5	0.0057	0.0557	1
Brugia malayi	phosphofructokinase	0.0124	0.1974	0.1965
Echinococcus granulosus	transcription factor Dp 1	0.0044	0.0282	0.0316
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	0.007	0.0847	0.0979
Brugia malayi	Tyrosyl-DNA phosphodiesterase family protein	0.0075	0.0949	0.0939
Brugia malayi	6-phosphofructokinase	0.0124	0.1974	0.1965
Entamoeba histolytica	phosphofructokinase, putative	0.0124	0.1974	1
Brugia malayi	Calcitonin receptor-like protein seb-1	0.011	0.168	0.167
Plasmodium falciparum	isocitrate dehydrogenase [NADP], mitochondrial	0.0035	0.0098	0.0589
Schistosoma mansoni	lozenge	0.0063	0.0698	0.0936
Chlamydia trachomatis	fructose-6-phosphate phosphotransferase	0.0034	0.0069	0.5
Giardia lamblia	Kinase, PLK	0.0111	0.1706	1
Brugia malayi	hypothetical protein	0.0172	0.2993	0.2984
Echinococcus multilocularis	lysine specific demethylase 5A	0.0042	0.0239	0.0266
Toxoplasma gondii	histone lysine acetyltransferase GCN5-B	0.0049	0.0405	0.4316
Echinococcus multilocularis	jumonji domain containing protein	0.0048	0.037	0.042
Trichomonas vaginalis	CAMK family protein kinase	0.0111	0.1706	0.3148
Toxoplasma gondii	kinesin motor domain-containing protein	0.0057	0.0557	0.6265
Trichomonas vaginalis	phosphofructokinase, putative	0.0124	0.1974	0.3665
Loa Loa (eye worm)	hypothetical protein	0.011	0.168	0.168
Echinococcus multilocularis	muscleblind protein 1	0.0171	0.2951	0.3446
Mycobacterium leprae	PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE)	0.0124	0.1974	0.5
Brugia malayi	Latrophilin receptor protein 2	0.0035	0.0097	0.0085
Loa Loa (eye worm)	runx1	0.0063	0.0698	0.0698
Toxoplasma gondii	aldehyde dehydrogenase	0.007	0.0847	1
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.011	0.168	0.167
Entamoeba histolytica	kinesin, putative	0.0057	0.0557	0.2557
Schistosoma mansoni	hypothetical protein	0.0181	0.3166	0.4298
Toxoplasma gondii	PHD-finger domain-containing protein	0.0034	0.0087	0.0225
Brugia malayi	jmjC domain containing protein	0.0113	0.1731	0.1721
Loa Loa (eye worm)	PHD-finger family protein	0.0034	0.0087	0.0087
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0035	0.0097	0.01
Trichomonas vaginalis	phosphofructokinase, putative	0.0124	0.1974	0.3665
Loa Loa (eye worm)	MH2 domain-containing protein	0.0139	0.2279	0.2279
Schistosoma mansoni	NADP-specific isocitrate dehydrogenase	0.0035	0.0098	0.0118
Echinococcus granulosus	histone acetyltransferase KAT2B	0.0164	0.2804	0.3273
Trypanosoma cruzi	polo-like protein kinase, putative	0.0111	0.1706	0.2466
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0097	0.0097
Trypanosoma cruzi	mitochondrial DNA polymerase beta, putative	0.0345	0.6616	1
Brugia malayi	O-Glycosyl hydrolase family 30 protein	0.0281	0.5267	0.5261
Schistosoma mansoni	hypothetical protein	0.0035	0.0097	0.0116
Trypanosoma cruzi	polo-like protein kinase, putative	0.0111	0.1706	0.2466
Brugia malayi	MH2 domain containing protein	0.0139	0.2279	0.227
Echinococcus multilocularis	peregrin	0.0038	0.0174	0.019
Brugia malayi	PHD-finger family protein	0.0034	0.0087	0.0075
Plasmodium falciparum	kinesin-5	0.0057	0.0557	1
Loa Loa (eye worm)	intermediate filament protein	0.0031	0.0012	0.0012

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 682180