Detailed information for compound 684220

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 386.832 | Formula: C19H19ClN4O3
  • H donors: 2 H acceptors: 2 LogP: 2.91 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: COCCCn1c(=O)[nH]c2c(c1=NC(=O)Nc1ccc(cc1)Cl)cccc2
  • InChi: 1S/C19H19ClN4O3/c1-27-12-4-11-24-17(15-5-2-3-6-16(15)22-19(24)26)23-18(25)21-14-9-7-13(20)8-10-14/h2-3,5-10H,4,11-12H2,1H3,(H,21,25)(H,22,26)/b23-17+
  • InChiKey: GKKYRNKHDYHAKO-HAVVHWLPSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.0122 1
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0007 0.0019 0.0051
Brugia malayi Ets-domain containing protein 0.0071 0.043 0.3176
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0023 0.0122 0.0277
Echinococcus granulosus dnaJ subfamily B 0.0396 0.2496 1
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0016 0.0112
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0007 0.0019 0.0077
Leishmania major pantothenate kinase subunit, putative 0.0005 0.0006 0.0487
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0007 0.0019 0.1563
Trypanosoma cruzi pantothenate kinase subunit, putative 0.0005 0.0006 0.0634
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0007 0.0019 0.0051
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0007 0.0019 0.2035
Trichomonas vaginalis helicase, putative 0.0006 0.0016 0.0112
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0008 0.0027 0.0027
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0016 0.0112
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0016 0.0112
Brugia malayi transcription factor E74 isoform 0.001 0.0042 0.031
Onchocerca volvulus 0.0007 0.0019 0.0131
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0023 0.0122 0.0277
Brugia malayi DNA-binding protein D-ETS-3 0.001 0.0042 0.031
Loa Loa (eye worm) hypothetical protein 0.0023 0.0122 0.0904
Schistosoma mansoni gabp alpha 0.0071 0.043 0.1721
Loa Loa (eye worm) DNA-binding protein D-ETS-3 0.001 0.0042 0.031
Loa Loa (eye worm) hypothetical protein 0.0017 0.0085 0.0631
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0017 0.0085 0.0228
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0045 0.026 0.1921
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0006 0.0016 0.0112
Onchocerca volvulus 0.0007 0.0019 0.0131
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0016 0.0112
Schistosoma mansoni hypothetical protein 0.001 0.0042 0.0168
Echinococcus granulosus ETS transcription factor Elf 2 0.001 0.0042 0.0168
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0019 0.0094 0.0201
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0016 0.0112
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0094 0.0695
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.0016 0.0112
Onchocerca volvulus 0.0028 0.0153 0.1047
Echinococcus multilocularis GA binding protein alpha chain 0.0071 0.043 0.043
Schistosoma mansoni ets-related 0.0216 0.1353 0.5418
Mycobacterium ulcerans pantoate--beta-alanine ligase 0.0592 0.3738 1
Brugia malayi AMP-binding enzyme family protein 0.0007 0.0019 0.0141
Loa Loa (eye worm) hypothetical protein 0.006 0.0358 0.2646
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0122 1
Treponema pallidum exodeoxyribonuclease (exoA) 0.0019 0.0094 1
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0016 0.0112
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.0122 1
Brugia malayi F/Y-rich N-terminus family protein 0.001 0.0037 0.0275
Mycobacterium ulcerans hypothetical protein 0.0023 0.0122 0.0277
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0094 1
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0094 0.0642
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.0079 0.0212
Trichomonas vaginalis antibiotic synthetase, putative 0.0007 0.0019 0.0131
Echinococcus granulosus short transient receptor potential channel 6 0.0063 0.0378 0.1515
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0071 0.043 0.3176
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0008 0.0027 0.0027
Echinococcus granulosus cpg binding protein 0.0029 0.0163 0.0654
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0007 0.0019 0.2035
Schistosoma mansoni elf1 0.001 0.0042 0.0168
Plasmodium falciparum acyl-CoA synthetase 0.0017 0.0085 0.9087
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.026 0.1041
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.0016 0.0112
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.001 0.0038 0.0152
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0017 0.0085 0.5
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0007 0.0019 0.0051
Echinococcus granulosus short transient receptor potential channel 6 0.0063 0.0378 0.1515
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0094 0.5628
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0094 0.7682
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0167 0.0669
Loa Loa (eye worm) hypothetical protein 0.0017 0.0085 0.0631
Loa Loa (eye worm) hypothetical protein 0.0032 0.0182 0.1345
Brugia malayi CXXC zinc finger family protein 0.0028 0.0153 0.1133
Onchocerca volvulus 0.0023 0.0122 0.0836
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0122 0.0277
Schistosoma mansoni acetyl-CoA synthetase 0.0007 0.0019 0.0077
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0122 0.0277
Leishmania major acetyl-CoA synthetase, putative 0.0007 0.0019 0.1563
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0007 0.0019 0.0051
Schistosoma mansoni cpg binding protein 0.0029 0.0163 0.0654
Brugia malayi Pre-SET motif family protein 0.0206 0.1283 0.9485
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0016 0.0112
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0023 0.0122 0.0327
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0094 1
Plasmodium vivax SET domain protein, putative 0.003 0.0167 1
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0019 0.0094 1
Loa Loa (eye worm) ets-domain-containing protein 0.001 0.0042 0.031
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.003 0.0167 0.0447
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0008 0.0027 0.0108
Loa Loa (eye worm) oxidoreductase 0.0007 0.0019 0.0141
Echinococcus multilocularis ets variant gene 4 0.001 0.0042 0.0042
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0019 0.0094 0.7682
Echinococcus granulosus transient receptor potential gamma protein 0.0096 0.0584 0.2339
Schistosoma mansoni transient receptor potential channel 0.0063 0.0378 0.1515
Loa Loa (eye worm) hypothetical protein 0.001 0.0042 0.031
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0094 0.0695
Schistosoma mansoni mixed-lineage leukemia protein mll 0.006 0.0358 0.1436
Loa Loa (eye worm) hypothetical protein 0.0023 0.0122 0.0904
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0007 0.0019 0.2035
Entamoeba histolytica acyl-coA synthetase, putative 0.0023 0.0122 1
Brugia malayi AMP-binding enzyme family protein 0.0007 0.0019 0.0141
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0019 0.0094 0.5
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.003 0.0167 0.0669
Loa Loa (eye worm) hypothetical protein 0.001 0.0042 0.031
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0006 0.0016 0.0112
Onchocerca volvulus 0.0234 0.1463 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.0016 0.0112
Echinococcus multilocularis ETS domain containing protein Elk 1 0.001 0.0042 0.0042
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.026 0.026
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0153 0.1133
Onchocerca volvulus 0.0007 0.0019 0.0131
Echinococcus multilocularis ETS transcription factor Elf 2 0.001 0.0042 0.0042
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0007 0.0019 0.0051
Loa Loa (eye worm) hypothetical protein 0.0017 0.0085 0.0631
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.026 0.1041
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.003 0.0167 0.0167
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0007 0.0019 0.0051
Echinococcus multilocularis protein C ets 2 0.001 0.0042 0.0042
Schistosoma mansoni ets-related 0.001 0.0042 0.0168
Trichomonas vaginalis antibiotic synthetase, putative 0.0007 0.0019 0.0131
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0167 0.0669
Brugia malayi AMP-binding enzyme family protein 0.0007 0.0019 0.0141
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0122 0.0904
Plasmodium vivax acetyl-CoA synthetase, putative 0.0007 0.0019 0.1145
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0007 0.0019 0.2035
Echinococcus granulosus histone lysine methyltransferase setb 0.003 0.0167 0.0669
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0122 1
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0094 1
Loa Loa (eye worm) hypothetical protein 0.0007 0.0019 0.0141
Mycobacterium tuberculosis PROBABLE FATTY-ACID-CoA LIGASE FADD18 (FRAGMENT) (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0006 0.0013 0.0035
Echinococcus granulosus GA binding protein alpha chain 0.0071 0.043 0.1721
Echinococcus multilocularis ETS transcription factor Elf 1 0.001 0.0042 0.0042
Loa Loa (eye worm) hypothetical protein 0.0017 0.0085 0.0631
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0008 0.0027 0.0108
Echinococcus granulosus mixed lineage leukemia protein mll 0.0008 0.0027 0.0108
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0007 0.0019 0.0051
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0007 0.0019 0.2035
Schistosoma mansoni hypothetical protein 0.0167 0.1037 0.4154
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0094 0.0094
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0167 0.0669
Brugia malayi Fli-1 protein 0.0216 0.1353 1
Schistosoma mansoni polyomavirus enhancer activator 3 pea3 0.001 0.0042 0.0168
Schistosoma mansoni hypothetical protein 0.0167 0.1037 0.4154
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0045 0.026 0.1921
Echinococcus multilocularis TRP (transient receptor potential) channel 0.0036 0.0202 0.0202
Leishmania major acetyl-CoA synthetase, putative 0.0007 0.0019 0.1563
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0023 0.0122 0.0277
Echinococcus granulosus ETS transcription factor Elf 5 0.001 0.0042 0.0168
Echinococcus multilocularis cpg binding protein 0.0029 0.0163 0.0163
Brugia malayi Ets-domain containing protein 0.0071 0.043 0.3176
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0007 0.0019 0.0141
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0007 0.0019 0.0051
Toxoplasma gondii pantoate-beta-alanine ligase 0.0592 0.3738 1
Echinococcus multilocularis short transient receptor potential channel 6 0.0063 0.0378 0.0378
Brugia malayi Ets-domain containing protein 0.001 0.0042 0.031
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0007 0.0019 0.0141
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.001 0.0042 0.031
Toxoplasma gondii propionate-CoA ligase 0.0007 0.0019 0.0051
Echinococcus multilocularis dnaJ subfamily B 0.0396 0.2496 0.2496
Onchocerca volvulus 0.003 0.0167 0.1141
Echinococcus multilocularis short transient receptor potential channel 6 0.0063 0.0378 0.0378
Brugia malayi AMP-binding enzyme family protein 0.0007 0.0019 0.0141
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0122 0.0904
Toxoplasma gondii exonuclease III APE 0.0019 0.0094 0.0251
Echinococcus granulosus ETS transcription factor Elf 1 0.001 0.0042 0.0168
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0017 0.0085 0.0178
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.026 0.1041
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0007 0.0019 0.0141
Onchocerca volvulus 0.0007 0.0019 0.0131
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0206 0.1283 0.9485
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0007 0.0019 0.0051
Schistosoma mansoni ap endonuclease 0.0019 0.0094 0.0376
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0007 0.0019 0.2035
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.0079 0.0212
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0016 0.0112
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0005 0.0008 0.0034
Brugia malayi Pre-SET motif family protein 0.003 0.0167 0.1234
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0023 0.0122 0.0277
Echinococcus granulosus TRP transient receptor potential channel 0.0036 0.0202 0.081
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.0016 0.0112
Loa Loa (eye worm) hypothetical protein 0.0007 0.0019 0.0141
Echinococcus granulosus ETS transcription factor Elf 2 0.001 0.0042 0.0168
Schistosoma mansoni transient receptor potential channel 0.0063 0.0378 0.1515
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0094 0.0376
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0007 0.0019 0.0051
Echinococcus multilocularis ewsr:fli fusion protein type 0.001 0.0042 0.0042
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0007 0.0019 0.0051
Mycobacterium leprae Probable pantoate--beta-alanine ligase PanC (pantothenate synthetase) (pantoate activating enzyme) 0.0592 0.3738 1
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0007 0.0019 0.0141
Brugia malayi Transient-receptor-potential like protein 0.0036 0.0202 0.1495
Schistosoma mansoni hypothetical protein 0.0396 0.2496 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0122 0.0277
Echinococcus granulosus ewsr:fli fusion protein type 0.001 0.0042 0.0168
Loa Loa (eye worm) hypothetical protein 0.0061 0.0364 0.269
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.001 0.0038 0.0038
Echinococcus multilocularis transient receptor potential gamma protein 0.0096 0.0584 0.0584
Loa Loa (eye worm) hypothetical protein 0.0036 0.0202 0.1495
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.0079 0.0212
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0007 0.0019 0.0019
Loa Loa (eye worm) D-ets-2 protein 0.001 0.0042 0.031
Loa Loa (eye worm) hypothetical protein 0.003 0.0167 0.1234
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0122 1
Echinococcus granulosus protein C ets 2 0.001 0.0042 0.0168
Echinococcus granulosus transient receptor potential ion channel A 0.0092 0.0564 0.2258
Echinococcus multilocularis ETS transcription factor Elf 2 0.001 0.0042 0.0042
Loa Loa (eye worm) hypothetical protein 0.0023 0.0122 0.0904
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.0079 0.0212
Loa Loa (eye worm) hypothetical protein 0.0096 0.0584 0.4317
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0023 0.0122 0.0327
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0007 0.0019 0.0051
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0156 0.0626
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0094 0.0642
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0122 0.0904
Trichomonas vaginalis set domain proteins, putative 0.0234 0.1463 1
Loa Loa (eye worm) histone methyltransferase 0.001 0.0038 0.028
Schistosoma mansoni cpg binding protein 0.0028 0.0153 0.0614
Schistosoma mansoni cpg binding protein 0.0029 0.0163 0.0654
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0007 0.0019 0.0051
Echinococcus multilocularis ETS transcription factor Elf 5 0.001 0.0042 0.0042
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.0016 0.0112
Echinococcus granulosus ETS domain containing protein Elk 1 0.001 0.0042 0.0168
Echinococcus granulosus geminin 0.0167 0.1037 0.4154
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0007 0.0019 0.1563
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0016 0.0112
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0007 0.0019 0.2035
Schistosoma mansoni transient receptor potential channel 4 0.0096 0.0584 0.2339
Mycobacterium tuberculosis Pantoate--beta-alanine ligase PanC (pantothenate synthetase) (pantoate activating enzyme) 0.0592 0.3738 1
Schistosoma mansoni hypothetical protein 0.001 0.0042 0.0168
Echinococcus multilocularis transient receptor potential ion channel A 0.0092 0.0564 0.0564
Schistosoma mansoni transient receptor potential channel 0.0096 0.0584 0.2339
Loa Loa (eye worm) fli-1 protein 0.0216 0.1353 1
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0094 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.026 0.1041
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.0167 0.0167
Plasmodium vivax acyl-CoA synthetase, putative 0.0017 0.0085 0.5114
Loa Loa (eye worm) hypothetical protein 0.0017 0.0085 0.0631
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.0016 0.0112
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.026 0.1041
Echinococcus multilocularis geminin 0.0167 0.1037 0.1037
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.026 0.026
Toxoplasma gondii histone lysine methyltransferase SET1 0.0054 0.0318 0.0852
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0023 0.0122 0.0277
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0023 0.0122 0.0277
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0019 0.0094 0.0251
Schistosoma mansoni ap endonuclease 0.0019 0.0094 0.0376
Schistosoma mansoni ets 0.001 0.0042 0.0168

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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