Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Treponema pallidum | diphosphate--fructose-6-phosphate 1-phosphotransferase | 0.0116 | 0.0482 | 0.2224 |
Schistosoma mansoni | 6-phosphofructokinase | 0.0116 | 0.0482 | 0.185 |
Giardia lamblia | Phenylalanyl-tRNA synthetase alpha chain | 0.0412 | 0.2077 | 1 |
Schistosoma mansoni | myelin transcription factor 1 myt1 | 0.0058 | 0.0169 | 0.0252 |
Echinococcus granulosus | histone acetyltransferase MYST2 | 0.0058 | 0.0169 | 0.0427 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.0102 | 0.0123 |
Loa Loa (eye worm) | hypothetical protein | 0.0076 | 0.0264 | 0.0931 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0049 | 0.012 | 0.0228 |
Leishmania major | phenylalanyl-tRNA synthetase alpha chain, putative | 0.0412 | 0.2077 | 1 |
Brugia malayi | mbt repeat family protein | 0.0051 | 0.0131 | 0.0631 |
Entamoeba histolytica | phosphofructokinase, putative | 0.0116 | 0.0482 | 0.2224 |
Echinococcus multilocularis | neuropeptide s receptor | 0.0498 | 0.254 | 1 |
Plasmodium vivax | phenylalanine--tRNA ligase, putative | 0.0185 | 0.0854 | 0.4039 |
Echinococcus granulosus | neuropeptide receptor A26 | 0.0498 | 0.254 | 1 |
Onchocerca volvulus | 0.0051 | 0.0131 | 0.5 | |
Brugia malayi | 6-phosphofructokinase | 0.0116 | 0.0482 | 0.232 |
Echinococcus multilocularis | polycomb protein SCMH1 | 0.0051 | 0.0131 | 0.0273 |
Echinococcus multilocularis | neuropeptide receptor A26 | 0.0498 | 0.254 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0049 | 0.012 | 0.0228 |
Schistosoma mansoni | 6-phosphofructokinase | 0.0116 | 0.0482 | 0.185 |
Plasmodium falciparum | phenylalanine--tRNA ligase | 0.0185 | 0.0854 | 0.4039 |
Schistosoma mansoni | hypothetical protein | 0.031 | 0.1525 | 0.7178 |
Mycobacterium ulcerans | phenylalanyl-tRNA synthetase subunit alpha | 0.1884 | 1 | 1 |
Brugia malayi | 6-phosphofructokinase | 0.0116 | 0.0482 | 0.232 |
Echinococcus granulosus | endonuclease exonuclease phosphatase | 0.0201 | 0.0938 | 0.3532 |
Echinococcus multilocularis | endonuclease exonuclease phosphatase | 0.0201 | 0.0938 | 0.3532 |
Echinococcus multilocularis | histone acetyltransferase MYST2 | 0.0058 | 0.0169 | 0.0427 |
Entamoeba histolytica | phosphofructokinase, putative | 0.0116 | 0.0482 | 0.2224 |
Echinococcus granulosus | neuropeptide s receptor | 0.0498 | 0.254 | 1 |
Treponema pallidum | phenylalanyl-tRNA synthetase subunit alpha | 0.0412 | 0.2077 | 1 |
Echinococcus granulosus | suppression of tumorigenicity 18 protein | 0.0058 | 0.0169 | 0.0427 |
Trichomonas vaginalis | phosphofructokinase, putative | 0.0116 | 0.0482 | 0.2224 |
Echinococcus granulosus | polycomb protein SCMH1 | 0.0051 | 0.0131 | 0.0273 |
Brugia malayi | mbt repeat family protein | 0.0051 | 0.0131 | 0.0631 |
Trichomonas vaginalis | phenylalanyl-tRNA synthetase alpha chain, putative | 0.0412 | 0.2077 | 1 |
Plasmodium vivax | phenylalanine--tRNA ligase alpha subunit, putative | 0.0412 | 0.2077 | 1 |
Schistosoma mansoni | scm-relatedprotein containing 4 mbt domains (sfmbt) | 0.0051 | 0.0131 | 0.0058 |
Loa Loa (eye worm) | 6-phosphofructokinase | 0.0116 | 0.0482 | 0.2023 |
Echinococcus granulosus | 6 phosphofructokinase | 0.0116 | 0.0482 | 0.169 |
Schistosoma mansoni | phenylalanyl-tRNA synthetase subunit alpha | 0.0135 | 0.0584 | 0.2371 |
Plasmodium falciparum | phenylalanine--tRNA ligase | 0.0154 | 0.0683 | 0.3205 |
Trichomonas vaginalis | phenylalanyl-tRNA synthetase alpha chain, putative | 0.0135 | 0.0584 | 0.2722 |
Schistosoma mansoni | sex comb on midleg homolog | 0.0051 | 0.0131 | 0.0058 |
Onchocerca volvulus | Polycomb protein Sfmbt homolog | 0.0051 | 0.0131 | 0.5 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0049 | 0.012 | 0.0212 |
Brugia malayi | phenylalanyl-tRNA synthetase, mitochondrial precursor, putative | 0.0185 | 0.0854 | 0.4113 |
Trichomonas vaginalis | phosphofructokinase, putative | 0.0116 | 0.0482 | 0.2224 |
Brugia malayi | phosphofructokinase | 0.0116 | 0.0482 | 0.232 |
Echinococcus multilocularis | SAM and MBT domain containing protein | 0.0051 | 0.0131 | 0.0273 |
Entamoeba histolytica | phenylalanyl-tRNA synthetase alpha subunit, putative | 0.0412 | 0.2077 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0058 | 0.0169 | 0.0458 |
Loa Loa (eye worm) | mbt repeat family protein | 0.0051 | 0.0131 | 0.0268 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0064 | 0.02 | 0.0552 |
Echinococcus multilocularis | 6 phosphofructokinase | 0.0116 | 0.0482 | 0.169 |
Echinococcus multilocularis | phenylalanyl tRNA synthetase alpha chain B | 0.0412 | 0.2077 | 0.8133 |
Echinococcus multilocularis | phenylalanyl tRNA synthetase | 0.0185 | 0.0854 | 0.3194 |
Plasmodium vivax | phenylalanine--tRNA ligase, putative | 0.0135 | 0.0584 | 0.2722 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0064 | 0.02 | 0.0552 |
Plasmodium falciparum | phenylalanine--tRNA ligase alpha subunit | 0.0412 | 0.2077 | 1 |
Toxoplasma gondii | phenylalanyl-tRNA synthetase alpha chain A, putative | 0.0412 | 0.2077 | 1 |
Schistosoma mansoni | sex comb on midleg homolog | 0.0051 | 0.0131 | 0.0058 |
Echinococcus granulosus | phenylalanyl tRNA synthetase alpha chain B | 0.0412 | 0.2077 | 0.8133 |
Loa Loa (eye worm) | phenylalanyl-tRNA synthetase | 0.0185 | 0.0854 | 0.3885 |
Toxoplasma gondii | Ferredoxin-fold anticodon binding domain-containing protein | 0.0185 | 0.0854 | 0.4039 |
Brugia malayi | Bromodomain containing protein | 0.0041 | 0.0077 | 0.0371 |
Entamoeba histolytica | phosphofructokinase, putative | 0.0116 | 0.0482 | 0.2224 |
Mycobacterium tuberculosis | Probable phenylalanyl-tRNA synthetase, alpha chain PheS | 0.1884 | 1 | 1 |
Brugia malayi | Bromodomain containing protein | 0.008 | 0.0288 | 0.1387 |
Echinococcus multilocularis | suppression of tumorigenicity 18 protein | 0.0058 | 0.0169 | 0.0427 |
Trichomonas vaginalis | phenylalanyl-tRNA synthetase alpha chain, putative | 0.0135 | 0.0584 | 0.2722 |
Loa Loa (eye worm) | phosphofructokinase | 0.0116 | 0.0482 | 0.2023 |
Loa Loa (eye worm) | 6-phosphofructokinase | 0.0116 | 0.0482 | 0.2023 |
Wolbachia endosymbiont of Brugia malayi | phenylalanyl-tRNA synthetase subunit alpha | 0.1884 | 1 | 0.5 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0049 | 0.012 | 0.0228 |
Trichomonas vaginalis | phosphofructokinase, putative | 0.0116 | 0.0482 | 0.2224 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.0091 | 0.0068 |
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 0.0131 | 0.0268 |
Loa Loa (eye worm) | hypothetical protein | 0.0412 | 0.2077 | 1 |
Brugia malayi | phenylalanyl (f) trna synthetase protein 1 | 0.0412 | 0.2077 | 1 |
Schistosoma mansoni | phenylalanyl-tRNA synthetase subunit alpha | 0.0412 | 0.2077 | 1 |
Echinococcus granulosus | phenylalanyl tRNA synthetase | 0.0185 | 0.0854 | 0.3194 |
Trichomonas vaginalis | phosphofructokinase, putative | 0.0116 | 0.0482 | 0.2224 |
Mycobacterium leprae | Probable phenylalanyl-tRNA synthetase, alpha chain PheS | 0.0277 | 0.135 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0049 | 0.012 | 0.0228 |
Trypanosoma cruzi | phenylalanyl-tRNA synthetase alpha chain, putative | 0.0412 | 0.2077 | 1 |
Schistosoma mansoni | phenylalanyl-tRNA synthetase mitochondrial | 0.0185 | 0.0854 | 0.3752 |
Trypanosoma brucei | phenylalanyl-tRNA synthetase alpha chain, putative | 0.0412 | 0.2077 | 1 |
Schistosoma mansoni | bromodomain containing protein | 0.0068 | 0.0221 | 0.0515 |
Echinococcus granulosus | SAM and MBT domain containing protein | 0.0051 | 0.0131 | 0.0273 |
Brugia malayi | C2-HC type zinc finger protein C.e-MyT1 | 0.0058 | 0.0169 | 0.0814 |
Loa Loa (eye worm) | MBCTL1 | 0.0058 | 0.0169 | 0.0458 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0049 | 0.012 | 0.0577 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.