Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0048 | 0.0132 | 0.0633 |
Echinococcus granulosus | SAM and MBT domain containing protein | 0.005 | 0.0143 | 0.0572 |
Toxoplasma gondii | Ferredoxin-fold anticodon binding domain-containing protein | 0.0184 | 0.0865 | 0.403 |
Trichomonas vaginalis | phosphofructokinase, putative | 0.0115 | 0.0491 | 0.2206 |
Plasmodium falciparum | phenylalanine--tRNA ligase | 0.0153 | 0.0695 | 0.3203 |
Trichomonas vaginalis | phenylalanyl-tRNA synthetase alpha chain, putative | 0.0134 | 0.0597 | 0.2723 |
Schistosoma mansoni | sex comb on midleg homolog | 0.005 | 0.0143 | 0.0686 |
Brugia malayi | C2-HC type zinc finger protein C.e-MyT1 | 0.0057 | 0.0181 | 0.0807 |
Echinococcus multilocularis | polycomb protein SCMH1 | 0.005 | 0.0143 | 0.0572 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0063 | 0.0212 | 0.0845 |
Echinococcus granulosus | 6 phosphofructokinase | 0.0115 | 0.0491 | 0.1959 |
Schistosoma mansoni | 6-phosphofructokinase | 0.0115 | 0.0491 | 0.2351 |
Echinococcus multilocularis | SAM and MBT domain containing protein | 0.005 | 0.0143 | 0.0572 |
Echinococcus granulosus | phenylalanyl tRNA synthetase alpha chain B | 0.0411 | 0.2088 | 0.8331 |
Schistosoma mansoni | phenylalanyl-tRNA synthetase subunit alpha | 0.0411 | 0.2088 | 1 |
Echinococcus multilocularis | suppression of tumorigenicity 18 protein | 0.0057 | 0.0181 | 0.0722 |
Echinococcus granulosus | neuropeptide receptor A26 | 0.0488 | 0.2506 | 1 |
Brugia malayi | mbt repeat family protein | 0.005 | 0.0143 | 0.0626 |
Entamoeba histolytica | phosphofructokinase, putative | 0.0115 | 0.0491 | 0.2206 |
Schistosoma mansoni | scm-relatedprotein containing 4 mbt domains (sfmbt) | 0.005 | 0.0143 | 0.0686 |
Echinococcus multilocularis | endonuclease exonuclease phosphatase | 0.0198 | 0.0943 | 0.3761 |
Echinococcus granulosus | endonuclease exonuclease phosphatase | 0.0198 | 0.0943 | 0.3761 |
Loa Loa (eye worm) | hypothetical protein | 0.0057 | 0.0181 | 0.0454 |
Brugia malayi | 6-phosphofructokinase | 0.0115 | 0.0491 | 0.2301 |
Loa Loa (eye worm) | hypothetical protein | 0.0045 | 0.0115 | 0.0122 |
Entamoeba histolytica | phosphofructokinase, putative | 0.0115 | 0.0491 | 0.2206 |
Trichomonas vaginalis | phosphofructokinase, putative | 0.0115 | 0.0491 | 0.2206 |
Plasmodium vivax | phenylalanine--tRNA ligase, putative | 0.0134 | 0.0597 | 0.2723 |
Onchocerca volvulus | 0.005 | 0.0143 | 0.5 | |
Giardia lamblia | Phenylalanyl-tRNA synthetase alpha chain | 0.0411 | 0.2088 | 1 |
Echinococcus multilocularis | phenylalanyl tRNA synthetase alpha chain B | 0.0411 | 0.2088 | 0.8331 |
Treponema pallidum | diphosphate--fructose-6-phosphate 1-phosphotransferase | 0.0115 | 0.0491 | 0.2206 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0038 | 0.0076 | 0.0304 |
Echinococcus granulosus | neuropeptide s receptor | 0.0488 | 0.2506 | 1 |
Plasmodium vivax | phenylalanine--tRNA ligase, putative | 0.0184 | 0.0865 | 0.403 |
Echinococcus multilocularis | 6 phosphofructokinase | 0.0115 | 0.0491 | 0.1959 |
Echinococcus multilocularis | neuropeptide s receptor | 0.0488 | 0.2506 | 1 |
Onchocerca volvulus | Polycomb protein Sfmbt homolog | 0.005 | 0.0143 | 0.5 |
Brugia malayi | phenylalanyl (f) trna synthetase protein 1 | 0.0411 | 0.2088 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0048 | 0.0132 | 0.0527 |
Loa Loa (eye worm) | mbt repeat family protein | 0.005 | 0.0143 | 0.0266 |
Echinococcus multilocularis | neuropeptide receptor A26 | 0.0488 | 0.2506 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0048 | 0.0132 | 0.0527 |
Loa Loa (eye worm) | 6-phosphofructokinase | 0.0115 | 0.0491 | 0.2006 |
Echinococcus granulosus | phenylalanyl tRNA synthetase | 0.0184 | 0.0865 | 0.345 |
Schistosoma mansoni | hypothetical protein | 0.0306 | 0.1524 | 0.7297 |
Trichomonas vaginalis | phosphofructokinase, putative | 0.0115 | 0.0491 | 0.2206 |
Wolbachia endosymbiont of Brugia malayi | phenylalanyl-tRNA synthetase subunit alpha | 0.1877 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.0104 | 0.0068 |
Schistosoma mansoni | sex comb on midleg homolog | 0.005 | 0.0143 | 0.0686 |
Loa Loa (eye worm) | phosphofructokinase | 0.0115 | 0.0491 | 0.2006 |
Trichomonas vaginalis | phosphofructokinase, putative | 0.0115 | 0.0491 | 0.2206 |
Loa Loa (eye worm) | hypothetical protein | 0.0411 | 0.2088 | 1 |
Echinococcus granulosus | histone acetyltransferase MYST2 | 0.0057 | 0.0181 | 0.0722 |
Loa Loa (eye worm) | hypothetical protein | 0.0075 | 0.0275 | 0.0923 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0048 | 0.0132 | 0.0633 |
Loa Loa (eye worm) | MBCTL1 | 0.0057 | 0.0181 | 0.0454 |
Loa Loa (eye worm) | phenylalanyl-tRNA synthetase | 0.0184 | 0.0865 | 0.3877 |
Loa Loa (eye worm) | 6-phosphofructokinase | 0.0115 | 0.0491 | 0.2006 |
Brugia malayi | phenylalanyl-tRNA synthetase, mitochondrial precursor, putative | 0.0184 | 0.0865 | 0.4103 |
Plasmodium falciparum | phenylalanine--tRNA ligase alpha subunit | 0.0411 | 0.2088 | 1 |
Schistosoma mansoni | bromodomain containing protein | 0.0067 | 0.0232 | 0.1112 |
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0.0143 | 0.0266 |
Echinococcus multilocularis | histone acetyltransferase MYST2 | 0.0057 | 0.0181 | 0.0722 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0048 | 0.0132 | 0.0572 |
Echinococcus granulosus | suppression of tumorigenicity 18 protein | 0.0057 | 0.0181 | 0.0722 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0048 | 0.0132 | 0.0527 |
Leishmania major | phenylalanyl-tRNA synthetase alpha chain, putative | 0.0411 | 0.2088 | 1 |
Mycobacterium leprae | Probable phenylalanyl-tRNA synthetase, alpha chain PheS | 0.0276 | 0.1363 | 1 |
Brugia malayi | 6-phosphofructokinase | 0.0115 | 0.0491 | 0.2301 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0038 | 0.0076 | 0.0304 |
Brugia malayi | phosphofructokinase | 0.0115 | 0.0491 | 0.2301 |
Trypanosoma brucei | phenylalanyl-tRNA synthetase alpha chain, putative | 0.0411 | 0.2088 | 1 |
Entamoeba histolytica | phenylalanyl-tRNA synthetase alpha subunit, putative | 0.0411 | 0.2088 | 1 |
Toxoplasma gondii | phenylalanyl-tRNA synthetase alpha chain A, putative | 0.0411 | 0.2088 | 1 |
Mycobacterium tuberculosis | Probable phenylalanyl-tRNA synthetase, alpha chain PheS | 0.1877 | 1 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0048 | 0.0132 | 0.0633 |
Schistosoma mansoni | 6-phosphofructokinase | 0.0115 | 0.0491 | 0.2351 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0048 | 0.0132 | 0.021 |
Brugia malayi | mbt repeat family protein | 0.005 | 0.0143 | 0.0626 |
Schistosoma mansoni | phenylalanyl-tRNA synthetase mitochondrial | 0.0184 | 0.0865 | 0.4142 |
Plasmodium falciparum | phenylalanine--tRNA ligase | 0.0184 | 0.0865 | 0.403 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0048 | 0.0132 | 0.0527 |
Echinococcus granulosus | polycomb protein SCMH1 | 0.005 | 0.0143 | 0.0572 |
Plasmodium vivax | phenylalanine--tRNA ligase alpha subunit, putative | 0.0411 | 0.2088 | 1 |
Brugia malayi | Bromodomain containing protein | 0.0079 | 0.0299 | 0.1376 |
Schistosoma mansoni | myelin transcription factor 1 myt1 | 0.0057 | 0.0181 | 0.0867 |
Trichomonas vaginalis | phenylalanyl-tRNA synthetase alpha chain, putative | 0.0134 | 0.0597 | 0.2723 |
Mycobacterium ulcerans | phenylalanyl-tRNA synthetase subunit alpha | 0.1877 | 1 | 1 |
Entamoeba histolytica | phosphofructokinase, putative | 0.0115 | 0.0491 | 0.2206 |
Echinococcus multilocularis | phenylalanyl tRNA synthetase | 0.0184 | 0.0865 | 0.345 |
Schistosoma mansoni | phenylalanyl-tRNA synthetase subunit alpha | 0.0134 | 0.0597 | 0.2859 |
Treponema pallidum | phenylalanyl-tRNA synthetase subunit alpha | 0.0411 | 0.2088 | 1 |
Trichomonas vaginalis | phenylalanyl-tRNA synthetase alpha chain, putative | 0.0411 | 0.2088 | 1 |
Trypanosoma cruzi | phenylalanyl-tRNA synthetase alpha chain, putative | 0.0411 | 0.2088 | 1 |
Brugia malayi | Bromodomain containing protein | 0.004 | 0.009 | 0.0368 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0063 | 0.0212 | 0.0845 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.