Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium vivax | phenylalanine--tRNA ligase alpha subunit, putative | 0.0328 | 0.2085 | 1 |
Entamoeba histolytica | phenylalanyl-tRNA synthetase alpha subunit, putative | 0.0328 | 0.2085 | 1 |
Schistosoma mansoni | phenylalanyl-tRNA synthetase subunit alpha | 0.0328 | 0.2085 | 1 |
Brugia malayi | mbt repeat family protein | 0.0052 | 0.0189 | 0.083 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.005 | 0.0175 | 0.0282 |
Brugia malayi | phosphofructokinase | 0.0119 | 0.0649 | 0.3051 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.005 | 0.0175 | 0.0838 |
Mycobacterium ulcerans | phenylalanyl-tRNA synthetase subunit alpha | 0.1479 | 1 | 1 |
Entamoeba histolytica | phosphofructokinase, putative | 0.0119 | 0.0649 | 0.2937 |
Trichomonas vaginalis | phosphofructokinase, putative | 0.0119 | 0.0649 | 0.2937 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0039 | 0.0101 | 0.0304 |
Echinococcus granulosus | suppression of tumorigenicity 18 protein | 0.0059 | 0.0239 | 0.0722 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.005 | 0.0175 | 0.0759 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.0189 | 0.0357 |
Echinococcus multilocularis | histone acetyltransferase MYST2 | 0.0059 | 0.0239 | 0.0722 |
Schistosoma mansoni | bromodomain containing protein | 0.0069 | 0.0307 | 0.1471 |
Schistosoma mansoni | phenylalanyl-tRNA synthetase mitochondrial | 0.0162 | 0.0947 | 0.4541 |
Giardia lamblia | Phenylalanyl-tRNA synthetase alpha chain | 0.0328 | 0.2085 | 1 |
Mycobacterium leprae | Probable phenylalanyl-tRNA synthetase, alpha chain PheS | 0.0217 | 0.1322 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.005 | 0.0175 | 0.0527 |
Trypanosoma brucei | phenylalanyl-tRNA synthetase alpha chain, putative | 0.0328 | 0.2085 | 1 |
Schistosoma mansoni | 6-phosphofructokinase | 0.0119 | 0.0649 | 0.3111 |
Plasmodium falciparum | phenylalanine--tRNA ligase | 0.0162 | 0.0947 | 0.4403 |
Brugia malayi | Bromodomain containing protein | 0.0042 | 0.0119 | 0.0488 |
Trypanosoma cruzi | phenylalanyl-tRNA synthetase alpha chain, putative | 0.0328 | 0.2085 | 1 |
Toxoplasma gondii | phenylalanyl-tRNA synthetase alpha chain A, putative | 0.0328 | 0.2085 | 1 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0065 | 0.028 | 0.0845 |
Trichomonas vaginalis | phosphofructokinase, putative | 0.0119 | 0.0649 | 0.2937 |
Echinococcus multilocularis | phenylalanyl tRNA synthetase | 0.0162 | 0.0947 | 0.2859 |
Echinococcus multilocularis | phenylalanyl tRNA synthetase alpha chain B | 0.0328 | 0.2085 | 0.6296 |
Trichomonas vaginalis | phosphofructokinase, putative | 0.0119 | 0.0649 | 0.2937 |
Schistosoma mansoni | myelin transcription factor 1 myt1 | 0.0059 | 0.0239 | 0.1147 |
Brugia malayi | Bromodomain containing protein | 0.0082 | 0.0395 | 0.1824 |
Loa Loa (eye worm) | 6-phosphofructokinase | 0.0119 | 0.0649 | 0.2693 |
Mycobacterium tuberculosis | Probable phenylalanyl-tRNA synthetase, alpha chain PheS | 0.1479 | 1 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.005 | 0.0175 | 0.0527 |
Plasmodium vivax | phenylalanine--tRNA ligase, putative | 0.0162 | 0.0947 | 0.4403 |
Loa Loa (eye worm) | phenylalanyl-tRNA synthetase | 0.0162 | 0.0947 | 0.421 |
Echinococcus granulosus | polycomb protein SCMH1 | 0.0052 | 0.0189 | 0.0572 |
Loa Loa (eye worm) | hypothetical protein | 0.0328 | 0.2085 | 1 |
Entamoeba histolytica | phosphofructokinase, putative | 0.0119 | 0.0649 | 0.2937 |
Trichomonas vaginalis | phenylalanyl-tRNA synthetase alpha chain, putative | 0.0111 | 0.0593 | 0.2665 |
Loa Loa (eye worm) | hypothetical protein | 0.0047 | 0.0151 | 0.0164 |
Loa Loa (eye worm) | 6-phosphofructokinase | 0.0119 | 0.0649 | 0.2693 |
Plasmodium falciparum | phenylalanine--tRNA ligase alpha subunit | 0.0328 | 0.2085 | 1 |
Leishmania major | phenylalanyl-tRNA synthetase alpha chain, putative | 0.0328 | 0.2085 | 1 |
Onchocerca volvulus | 0.0052 | 0.0189 | 0.5 | |
Schistosoma mansoni | scm-relatedprotein containing 4 mbt domains (sfmbt) | 0.0052 | 0.0189 | 0.0908 |
Brugia malayi | mbt repeat family protein | 0.0052 | 0.0189 | 0.083 |
Schistosoma mansoni | 6-phosphofructokinase | 0.0119 | 0.0649 | 0.3111 |
Echinococcus multilocularis | neuropeptide s receptor | 0.0506 | 0.3312 | 1 |
Echinococcus multilocularis | suppression of tumorigenicity 18 protein | 0.0059 | 0.0239 | 0.0722 |
Echinococcus granulosus | phenylalanyl tRNA synthetase alpha chain B | 0.0328 | 0.2085 | 0.6296 |
Trichomonas vaginalis | phosphofructokinase, putative | 0.0119 | 0.0649 | 0.2937 |
Loa Loa (eye worm) | hypothetical protein | 0.0059 | 0.0239 | 0.061 |
Echinococcus granulosus | endonuclease exonuclease phosphatase | 0.0206 | 0.1245 | 0.3761 |
Echinococcus multilocularis | endonuclease exonuclease phosphatase | 0.0206 | 0.1245 | 0.3761 |
Schistosoma mansoni | phenylalanyl-tRNA synthetase subunit alpha | 0.0111 | 0.0593 | 0.2846 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0065 | 0.028 | 0.0845 |
Echinococcus multilocularis | polycomb protein SCMH1 | 0.0052 | 0.0189 | 0.0572 |
Brugia malayi | C2-HC type zinc finger protein C.e-MyT1 | 0.0059 | 0.0239 | 0.107 |
Trichomonas vaginalis | phenylalanyl-tRNA synthetase alpha chain, putative | 0.0328 | 0.2085 | 1 |
Echinococcus multilocularis | SAM and MBT domain containing protein | 0.0052 | 0.0189 | 0.0572 |
Plasmodium vivax | phenylalanine--tRNA ligase, putative | 0.0111 | 0.0593 | 0.2665 |
Brugia malayi | 6-phosphofructokinase | 0.0119 | 0.0649 | 0.3051 |
Echinococcus granulosus | phenylalanyl tRNA synthetase | 0.0162 | 0.0947 | 0.2859 |
Echinococcus granulosus | SAM and MBT domain containing protein | 0.0052 | 0.0189 | 0.0572 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.005 | 0.0175 | 0.0838 |
Schistosoma mansoni | sex comb on midleg homolog | 0.0052 | 0.0189 | 0.0908 |
Entamoeba histolytica | phosphofructokinase, putative | 0.0119 | 0.0649 | 0.2937 |
Plasmodium falciparum | phenylalanine--tRNA ligase | 0.013 | 0.0723 | 0.3303 |
Loa Loa (eye worm) | hypothetical protein | 0.0077 | 0.0363 | 0.1239 |
Loa Loa (eye worm) | MBCTL1 | 0.0059 | 0.0239 | 0.061 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.005 | 0.0175 | 0.0838 |
Echinococcus granulosus | histone acetyltransferase MYST2 | 0.0059 | 0.0239 | 0.0722 |
Treponema pallidum | phenylalanyl-tRNA synthetase subunit alpha | 0.0328 | 0.2085 | 1 |
Treponema pallidum | diphosphate--fructose-6-phosphate 1-phosphotransferase | 0.0119 | 0.0649 | 0.2937 |
Loa Loa (eye worm) | phosphofructokinase | 0.0119 | 0.0649 | 0.2693 |
Wolbachia endosymbiont of Brugia malayi | phenylalanyl-tRNA synthetase subunit alpha | 0.1479 | 1 | 0.5 |
Trichomonas vaginalis | phenylalanyl-tRNA synthetase alpha chain, putative | 0.0111 | 0.0593 | 0.2665 |
Schistosoma mansoni | hypothetical protein | 0.0318 | 0.2013 | 0.9655 |
Echinococcus multilocularis | 6 phosphofructokinase | 0.0119 | 0.0649 | 0.1959 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.005 | 0.0175 | 0.0527 |
Toxoplasma gondii | Ferredoxin-fold anticodon binding domain-containing protein | 0.0162 | 0.0947 | 0.4403 |
Echinococcus multilocularis | neuropeptide receptor A26 | 0.0506 | 0.3312 | 1 |
Schistosoma mansoni | sex comb on midleg homolog | 0.0052 | 0.0189 | 0.0908 |
Loa Loa (eye worm) | hypothetical protein | 0.0045 | 0.0137 | 0.0091 |
Onchocerca volvulus | Polycomb protein Sfmbt homolog | 0.0052 | 0.0189 | 0.5 |
Brugia malayi | 6-phosphofructokinase | 0.0119 | 0.0649 | 0.3051 |
Echinococcus granulosus | neuropeptide receptor A26 | 0.0506 | 0.3312 | 1 |
Brugia malayi | phenylalanyl-tRNA synthetase, mitochondrial precursor, putative | 0.0162 | 0.0947 | 0.4494 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0039 | 0.0101 | 0.0304 |
Echinococcus granulosus | neuropeptide s receptor | 0.0506 | 0.3312 | 1 |
Echinococcus granulosus | 6 phosphofructokinase | 0.0119 | 0.0649 | 0.1959 |
Loa Loa (eye worm) | mbt repeat family protein | 0.0052 | 0.0189 | 0.0357 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.005 | 0.0175 | 0.0527 |
Brugia malayi | phenylalanyl (f) trna synthetase protein 1 | 0.0328 | 0.2085 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.