Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Toxoplasma gondii | phenylalanyl-tRNA synthetase alpha chain A, putative | 0.0371 | 0.2203 | 1 |
Chlamydia trachomatis | phenylalanine--tRNA ligase subunit beta | 0.004 | 0.0085 | 0.0054 |
Trichomonas vaginalis | phosphofructokinase, putative | 0.0118 | 0.0581 | 0.2533 |
Mycobacterium leprae | Probable phenylalanyl-tRNA synthetase, alpha chain PheS | 0.0229 | 0.1297 | 1 |
Trypanosoma cruzi | phenylalanyl-tRNA synthetase alpha chain, putative | 0.0371 | 0.2203 | 1 |
Echinococcus multilocularis | neuropeptide receptor A26 | 0.05 | 0.3035 | 1 |
Plasmodium vivax | phenylalanine--tRNA ligase alpha subunit, putative | 0.0371 | 0.2203 | 1 |
Echinococcus multilocularis | phenylalanyl tRNA synthetase alpha chain B | 0.0371 | 0.2203 | 0.719 |
Trichomonas vaginalis | phenylalanyl-tRNA synthetase alpha chain, putative | 0.0141 | 0.0734 | 0.3235 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0049 | 0.0144 | 0.023 |
Trichomonas vaginalis | phosphofructokinase, putative | 0.0118 | 0.0581 | 0.2533 |
Loa Loa (eye worm) | hypothetical protein | 0.0059 | 0.0204 | 0.0524 |
Onchocerca volvulus | 0.0052 | 0.0158 | 0.5 | |
Trichomonas vaginalis | phosphofructokinase, putative | 0.0118 | 0.0581 | 0.2533 |
Trichomonas vaginalis | phenylalanyl-tRNA synthetase alpha chain, putative | 0.0371 | 0.2203 | 1 |
Treponema pallidum | phenylalanyl-tRNA synthetase subunit alpha | 0.0371 | 0.2203 | 1 |
Echinococcus granulosus | suppression of tumorigenicity 18 protein | 0.0059 | 0.0204 | 0.0431 |
Mycobacterium tuberculosis | Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) | 0.0118 | 0.0581 | 0.0501 |
Loa Loa (eye worm) | MBCTL1 | 0.0059 | 0.0204 | 0.0524 |
Schistosoma mansoni | scm-relatedprotein containing 4 mbt domains (sfmbt) | 0.0052 | 0.0158 | 0.0066 |
Entamoeba histolytica | phenylalanyl-tRNA synthetase alpha subunit, putative | 0.0371 | 0.2203 | 1 |
Schistosoma mansoni | phenylalanyl-tRNA synthetase subunit alpha | 0.0371 | 0.2203 | 1 |
Echinococcus multilocularis | suppression of tumorigenicity 18 protein | 0.0059 | 0.0204 | 0.0431 |
Echinococcus multilocularis | 6 phosphofructokinase | 0.0118 | 0.0581 | 0.1706 |
Wolbachia endosymbiont of Brugia malayi | phenylalanyl-tRNA synthetase subunit alpha | 0.1586 | 1 | 1 |
Loa Loa (eye worm) | mbt repeat family protein | 0.0052 | 0.0158 | 0.0307 |
Mycobacterium ulcerans | 6-phosphofructokinase | 0.0118 | 0.0581 | 0.0501 |
Trypanosoma brucei | phenylalanyl-tRNA synthetase alpha chain, putative | 0.0371 | 0.2203 | 1 |
Schistosoma mansoni | bromodomain containing protein | 0.0068 | 0.0266 | 0.0591 |
Loa Loa (eye worm) | 6-phosphofructokinase | 0.0118 | 0.0581 | 0.2312 |
Brugia malayi | Bromodomain containing protein | 0.0041 | 0.0093 | 0.0421 |
Schistosoma mansoni | phenylalanyl-tRNA synthetase subunit alpha | 0.0141 | 0.0734 | 0.2862 |
Echinococcus multilocularis | phenylalanyl tRNA synthetase | 0.0251 | 0.1435 | 0.4592 |
Brugia malayi | Bromodomain containing protein | 0.0081 | 0.0347 | 0.1577 |
Brugia malayi | phenylalanyl-tRNA synthetase, mitochondrial precursor, putative | 0.0251 | 0.1435 | 0.6512 |
Echinococcus granulosus | neuropeptide receptor A26 | 0.05 | 0.3035 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0314 | 0.1838 | 0.8228 |
Loa Loa (eye worm) | phosphofructokinase | 0.0118 | 0.0581 | 0.2312 |
Mycobacterium ulcerans | phenylalanyl-tRNA synthetase subunit alpha | 0.1586 | 1 | 1 |
Echinococcus granulosus | histone acetyltransferase MYST2 | 0.0059 | 0.0204 | 0.0431 |
Giardia lamblia | Phenylalanyl-tRNA synthetase alpha chain | 0.0371 | 0.2203 | 1 |
Brugia malayi | C2-HC type zinc finger protein C.e-MyT1 | 0.0059 | 0.0204 | 0.0925 |
Echinococcus multilocularis | histone acetyltransferase MYST2 | 0.0059 | 0.0204 | 0.0431 |
Plasmodium falciparum | phenylalanine--tRNA ligase | 0.0181 | 0.0991 | 0.442 |
Brugia malayi | 6-phosphofructokinase | 0.0118 | 0.0581 | 0.2638 |
Loa Loa (eye worm) | phenylalanyl-tRNA synthetase | 0.0251 | 0.1435 | 0.6357 |
Treponema pallidum | diphosphate--fructose-6-phosphate 1-phosphotransferase | 0.0118 | 0.0581 | 0.2533 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0065 | 0.0241 | 0.0557 |
Echinococcus multilocularis | SAM and MBT domain containing protein | 0.0052 | 0.0158 | 0.0276 |
Loa Loa (eye worm) | 6-phosphofructokinase | 0.0118 | 0.0581 | 0.2312 |
Brugia malayi | phenylalanyl (f) trna synthetase protein 1 | 0.0371 | 0.2203 | 1 |
Brugia malayi | mbt repeat family protein | 0.0052 | 0.0158 | 0.0717 |
Plasmodium falciparum | phenylalanine--tRNA ligase | 0.0251 | 0.1435 | 0.6462 |
Schistosoma mansoni | 6-phosphofructokinase | 0.0118 | 0.0581 | 0.2121 |
Leishmania major | phenylalanyl-tRNA synthetase alpha chain, putative | 0.0371 | 0.2203 | 1 |
Echinococcus granulosus | phenylalanyl tRNA synthetase alpha chain B | 0.0371 | 0.2203 | 0.719 |
Echinococcus granulosus | SAM and MBT domain containing protein | 0.0052 | 0.0158 | 0.0276 |
Schistosoma mansoni | sex comb on midleg homolog | 0.0052 | 0.0158 | 0.0066 |
Trichomonas vaginalis | phosphofructokinase, putative | 0.0118 | 0.0581 | 0.2533 |
Schistosoma mansoni | phenylalanyl-tRNA synthetase mitochondrial | 0.0251 | 0.1435 | 0.6267 |
Echinococcus multilocularis | neuropeptide s receptor | 0.05 | 0.3035 | 1 |
Brugia malayi | phosphofructokinase | 0.0118 | 0.0581 | 0.2638 |
Echinococcus granulosus | neuropeptide s receptor | 0.05 | 0.3035 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0049 | 0.0144 | 0.023 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0049 | 0.0144 | 0.0242 |
Schistosoma mansoni | myelin transcription factor 1 myt1 | 0.0059 | 0.0204 | 0.0288 |
Echinococcus granulosus | 6 phosphofructokinase | 0.0118 | 0.0581 | 0.1706 |
Plasmodium falciparum | phenylalanine--tRNA ligase alpha subunit | 0.0371 | 0.2203 | 1 |
Echinococcus multilocularis | endonuclease exonuclease phosphatase | 0.0203 | 0.1131 | 0.3565 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0049 | 0.0144 | 0.023 |
Brugia malayi | 6-phosphofructokinase | 0.0118 | 0.0581 | 0.2638 |
Echinococcus granulosus | polycomb protein SCMH1 | 0.0052 | 0.0158 | 0.0276 |
Plasmodium vivax | phenylalanine--tRNA ligase, putative | 0.0141 | 0.0734 | 0.3235 |
Loa Loa (eye worm) | hypothetical protein | 0.0076 | 0.0318 | 0.1064 |
Entamoeba histolytica | phosphofructokinase, putative | 0.0118 | 0.0581 | 0.2533 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.011 | 0.0078 |
Echinococcus multilocularis | polycomb protein SCMH1 | 0.0052 | 0.0158 | 0.0276 |
Brugia malayi | mbt repeat family protein | 0.0052 | 0.0158 | 0.0717 |
Schistosoma mansoni | 6-phosphofructokinase | 0.0118 | 0.0581 | 0.2121 |
Loa Loa (eye worm) | hypothetical protein | 0.0371 | 0.2203 | 1 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0049 | 0.0144 | 0.0656 |
Echinococcus granulosus | phenylalanyl tRNA synthetase | 0.0251 | 0.1435 | 0.4592 |
Plasmodium vivax | phenylalanine--tRNA ligase, putative | 0.0251 | 0.1435 | 0.6462 |
Trichomonas vaginalis | phenylalanyl-tRNA synthetase alpha chain, putative | 0.0141 | 0.0734 | 0.3235 |
Toxoplasma gondii | Ferredoxin-fold anticodon binding domain-containing protein | 0.0251 | 0.1435 | 0.6462 |
Schistosoma mansoni | sex comb on midleg homolog | 0.0052 | 0.0158 | 0.0066 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.0158 | 0.0307 |
Onchocerca volvulus | Polycomb protein Sfmbt homolog | 0.0052 | 0.0158 | 0.5 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0049 | 0.0144 | 0.023 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.0123 | 0.0141 |
Echinococcus granulosus | endonuclease exonuclease phosphatase | 0.0203 | 0.1131 | 0.3565 |
Entamoeba histolytica | phosphofructokinase, putative | 0.0118 | 0.0581 | 0.2533 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0065 | 0.0241 | 0.0557 |
Entamoeba histolytica | phosphofructokinase, putative | 0.0118 | 0.0581 | 0.2533 |
Mycobacterium tuberculosis | Probable phenylalanyl-tRNA synthetase, alpha chain PheS | 0.1586 | 1 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.