Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium vivax | phenylalanine--tRNA ligase, putative | 0.0263 | 0.1261 | 0.5743 |
Loa Loa (eye worm) | phosphofructokinase | 0.0118 | 0.0488 | 0.1954 |
Echinococcus multilocularis | endonuclease exonuclease phosphatase | 0.0205 | 0.095 | 0.3565 |
Trypanosoma cruzi | phenylalanyl-tRNA synthetase alpha chain, putative | 0.0434 | 0.2176 | 1 |
Schistosoma mansoni | sex comb on midleg homolog | 0.0052 | 0.0133 | 0.0056 |
Entamoeba histolytica | phosphofructokinase, putative | 0.0118 | 0.0488 | 0.215 |
Echinococcus granulosus | SAM and MBT domain containing protein | 0.0052 | 0.0133 | 0.0276 |
Mycobacterium ulcerans | phenylalanyl-tRNA synthetase subunit alpha | 0.1895 | 1 | 1 |
Echinococcus multilocularis | SAM and MBT domain containing protein | 0.0052 | 0.0133 | 0.0276 |
Echinococcus multilocularis | phenylalanyl tRNA synthetase | 0.0263 | 0.1261 | 0.4814 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.005 | 0.0121 | 0.0205 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0065 | 0.0203 | 0.0557 |
Brugia malayi | mbt repeat family protein | 0.0052 | 0.0133 | 0.061 |
Echinococcus multilocularis | neuropeptide s receptor | 0.0503 | 0.2549 | 1 |
Schistosoma mansoni | sex comb on midleg homolog | 0.0052 | 0.0133 | 0.0056 |
Brugia malayi | 6-phosphofructokinase | 0.0118 | 0.0488 | 0.2244 |
Toxoplasma gondii | Ferredoxin-fold anticodon binding domain-containing protein | 0.0263 | 0.1261 | 0.5743 |
Loa Loa (eye worm) | hypothetical protein | 0.0059 | 0.0171 | 0.0443 |
Treponema pallidum | diphosphate--fructose-6-phosphate 1-phosphotransferase | 0.0118 | 0.0488 | 0.215 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.005 | 0.0121 | 0.023 |
Brugia malayi | phenylalanyl (f) trna synthetase protein 1 | 0.0434 | 0.2176 | 1 |
Echinococcus multilocularis | polycomb protein SCMH1 | 0.0052 | 0.0133 | 0.0276 |
Brugia malayi | 6-phosphofructokinase | 0.0118 | 0.0488 | 0.2244 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.005 | 0.0121 | 0.0558 |
Trichomonas vaginalis | phosphofructokinase, putative | 0.0118 | 0.0488 | 0.215 |
Mycobacterium tuberculosis | Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) | 0.0118 | 0.0488 | 0.0431 |
Schistosoma mansoni | myelin transcription factor 1 myt1 | 0.0059 | 0.0171 | 0.0243 |
Trypanosoma brucei | phenylalanyl-tRNA synthetase alpha chain, putative | 0.0434 | 0.2176 | 1 |
Onchocerca volvulus | 0.0052 | 0.0133 | 0.5 | |
Echinococcus granulosus | neuropeptide s receptor | 0.0503 | 0.2549 | 1 |
Brugia malayi | mbt repeat family protein | 0.0052 | 0.0133 | 0.061 |
Echinococcus multilocularis | neuropeptide receptor A26 | 0.0503 | 0.2549 | 1 |
Brugia malayi | phosphofructokinase | 0.0118 | 0.0488 | 0.2244 |
Loa Loa (eye worm) | mbt repeat family protein | 0.0052 | 0.0133 | 0.0259 |
Schistosoma mansoni | hypothetical protein | 0.0316 | 0.1545 | 0.6927 |
Chlamydia trachomatis | phenylalanine--tRNA ligase subunit beta | 0.0038 | 0.006 | 0.0034 |
Entamoeba histolytica | phenylalanyl-tRNA synthetase alpha subunit, putative | 0.0434 | 0.2176 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.0092 | 0.0066 |
Toxoplasma gondii | phenylalanyl-tRNA synthetase alpha chain A, putative | 0.0434 | 0.2176 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0434 | 0.2176 | 1 |
Onchocerca volvulus | Polycomb protein Sfmbt homolog | 0.0052 | 0.0133 | 0.5 |
Echinococcus multilocularis | histone acetyltransferase MYST2 | 0.0059 | 0.0171 | 0.0431 |
Entamoeba histolytica | phosphofructokinase, putative | 0.0118 | 0.0488 | 0.215 |
Trichomonas vaginalis | phosphofructokinase, putative | 0.0118 | 0.0488 | 0.215 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.0133 | 0.0259 |
Brugia malayi | phenylalanyl-tRNA synthetase, mitochondrial precursor, putative | 0.0263 | 0.1261 | 0.5794 |
Treponema pallidum | phenylalanyl-tRNA synthetase subunit alpha | 0.0434 | 0.2176 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0077 | 0.0267 | 0.0899 |
Mycobacterium tuberculosis | Probable phenylalanyl-tRNA synthetase, alpha chain PheS | 0.1895 | 1 | 1 |
Trichomonas vaginalis | phenylalanyl-tRNA synthetase alpha chain, putative | 0.0434 | 0.2176 | 1 |
Trichomonas vaginalis | phenylalanyl-tRNA synthetase alpha chain, putative | 0.0158 | 0.0701 | 0.3141 |
Echinococcus granulosus | 6 phosphofructokinase | 0.0118 | 0.0488 | 0.1706 |
Echinococcus granulosus | suppression of tumorigenicity 18 protein | 0.0059 | 0.0171 | 0.0431 |
Schistosoma mansoni | phenylalanyl-tRNA synthetase mitochondrial | 0.0263 | 0.1261 | 0.5545 |
Plasmodium vivax | phenylalanine--tRNA ligase, putative | 0.0158 | 0.0701 | 0.3141 |
Loa Loa (eye worm) | MBCTL1 | 0.0059 | 0.0171 | 0.0443 |
Schistosoma mansoni | phenylalanyl-tRNA synthetase subunit alpha | 0.0434 | 0.2176 | 1 |
Echinococcus multilocularis | phenylalanyl tRNA synthetase alpha chain B | 0.0434 | 0.2176 | 0.8497 |
Loa Loa (eye worm) | phenylalanyl-tRNA synthetase | 0.0263 | 0.1261 | 0.5637 |
Schistosoma mansoni | scm-relatedprotein containing 4 mbt domains (sfmbt) | 0.0052 | 0.0133 | 0.0056 |
Echinococcus granulosus | neuropeptide receptor A26 | 0.0503 | 0.2549 | 1 |
Giardia lamblia | Phenylalanyl-tRNA synthetase alpha chain | 0.0434 | 0.2176 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.005 | 0.0121 | 0.023 |
Plasmodium falciparum | phenylalanine--tRNA ligase | 0.0196 | 0.0907 | 0.4096 |
Schistosoma mansoni | bromodomain containing protein | 0.0069 | 0.0224 | 0.0497 |
Echinococcus granulosus | polycomb protein SCMH1 | 0.0052 | 0.0133 | 0.0276 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.005 | 0.0121 | 0.023 |
Schistosoma mansoni | 6-phosphofructokinase | 0.0118 | 0.0488 | 0.1786 |
Loa Loa (eye worm) | 6-phosphofructokinase | 0.0118 | 0.0488 | 0.1954 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.0103 | 0.0119 |
Trichomonas vaginalis | phosphofructokinase, putative | 0.0118 | 0.0488 | 0.215 |
Wolbachia endosymbiont of Brugia malayi | phenylalanyl-tRNA synthetase subunit alpha | 0.1895 | 1 | 1 |
Plasmodium falciparum | phenylalanine--tRNA ligase alpha subunit | 0.0434 | 0.2176 | 1 |
Echinococcus granulosus | phenylalanyl tRNA synthetase | 0.0263 | 0.1261 | 0.4814 |
Schistosoma mansoni | 6-phosphofructokinase | 0.0118 | 0.0488 | 0.1786 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.005 | 0.0121 | 0.023 |
Echinococcus multilocularis | 6 phosphofructokinase | 0.0118 | 0.0488 | 0.1706 |
Echinococcus granulosus | endonuclease exonuclease phosphatase | 0.0205 | 0.095 | 0.3565 |
Mycobacterium leprae | Probable phenylalanyl-tRNA synthetase, alpha chain PheS | 0.0275 | 0.1329 | 1 |
Echinococcus granulosus | histone acetyltransferase MYST2 | 0.0059 | 0.0171 | 0.0431 |
Leishmania major | phenylalanyl-tRNA synthetase alpha chain, putative | 0.0434 | 0.2176 | 1 |
Schistosoma mansoni | phenylalanyl-tRNA synthetase subunit alpha | 0.0158 | 0.0701 | 0.2823 |
Brugia malayi | Bromodomain containing protein | 0.0082 | 0.0292 | 0.1341 |
Entamoeba histolytica | phosphofructokinase, putative | 0.0118 | 0.0488 | 0.215 |
Trichomonas vaginalis | phenylalanyl-tRNA synthetase alpha chain, putative | 0.0158 | 0.0701 | 0.3141 |
Plasmodium vivax | phenylalanine--tRNA ligase alpha subunit, putative | 0.0434 | 0.2176 | 1 |
Echinococcus multilocularis | suppression of tumorigenicity 18 protein | 0.0059 | 0.0171 | 0.0431 |
Echinococcus granulosus | phenylalanyl tRNA synthetase alpha chain B | 0.0434 | 0.2176 | 0.8497 |
Trichomonas vaginalis | phosphofructokinase, putative | 0.0118 | 0.0488 | 0.215 |
Brugia malayi | C2-HC type zinc finger protein C.e-MyT1 | 0.0059 | 0.0171 | 0.0787 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0065 | 0.0203 | 0.0557 |
Loa Loa (eye worm) | 6-phosphofructokinase | 0.0118 | 0.0488 | 0.1954 |
Mycobacterium ulcerans | 6-phosphofructokinase | 0.0118 | 0.0488 | 0.0431 |
Plasmodium falciparum | phenylalanine--tRNA ligase | 0.0263 | 0.1261 | 0.5743 |
Brugia malayi | Bromodomain containing protein | 0.0042 | 0.0078 | 0.0359 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.