TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 439.938 | Formula: C23H26ClN5O2
H donors: 1 H acceptors: 3 LogP: 3.74 Rotable bonds: 8
Rule of 5 violations (Lipinski): 1
SMILES: CCOc1ccc(cc1)N(C(=O)Nc1ccccc1Cl)Cc1nnc2n1CCCCC2
InChi: 1S/C23H26ClN5O2/c1-2-31-18-13-11-17(12-14-18)29(23(30)25-20-9-6-5-8-19(20)24)16-22-27-26-21-10-4-3-7-15-28(21)22/h5-6,8-9,11-14H,2-4,7,10,15-16H2,1H3,(H,25,30)
InChiKey: QZXUVJXPRFDYNC-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Wolbachia endosymbiont of Brugia malayi	threonyl-tRNA synthetase	0.0024	0.0028	0.1242
Brugia malayi	Cytochrome P450 family protein	0.0029	0.006	0.0265
Giardia lamblia	Sugar-proton symporter	0.0059	0.0229	0.3766
Schistosoma mansoni	protein kinase	0.0129	0.0624	0.274
Echinococcus granulosus	Threonyl tRNA synthetase C	0.0024	0.0028	0.0125
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0421	0.2276	0.4674
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0229	0.1008
Echinococcus multilocularis	atpase aaa+ type core atpase aaa type core	0.0879	0.4869	1
Trypanosoma brucei	glucose transporter, putative	0.013	0.0633	0.8704
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0129	0.0624	0.1281
Leishmania major	prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative	0.0147	0.0727	1
Echinococcus multilocularis	synaptic vesicle 2 protein	0.0059	0.0229	0.0471
Trichomonas vaginalis	lysyl-tRNA synthetase, putative	0.0082	0.036	0.1584
Trichomonas vaginalis	sugar transporter, putative	0.0059	0.0229	0.1008
Toxoplasma gondii	calcium-dependent protein kinase CDPK3	0.0129	0.0624	0.0942
Trichomonas vaginalis	sugar transporter, putative	0.0059	0.0229	0.1008
Loa Loa (eye worm)	CAMK/CAMK2 protein kinase	0.0129	0.0624	0.274
Brugia malayi	major facilitator superfamily protein	0.0059	0.0229	0.1008
Brugia malayi	glutaminase DH11.1	0.0296	0.1571	0.6906
Entamoeba histolytica	threonyl-tRNA synthetase, putative	0.0024	0.0028	0.0457
Mycobacterium tuberculosis	Probable conserved integral membrane transport protein	0.0059	0.0229	0.663
Trichomonas vaginalis	sugar transporter, putative	0.0059	0.0229	0.1008
Trichomonas vaginalis	sugar transporter, putative	0.0059	0.0229	0.1008
Leishmania major	prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative	0.0147	0.0727	1
Leishmania major	glucose transporter/membrane transporter D2, putative	0.013	0.0633	0.8704
Mycobacterium tuberculosis	Probable threonyl-tRNA synthetase ThrS (threonine-tRNA synthetase)(ThrRS) (threonine-tRNA ligase)	0.0024	0.0028	0.0823
Toxoplasma gondii	lysine-tRNA ligase	0.0094	0.0426	0.0643
Plasmodium vivax	proline--tRNA ligase, putative	0.0147	0.0727	0.0727
Schistosoma mansoni	lysyl-tRNA synthetase	0.0094	0.0426	0.1872
Chlamydia trachomatis	lysine--tRNA ligase	0.0094	0.0426	1
Brugia malayi	Cytochrome P450 family protein	0.0019	0.0003	0.0012
Trichomonas vaginalis	sugar transport protein, putative	0.0059	0.0229	0.1008
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0021	0.0013	0.0373
Trypanosoma cruzi	sugar transporter, putative	0.0059	0.0229	0.3153
Echinococcus granulosus	General substrate transporter	0.0362	0.1941	0.8529
Onchocerca volvulus		0.0059	0.0229	0.5
Schistosoma mansoni	hypothetical protein	0.0421	0.2276	1
Plasmodium falciparum	mitogen-activated protein kinase 2	0.068	0.3742	0.3742
Mycobacterium ulcerans	glutaminase	0.0296	0.1571	1
Plasmodium vivax	calcium-dependent protein kinase, putative	0.0129	0.0624	0.0624
Giardia lamblia	Threonyl-tRNA synthetase	0.0024	0.0028	0.0468
Brugia malayi	Cam kinase protein 1	0.0129	0.0624	0.274
Onchocerca volvulus		0.0059	0.0229	0.5
Loa Loa (eye worm)	bifunctional aminoacyl-tRNA synthetase	0.0052	0.0188	0.0825
Trypanosoma cruzi	hexose transporter, putative	0.0059	0.0229	0.3153
Mycobacterium ulcerans	sugar transporter	0.0059	0.0229	0.1459
Plasmodium vivax	hexose transporter	0.0421	0.2276	0.2276
Leishmania major	threonyl-tRNA synthetase, putative	0.0024	0.0028	0.0392
Giardia lamblia	Hexose transporter	0.0059	0.0229	0.3766
Plasmodium falciparum	lysine--tRNA ligase	0.0094	0.0426	0.0426
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0229	0.1008
Wolbachia endosymbiont of Brugia malayi	prolyl-tRNA synthetase	0.0024	0.0028	0.1242
Trichomonas vaginalis	sugar transporter, putative	0.0059	0.0229	0.1008
Mycobacterium ulcerans	lysyl-tRNA synthetase	0.0094	0.0426	0.2711
Trichomonas vaginalis	sugar transporter, putative	0.0059	0.0229	0.1008
Chlamydia trachomatis	proline--tRNA ligase	0.0045	0.0147	0.2978
Toxoplasma gondii	calcium-dependent protein kinase CDPK2B	0.0129	0.0624	0.0942
Trypanosoma cruzi	Aminoacyl-tRNA editing domain containing protein, putative	0.0021	0.0013	0.0177
Toxoplasma gondii	protein kinase, putative	0.1189	0.6622	1
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0129	0.0624	0.1281
Plasmodium falciparum	proline--tRNA ligase	0.0147	0.0727	0.0727
Leishmania major	hypothetical protein, conserved	0.0059	0.0229	0.3153
Brugia malayi	Major Facilitator Superfamily protein	0.0059	0.0229	0.1008
Onchocerca volvulus		0.0059	0.0229	0.5
Schistosoma mansoni	glutaminase	0.0296	0.1571	0.6906
Brugia malayi	lysyl-tRNA synthetase	0.0094	0.0426	0.1872
Echinococcus granulosus	solute carrier family 22	0.0059	0.0229	0.1008
Echinococcus multilocularis	General substrate transporter	0.0362	0.1941	0.3986
Plasmodium vivax	threonine--tRNA ligase, putative	0.0024	0.0028	0.0028
Onchocerca volvulus		0.0059	0.0229	0.5
Loa Loa (eye worm)	calcium/calmodulin-dependent protein kinase ID	0.0129	0.0624	0.274
Onchocerca volvulus	Putative transporter	0.0059	0.0229	0.5
Plasmodium falciparum	calcium-dependent protein kinase 3	0.0129	0.0624	0.0624
Trichomonas vaginalis	sugar transporter, putative	0.0059	0.0229	0.1008
Mycobacterium ulcerans	prolyl-tRNA synthetase	0.0045	0.0147	0.0934
Toxoplasma gondii	sugar transporter ST3	0.0059	0.0229	0.0346
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0229	0.1008
Brugia malayi	threonyl-tRNA synthetase, cytoplasmic	0.0024	0.0028	0.0125
Echinococcus multilocularis	glutamyl tRNA synthetase cytoplasmic	0.0126	0.0609	0.1251
Schistosoma mansoni	protein kinase	0.0129	0.0624	0.274
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0129	0.0624	0.1281
Schistosoma mansoni	sugar transporter	0.0059	0.0229	0.1008
Plasmodium falciparum	calcium-dependent protein kinase 2	0.0129	0.0624	0.0624
Brugia malayi	hypothetical protein	0.0059	0.0229	0.1008
Trichomonas vaginalis	sugar transporter, putative	0.0059	0.0229	0.1008
Onchocerca volvulus		0.0059	0.0229	0.5
Giardia lamblia	Lysyl-tRNA synthetase	0.0094	0.0426	0.6997
Trypanosoma brucei	THT1 - hexose transporter, putative	0.013	0.0633	0.8704
Toxoplasma gondii	calcium-dependent protein kinase CDPK2A	0.0129	0.0624	0.0942
Mycobacterium leprae	Probable prolyl tRNA synthetase ProS	0.0126	0.0609	1
Trichomonas vaginalis	threonyl-tRNA synthetase, putative	0.0024	0.0028	0.0125
Mycobacterium tuberculosis	Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase)	0.008	0.0346	1
Trypanosoma cruzi	hypothetical protein, conserved	0.0021	0.0013	0.0177
Plasmodium falciparum	major facilitator superfamily domain-containing protein, putative	0.0059	0.0229	0.0229
Brugia malayi	bifunctional aminoacyl-tRNA synthetase	0.0126	0.0609	0.2676
Echinococcus granulosus	solute carrier family 22	0.0059	0.0229	0.1008
Onchocerca volvulus		0.0059	0.0229	0.5
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0229	0.1008
Trypanosoma brucei	glucose transporter, putative	0.013	0.0633	0.8704
Onchocerca volvulus		0.0059	0.0229	0.5
Echinococcus multilocularis	glycyl tRNA synthetase	0.0024	0.0028	0.0058
Trypanosoma brucei	glucose transporter, putative	0.013	0.0633	0.8704
Trichomonas vaginalis	sugar transporter, putative	0.0059	0.0229	0.1008
Loa Loa (eye worm)	glycyl-tRNA synthetase	0.0024	0.0028	0.0125
Trypanosoma brucei	glucose transporter, putative	0.013	0.0633	0.8704
Trichomonas vaginalis	prolyl-tRNA synthetase, putative	0.0126	0.0609	0.2676
Trichomonas vaginalis	lysyl-tRNA synthetase, putative	0.0094	0.0426	0.1872
Echinococcus granulosus	solute carrier family 22	0.0059	0.0229	0.1008
Trichomonas vaginalis	sugar transporter, putative	0.0059	0.0229	0.1008
Echinococcus granulosus	solute carrier family 22	0.0059	0.0229	0.1008
Trypanosoma brucei	myo-inositol/proton symporter (MIT)	0.0059	0.0229	0.3153
Trichomonas vaginalis	sugar transporter, putative	0.0059	0.0229	0.1008
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0421	0.2276	1
Mycobacterium ulcerans	sugar-transport integral membrane protein SugI	0.0059	0.0229	0.1459
Schistosoma mansoni	glucose transport protein	0.0421	0.2276	1
Leishmania major	glucose transporter, lmgt1	0.013	0.0633	0.8704
Trichomonas vaginalis	glutaminase, putative	0.0296	0.1571	0.6906
Echinococcus multilocularis	Sugar transporter ERD6 protein	0.0059	0.0229	0.0471
Toxoplasma gondii	sugar transporter ST2	0.0059	0.0229	0.0346
Trichomonas vaginalis	sugar transporter, putative	0.0059	0.0229	0.1008
Plasmodium vivax	CDK-related protein kinase 6, putative	0.1785	1	1
Echinococcus multilocularis	Threonyl tRNA synthetase, C	0.0024	0.0028	0.0058
Echinococcus granulosus	Sugar transporter ERD6 protein	0.0059	0.0229	0.1008
Toxoplasma gondii	sugar transporter ST1	0.0059	0.0229	0.0346
Toxoplasma gondii	facilitative glucose transporter GT1	0.0421	0.2276	0.3436
Schistosoma mansoni	sugar transporter	0.0059	0.0229	0.1008
Leishmania major	hypothetical protein, conserved	0.0021	0.0013	0.0177
Echinococcus multilocularis	solute carrier family 22	0.0059	0.0229	0.0471
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0421	0.2276	1
Trichomonas vaginalis	conserved hypothetical protein	0.0021	0.0013	0.0057
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0129	0.0624	0.274
Schistosoma mansoni	glycyl-tRNA synthetase	0.0024	0.0028	0.0125
Schistosoma mansoni	serine/threonine protein kinase	0.0129	0.0624	0.274
Echinococcus granulosus	synaptic vesicle 2 protein	0.0059	0.0229	0.1008
Trypanosoma brucei	glucose transporter, putative	0.013	0.0633	0.8704
Trichomonas vaginalis	sugar transporter, putative	0.0059	0.0229	0.1008
Brugia malayi	probable proline-trna synthetase - fission yeast, putative	0.0024	0.0028	0.0125
Schistosoma mansoni	protein kinase	0.0129	0.0624	0.274
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0028	0.0125
Loa Loa (eye worm)	major facilitator superfamily transporter	0.0059	0.0229	0.1008
Plasmodium vivax	mitogen-activated protein kinase 2, putative	0.068	0.3742	0.3742
Brugia malayi	Sugar transporter family protein	0.0059	0.0229	0.1008
Trypanosoma cruzi	hypothetical protein, conserved	0.0021	0.0013	0.0177
Trichomonas vaginalis	sugar transporter, putative	0.0059	0.0229	0.1008
Trypanosoma cruzi	glucose transporter, putative	0.0059	0.0229	0.3153
Mycobacterium ulcerans	integral membrane transport protein	0.0059	0.0229	0.1459
Trichomonas vaginalis	sugar transporter, putative	0.0059	0.0229	0.1008
Brugia malayi	hypothetical protein	0.0059	0.0229	0.1008
Brugia malayi	major facilitator superfamily protein	0.0059	0.0229	0.1008
Trichomonas vaginalis	sugar transporter, putative	0.0059	0.0229	0.1008
Toxoplasma gondii	glycyl-tRNA synthetase	0.0024	0.0028	0.0043
Toxoplasma gondii	cell-cycle-associated protein kinase MAPK, putative	0.068	0.3742	0.5651
Trichomonas vaginalis	conserved hypothetical protein	0.013	0.0633	0.2782
Loa Loa (eye worm)	hypothetical protein	0.0129	0.0624	0.274
Wolbachia endosymbiont of Brugia malayi	major facilitator superfamily permease	0.0059	0.0229	1
Loa Loa (eye worm)	CYP4Cod1	0.0019	0.0003	0.0012
Echinococcus multilocularis	solute carrier family 2, facilitated glucose	0.0421	0.2276	0.4674
Brugia malayi	glycyl-tRNA synthetase	0.0024	0.0028	0.0125
Trypanosoma cruzi	threonyl-tRNA synthetase, putative	0.0024	0.0028	0.0392
Plasmodium falciparum	hexose transporter	0.0421	0.2276	0.2276
Plasmodium falciparum	threonine--tRNA ligase	0.0024	0.0028	0.0028
Toxoplasma gondii	YbaK/proline-tRNA ligase associated domain-containing protein	0.0021	0.0013	0.0019
Trichomonas vaginalis	sugar transporter, putative	0.0059	0.0229	0.1008
Trichomonas vaginalis	sugar transporter, putative	0.013	0.0633	0.2782
Loa Loa (eye worm)	hypothetical protein	0.0103	0.0475	0.2087
Schistosoma mansoni	glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs)	0.0126	0.0609	0.2676
Loa Loa (eye worm)	hypothetical protein	0.0094	0.0426	0.1872
Trichomonas vaginalis	sugar transporter, putative	0.0059	0.0229	0.1008
Onchocerca volvulus		0.0059	0.0229	0.5
Toxoplasma gondii	transporter, major facilitator family protein	0.0059	0.0229	0.0346
Toxoplasma gondii	threonyl-tRNA synthetase family protein	0.0024	0.0028	0.0043
Mycobacterium tuberculosis	Probable dicarboxylic acid transport integral membrane protein KgtP (dicarboxylate transporter)	0.0059	0.0229	0.663
Loa Loa (eye worm)	glutaminase	0.0296	0.1571	0.6906
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0229	0.1008
Schistosoma mansoni	nuclear transcription factor X-box binding 1 (nfx1)	0.0059	0.0229	0.1008
Onchocerca volvulus		0.0059	0.0229	0.5
Trypanosoma cruzi	cytochrome P450, putative	0.0019	0.0003	0.0037
Leishmania major	protein kinase, putative	0.0129	0.0624	0.8575
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0421	0.2276	0.4674
Trypanosoma brucei	calcium/calmodulin-dependent protein kinase, putative	0.0129	0.0624	0.8575
Entamoeba histolytica	protein kinase, putative	0.0129	0.0624	1
Loa Loa (eye worm)	hypothetical protein	0.0126	0.0609	0.2676
Trichomonas vaginalis	CAMK family protein kinase	0.0129	0.0624	0.274
Plasmodium falciparum	calcium-dependent protein kinase 4	0.0129	0.0624	0.0624
Echinococcus granulosus	calcium dependent protein kinase	0.0121	0.0579	0.2542
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type 1	0.0129	0.0624	0.274
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0129	0.0624	0.1281
Trypanosoma cruzi	hexose transporter, putative	0.013	0.0633	0.8704
Loa Loa (eye worm)	glutaminase 2	0.0296	0.1571	0.6906
Trichomonas vaginalis	conserved hypothetical protein	0.0021	0.0013	0.0057
Trichomonas vaginalis	sugar transporter, putative	0.0059	0.0229	0.1008
Toxoplasma gondii	prolyl-tRNA synthetase (ProRS)	0.0147	0.0727	0.1098
Entamoeba histolytica	glycyl-tRNA synthetase, putative	0.0024	0.0028	0.0457
Trichomonas vaginalis	sugar transporter, putative	0.013	0.0633	0.2782
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0421	0.2276	0.4674
Schistosoma mansoni	glucose transport protein	0.0421	0.2276	1
Trypanosoma cruzi	Aminoacyl-tRNA editing domain containing protein, putative	0.0021	0.0013	0.0177
Trichomonas vaginalis	sugar transporter, putative	0.0059	0.0229	0.1008
Onchocerca volvulus		0.0059	0.0229	0.5
Trypanosoma cruzi	prolyl-tRNA synthetase, putative	0.0147	0.0727	1
Mycobacterium ulcerans	fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT	0.0059	0.0229	0.1459
Leishmania major	myo-inositol/proton symporter (MIT)	0.0059	0.0229	0.3153
Brugia malayi	Cytochrome P450 family protein	0.0019	0.0003	0.0012
Trichomonas vaginalis	conserved hypothetical protein	0.0421	0.2276	1
Plasmodium falciparum	protein kinase 7	0.1189	0.6622	0.6622
Trypanosoma brucei	glucose transporter, putative	0.013	0.0633	0.8704
Trypanosoma brucei	glucose transporter 1E	0.013	0.0633	0.8704
Loa Loa (eye worm)	cytochrome P450 family protein	0.0019	0.0003	0.0012
Trichomonas vaginalis	sugar transporter, putative	0.013	0.0633	0.2782
Trichomonas vaginalis	conserved hypothetical protein	0.0059	0.0229	0.1008
Leishmania major	glucose transporter, lmgt2	0.013	0.0633	0.8704
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0421	0.2276	1
Loa Loa (eye worm)	hypothetical protein	0.0126	0.0609	0.2676
Trichomonas vaginalis	conserved hypothetical protein	0.0059	0.0229	0.1008
Trypanosoma brucei	Aminoacyl-tRNA editing domain containing protein, putative	0.0021	0.0013	0.0177
Onchocerca volvulus		0.0059	0.0229	0.5
Mycobacterium leprae	Probable lysyl-tRNA synthase LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase)	0.008	0.0346	0.5587
Trypanosoma brucei	bifunctional aminoacyl-tRNA synthetase, putative	0.0147	0.0727	1
Trichomonas vaginalis	sugar transporter, putative	0.0059	0.0229	0.1008
Trypanosoma brucei	threonyl-tRNA synthetase, putative	0.0024	0.0028	0.0392
Brugia malayi	Sugar transporter family protein	0.0421	0.2276	1
Trypanosoma cruzi	hexose transporter, putative	0.0071	0.0298	0.41
Mycobacterium leprae	Possible lysyl-tRNA synthetase 2 LysX	0.0094	0.0426	0.6932
Trypanosoma cruzi	hexose transporter, putative	0.013	0.0633	0.8704
Brugia malayi	hypothetical protein	0.0059	0.0229	0.1008
Onchocerca volvulus		0.0059	0.0229	0.5
Trypanosoma brucei	THT1 - hexose transporter, putative	0.013	0.0633	0.8704
Entamoeba histolytica	protein kinase, putative	0.0129	0.0624	1
Trichomonas vaginalis	sugar transporter, putative	0.0059	0.0229	0.1008
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0229	0.1008
Leishmania major	glucose transporter, lmgt3	0.013	0.0633	0.8704
Plasmodium vivax	calcium-dependent protein kinase 1, putative	0.0129	0.0624	0.0624
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0421	0.2276	1
Trypanosoma brucei	cytochrome P450, putative	0.0019	0.0003	0.0037
Echinococcus granulosus	glycyl tRNA synthetase	0.0024	0.0028	0.0125
Plasmodium vivax	calcium-dependent protein kinase 4, putative	0.0129	0.0624	0.0624
Onchocerca volvulus		0.0059	0.0229	0.5
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0229	0.1008
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0229	0.1008
Schistosoma mansoni	sugar transporter	0.0059	0.0229	0.1008
Trichomonas vaginalis	sugar transporter, putative	0.0059	0.0229	0.1008
Schistosoma mansoni	lysyl-tRNA synthetase	0.0094	0.0426	0.1872
Trypanosoma cruzi	cytochrome P450, putative	0.0019	0.0003	0.0037
Echinococcus granulosus	lysyl tRNA synthetase	0.0094	0.0426	0.1872
Leishmania major	lysyl-tRNA synthetase, putative	0.0094	0.0426	0.5858
Mycobacterium ulcerans	hypothetical protein	0.0021	0.0013	0.0082
Trypanosoma cruzi	lysyl-tRNA synthetase, putative	0.0094	0.0426	0.5858
Mycobacterium ulcerans	glycyl-tRNA synthetase	0.0024	0.0028	0.0181
Trichomonas vaginalis	sugar transporter, putative	0.0059	0.0229	0.1008
Giardia lamblia	Prolyl-tRNA synthetase	0.0126	0.0609	1
Trichomonas vaginalis	sugar transporter, putative	0.0059	0.0229	0.1008
Mycobacterium tuberculosis	Lysyl-tRNA synthetase 2 LysX	0.008	0.0346	1
Echinococcus granulosus	glutamyl tRNA synthetase cytoplasmic	0.0126	0.0609	0.2676
Echinococcus multilocularis	solute carrier family 22	0.0059	0.0229	0.0471
Brugia malayi	Calcium/calmodulin-dependent protein kinase type II alpha chain	0.0129	0.0624	0.274
Plasmodium vivax	glycine--tRNA ligase, putative	0.0024	0.0028	0.0028
Schistosoma mansoni	glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs)	0.0126	0.0609	0.2676
Giardia lamblia	Glycyl-tRNA synthetase	0.0024	0.0028	0.0468
Entamoeba histolytica	prolyl-tRNA synthetase, putative	0.0126	0.0609	0.9763
Onchocerca volvulus		0.0059	0.0229	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0059	0.0229	0.1008
Loa Loa (eye worm)	major facilitator superfamily transporter	0.0059	0.0229	0.1008
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0229	0.1008
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0229	0.1008
Schistosoma mansoni	glucose transporter	0.0059	0.0229	0.1008
Trichomonas vaginalis	sugar transporter, putative	0.0059	0.0229	0.1008
Loa Loa (eye worm)	sugar transporter	0.0421	0.2276	1
Plasmodium falciparum	calcium-dependent protein kinase 5	0.0129	0.0624	0.0624
Plasmodium vivax	calcium-dependent protein kinase 3, putative	0.0129	0.0624	0.0624
Mycobacterium leprae	Probable threonyl-tRNA synthetase ThrS (threonine-tRNA synthetase) (ThrRS) (Threonine-tRNA ligase)	0.0024	0.0028	0.0262
Trichomonas vaginalis	sugar transporter, putative	0.0059	0.0229	0.1008
Trypanosoma cruzi	hexose transporter	0.013	0.0633	0.8704
Loa Loa (eye worm)	cytochrome P450 family protein	0.0019	0.0003	0.0012
Trichomonas vaginalis	conserved hypothetical protein	0.0021	0.0013	0.0057
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0229	0.1008
Trichomonas vaginalis	sugar transporter, putative	0.0059	0.0229	0.1008
Trichomonas vaginalis	glucose transporter, putative	0.013	0.0633	0.2782
Trichomonas vaginalis	conserved hypothetical protein	0.0059	0.0229	0.1008
Brugia malayi	Major Facilitator Superfamily protein	0.0059	0.0229	0.1008
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0229	0.1008
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0129	0.0624	0.274
Trichomonas vaginalis	sugar transporter, putative	0.0059	0.0229	0.1008
Leishmania major	hypothetical protein, conserved	0.0021	0.0013	0.0177
Entamoeba histolytica	hypothetical protein	0.0094	0.0426	0.6831
Trichomonas vaginalis	sugar transporter, putative	0.0059	0.0229	0.1008
Mycobacterium ulcerans	lysyl-tRNA synthetase	0.0094	0.0426	0.2711
Treponema pallidum	threonyl-tRNA synthetase	0.0024	0.0028	0.1939
Leishmania major	cytochrome p450-like protein	0.0019	0.0003	0.0037
Trichomonas vaginalis	myo-inositol transporter, putative	0.0059	0.0229	0.1008
Trypanosoma cruzi	prolyl-tRNA synthetase, putative	0.0147	0.0727	1
Brugia malayi	Sugar transporter family protein	0.0059	0.0229	0.1008
Mycobacterium ulcerans	cytochrome P450 185A4 Cyp185A4	0.0019	0.0003	0.0017
Brugia malayi	Major Facilitator Superfamily protein	0.0059	0.0229	0.1008
Trypanosoma brucei	glucose transporter, putative	0.013	0.0633	0.8704
Echinococcus multilocularis	lysyl tRNA synthetase	0.0094	0.0426	0.0875
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0229	0.1008
Onchocerca volvulus		0.0059	0.0229	0.5
Plasmodium vivax	sugar transporter, putative	0.0059	0.0229	0.0229
Trypanosoma brucei	glycyl-tRNA synthetase, putative	0.0024	0.0028	0.0392
Echinococcus multilocularis	calcium dependent protein kinase	0.0121	0.0579	0.1188
Trypanosoma cruzi	hexose transporter, putative	0.013	0.0633	0.8704
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0129	0.0624	0.274
Loa Loa (eye worm)	sugar transporter	0.0059	0.0229	0.1008
Echinococcus multilocularis	solute carrier family 22	0.0059	0.0229	0.0471
Trichomonas vaginalis	sugar transporter, putative	0.0059	0.0229	0.1008
Trichomonas vaginalis	sugar transporter, putative	0.0059	0.0229	0.1008
Trichomonas vaginalis	sugar transporter, putative	0.0059	0.0229	0.1008
Plasmodium vivax	lysine--tRNA ligase, putative	0.0094	0.0426	0.0426
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0229	0.1008
Trichomonas vaginalis	sugar transporter, putative	0.0059	0.0229	0.1008
Plasmodium falciparum	calcium-dependent protein kinase 1	0.0129	0.0624	0.0624
Trichomonas vaginalis	glucose transporter, putative	0.013	0.0633	0.2782
Schistosoma mansoni	glucose transport protein	0.0421	0.2276	1
Onchocerca volvulus		0.0059	0.0229	0.5
Trypanosoma brucei	glucose transporter 2A	0.013	0.0633	0.8704
Brugia malayi	Bifunctional aminoacyl-tRNA synthetase	0.0126	0.0609	0.2676
Mycobacterium ulcerans	threonyl-tRNA synthetase	0.0024	0.0028	0.0181
Trypanosoma brucei	THT1 - hexose transporter, putative	0.013	0.0633	0.8704
Trypanosoma brucei	sugar transporter, putative	0.0059	0.0229	0.3153
Schistosoma mansoni	sugar transporter	0.0059	0.0229	0.1008
Trichomonas vaginalis	conserved hypothetical protein	0.013	0.0633	0.2782
Loa Loa (eye worm)	cytochrome P450 family protein	0.0029	0.006	0.0265
Echinococcus multilocularis	solute carrier family 22	0.0059	0.0229	0.0471
Loa Loa (eye worm)	threonyl-tRNA synthetase	0.0024	0.0028	0.0125
Trypanosoma cruzi	threonyl-tRNA synthetase, putative	0.0024	0.0028	0.0392
Trichomonas vaginalis	conserved hypothetical protein	0.0059	0.0229	0.1008
Trypanosoma brucei	lysyl-tRNA synthetase, putative	0.0094	0.0426	0.5858
Treponema pallidum	prolyl-tRNA synthetase	0.0045	0.0147	1
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0229	0.1008
Trichomonas vaginalis	sugar transporter, putative	0.0059	0.0229	0.1008
Trypanosoma brucei	glucose transporter, putative	0.013	0.0633	0.8704
Trichomonas vaginalis	glucose transporter, putative	0.0059	0.0229	0.1008

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 687371