TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 409.263 | Formula: C19H18Cl2N2O4
H donors: 1 H acceptors: 1 LogP: 4.06 Rotable bonds: 3
Rule of 5 violations (Lipinski): 1
SMILES: COc1ccc(cc1OC)N1C(=O)NC2CC1(C)Oc1c2cc(cc1Cl)Cl
InChi: 1S/C19H18Cl2N2O4/c1-19-9-14(12-6-10(20)7-13(21)17(12)27-19)22-18(24)23(19)11-4-5-15(25-2)16(8-11)26-3/h4-8,14H,9H2,1-3H3,(H,22,24)
InChiKey: KZKFRZILAQMAET-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trypanosoma cruzi	hexose transporter, putative	0.0044	0.0244	0.3295
Plasmodium vivax	mitogen-activated protein kinase 2, putative	0.0511	0.3752	0.3724
Trypanosoma cruzi	hexose transporter, putative	0.0054	0.0313	0.4222
Giardia lamblia	Sugar-proton symporter	0.0044	0.0244	0.346
Wolbachia endosymbiont of Brugia malayi	major facilitator superfamily permease	0.0044	0.0244	1
Trypanosoma brucei	threonyl-tRNA synthetase, putative	0.0018	0.0044	0.0591
Mycobacterium ulcerans	beta-lactamase	0.0035	0.0173	0.3934
Onchocerca volvulus		0.0044	0.0244	1
Trichomonas vaginalis	sugar transporter, putative	0.0044	0.0244	0.0956
Onchocerca volvulus		0.0044	0.0244	1
Mycobacterium ulcerans	esterase/lipase LipP	0.0035	0.0173	0.3934
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0244	0.1068
Schistosoma mansoni	glucose transport protein	0.0316	0.2287	1
Mycobacterium ulcerans	lipase LipD	0.0035	0.0173	0.3934
Schistosoma mansoni	sugar transporter	0.0044	0.0244	0.0894
Onchocerca volvulus		0.0044	0.0244	1
Trypanosoma cruzi	hypothetical protein, conserved	0.0035	0.0173	0.2338
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0097	0.0638	0.1829
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0173	0.0758
Schistosoma mansoni	serine/threonine protein kinase	0.0097	0.0638	0.2648
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0035	0.0173	0.0928
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0097	0.0638	0.1829
Toxoplasma gondii	sugar transporter ST3	0.0044	0.0244	0.0327
Trichomonas vaginalis	sugar transporter, putative	0.0098	0.0647	0.274
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0244	0.1068
Leishmania major	glucose transporter/membrane transporter D2, putative	0.0098	0.0647	0.8731
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0316	0.2287	0.6907
Mycobacterium tuberculosis	Probable esterase LipL	0.0035	0.0173	0.0928
Toxoplasma gondii	sugar transporter ST1	0.0044	0.0244	0.0327
Plasmodium vivax	hexose transporter	0.0316	0.2287	0.2253
Echinococcus granulosus	solute carrier family 22	0.0044	0.0244	0.0617
Echinococcus granulosus	General substrate transporter	0.0272	0.1953	0.5878
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0244	0.1068
Trypanosoma cruzi	glucose transporter, putative	0.0044	0.0244	0.3295
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0244	0.1068
Plasmodium vivax	CDK-related protein kinase 6, putative	0.1342	1	1
Mycobacterium leprae	Probable prolyl tRNA synthetase ProS	0.0095	0.0623	1
Mycobacterium ulcerans	lysyl-tRNA synthetase	0.0071	0.0441	1
Mycobacterium ulcerans	hypothetical protein	0.0016	0.0028	0.064
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0316	0.2287	0.6907
Brugia malayi	Major Facilitator Superfamily protein	0.0044	0.0244	0.1068
Trichomonas vaginalis	sugar transporter, putative	0.0044	0.0244	0.0956
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0244	0.1068
Brugia malayi	hypothetical protein	0.0044	0.0244	0.1068
Trichomonas vaginalis	sugar transporter, putative	0.0044	0.0244	0.0956
Chlamydia trachomatis	proline--tRNA ligase	0.0034	0.0162	0.2978
Giardia lamblia	Prolyl-tRNA synthetase	0.0095	0.0623	1
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0244	0.1068
Trypanosoma cruzi	Aminoacyl-tRNA editing domain containing protein, putative	0.0016	0.0028	0.0381
Toxoplasma gondii	sugar transporter ST2	0.0044	0.0244	0.0327
Trichomonas vaginalis	lysyl-tRNA synthetase, putative	0.0062	0.0375	0.1536
Trypanosoma brucei	glucose transporter, putative	0.0098	0.0647	0.8731
Trichomonas vaginalis	sugar transporter, putative	0.0044	0.0244	0.0956
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0035	0.0173	0.0399
Trypanosoma brucei	glucose transporter, putative	0.0098	0.0647	0.8731
Trichomonas vaginalis	sugar transporter, putative	0.0044	0.0244	0.0956
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0244	0.1068
Trichomonas vaginalis	glucose transporter, putative	0.0098	0.0647	0.274
Trichomonas vaginalis	penicillin-binding protein, putative	0.0035	0.0173	0.0642
Echinococcus multilocularis	synaptic vesicle 2 protein	0.0044	0.0244	0.0617
Brugia malayi	lysyl-tRNA synthetase	0.0071	0.0441	0.1927
Trichomonas vaginalis	conserved hypothetical protein	0.0098	0.0647	0.274
Echinococcus granulosus	solute carrier family 22	0.0044	0.0244	0.0617
Loa Loa (eye worm)	sugar transporter	0.0044	0.0244	0.1068
Trichomonas vaginalis	sugar transporter, putative	0.0044	0.0244	0.0956
Trichomonas vaginalis	D-aminoacylase, putative	0.0035	0.0173	0.0642
Trichomonas vaginalis	CAMK family protein kinase	0.0097	0.0638	0.2699
Echinococcus multilocularis	glutamyl tRNA synthetase cytoplasmic	0.0095	0.0623	0.1784
Brugia malayi	bifunctional aminoacyl-tRNA synthetase	0.0095	0.0623	0.2725
Plasmodium falciparum	calcium-dependent protein kinase 2	0.0097	0.0638	0.0597
Entamoeba histolytica	protein kinase, putative	0.0097	0.0638	1
Trichomonas vaginalis	conserved hypothetical protein	0.0044	0.0244	0.0956
Plasmodium vivax	hypothetical protein, conserved	0.0035	0.0173	0.013
Plasmodium vivax	calcium-dependent protein kinase 3, putative	0.0097	0.0638	0.0597
Brugia malayi	major facilitator superfamily protein	0.0044	0.0244	0.1068
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0316	0.2287	0.6907
Plasmodium vivax	lysine--tRNA ligase, putative	0.0071	0.0441	0.0399
Trichomonas vaginalis	sugar transporter, putative	0.0044	0.0244	0.0956
Onchocerca volvulus		0.0044	0.0244	1
Plasmodium vivax	calcium-dependent protein kinase 4, putative	0.0097	0.0638	0.0597
Loa Loa (eye worm)	bifunctional aminoacyl-tRNA synthetase	0.0039	0.0203	0.0887
Schistosoma mansoni	glucose transporter	0.0044	0.0244	0.0894
Brugia malayi	hypothetical protein	0.0044	0.0244	0.1068
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0316	0.2287	0.6907
Mycobacterium leprae	conserved hypothetical protein	0.0035	0.0173	0.2439
Mycobacterium tuberculosis	Probable dicarboxylic acid transport integral membrane protein KgtP (dicarboxylate transporter)	0.0044	0.0244	0.1382
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type 1	0.0097	0.0638	0.1829
Trypanosoma cruzi	hypothetical protein, conserved	0.0016	0.0028	0.0381
Toxoplasma gondii	protein kinase, putative	0.0893	0.6627	1
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0097	0.0638	0.1829
Toxoplasma gondii	glycyl-tRNA synthetase	0.0018	0.0044	0.0024
Leishmania major	myo-inositol/proton symporter (MIT)	0.0044	0.0244	0.3295
Loa Loa (eye worm)	major facilitator superfamily transporter	0.0044	0.0244	0.1068
Echinococcus multilocularis	solute carrier family 22	0.0044	0.0244	0.0617
Toxoplasma gondii	prolyl-tRNA synthetase (ProRS)	0.0111	0.0741	0.1081
Plasmodium vivax	calcium-dependent protein kinase 1, putative	0.0097	0.0638	0.0597
Trypanosoma brucei	glycyl-tRNA synthetase, putative	0.0018	0.0044	0.0591
Trichomonas vaginalis	sugar transporter, putative	0.0044	0.0244	0.0956
Trichomonas vaginalis	sugar transporter, putative	0.0044	0.0244	0.0956
Trypanosoma cruzi	hypothetical protein, conserved	0.0016	0.0028	0.0381
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0035	0.0173	0.3934
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0173	0.0758
Echinococcus granulosus	solute carrier family 22	0.0044	0.0244	0.0617
Trichomonas vaginalis	sugar transporter, putative	0.0044	0.0244	0.0956
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0316	0.2287	0.6907
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0244	0.1068
Trichomonas vaginalis	esterase, putative	0.0035	0.0173	0.0642
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0244	0.1068
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0441	0.1927
Leishmania major	lysyl-tRNA synthetase, putative	0.0071	0.0441	0.5944
Onchocerca volvulus		0.0044	0.0244	1
Mycobacterium ulcerans	fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT	0.0044	0.0244	0.5544
Echinococcus multilocularis	neuropeptide receptor A26	0.045	0.3292	1
Treponema pallidum	prolyl-tRNA synthetase	0.0034	0.0162	1
Trichomonas vaginalis	sugar transporter, putative	0.0044	0.0244	0.0956
Trypanosoma brucei	sugar transporter, putative	0.0044	0.0244	0.3295
Echinococcus multilocularis	solute carrier family 2, facilitated glucose	0.0316	0.2287	0.6907
Trichomonas vaginalis	sugar transporter, putative	0.0044	0.0244	0.0956
Mycobacterium ulcerans	sugar transporter	0.0044	0.0244	0.5544
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0035	0.0173	0.0577
Echinococcus multilocularis	General substrate transporter	0.0272	0.1953	0.5878
Plasmodium falciparum	mitogen-activated protein kinase 2	0.0511	0.3752	0.3724
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0097	0.0638	0.1829
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0097	0.0638	0.1829
Mycobacterium tuberculosis	Probable lipase LipD	0.0035	0.0173	0.0928
Chlamydia trachomatis	lysine--tRNA ligase	0.0071	0.0441	1
Trypanosoma cruzi	prolyl-tRNA synthetase, putative	0.0111	0.0741	1
Trypanosoma cruzi	prolyl-tRNA synthetase, putative	0.0111	0.0741	1
Trichomonas vaginalis	glucose transporter, putative	0.0098	0.0647	0.274
Mycobacterium ulcerans	threonyl-tRNA synthetase	0.0018	0.0044	0.0994
Trypanosoma cruzi	lysyl-tRNA synthetase, putative	0.0071	0.0441	0.5944
Entamoeba histolytica	hypothetical protein	0.0071	0.0441	0.6679
Trichomonas vaginalis	conserved hypothetical protein	0.0044	0.0244	0.0956
Schistosoma mansoni	hypothetical protein	0.0164	0.1142	0.4897
Mycobacterium leprae	Probable lipase LipE	0.0035	0.0173	0.2439
Schistosoma mansoni	protein kinase	0.0097	0.0638	0.2648
Trichomonas vaginalis	sugar transporter, putative	0.0044	0.0244	0.0956
Onchocerca volvulus		0.0044	0.0244	1
Trichomonas vaginalis	sugar transporter, putative	0.0044	0.0244	0.0956
Trypanosoma brucei	glucose transporter 2A	0.0098	0.0647	0.8731
Plasmodium falciparum	proline--tRNA ligase	0.0111	0.0741	0.0701
Loa Loa (eye worm)	hypothetical protein	0.0097	0.0638	0.2789
Onchocerca volvulus	Putative transporter	0.0044	0.0244	1
Trypanosoma cruzi	threonyl-tRNA synthetase, putative	0.0018	0.0044	0.0591
Toxoplasma gondii	cell-cycle-associated protein kinase MAPK, putative	0.0511	0.3752	0.5643
Loa Loa (eye worm)	CAMK/CAMK2 protein kinase	0.0097	0.0638	0.2789
Trichomonas vaginalis	sugar transport protein, putative	0.0044	0.0244	0.0956
Schistosoma mansoni	lysyl-tRNA synthetase	0.0071	0.0441	0.1769
Trichomonas vaginalis	sugar transporter, putative	0.0044	0.0244	0.0956
Echinococcus granulosus	synaptic vesicle 2 protein	0.0044	0.0244	0.0617
Toxoplasma gondii	calcium-dependent protein kinase CDPK2B	0.0097	0.0638	0.0925
Brugia malayi	beta-lactamase family protein	0.0035	0.0173	0.0758
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0035	0.0173	0.0928
Brugia malayi	probable proline-trna synthetase - fission yeast, putative	0.0018	0.0044	0.0191
Trypanosoma cruzi	Aminoacyl-tRNA editing domain containing protein, putative	0.0016	0.0028	0.0381
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0244	0.1068
Trichomonas vaginalis	penicillin-binding protein, putative	0.0035	0.0173	0.0642
Schistosoma mansoni	glucose transport protein	0.0316	0.2287	1
Mycobacterium tuberculosis	Probable lipase LipE	0.0035	0.0173	0.0928
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0244	0.1068
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0173	0.0758
Toxoplasma gondii	ABC1 family protein	0.0035	0.0173	0.022
Leishmania major	glucose transporter, lmgt2	0.0098	0.0647	0.8731
Trichomonas vaginalis	sugar transporter, putative	0.0044	0.0244	0.0956
Plasmodium vivax	sugar transporter, putative	0.0044	0.0244	0.0201
Trypanosoma brucei	glucose transporter, putative	0.0098	0.0647	0.8731
Trichomonas vaginalis	sugar transporter, putative	0.0044	0.0244	0.0956
Trichomonas vaginalis	sugar transporter, putative	0.0044	0.0244	0.0956
Trichomonas vaginalis	sugar transporter, putative	0.0044	0.0244	0.0956
Mycobacterium ulcerans	lysyl-tRNA synthetase	0.0071	0.0441	1
Trichomonas vaginalis	conserved hypothetical protein	0.0044	0.0244	0.0956
Brugia malayi	beta-lactamase	0.0035	0.0173	0.0758
Toxoplasma gondii	threonyl-tRNA synthetase family protein	0.0018	0.0044	0.0024
Trypanosoma brucei	myo-inositol/proton symporter (MIT)	0.0044	0.0244	0.3295
Plasmodium falciparum	major facilitator superfamily domain-containing protein, putative	0.0044	0.0244	0.0201
Trichomonas vaginalis	sugar transporter, putative	0.0044	0.0244	0.0956
Toxoplasma gondii	lysine-tRNA ligase	0.0071	0.0441	0.0625
Trichomonas vaginalis	sugar transporter, putative	0.0044	0.0244	0.0956
Schistosoma mansoni	protein kinase	0.0097	0.0638	0.2648
Giardia lamblia	Hexose transporter	0.0044	0.0244	0.346
Onchocerca volvulus		0.0044	0.0244	1
Onchocerca volvulus		0.0044	0.0244	1
Trypanosoma brucei	glucose transporter, putative	0.0098	0.0647	0.8731
Schistosoma mansoni	glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs)	0.0095	0.0623	0.2583
Trypanosoma cruzi	hypothetical protein, conserved	0.0035	0.0173	0.2338
Trypanosoma cruzi	hexose transporter, putative	0.0098	0.0647	0.8731
Plasmodium vivax	proline--tRNA ligase, putative	0.0111	0.0741	0.0701
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0316	0.2287	0.6907
Brugia malayi	Sugar transporter family protein	0.0044	0.0244	0.1068
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0035	0.0173	0.0928
Brugia malayi	threonyl-tRNA synthetase, cytoplasmic	0.0018	0.0044	0.0191
Trichomonas vaginalis	sugar transporter, putative	0.0044	0.0244	0.0956
Loa Loa (eye worm)	hypothetical protein	0.0077	0.049	0.214
Trypanosoma brucei	bifunctional aminoacyl-tRNA synthetase, putative	0.0111	0.0741	1
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0244	0.1068
Echinococcus multilocularis	solute carrier family 22	0.0044	0.0244	0.0617
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0098	0.0647	0.8731
Onchocerca volvulus		0.0044	0.0244	1
Leishmania major	glucose transporter, lmgt1	0.0098	0.0647	0.8731
Loa Loa (eye worm)	hypothetical protein	0.0095	0.0623	0.2725
Trichomonas vaginalis	sugar transporter, putative	0.0044	0.0244	0.0956
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0035	0.0173	0.0577
Mycobacterium ulcerans	glycyl-tRNA synthetase	0.0018	0.0044	0.0994
Trichomonas vaginalis	lysyl-tRNA synthetase, putative	0.0071	0.0441	0.1826
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0173	0.0758
Echinococcus multilocularis	lysyl tRNA synthetase	0.0071	0.0441	0.1222
Trichomonas vaginalis	sugar transporter, putative	0.0044	0.0244	0.0956
Echinococcus multilocularis	geminin	0.0164	0.1142	0.3382
Trypanosoma cruzi	sugar transporter, putative	0.0044	0.0244	0.3295
Schistosoma mansoni	sugar transporter	0.0044	0.0244	0.0894
Trypanosoma brucei	glucose transporter, putative	0.0098	0.0647	0.8731
Trichomonas vaginalis	sugar transporter, putative	0.0044	0.0244	0.0956
Trichomonas vaginalis	conserved hypothetical protein	0.0044	0.0244	0.0956
Leishmania major	glucose transporter, lmgt3	0.0098	0.0647	0.8731
Loa Loa (eye worm)	threonyl-tRNA synthetase	0.0018	0.0044	0.0191
Mycobacterium ulcerans	prolyl-tRNA synthetase	0.0034	0.0162	0.3675
Trichomonas vaginalis	sugar transporter, putative	0.0044	0.0244	0.0956
Trypanosoma brucei	calcium/calmodulin-dependent protein kinase, putative	0.0097	0.0638	0.8605
Trichomonas vaginalis	conserved hypothetical protein	0.0044	0.0244	0.0956
Brugia malayi	major facilitator superfamily protein	0.0044	0.0244	0.1068
Onchocerca volvulus		0.0044	0.0244	1
Echinococcus multilocularis	Sugar transporter ERD6 protein	0.0044	0.0244	0.0617
Onchocerca volvulus		0.0044	0.0244	1
Trichomonas vaginalis	sugar transporter, putative	0.0044	0.0244	0.0956
Leishmania major	hypothetical protein, conserved	0.0044	0.0244	0.3295
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0244	0.1068
Toxoplasma gondii	calcium-dependent protein kinase CDPK2A	0.0097	0.0638	0.0925
Trypanosoma brucei	hypothetical protein, conserved	0.0035	0.0173	0.2338
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0035	0.0173	0.0758
Brugia malayi	Major Facilitator Superfamily protein	0.0044	0.0244	0.1068
Trichomonas vaginalis	myo-inositol transporter, putative	0.0044	0.0244	0.0956
Toxoplasma gondii	facilitative glucose transporter GT1	0.0316	0.2287	0.3424
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0097	0.0638	0.1829
Toxoplasma gondii	calcium-dependent protein kinase CDPK3	0.0097	0.0638	0.0925
Mycobacterium tuberculosis	Lysyl-tRNA synthetase 2 LysX	0.006	0.0361	0.2126
Trichomonas vaginalis	prolyl-tRNA synthetase, putative	0.0095	0.0623	0.2634
Mycobacterium tuberculosis	Probable hydrolase	0.0035	0.0173	0.0928
Schistosoma mansoni	glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs)	0.0095	0.0623	0.2583
Onchocerca volvulus		0.0044	0.0244	1
Plasmodium falciparum	calcium-dependent protein kinase 5	0.0097	0.0638	0.0597
Giardia lamblia	Lysyl-tRNA synthetase	0.0071	0.0441	0.6849
Schistosoma mansoni	lysyl-tRNA synthetase	0.0071	0.0441	0.1769
Leishmania major	threonyl-tRNA synthetase, putative	0.0018	0.0044	0.0591
Trichomonas vaginalis	glucose transporter, putative	0.0044	0.0244	0.0956
Leishmania major	protein kinase, putative	0.0097	0.0638	0.8605
Echinococcus granulosus	Sugar transporter ERD6 protein	0.0044	0.0244	0.0617
Mycobacterium ulcerans	hypothetical protein	0.0035	0.0173	0.3934
Mycobacterium leprae	Possible lysyl-tRNA synthetase 2 LysX	0.0071	0.0441	0.6932
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0173	0.0758
Mycobacterium leprae	Probable threonyl-tRNA synthetase ThrS (threonine-tRNA synthetase) (ThrRS) (Threonine-tRNA ligase)	0.0018	0.0044	0.0262
Trypanosoma cruzi	hexose transporter	0.0098	0.0647	0.8731
Loa Loa (eye worm)	calcium/calmodulin-dependent protein kinase ID	0.0097	0.0638	0.2789
Schistosoma mansoni	hypothetical protein	0.0316	0.2287	1
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0244	0.1068
Schistosoma mansoni	sugar transporter	0.0044	0.0244	0.0894
Brugia malayi	hypothetical protein	0.0044	0.0244	0.1068
Echinococcus granulosus	calcium dependent protein kinase	0.0091	0.0593	0.1691
Mycobacterium tuberculosis	Conserved protein	0.0035	0.0173	0.0928
Plasmodium vivax	calcium-dependent protein kinase, putative	0.0097	0.0638	0.0597
Onchocerca volvulus		0.0044	0.0244	1
Toxoplasma gondii	transporter, major facilitator family protein	0.0044	0.0244	0.0327
Echinococcus granulosus	lysyl tRNA synthetase	0.0071	0.0441	0.1222
Echinococcus multilocularis	solute carrier family 22	0.0044	0.0244	0.0617
Trypanosoma cruzi	hexose transporter, putative	0.0098	0.0647	0.8731
Brugia malayi	Sugar transporter family protein	0.0044	0.0244	0.1068
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0316	0.2287	0.6907
Mycobacterium tuberculosis	Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase)	0.006	0.0361	0.2126
Trichomonas vaginalis	sugar transporter, putative	0.0044	0.0244	0.0956
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0244	0.1068
Trypanosoma brucei	glucose transporter, putative	0.0098	0.0647	0.8731
Plasmodium falciparum	calcium-dependent protein kinase 1	0.0097	0.0638	0.0597
Trypanosoma brucei	glucose transporter, putative	0.0098	0.0647	0.8731
Echinococcus granulosus	glutamyl tRNA synthetase cytoplasmic	0.0095	0.0623	0.1784
Schistosoma mansoni	glucose transport protein	0.0316	0.2287	1
Trichomonas vaginalis	sugar transporter, putative	0.0044	0.0244	0.0956
Plasmodium falciparum	lysine--tRNA ligase	0.0071	0.0441	0.0399
Schistosoma mansoni	hypothetical protein	0.0164	0.1142	0.4897
Echinococcus granulosus	solute carrier family 22	0.0044	0.0244	0.0617
Leishmania major	hypothetical protein, conserved	0.0035	0.0173	0.2338
Brugia malayi	glycyl-tRNA synthetase	0.0018	0.0044	0.0191
Trichomonas vaginalis	sugar transporter, putative	0.0044	0.0244	0.0956
Mycobacterium ulcerans	sugar-transport integral membrane protein SugI	0.0044	0.0244	0.5544
Leishmania major	prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative	0.0111	0.0741	1
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0098	0.0647	0.8731
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0173	0.0758
Loa Loa (eye worm)	sugar transporter	0.0316	0.2287	1
Echinococcus granulosus	neuropeptide receptor A26	0.045	0.3292	1
Loa Loa (eye worm)	beta-lactamase	0.0035	0.0173	0.0758
Leishmania major	prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative	0.0111	0.0741	1
Echinococcus multilocularis	solute carrier family 22	0.0044	0.0244	0.0617
Trichomonas vaginalis	sugar transporter, putative	0.0044	0.0244	0.0956
Trypanosoma brucei	Aminoacyl-tRNA editing domain containing protein, putative	0.0016	0.0028	0.0381
Trichomonas vaginalis	sugar transporter, putative	0.0044	0.0244	0.0956
Echinococcus granulosus	neuropeptide s receptor	0.045	0.3292	1
Plasmodium falciparum	protein kinase 7	0.0893	0.6627	0.6612
Trypanosoma brucei	glucose transporter 1E	0.0098	0.0647	0.8731
Trichomonas vaginalis	conserved hypothetical protein	0.0098	0.0647	0.274
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0098	0.0647	0.8731
Trypanosoma cruzi	threonyl-tRNA synthetase, putative	0.0018	0.0044	0.0591
Onchocerca volvulus		0.0044	0.0244	1
Loa Loa (eye worm)	glycyl-tRNA synthetase	0.0018	0.0044	0.0191
Loa Loa (eye worm)	major facilitator superfamily transporter	0.0044	0.0244	0.1068
Brugia malayi	Cam kinase protein 1	0.0097	0.0638	0.2789
Brugia malayi	Bifunctional aminoacyl-tRNA synthetase	0.0095	0.0623	0.2725
Plasmodium falciparum	calcium-dependent protein kinase 3	0.0097	0.0638	0.0597
Mycobacterium tuberculosis	Conserved protein	0.0035	0.0173	0.0928
Entamoeba histolytica	prolyl-tRNA synthetase, putative	0.0095	0.0623	0.9752
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0097	0.0638	0.1829
Brugia malayi	Calcium/calmodulin-dependent protein kinase type II alpha chain	0.0097	0.0638	0.2789
Trichomonas vaginalis	sugar transporter, putative	0.0098	0.0647	0.274
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0224	0.1592	1
Mycobacterium leprae	Probable lysyl-tRNA synthase LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase)	0.006	0.0361	0.5587
Brugia malayi	Major Facilitator Superfamily protein	0.0044	0.0244	0.1068
Mycobacterium ulcerans	integral membrane transport protein	0.0044	0.0244	0.5544
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0035	0.0173	0.0758
Mycobacterium tuberculosis	Probable conserved integral membrane transport protein	0.0044	0.0244	0.1382
Leishmania major	hypothetical protein, conserved	0.0016	0.0028	0.0381
Echinococcus granulosus	geminin	0.0164	0.1142	0.3382
Entamoeba histolytica	protein kinase, putative	0.0097	0.0638	1
Schistosoma mansoni	protein kinase	0.0097	0.0638	0.2648
Leishmania major	hypothetical protein, conserved	0.0016	0.0028	0.0381
Trypanosoma cruzi	hexose transporter, putative	0.0098	0.0647	0.8731
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0044	0.0191
Brugia malayi	Sugar transporter family protein	0.0316	0.2287	1
Echinococcus granulosus	beta LACTamase domain containing family member	0.0035	0.0173	0.0399
Trypanosoma brucei	glucose transporter, putative	0.0098	0.0647	0.8731
Onchocerca volvulus		0.0044	0.0244	1
Echinococcus multilocularis	calcium dependent protein kinase	0.0091	0.0593	0.1691
Trichomonas vaginalis	threonyl-tRNA synthetase, putative	0.0018	0.0044	0.0069
Trichomonas vaginalis	conserved hypothetical protein	0.0316	0.2287	1
Mycobacterium tuberculosis	Conserved protein	0.0035	0.0173	0.0928
Trichomonas vaginalis	D-aminoacylase, putative	0.0035	0.0173	0.0642
Brugia malayi	beta-lactamase family protein	0.0035	0.0173	0.0758
Plasmodium falciparum	hexose transporter	0.0316	0.2287	0.2253
Trichomonas vaginalis	sugar transporter, putative	0.0044	0.0244	0.0956
Mycobacterium tuberculosis	Probable threonyl-tRNA synthetase ThrS (threonine-tRNA synthetase)(ThrRS) (threonine-tRNA ligase)	0.0018	0.0044	0.01
Onchocerca volvulus		0.0044	0.0244	1
Schistosoma mansoni	nuclear transcription factor X-box binding 1 (nfx1)	0.0044	0.0244	0.0894
Loa Loa (eye worm)	hypothetical protein	0.0095	0.0623	0.2725
Trypanosoma brucei	lysyl-tRNA synthetase, putative	0.0071	0.0441	0.5944
Trichomonas vaginalis	D-aminoacylase, putative	0.0035	0.0173	0.0642
Trichomonas vaginalis	sugar transporter, putative	0.0044	0.0244	0.0956
Schistosoma mansoni	sugar transporter	0.0044	0.0244	0.0894
Trichomonas vaginalis	sugar transporter, putative	0.0044	0.0244	0.0956
Echinococcus multilocularis	neuropeptide s receptor	0.045	0.3292	1
Trichomonas vaginalis	sugar transporter, putative	0.0098	0.0647	0.274
Plasmodium falciparum	calcium-dependent protein kinase 4	0.0097	0.0638	0.0597

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 692301