Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | mitogen activated protein kinase 3 | 0.005 | 0.2499 | 0.2499 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0158 | 1 | 1 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0158 | 1 | 1 |
Schistosoma mansoni | intermediate filament proteins | 0.0028 | 0.0993 | 0.0406 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0116 | 0.7099 | 0.7099 |
Trichomonas vaginalis | CMGC family protein kinase | 0.005 | 0.2499 | 0.176 |
Brugia malayi | Carboxylesterase family protein | 0.0027 | 0.092 | 0.0826 |
Loa Loa (eye worm) | carboxylesterase | 0.0027 | 0.092 | 0.092 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0026 | 0.0852 | 0.2655 |
Schistosoma mansoni | BC026374 protein (S09 family) | 0.0027 | 0.092 | 0.0328 |
Echinococcus multilocularis | para nitrobenzyl esterase | 0.0027 | 0.092 | 0.092 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0027 | 0.092 | 0.0332 |
Leishmania major | mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 | 0.005 | 0.2499 | 1 |
Echinococcus granulosus | Aminotransferase class III | 0.0022 | 0.0612 | 0.0612 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.0958 | 0.0958 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.092 | 0.092 |
Echinococcus multilocularis | ornithine aminotransferase | 0.0022 | 0.0612 | 0.0612 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0027 | 0.092 | 0.0332 |
Echinococcus granulosus | mitogen activated protein kinase | 0.005 | 0.2499 | 0.2499 |
Echinococcus granulosus | lamin dm0 | 0.0028 | 0.0993 | 0.0993 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0027 | 0.092 | 0.0332 |
Brugia malayi | Carboxylesterase family protein | 0.0158 | 1 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0139 | 0.8657 | 0.8657 |
Brugia malayi | intermediate filament protein | 0.0028 | 0.0993 | 0.09 |
Chlamydia trachomatis | glutamate-1-semialdehyde-2,1-aminomutase | 0.0022 | 0.0612 | 0.5 |
Echinococcus granulosus | lamin | 0.0028 | 0.0993 | 0.0993 |
Echinococcus multilocularis | mitogen activated protein kinase 3 | 0.005 | 0.2499 | 0.2499 |
Echinococcus granulosus | acetylcholinesterase | 0.0158 | 1 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.0027 | 0.092 | 0.092 |
Giardia lamblia | Kinase, CMGC MAPK | 0.005 | 0.2499 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.092 | 0.092 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0139 | 0.8657 | 0.8657 |
Echinococcus multilocularis | FAD linked sulfhydryl oxidase ALR | 0.0035 | 0.1515 | 0.1515 |
Echinococcus multilocularis | Aminotransferase class III | 0.0022 | 0.0612 | 0.0612 |
Echinococcus granulosus | FAD linked sulfhydryl oxidase ALR | 0.0035 | 0.1515 | 0.1515 |
Echinococcus multilocularis | family S9 non peptidase ue (S09 family) | 0.0027 | 0.092 | 0.092 |
Brugia malayi | Carboxylesterase family protein | 0.0027 | 0.092 | 0.0826 |
Trypanosoma cruzi | mitogen activated protein kinase 4, putative | 0.005 | 0.2499 | 1 |
Trypanosoma cruzi | ERV/ALR sulfhydryl oxidase domain-containing protein | 0.0035 | 0.1515 | 0.4027 |
Brugia malayi | hypothetical protein | 0.0027 | 0.092 | 0.0826 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0028 | 0.0993 | 0.09 |
Schistosoma mansoni | neuroligin 3 (S09 family) | 0.0027 | 0.092 | 0.0328 |
Toxoplasma gondii | Erv1 / Alr family protein | 0.0035 | 0.1515 | 0.4786 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0026 | 0.0852 | 0.2655 |
Leishmania major | hypothetical protein, conserved | 0.0035 | 0.1515 | 0.4027 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.092 | 0.092 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.092 | 0.092 |
Schistosoma mansoni | lamin | 0.0028 | 0.0993 | 0.0406 |
Echinococcus multilocularis | musashi | 0.0028 | 0.0993 | 0.0993 |
Trichomonas vaginalis | acetylornithine aminotransferase, putative | 0.0156 | 0.9892 | 1 |
Echinococcus granulosus | intermediate filament protein | 0.0028 | 0.0993 | 0.0993 |
Brugia malayi | MAP kinase sur-1 | 0.005 | 0.2499 | 0.2422 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0028 | 0.0993 | 0.0993 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0116 | 0.7099 | 0.7099 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0027 | 0.092 | 0.0328 |
Trichomonas vaginalis | CMGC family protein kinase | 0.005 | 0.2499 | 0.176 |
Brugia malayi | hypothetical protein | 0.0017 | 0.0222 | 0.0121 |
Loa Loa (eye worm) | CMGC/MAPK/ERK1 protein kinase | 0.005 | 0.2499 | 0.2499 |
Loa Loa (eye worm) | hypothetical protein | 0.0158 | 1 | 1 |
Toxoplasma gondii | Erv1 / Alr family protein | 0.0035 | 0.1515 | 0.4786 |
Schistosoma mansoni | serine/threonine protein kinase | 0.005 | 0.2499 | 0.201 |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.0015 | 0.0102 | 0.0102 |
Brugia malayi | hypothetical protein | 0.0026 | 0.0852 | 0.0757 |
Brugia malayi | Carboxylesterase family protein | 0.0027 | 0.092 | 0.0826 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.092 | 0.092 |
Trypanosoma brucei | ERV/ALR sulfhydryl oxidase domain-containing protein | 0.0035 | 0.1515 | 0.4027 |
Mycobacterium ulcerans | adenosylmethionine-8-amino-7-oxononanoate aminotransferase | 0.0156 | 0.9892 | 1 |
Trypanosoma cruzi | mitogen activated protein kinase 2, putative | 0.005 | 0.2499 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.005 | 0.2499 | 0.176 |
Echinococcus multilocularis | acetylcholinesterase | 0.0158 | 1 | 1 |
Echinococcus multilocularis | lamin | 0.0028 | 0.0993 | 0.0993 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0139 | 0.8657 | 0.8657 |
Echinococcus granulosus | ornithine aminotransferase | 0.0022 | 0.0612 | 0.0612 |
Brugia malayi | MH2 domain containing protein | 0.0116 | 0.7099 | 0.707 |
Echinococcus granulosus | para nitrobenzyl esterase | 0.0027 | 0.092 | 0.092 |
Brugia malayi | Carboxylesterase family protein | 0.0027 | 0.092 | 0.0826 |
Echinococcus multilocularis | acetylcholinesterase | 0.0158 | 1 | 1 |
Plasmodium falciparum | FAD-linked sulfhydryl oxidase ERV1, putative | 0.0035 | 0.1515 | 1 |
Echinococcus granulosus | BC026374 protein S09 family | 0.0027 | 0.092 | 0.092 |
Mycobacterium leprae | PROBABLE ADENOSYLMETHIONINE-8-AMINO-7-OXONONANOATE AMINOTRANSFERASE BIOA | 0.0156 | 0.9892 | 1 |
Echinococcus multilocularis | mitogen activated protein kinase | 0.005 | 0.2499 | 0.2499 |
Plasmodium vivax | FAD-linked sulfhydryl oxidase ERV1, putative | 0.0035 | 0.1515 | 1 |
Onchocerca volvulus | 0.0028 | 0.0993 | 1 | |
Onchocerca volvulus | 0.0028 | 0.0993 | 1 | |
Echinococcus multilocularis | neuroligin | 0.0027 | 0.092 | 0.092 |
Wolbachia endosymbiont of Brugia malayi | acetylornithine transaminase protein | 0.0022 | 0.0612 | 0.5 |
Trypanosoma brucei | mitogen activated protein kinase 4, putative | 0.005 | 0.2499 | 1 |
Loa Loa (eye worm) | hepatopoietin HPO2 | 0.0035 | 0.1515 | 0.1515 |
Brugia malayi | 4-aminobutyrate aminotransferase, mitochondrial precursor | 0.0022 | 0.0612 | 0.0515 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0158 | 1 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0139 | 0.8657 | 0.8569 |
Echinococcus multilocularis | ornithine aminotransferase | 0.0022 | 0.0612 | 0.0612 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0139 | 0.8657 | 0.8657 |
Loa Loa (eye worm) | carboxylesterase | 0.0158 | 1 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0139 | 0.8657 | 0.8569 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0852 | 0.0852 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0026 | 0.0852 | 0.1271 |
Echinococcus granulosus | neuroligin | 0.0027 | 0.092 | 0.092 |
Toxoplasma gondii | CMGC kinase, MAPK family (ERK) MAPK-1 | 0.005 | 0.2499 | 1 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0027 | 0.092 | 0.0332 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.005 | 0.2499 | 1 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.005 | 0.2499 | 1 |
Mycobacterium tuberculosis | Probable aminotransferase | 0.0156 | 0.9892 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.092 | 0.092 |
Schistosoma mansoni | lamin | 0.0028 | 0.0993 | 0.0406 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0027 | 0.092 | 0.0328 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0139 | 0.8657 | 0.8657 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0027 | 0.092 | 0.0328 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0139 | 0.8657 | 0.8643 |
Echinococcus multilocularis | BC026374 protein (S09 family) | 0.0027 | 0.092 | 0.092 |
Mycobacterium tuberculosis | Adenosylmethionine-8-amino-7-oxononanoate aminotransferase BioA | 0.0156 | 0.9892 | 1 |
Echinococcus multilocularis | lamin dm0 | 0.0028 | 0.0993 | 0.0993 |
Echinococcus granulosus | carboxylesterase 5A | 0.0158 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.0993 | 0.0993 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0139 | 0.8657 | 0.8569 |
Leishmania major | mitogen activated protein kinase, putative,map kinase, putative | 0.005 | 0.2499 | 1 |
Trypanosoma cruzi | Present in the outer mitochondrial membrane proteome 4 | 0.0035 | 0.1515 | 0.4027 |
Echinococcus granulosus | acetylcholinesterase | 0.0158 | 1 | 1 |
Echinococcus granulosus | family S9 non peptidase ue S09 family | 0.0027 | 0.092 | 0.092 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0026 | 0.0852 | 0.2655 |
Loa Loa (eye worm) | hypothetical protein | 0.0158 | 1 | 1 |
Loa Loa (eye worm) | intermediate filament protein | 0.0028 | 0.0993 | 0.0993 |
Schistosoma mansoni | gliotactin | 0.0027 | 0.092 | 0.0328 |
Trypanosoma brucei | protein kinase, putative | 0.005 | 0.2499 | 1 |
Schistosoma mansoni | acetylcholinesterase | 0.0027 | 0.092 | 0.0328 |
Mycobacterium ulcerans | hypothetical protein | 0.0156 | 0.9892 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.005 | 0.2499 | 0.176 |
Trypanosoma cruzi | Present in the outer mitochondrial membrane proteome 4 | 0.0035 | 0.1515 | 0.4027 |
Brugia malayi | Augmenter of liver regeneration | 0.0035 | 0.1515 | 0.1428 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.092 | 0.092 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.