TDR Targets

Basic information

Technical information

TDR Targets ID: 708248
Name: (2-hydroxyphenyl)-(4-phenylpiperazin-1-yl)met hanone
MW: 282.337 | Formula: C17H18N2O2
H donors: 1 H acceptors: 2 LogP: 3.17 Rotable bonds: 3
Rule of 5 violations (Lipinski): 1
SMILES: Oc1ccccc1C(=O)N1CCN(CC1)c1ccccc1
InChi: 1S/C17H18N2O2/c20-16-9-5-4-8-15(16)17(21)19-12-10-18(11-13-19)14-6-2-1-3-7-14/h1-9,20H,10-13H2
InChiKey: NOHGADGSCOCIER-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

(2-hydroxyphenyl)-(4-phenyl-1-piperazinyl)methanone
SBB009869
AG-205/40776331
ZINC00340345

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Entamoeba histolytica	hypothetical protein	0.0035	0.0787	0.2184
Echinococcus granulosus	cation transporting ATPase 13A3	0.0008	0.0107	0.0033
Schistosoma mansoni	ferritin	0.0008	0.0108	0.0108
Echinococcus multilocularis	cation transporting atpase worm	0.0008	0.0107	0.0033
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0048	0.1129	0.1232
Echinococcus multilocularis	dihydropyrimidine dehydrogenase (NADP+)	0.013	0.3219	0.3168
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0009	0.0118	0.0044
Brugia malayi	Dihydroorotate dehydrogenase, mitochondrial precursor, putative	0.0333	0.8403	1
Schistosoma mansoni	hypothetical protein	0.0395	1	1
Echinococcus multilocularis	phosphoserine phosphatase	0.0008	0.0107	0.0033
Schistosoma mansoni	type V p-type atpase isoform	0.0008	0.0107	0.0107
Schistosoma mansoni	apoferritin-2	0.0008	0.0108	0.0108
Schistosoma mansoni	cation-transporting atpase worm	0.0008	0.0107	0.0107
Echinococcus granulosus	ferritin	0.0008	0.0108	0.0033
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0059	0.1403	0.1403
Schistosoma mansoni	apoferritin-2	0.0008	0.0108	0.0108
Mycobacterium ulcerans	bacterioferritin BfrB	0.0008	0.0108	0.0001
Echinococcus granulosus	dihydropyrimidine dehydrogenase NADP	0.013	0.3219	0.3168
Schistosoma mansoni	ATPase	0.0008	0.0107	0.0107
Plasmodium vivax	dihydroorotate dehydrogenase, mitochondrial precursor, putative	0.0333	0.8403	1
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0009	0.0118	0.0044
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0007	0.0074	0.0074
Loa Loa (eye worm)	hypothetical protein	0.0085	0.2075	1
Mycobacterium ulcerans	bacterioferritin BfrA	0.0008	0.0108	0.0001
Echinococcus granulosus	plasma membrane calcium transporting ATPase 2	0.0008	0.0107	0.0033
Trichomonas vaginalis	phospholipid-transporting ATPase, putative	0.0008	0.0107	0.0152
Echinococcus multilocularis	phosphoserine phosphatase	0.0008	0.0107	0.0033
Trichomonas vaginalis	plasma membrane calcium-transporting ATPase, putative	0.0008	0.0107	0.0152
Trichomonas vaginalis	dihydroorotate dehydrogenase, putative	0.013	0.3219	1
Trichomonas vaginalis	plasma membrane calcium-transporting ATPase, putative	0.0008	0.0107	0.0152
Echinococcus multilocularis	phospholipid transporting ATPase VA	0.0008	0.0107	0.0033
Trichomonas vaginalis	cation-transporting ATPase, putative	0.0008	0.0107	0.0152
Brugia malayi	hypothetical protein	0.0085	0.2075	0.2372
Echinococcus multilocularis	sarco:endoplasmic reticulum calcium ATPase	0.0008	0.0107	0.0033
Schistosoma mansoni	cpg binding protein	0.0028	0.0608	0.0608
Trichomonas vaginalis	cation-transporting ATPase, putative	0.0008	0.0107	0.0152
Schistosoma mansoni	ferritin	0.0008	0.0108	0.0108
Onchocerca volvulus		0.0028	0.0608	1
Giardia lamblia	Plasma membrane calcium-transporting ATPase 2	0.0008	0.0107	0.5
Loa Loa (eye worm)	hypothetical protein	0.0048	0.1129	0.5196
Schistosoma mansoni	Na+/K+ transporting ATPase subunit alpha	0.0008	0.0107	0.0107
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0015	0.0288	0.0215
Schistosoma mansoni	ATPase	0.0008	0.0107	0.0107
Brugia malayi	hypothetical protein	0.0035	0.0787	0.0819
Treponema pallidum	bacterioferrin (TpF1)	0.0008	0.0108	1
Schistosoma mansoni	ferritin light chain	0.0008	0.0108	0.0108
Trypanosoma cruzi	dihydroorotate dehydrogenase, putative	0.0333	0.8403	1
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0288	0.0919
Schistosoma mansoni	transcription factor LCR-F1	0.0035	0.0787	0.0787
Trichomonas vaginalis	plasma membrane calcium-transporting ATPase, putative	0.0008	0.0107	0.0152
Brugia malayi	Zinc finger, C2H2 type family protein	0.013	0.3219	0.3751
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0053	0.1242	0.1368
Schistosoma mansoni	ferritin light chain	0.0008	0.0108	0.0108
Echinococcus granulosus	phospholipid transporting ATPase IIB	0.0008	0.0107	0.0033
Loa Loa (eye worm)	histone methyltransferase	0.0009	0.0118	0.0054
Echinococcus multilocularis	phosphoserine phosphatase	0.0008	0.0107	0.0033
Mycobacterium tuberculosis	Probable bacterioferritin BfrA	0.0008	0.0108	0.0001
Schistosoma mansoni	cpg binding protein	0.0029	0.0648	0.0648
Brugia malayi	Latrophilin receptor protein 2	0.0015	0.0288	0.0218
Giardia lamblia	Phospholipid-transporting ATPase IA, putative	0.0008	0.0107	0.5
Echinococcus granulosus	sarco:endoplasmic reticulum calcium ATPase	0.0008	0.0107	0.0033
Echinococcus multilocularis	calcium transporting ATPase type 2C member	0.0008	0.0107	0.0033
Echinococcus granulosus	cpg binding protein	0.0029	0.0648	0.0578
Echinococcus multilocularis	phosphoserine phosphatase	0.0008	0.0107	0.0033
Echinococcus multilocularis	phospholipid transporting ATPase IIB	0.0008	0.0107	0.0033
Schistosoma mansoni	ferritin	0.0008	0.0108	0.0108
Trypanosoma brucei	dihydroorotate dehydrogenase (fumarate)	0.0333	0.8403	1
Schistosoma mansoni	hypothetical protein	0.0015	0.0288	0.0288
Schistosoma mansoni	cpg binding protein	0.0029	0.0648	0.0648
Echinococcus multilocularis	phosphoserine phosphatase	0.0008	0.0107	0.0033
Mycobacterium leprae	Probable dihydroorotate dehydrogenase PyrD	0.0333	0.8403	1
Schistosoma mansoni	hypothetical protein	0.0035	0.0787	0.0787
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0048	0.1129	0.1232
Mycobacterium ulcerans	dihydroorotate dehydrogenase 2	0.0333	0.8403	1
Entamoeba histolytica	dihydropyrimidine dehydrogenase, putative	0.013	0.3219	1
Schistosoma mansoni	hypothetical protein	0.0015	0.0288	0.0288
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0028	0.0608	0.2544
Toxoplasma gondii	dihydroorotate dehydrogenase reveal, putative	0.0333	0.8403	1
Schistosoma mansoni	eyes absent homolog	0.0085	0.2075	0.2075
Trichomonas vaginalis	ATPase, class VI, type 11C, putative	0.0008	0.0107	0.0152
Trichomonas vaginalis	ATPase, class I, type 8B, putative	0.0008	0.0107	0.0152
Entamoeba histolytica	hypothetical protein	0.0035	0.0787	0.2184
Echinococcus granulosus	copper transporting ATPase 1	0.0008	0.0107	0.0033
Schistosoma mansoni	copper ABC transporter ATPase	0.0008	0.0107	0.0107
Schistosoma mansoni	cation-transporting atpase worm	0.0008	0.0107	0.0107
Echinococcus granulosus	GPCR family 2	0.0015	0.0288	0.0215
Entamoeba histolytica	hypothetical protein	0.0035	0.0787	0.2184
Echinococcus multilocularis	Tetracycline resistance leader peptide, TetL	0.0008	0.0107	0.0033
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0015	0.0288	0.0919
Echinococcus multilocularis	GPCR, family 2	0.0015	0.0288	0.0215
Trichomonas vaginalis	cation-transporting ATPase, putative	0.0008	0.0107	0.0152
Trypanosoma cruzi	dihydroorotate dehydrogenase, putative	0.013	0.3219	0.3751
Echinococcus granulosus	cation transporting ATPase 13A1	0.0008	0.0107	0.0033
Schistosoma mansoni	atpase class VI type 11c	0.0008	0.0107	0.0107
Echinococcus multilocularis	copper transporting ATPase 1	0.0008	0.0107	0.0033
Brugia malayi	CXXC zinc finger family protein	0.0028	0.0608	0.0603
Mycobacterium leprae	PROBABLE BACTERIOFERRITIN BFRA	0.0008	0.0108	0.0001
Trypanosoma cruzi	dihydroorotate dehydrogenase, putative	0.0333	0.8403	1
Echinococcus multilocularis	dihydropyrimidine dehydrogenase (NADP+)	0.013	0.3219	0.3168
Schistosoma mansoni	hypothetical protein	0.0015	0.0288	0.0288
Echinococcus multilocularis	expressed protein	0.0008	0.0108	0.0033
Echinococcus multilocularis	cation transporting ATPase 13A3	0.0008	0.0107	0.0033
Trichomonas vaginalis	plasma membrane calcium-transporting ATPase, putative	0.0008	0.0107	0.0152
Schistosoma mansoni	cation-transporting ATPase	0.0008	0.0107	0.0107
Trichomonas vaginalis	dihydroorotate dehydrogenase, putative	0.013	0.3219	1
Echinococcus multilocularis	cation transporting ATPase 13A1	0.0008	0.0107	0.0033
Trichomonas vaginalis	dihydroorotate dehydrogenase, putative	0.013	0.3219	1
Echinococcus granulosus	cation transporting atpase worm	0.0008	0.0107	0.0033
Mycobacterium tuberculosis	Probable dihydroorotate dehydrogenase PyrD	0.0333	0.8403	1
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0015	0.0288	0.0215
Wolbachia endosymbiont of Brugia malayi	dihydroorotate dehydrogenase 2	0.0333	0.8403	1
Schistosoma mansoni	hypothetical protein	0.0015	0.0288	0.0288
Echinococcus granulosus	expressed protein	0.0008	0.0108	0.0033
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0015	0.0288	0.0215
Entamoeba histolytica	hypothetical protein	0.0035	0.0787	0.2184
Echinococcus granulosus	phospholipid transporting ATPase VA	0.0008	0.0107	0.0033
Trichomonas vaginalis	dihydropyrimidine dehydrogenase, putative	0.013	0.3219	1
Echinococcus granulosus	dihydropyrimidine dehydrogenase NADP	0.013	0.3219	0.3168
Plasmodium falciparum	dihydroorotate dehydrogenase	0.0333	0.8403	1
Giardia lamblia	Copper-transporting P-type ATPase	0.0008	0.0107	0.5
Trichomonas vaginalis	dihydroorotate dehydrogenase, putative	0.013	0.3219	1
Trypanosoma cruzi	dihydroorotate dehydrogenase (fumarate), putative	0.0333	0.8403	1
Echinococcus multilocularis	phosphoserine phosphatase	0.0008	0.0107	0.0033
Trichomonas vaginalis	cation-transporting ATPase, putative	0.0008	0.0107	0.0152
Trichomonas vaginalis	cation-transporting ATPase fungi, putative	0.0008	0.0107	0.0152
Schistosoma mansoni	dihydroorotate dehydrogenase	0.0333	0.8403	0.8403
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0035	0.0787	0.0718
Schistosoma mansoni	cation-transporting atpase 13a1 (G-box binding protein)	0.0008	0.0107	0.0107
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0035	0.0787	0.0718
Schistosoma mansoni	hypothetical protein	0.0033	0.074	0.074
Leishmania major	dihydroorotate dehydrogenase	0.0333	0.8403	1
Schistosoma mansoni	ferritin	0.0008	0.0108	0.0108
Loa Loa (eye worm)	hypothetical protein	0.0085	0.2075	1
Mycobacterium tuberculosis	Bacterioferritin BfrB	0.0008	0.0108	0.0001
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0015	0.0288	0.0218
Chlamydia trachomatis	metal transport ATPase	0.0008	0.0107	0.5
Loa Loa (eye worm)	hypothetical protein	0.0033	0.074	0.3217
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0048	0.1129	0.5196
Trichomonas vaginalis	dihydroorotate dehydrogenase, putative	0.013	0.3219	1
Trichomonas vaginalis	ferritin, putative	0.0008	0.0108	0.0154
Echinococcus multilocularis	dnaJ subfamily B	0.0395	1	1
Echinococcus granulosus	calcium transporting ATPase type 2C member	0.0008	0.0107	0.0033
Trichomonas vaginalis	cation-transporting ATPase, putative	0.0008	0.0107	0.0152
Brugia malayi	F/Y-rich N-terminus family protein	0.0008	0.0115	0.001
Echinococcus multilocularis	cpg binding protein	0.0029	0.0648	0.0578
Brugia malayi	Dihydroorotate dehydrogenase, mitochondrial precursor, putative	0.0333	0.8403	1
Echinococcus multilocularis	ferritin	0.0008	0.0108	0.0033
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0015	0.0288	0.0215
Trichomonas vaginalis	plasma membrane calcium-transporting ATPase, putative	0.0008	0.0107	0.0152
Brugia malayi	latrophilin 2 splice variant baaae	0.0033	0.074	0.0763
Schistosoma mansoni	phosphoserine phosphatase	0.0008	0.0107	0.0107

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 708248