Detailed information for compound 709809

Basic information

Technical information
  • TDR Targets ID: 709809
  • Name: N-[4-[[[2-(4-methoxyphenyl)acetyl]amino]carba moyl]phenyl]pentanamide
  • MW: 383.441 | Formula: C21H25N3O4
  • H donors: 3 H acceptors: 3 LogP: 2.82 Rotable bonds: 12
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCCC(=O)Nc1ccc(cc1)C(=O)NNC(=O)Cc1ccc(cc1)OC
  • InChi: 1S/C21H25N3O4/c1-3-4-5-19(25)22-17-10-8-16(9-11-17)21(27)24-23-20(26)14-15-6-12-18(28-2)13-7-15/h6-13H,3-5,14H2,1-2H3,(H,22,25)(H,23,26)(H,24,27)
  • InChiKey: RPMVLVXONBGEKL-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-[4-[[N'-[2-(4-methoxyphenyl)-1-oxoethyl]hydrazino]-oxomethyl]phenyl]pentanamide
  • N-[4-[[[2-(4-methoxyphenyl)acetyl]amino]carbamoyl]phenyl]valeramide
  • N-[4-[[2-(4-methoxyphenyl)ethanoylamino]carbamoyl]phenyl]pentanamide
  • ARONIS008152
  • ZINC02868959
  • ALD-N009165

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0023 0.0305 0.4997
Onchocerca volvulus 0.0015 0.0105 0.1794
Brugia malayi beta-lactamase 0.0035 0.0588 0.2699
Echinococcus multilocularis Sugar transporter ERD6 protein 0.0015 0.0105 0.0362
Trichomonas vaginalis conserved hypothetical protein 0.0104 0.2178 1
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.0168 0.3663 0.3595
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0588 0.9564
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0023 0.0305 0.0961
Schistosoma mansoni thyroid hormone receptor 0.0136 0.291 1
Loa Loa (eye worm) hypothetical protein 0.0031 0.049 0.2249
Trypanosoma brucei THT1 - hexose transporter, putative 0.0032 0.0514 0.8218
Toxoplasma gondii facilitative glucose transporter GT1 0.0104 0.2178 0.3201
Brugia malayi Major Facilitator Superfamily protein 0.0015 0.0105 0.0484
Trypanosoma brucei glucose transporter, putative 0.0032 0.0514 0.8218
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0212 0.2123
Leishmania major glucose transporter, lmgt3 0.0032 0.0514 0.8107
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0032 0.0505 0.1735
Trypanosoma brucei sugar transporter, putative 0.0015 0.0105 0.0586
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0019 0.0212 0.2123
Schistosoma mansoni protein kinase 0.0032 0.0505 0.1735
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0212 0.2123
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0104 0.2178 0.8137
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0035 0.0588 0.0983
Echinococcus multilocularis calcium dependent protein kinase 0.003 0.0459 0.1578
Trypanosoma brucei myo-inositol/proton symporter (MIT) 0.0015 0.0105 0.0586
Plasmodium vivax calcium-dependent protein kinase, putative 0.0032 0.0505 0.0404
Onchocerca volvulus 0.0015 0.0105 0.1794
Schistosoma mansoni lysyl-tRNA synthetase 0.0023 0.0305 0.1047
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0036 0.061 1
Toxoplasma gondii protein kinase, putative 0.0294 0.6579 1
Loa Loa (eye worm) hypothetical protein 0.0035 0.0588 0.2699
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0032 0.0505 0.1735
Loa Loa (eye worm) sugar transporter 0.0015 0.0105 0.0484
Schistosoma mansoni glucose transport protein 0.0104 0.2178 0.7484
Trypanosoma brucei DNA polymerase eta, putative 0.0019 0.0212 0.2585
Mycobacterium tuberculosis Conserved protein 0.0035 0.0588 0.0983
Wolbachia endosymbiont of Brugia malayi major facilitator superfamily permease 0.0015 0.0105 0.5
Brugia malayi Sugar transporter family protein 0.0015 0.0105 0.0484
Mycobacterium ulcerans hypothetical protein 0.0035 0.0588 1
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0031 0.049 0.1683
Trypanosoma cruzi hexose transporter 0.0032 0.0514 0.8107
Echinococcus granulosus solute carrier family 22 0.0015 0.0105 0.0394
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0588 0.9564
Schistosoma mansoni transcription factor LCR-F1 0.0036 0.0598 0.2055
Entamoeba histolytica hypothetical protein 0.0036 0.0598 1
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0212 0.2585
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0227 0.5013 1
Giardia lamblia Prolyl-tRNA synthetase 0.0031 0.049 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0212 0.2585
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0031 0.049 0.1683
Echinococcus granulosus solute carrier family 22 0.0015 0.0105 0.0394
Echinococcus granulosus General substrate transporter 0.0089 0.1839 0.687
Loa Loa (eye worm) hypothetical protein 0.0015 0.0105 0.0484
Mycobacterium tuberculosis Probable hydrolase 0.0035 0.0588 0.0983
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0032 0.0505 0.0617
Trypanosoma brucei glucose transporter, putative 0.0032 0.0514 0.8218
Loa Loa (eye worm) hypothetical protein 0.0015 0.0105 0.0484
Trypanosoma cruzi hexose transporter, putative 0.0032 0.0514 0.8107
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0036 0.061 1
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.0036 0.061 0.0779
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0588 0.2019
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0126 0.2676 1
Echinococcus multilocularis solute carrier family 22 0.0015 0.0105 0.0362
Onchocerca volvulus 0.0015 0.0105 0.1794
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0212 0.2585
Echinococcus granulosus synaptic vesicle 2 protein 0.0015 0.0105 0.0394
Onchocerca volvulus 0.0015 0.0105 0.1794
Plasmodium falciparum calcium-dependent protein kinase 2 0.0032 0.0505 0.0404
Leishmania major glucose transporter, lmgt2 0.0032 0.0514 0.8107
Brugia malayi Sugar transporter family protein 0.0015 0.0105 0.0484
Schistosoma mansoni DNA polymerase eta 0.0019 0.0212 0.073
Trypanosoma cruzi hexose transporter, putative 0.0018 0.0175 0.1383
Schistosoma mansoni hypothetical protein 0.0126 0.2676 0.9197
Echinococcus multilocularis dna polymerase eta 0.0019 0.0212 0.073
Schistosoma mansoni glucose transport protein 0.0104 0.2178 0.7484
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0212 0.2585
Echinococcus granulosus calcium dependent protein kinase 0.003 0.0459 0.1715
Plasmodium vivax CDK-related protein kinase 6, putative 0.0442 1 1
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0212 0.3368
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0035 0.0588 0.2699
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0104 0.2178 0.7484
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.0031 0.049 0.1855
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0035 0.0588 0.0983
Loa Loa (eye worm) hypothetical protein 0.0015 0.0105 0.0484
Loa Loa (eye worm) hypothetical protein 0.0015 0.0105 0.0484
Loa Loa (eye worm) hypothetical protein 0.0015 0.0105 0.0484
Onchocerca volvulus 0.0035 0.0588 1
Mycobacterium tuberculosis Probable lipase LipE 0.0035 0.0588 0.0983
Trichomonas vaginalis esterase, putative 0.0035 0.0588 0.2327
Echinococcus multilocularis solute carrier family 22 0.0015 0.0105 0.0362
Echinococcus multilocularis lysyl tRNA synthetase 0.0023 0.0305 0.1047
Schistosoma mansoni glucose transport protein 0.0104 0.2178 0.7484
Schistosoma mansoni terminal deoxycytidyl transferase 0.0019 0.0212 0.073
Echinococcus granulosus dna polymerase kappa 0.0019 0.0212 0.0794
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0212 0.2585
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0032 0.0505 0.1735
Leishmania major glucose transporter/membrane transporter D2, putative 0.0032 0.0514 0.8107
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0212 0.2123
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0019 0.0212 0.0218
Plasmodium falciparum mitogen-activated protein kinase 2 0.0168 0.3663 0.3595
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0514 0.1973
Leishmania major hypothetical protein, conserved 0.0035 0.0588 0.9564
Chlamydia trachomatis lysine--tRNA ligase 0.0023 0.0305 1
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0031 0.049 0.2249
Schistosoma mansoni glucose transporter 0.0015 0.0105 0.0362
Echinococcus multilocularis synaptic vesicle 2 protein 0.0015 0.0105 0.0362
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0212 0.2585
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0104 0.2178 0.8137
Loa Loa (eye worm) hypothetical protein 0.0015 0.0105 0.0484
Entamoeba histolytica hypothetical protein 0.0023 0.0305 0.239
Mycobacterium ulcerans lipase LipD 0.0035 0.0588 1
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0104 0.2178 0.8137
Trypanosoma cruzi hexose transporter, putative 0.0032 0.0514 0.8107
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0212 0.2585
Mycobacterium tuberculosis Probable lipase LipD 0.0035 0.0588 0.0983
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0032 0.0505 0.1886
Loa Loa (eye worm) hypothetical protein 0.0035 0.0588 0.2699
Loa Loa (eye worm) hypothetical protein 0.0035 0.0588 0.2699
Leishmania major lysyl-tRNA synthetase, putative 0.0023 0.0305 0.395
Mycobacterium ulcerans integral membrane transport protein 0.0015 0.0105 0.1476
Loa Loa (eye worm) hypothetical protein 0.0015 0.0105 0.0484
Mycobacterium tuberculosis Probable esterase LipL 0.0035 0.0588 0.0983
Plasmodium falciparum calcium-dependent protein kinase 1 0.0032 0.0505 0.0404
Trypanosoma brucei glucose transporter, putative 0.0032 0.0514 0.8218
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0588 0.2327
Leishmania major DNA polymerase kappa, putative 0.0019 0.0212 0.2123
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.002 0.0223 0.0241
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.0031 0.049 0.183
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.0031 0.049 0.7313
Brugia malayi hypothetical protein 0.0036 0.0598 0.2746
Loa Loa (eye worm) hypothetical protein 0.0015 0.0105 0.0484
Loa Loa (eye worm) hypothetical protein 0.0035 0.0588 0.2699
Plasmodium falciparum lysine--tRNA ligase 0.0023 0.0305 0.0201
Brugia malayi beta-lactamase family protein 0.0035 0.0588 0.2699
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0032 0.0505 0.1735
Loa Loa (eye worm) hypothetical protein 0.0015 0.0105 0.0484
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX 0.002 0.0223 0.0241
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.002 0.0238 0.0641
Entamoeba histolytica protein kinase, putative 0.0032 0.0505 0.7581
Trichomonas vaginalis DNA polymerase eta, putative 0.0019 0.0212 0.0517
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0032 0.0505 0.2318
Echinococcus multilocularis thyroid hormone receptor alpha 0.0136 0.291 1
Plasmodium falciparum protein kinase 7 0.0294 0.6579 0.6542
Schistosoma mansoni hypothetical protein 0.0036 0.0598 0.2055
Loa Loa (eye worm) beta-lactamase 0.0035 0.0588 0.2699
Entamoeba histolytica hypothetical protein 0.0036 0.0598 1
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0212 0.3368
Loa Loa (eye worm) hypothetical protein 0.0019 0.0212 0.0976
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.0036 0.061 1
Loa Loa (eye worm) hypothetical protein 0.0015 0.0105 0.0484
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0588 0.0487
Schistosoma mansoni thyroid hormone receptor 0.0136 0.291 1
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0104 0.2178 0.8137
Loa Loa (eye worm) bifunctional aminoacyl-tRNA synthetase 0.0013 0.0063 0.0291
Echinococcus granulosus lysyl tRNA synthetase 0.0023 0.0305 0.1138
Onchocerca volvulus Putative transporter 0.0015 0.0105 0.1794
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0036 0.061 1
Onchocerca volvulus 0.0015 0.0105 0.1794
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0514 0.1973
Plasmodium vivax proline--tRNA ligase, putative 0.0036 0.061 0.051
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0212 0.0976
Brugia malayi major facilitator superfamily protein 0.0015 0.0105 0.0484
Onchocerca volvulus 0.0015 0.0105 0.1794
Loa Loa (eye worm) hypothetical protein 0.0023 0.0305 0.1399
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0588 0.2327
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0126 0.2676 0.9197
Trypanosoma brucei glucose transporter 1E 0.0032 0.0514 0.8218
Schistosoma mansoni sugar transporter 0.0015 0.0105 0.0362
Onchocerca volvulus 0.0015 0.0105 0.1794
Leishmania major protein kinase, putative 0.0032 0.0505 0.7919
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0588 0.2327
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0514 0.1973
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0032 0.0505 0.0617
Mycobacterium leprae Probable lipase LipE 0.0035 0.0588 1
Giardia lamblia Lysyl-tRNA synthetase 0.0023 0.0305 0.5182
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0019 0.0212 0.073
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0104 0.2178 0.7484
Loa Loa (eye worm) hypothetical protein 0.0032 0.0505 0.2318
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0032 0.0505 0.0404
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0019 0.0212 0.0517
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0019 0.0212 0.0794
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0032 0.0505 0.1886
Loa Loa (eye worm) major facilitator superfamily transporter 0.0015 0.0105 0.0484
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0035 0.0588 0.0983
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0212 0.2585
Trypanosoma brucei glucose transporter, putative 0.0032 0.0514 0.8218
Toxoplasma gondii ABC1 family protein 0.0035 0.0588 0.0745
Onchocerca volvulus 0.0035 0.0588 1
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0104 0.2178 0.7484
Onchocerca volvulus 0.0015 0.0105 0.1794
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.0168 0.3663 0.5495
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0036 0.0598 0.2234
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0032 0.0505 0.0404
Loa Loa (eye worm) hypothetical protein 0.0015 0.0105 0.0484
Schistosoma mansoni nuclear transcription factor X-box binding 1 (nfx1) 0.0015 0.0105 0.0362
Loa Loa (eye worm) hypothetical protein 0.0025 0.0354 0.1626
Onchocerca volvulus 0.0015 0.0105 0.1794
Toxoplasma gondii lysine-tRNA ligase 0.0023 0.0305 0.0308
Onchocerca volvulus 0.0015 0.0105 0.1794
Plasmodium falciparum calcium-dependent protein kinase 5 0.0032 0.0505 0.0404
Plasmodium falciparum calcium-dependent protein kinase 4 0.0032 0.0505 0.0404
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0032 0.0505 0.0404
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0036 0.0598 0.2055
Entamoeba histolytica protein kinase, putative 0.0032 0.0505 0.7581
Schistosoma mansoni hypothetical protein 0.0104 0.2178 0.7484
Brugia malayi hypothetical protein 0.0015 0.0105 0.0484
Plasmodium falciparum hexose transporter 0.0104 0.2178 0.2094
Loa Loa (eye worm) major facilitator superfamily transporter 0.0015 0.0105 0.0484
Brugia malayi Major Facilitator Superfamily protein 0.0015 0.0105 0.0484
Onchocerca volvulus 0.0035 0.0588 1
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0035 0.0588 0.2699
Mycobacterium leprae conserved hypothetical protein 0.0035 0.0588 1
Loa Loa (eye worm) sugar transporter 0.0104 0.2178 1
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0032 0.0505 0.2318
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0212 0.2585
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0023 0.0305 0.2228
Brugia malayi hypothetical protein 0.0015 0.0105 0.0484
Echinococcus multilocularis General substrate transporter 0.0089 0.1839 0.6318
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0212 0.2585
Brugia malayi hypothetical protein 0.0015 0.0105 0.0484
Plasmodium falciparum calcium-dependent protein kinase 3 0.0032 0.0505 0.0404
Mycobacterium tuberculosis Conserved protein 0.0035 0.0588 0.0983
Trypanosoma brucei THT1 - hexose transporter, putative 0.0032 0.0514 0.8218
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0588 0.2019
Plasmodium vivax hexose transporter 0.0104 0.2178 0.2094
Schistosoma mansoni protein kinase 0.0032 0.0505 0.1735
Trichomonas vaginalis glucose transporter, putative 0.0032 0.0514 0.1973
Echinococcus multilocularis beta LACTamase domain containing family member 0.0035 0.0588 0.2019
Onchocerca volvulus 0.0015 0.0105 0.1794
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0036 0.061 1
Echinococcus granulosus dna polymerase eta 0.0019 0.0212 0.0794
Echinococcus granulosus solute carrier family 22 0.0015 0.0105 0.0394
Loa Loa (eye worm) hypothetical protein 0.0015 0.0105 0.0484
Trypanosoma brucei glucose transporter, putative 0.0032 0.0514 0.8218
Mycobacterium ulcerans sugar transporter 0.0015 0.0105 0.1476
Trichomonas vaginalis glucose transporter, putative 0.0032 0.0514 0.1973
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0588 0.2327
Echinococcus granulosus beta LACTamase domain containing family member 0.0035 0.0588 0.2196
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0212 0.2123
Trypanosoma brucei glucose transporter, putative 0.0032 0.0514 0.8218
Loa Loa (eye worm) hypothetical protein 0.0015 0.0105 0.0484
Giardia lamblia DINP protein human, muc B family 0.0019 0.0212 0.2785
Onchocerca volvulus 0.0015 0.0105 0.1794
Plasmodium falciparum proline--tRNA ligase 0.0036 0.061 0.051
Trypanosoma brucei glucose transporter 2A 0.0032 0.0514 0.8218
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0019 0.0212 0.073
Brugia malayi lysyl-tRNA synthetase 0.0023 0.0305 0.1399
Schistosoma mansoni lysyl-tRNA synthetase 0.0023 0.0305 0.1047
Mycobacterium ulcerans esterase/lipase LipP 0.0035 0.0588 1
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0032 0.0505 0.1886
Mycobacterium ulcerans sugar-transport integral membrane protein SugI 0.0015 0.0105 0.1476
Brugia malayi beta-lactamase family protein 0.0035 0.0588 0.2699
Entamoeba histolytica hypothetical protein 0.0036 0.0598 1
Brugia malayi Sugar transporter family protein 0.0104 0.2178 1
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.0031 0.049 0.1683
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.0031 0.049 0.7194
Echinococcus granulosus solute carrier family 22 0.0015 0.0105 0.0394
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0032 0.0505 0.0617
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0514 0.1973
Mycobacterium tuberculosis Conserved protein 0.0035 0.0588 0.0983
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0212 0.0976
Mycobacterium tuberculosis Conserved hypothetical protein 0.0019 0.0212 0.0218
Loa Loa (eye worm) hypothetical protein 0.0035 0.0588 0.2699
Onchocerca volvulus 0.0015 0.0105 0.1794
Schistosoma mansoni sugar transporter 0.0015 0.0105 0.0362
Onchocerca volvulus 0.0015 0.0105 0.1794
Leishmania major glucose transporter, lmgt1 0.0032 0.0514 0.8107
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0023 0.0305 0.4305
Schistosoma mansoni sugar transporter 0.0015 0.0105 0.0362
Loa Loa (eye worm) hypothetical protein 0.0015 0.0105 0.0484
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0212 0.2585
Echinococcus multilocularis solute carrier family 22 0.0015 0.0105 0.0362
Loa Loa (eye worm) hypothetical protein 0.0015 0.0105 0.0484
Trypanosoma brucei unspecified product 0.0019 0.0212 0.2585
Plasmodium vivax lysine--tRNA ligase, putative 0.0023 0.0305 0.0201
Loa Loa (eye worm) hypothetical protein 0.0035 0.0588 0.2699
Onchocerca volvulus 0.0015 0.0105 0.1794
Trypanosoma brucei THT1 - hexose transporter, putative 0.0032 0.0514 0.8218
Leishmania major DNA polymerase eta, putative 0.0019 0.0212 0.2123
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0514 0.1973
Treponema pallidum prolyl-tRNA synthetase 0.0011 0.0022 0.5
Mycobacterium ulcerans fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT 0.0015 0.0105 0.1476
Trypanosoma cruzi hexose transporter, putative 0.0032 0.0514 0.8107
Trypanosoma brucei glucose transporter, putative 0.0032 0.0514 0.8218
Brugia malayi major facilitator superfamily protein 0.0015 0.0105 0.0484
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0032 0.0505 0.8041
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0023 0.0305 0.4997
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0035 0.0588 1
Brugia malayi Cam kinase protein 1 0.0032 0.0505 0.2318
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0032 0.0505 0.1886
Brugia malayi Major Facilitator Superfamily protein 0.0015 0.0105 0.0484
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0212 0.2585
Loa Loa (eye worm) hypothetical protein 0.0031 0.049 0.2249
Trypanosoma brucei hypothetical protein, conserved 0.0035 0.0588 0.9589
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0104 0.2178 0.7484
Mycobacterium ulcerans beta-lactamase 0.0035 0.0588 1
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0023 0.0305 0.395
Schistosoma mansoni serine/threonine protein kinase 0.0032 0.0505 0.1735
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.0212 0.0976
Trypanosoma brucei glucose transporter, putative 0.0032 0.0514 0.8218
Echinococcus multilocularis dna polymerase kappa 0.0019 0.0212 0.073
Schistosoma mansoni protein kinase 0.0032 0.0505 0.1735
Echinococcus multilocularis solute carrier family 22 0.0015 0.0105 0.0362
Trichomonas vaginalis CAMK family protein kinase 0.0032 0.0505 0.1927
Onchocerca volvulus 0.0015 0.0105 0.1794
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0212 0.2585
Trypanosoma cruzi DNA polymerase eta, putative 0.0019 0.0212 0.2123
Schistosoma mansoni sugar transporter 0.0015 0.0105 0.0362
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.0031 0.049 0.2249
Entamoeba histolytica hypothetical protein 0.0036 0.0598 1
Echinococcus granulosus Sugar transporter ERD6 protein 0.0015 0.0105 0.0394
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0588 0.2327
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0032 0.0505 0.2318

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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