TDR Targets

Basic information

Technical information

TDR Targets ID: 710870
Name: 5-amino-3-[2-(5-bromo-2-prop-2-enoxyphenyl)-1 -cyanoethenyl]-1-phenylpyrazole-4-carbonitril e
MW: 446.299 | Formula: C22H16BrN5O
H donors: 1 H acceptors: 3 LogP: 4.94 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: C=CCOc1ccc(cc1C=C(c1nn(c(c1C#N)N)c1ccccc1)C#N)Br
InChi: 1S/C22H16BrN5O/c1-2-10-29-20-9-8-17(23)12-15(20)11-16(13-24)21-19(14-25)22(26)28(27-21)18-6-4-3-5-7-18/h2-9,11-12H,1,10,26H2/b16-11+
InChiKey: WTQDKKWCWFIWKH-LFIBNONCSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

5-amino-3-[(Z)-2-(5-bromo-2-prop-2-enoxyphenyl)-1-cyanoethenyl]-1-phenylpyrazole-4-carbonitrile
3-[2-(2-allyloxy-5-bromo-phenyl)-1-cyano-vinyl]-5-amino-1-phenyl-pyrazole-4-carbonitrile
3-[(Z)-2-(2-allyloxy-5-bromo-phenyl)-1-cyano-vinyl]-5-amino-1-phenyl-pyrazole-4-carbonitrile
3-[2-(2-allyloxy-5-bromophenyl)-1-cyanovinyl]-5-amino-1-phenyl-4-pyrazolecarbonitrile
3-[(Z)-2-(2-allyloxy-5-bromophenyl)-1-cyanovinyl]-5-amino-1-phenyl-4-pyrazolecarbonitrile
5-amino-3-[2-(5-bromo-2-prop-2-enoxy-phenyl)-1-cyano-ethenyl]-1-phenyl-pyrazole-4-carbonitrile
5-amino-3-[(Z)-2-(5-bromo-2-prop-2-enoxy-phenyl)-1-cyano-ethenyl]-1-phenyl-pyrazole-4-carbonitrile

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0095	0.0122
Echinococcus granulosus	mixed lineage leukemia protein mll	0.0008	0.001	0.0001
Loa Loa (eye worm)	hypothetical protein	0.0527	0.7105	1
Mycobacterium tuberculosis	Probable lipase LipD	0.0116	0.1478	0.147
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0008	0.001	0.0001
Mycobacterium leprae	PROBABLE AMINOPEPTIDASE PEPC	0.0527	0.7105	1
Trichomonas vaginalis	penicillin-binding protein, putative	0.0116	0.1478	0.208
Brugia malayi	latrophilin 2 splice variant baaae	0.0035	0.0376	0.0517
Onchocerca volvulus		0.0033	0.0353	0.0241
Loa Loa (eye worm)	intermediate filament protein	0.0031	0.0325	0.0445
Loa Loa (eye worm)	hypothetical protein	0.0527	0.7105	1
Loa Loa (eye worm)	cytochrome P450 family protein	0.0018	0.0148	0.0196
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0376	0.0517
Mycobacterium ulcerans	cytochrome P450 185A4 Cyp185A4	0.0018	0.0148	0.0946
Mycobacterium tuberculosis	Probable hydrolase	0.0116	0.1478	0.147
Trypanosoma cruzi	aspartyl aminopeptidase, putative	0.0527	0.7105	1
Schistosoma mansoni	lamin	0.0031	0.0325	0.0445
Loa Loa (eye worm)	histone methyltransferase	0.001	0.0038	0.004
Trichomonas vaginalis	phosphofructokinase, putative	0.0031	0.0324	0.0456
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0016	0.0119	0.0154
Toxoplasma gondii	phosphofructokinase PFKII	0.0031	0.0324	0.2143
Mycobacterium tuberculosis	Conserved protein	0.0116	0.1478	0.147
Echinococcus multilocularis	lamin dm0	0.0031	0.0325	0.0445
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0116	0.1478	0.147
Brugia malayi	beta-lactamase family protein	0.0116	0.1478	0.207
Trichomonas vaginalis	conserved hypothetical protein	0.0247	0.3275	0.461
Schistosoma mansoni	cpg binding protein	0.0033	0.0353	0.0484
Loa Loa (eye worm)	hypothetical protein	0.0159	0.207	0.2904
Trypanosoma cruzi	hypothetical protein, conserved	0.0116	0.1478	0.207
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0016	0.0119	0.0154
Trichomonas vaginalis	conserved hypothetical protein	0.0247	0.3275	0.461
Mycobacterium leprae	Probable lipase LipE	0.0116	0.1478	0.207
Trypanosoma cruzi	cytochrome P450, putative	0.0018	0.0148	0.0196
Leishmania major	apurinic/apyrimidinic endonuclease-redox protein	0.002	0.017	0.0227
Chlamydia trachomatis	fructose-6-phosphate phosphotransferase	0.0031	0.0324	0.5
Loa Loa (eye worm)	hypothetical protein	0.0116	0.1478	0.207
Echinococcus granulosus	GPCR family 2	0.0016	0.0119	0.0154
Mycobacterium tuberculosis	Probable lipase LipE	0.0116	0.1478	0.147
Leishmania major	ATP-dependent phosphofructokinase	0.0116	0.1478	0.207
Echinococcus granulosus	aspartyl aminopeptidase	0.0527	0.7105	1
Loa Loa (eye worm)	cytoplasmic intermediate filament protein	0.0017	0.0126	0.0165
Mycobacterium tuberculosis	Conserved protein	0.0116	0.1478	0.147
Entamoeba histolytica	aspartyl aminopeptidase, putative	0.0527	0.7105	1
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.001	0.0038	0.004
Onchocerca volvulus		0.0116	0.1478	1
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0033	0.0353	0.0484
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0317	0.0434
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.015	0.1947	0.2731
Trichomonas vaginalis	conserved hypothetical protein	0.0247	0.3275	0.461
Trypanosoma brucei	apurinic/apyrimidinic endonuclease, putative	0.002	0.017	0.0227
Trypanosoma cruzi	metallo-peptidase, Clan MH, Family M20	0.0527	0.7105	1
Plasmodium vivax	6-phosphofructokinase, putative	0.0031	0.0324	0.0222
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.015	0.1947	0.2731
Schistosoma mansoni	6-phosphofructokinase	0.0116	0.1478	0.207
Loa Loa (eye worm)	hypothetical protein	0.001	0.0036	0.0038
Mycobacterium tuberculosis	Probable aminopeptidase PepC	0.0527	0.7105	0.7102
Echinococcus granulosus	lamin dm0	0.0031	0.0325	0.0445
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0119	0.0154
Trypanosoma cruzi	ATP-dependent 6-phosphofructokinase, glycosomal	0.0116	0.1478	0.207
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.002	0.017	0.0227
Trichomonas vaginalis	phosphofructokinase, putative	0.0116	0.1478	0.208
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease	0.002	0.017	0.0227
Plasmodium falciparum	ATP-dependent 6-phosphofructokinase	0.0031	0.0324	0.0222
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0031	0.0325	0.0445
Schistosoma mansoni	aspartyl aminopeptidase (M18 family)	0.0527	0.7105	1
Trichomonas vaginalis	6-phosphofructokinase, putative	0.0031	0.0324	0.0456
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0116	0.1478	0.207
Mycobacterium tuberculosis	Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI)	0.002	0.017	0.0161
Echinococcus multilocularis	cytoplasmic intermediate filament protein	0.0015	0.0103	0.0133
Brugia malayi	Cytochrome P450 family protein	0.0018	0.0148	0.0196
Loa Loa (eye worm)	hypothetical protein	0.0116	0.1478	0.207
Echinococcus granulosus	cytoplasmic intermediate filament protein	0.0015	0.0103	0.0133
Echinococcus granulosus	intermediate filament protein	0.0031	0.0325	0.0445
Plasmodium vivax	hypothetical protein, conserved	0.0116	0.1478	0.1886
Trichomonas vaginalis	Clan MH, family M18, aspartyl aminopeptidase-like metallopeptidase	0.0247	0.3275	0.461
Loa Loa (eye worm)	6-phosphofructokinase	0.0116	0.1478	0.207
Loa Loa (eye worm)	hypothetical protein	0.0116	0.1478	0.207
Trichomonas vaginalis	Clan MH, family M18, aspartyl aminopeptidase-like metallopeptidase	0.0247	0.3275	0.461
Brugia malayi	intermediate filament protein	0.0031	0.0325	0.0445
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.015	0.1947	0.2731
Onchocerca volvulus		0.0116	0.1478	1
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease, putative	0.002	0.017	0.0227
Trichomonas vaginalis	phosphofructokinase, putative	0.0116	0.1478	0.208
Entamoeba histolytica	phosphofructokinase, putative	0.0116	0.1478	0.1886
Trypanosoma brucei	ATP-dependent 6-phosphofructokinase, glycosomal	0.0116	0.1478	0.207
Echinococcus granulosus	lamin	0.0031	0.0325	0.0445
Loa Loa (eye worm)	hypothetical protein	0.0116	0.1478	0.207
Treponema pallidum	diphosphate--fructose-6-phosphate 1-phosphotransferase	0.0116	0.1478	1
Entamoeba histolytica	aminopeptidase, putative	0.0527	0.7105	1
Loa Loa (eye worm)	aspartyl aminopeptidase	0.0527	0.7105	1
Brugia malayi	beta-lactamase family protein	0.0116	0.1478	0.207
Wolbachia endosymbiont of Brugia malayi	exonuclease III	0.002	0.017	0.5
Entamoeba histolytica	phosphofructokinase, putative	0.0116	0.1478	0.1886
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0016	0.0119	0.0154
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0325	0.0445
Loa Loa (eye worm)	hypothetical protein	0.0159	0.207	0.2904
Trichomonas vaginalis	phosphofructokinase, putative	0.0031	0.0324	0.0456
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0016	0.0119	0.0154
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.015	0.1947	0.2731
Toxoplasma gondii	6-phosphofructokinase	0.0031	0.0324	0.2143
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0116	0.1478	0.147
Trichomonas vaginalis	Clan MH, family M18, aspartyl aminopeptidase-like metallopeptidase	0.0527	0.7105	1
Brugia malayi	6-phosphofructokinase	0.0116	0.1478	0.207
Trichomonas vaginalis	phosphofructokinase, putative	0.0031	0.0324	0.0456
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0103	0.0133
Toxoplasma gondii	phosphofructokinase domain-containing protein	0.0031	0.0324	0.2143
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0008	0.001	0.0001
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.015	0.1947	0.2731
Schistosoma mansoni	ap endonuclease	0.002	0.017	0.0227
Loa Loa (eye worm)	6-phosphofructokinase	0.0116	0.1478	0.207
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0051	0.0598	0.083
Brugia malayi	exodeoxyribonuclease III family protein	0.002	0.017	0.0227
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0095	0.0122
Echinococcus multilocularis	GPCR, family 2	0.0016	0.0119	0.0154
Brugia malayi	Cytochrome P450 family protein	0.0018	0.0148	0.0196
Mycobacterium ulcerans	esterase/lipase LipP	0.0116	0.1478	1
Brugia malayi	6-phosphofructokinase	0.0116	0.1478	0.207
Trichomonas vaginalis	esterase, putative	0.0116	0.1478	0.208
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.015	0.1947	0.2731
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0071	0.0863	0.1204
Trypanosoma cruzi	cytochrome P450, putative	0.0018	0.0148	0.0196
Schistosoma mansoni	hypothetical protein	0.0016	0.0119	0.0154
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0116	0.1478	0.207
Schistosoma mansoni	cpg binding protein	0.0035	0.0378	0.0521
Trichomonas vaginalis	hypothetical protein	0.0247	0.3275	0.461
Trichomonas vaginalis	penicillin-binding protein, putative	0.0116	0.1478	0.208
Trichomonas vaginalis	Clan MH, family M18, aspartyl aminopeptidase-like metallopeptidase	0.0527	0.7105	1
Echinococcus granulosus	cpg binding protein	0.0035	0.0378	0.0521
Echinococcus granulosus	beta LACTamase domain containing family member	0.0116	0.1478	0.207
Echinococcus multilocularis	muscleblind protein 1	0.0159	0.207	0.2904
Trypanosoma brucei	aspartyl aminopeptidase, putative	0.0527	0.7105	1
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0116	0.1478	1
Loa Loa (eye worm)	hypothetical protein	0.0116	0.1478	0.207
Trichomonas vaginalis	phosphofructokinase, putative	0.0116	0.1478	0.208
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0051	0.0598	0.083
Onchocerca volvulus		0.0116	0.1478	1
Plasmodium vivax	6-phosphofructokinase, putative	0.0031	0.0324	0.0222
Echinococcus multilocularis	mixed lineage leukemia protein mll	0.0008	0.001	0.0001
Mycobacterium ulcerans	6-phosphofructokinase	0.0116	0.1478	0.9999
Toxoplasma gondii	exonuclease III APE	0.002	0.017	0.1098
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	0.002	0.017	0.0227
Mycobacterium ulcerans	exodeoxyribonuclease III protein XthA	0.002	0.017	0.1098
Plasmodium vivax	M18 aspartyl aminopeptidase, putative	0.0527	0.7105	1
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.015	0.1947	0.2731
Mycobacterium ulcerans	lipase LipD	0.0116	0.1478	1
Trichomonas vaginalis	D-aminoacylase, putative	0.0116	0.1478	0.208
Trypanosoma brucei	aspartyl aminopeptidase, putative	0.0527	0.7105	1
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0051	0.0598	0.083
Schistosoma mansoni	6-phosphofructokinase	0.0116	0.1478	0.207
Brugia malayi	cytoplasmic intermediate filament protein	0.0017	0.0126	0.0165
Plasmodium falciparum	M18 aspartyl aminopeptidase	0.0527	0.7105	1
Chlamydia trachomatis	fructose-6-phosphate phosphotransferase	0.0031	0.0324	0.5
Loa Loa (eye worm)	phosphofructokinase	0.0116	0.1478	0.207
Mycobacterium leprae	PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE)	0.0116	0.1478	0.207
Plasmodium falciparum	ATP-dependent 6-phosphofructokinase	0.0031	0.0324	0.0222
Trypanosoma cruzi	hypothetical protein, conserved	0.0116	0.1478	0.207
Leishmania major	cytochrome p450-like protein	0.0018	0.0148	0.0196
Schistosoma mansoni	aspartyl aminopeptidase (M18 family)	0.0527	0.7105	1
Trichomonas vaginalis	ap endonuclease, putative	0.002	0.017	0.024
Leishmania major	hypothetical protein, conserved	0.0116	0.1478	0.207
Echinococcus granulosus	6 phosphofructokinase	0.0116	0.1478	0.207
Echinococcus multilocularis	6 phosphofructokinase	0.0116	0.1478	0.207
Trypanosoma brucei	cytochrome P450, putative	0.0018	0.0148	0.0196
Schistosoma mansoni	ap endonuclease	0.002	0.017	0.0227
Trichomonas vaginalis	D-aminoacylase, putative	0.0116	0.1478	0.208
Trichomonas vaginalis	phosphofructokinase, putative	0.0031	0.0324	0.0456
Trichomonas vaginalis	phosphofructokinase, putative	0.0116	0.1478	0.208
Schistosoma mansoni	intermediate filament proteins	0.0031	0.0325	0.0445
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0016	0.0119	0.0154
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0116	0.1478	0.207
Loa Loa (eye worm)	cytochrome P450 family protein	0.0018	0.0148	0.0196
Brugia malayi	CXXC zinc finger family protein	0.0033	0.0353	0.0484
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0598	0.083
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0116	0.1478	0.207
Mycobacterium leprae	conserved hypothetical protein	0.0116	0.1478	0.207
Schistosoma mansoni	hypothetical protein	0.0035	0.0376	0.0517
Leishmania major	aspartyl aminopeptidase, putative,metallo-peptidase, Clan MH, Family M20	0.0527	0.7105	1
Brugia malayi	F/Y-rich N-terminus family protein	0.001	0.0036	0.0038
Trichomonas vaginalis	D-aminoacylase, putative	0.0116	0.1478	0.208
Trichomonas vaginalis	ap endonuclease, putative	0.002	0.017	0.024
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0063	0.076	0.5113
Brugia malayi	Latrophilin receptor protein 2	0.0016	0.0119	0.0154
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0008	0.001	0.0001
Loa Loa (eye worm)	CYP4Cod1	0.0018	0.0148	0.0196
Mycobacterium tuberculosis	Conserved protein	0.0116	0.1478	0.147
Trypanosoma brucei	hypothetical protein, conserved	0.0116	0.1478	0.207
Trichomonas vaginalis	phosphofructokinase, putative	0.0031	0.0324	0.0456
Brugia malayi	Intermediate filament tail domain containing protein	0.0031	0.0325	0.0445
Echinococcus granulosus	muscleblind protein	0.0159	0.207	0.2904
Schistosoma mansoni	hypothetical protein	0.0016	0.0119	0.0154
Echinococcus multilocularis	aspartyl aminopeptidase	0.0527	0.7105	1
Echinococcus multilocularis	muscleblind protein	0.0159	0.207	0.2904
Echinococcus multilocularis	musashi	0.0031	0.0325	0.0445
Mycobacterium ulcerans	beta-lactamase	0.0116	0.1478	1
Trichomonas vaginalis	Clan MH, family M18, aspartyl aminopeptidase-like metallopeptidase	0.0527	0.7105	1
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.015	0.1947	0.2731
Entamoeba histolytica	phosphofructokinase, putative	0.0116	0.1478	0.1886
Schistosoma mansoni	hypothetical protein	0.0016	0.0119	0.0154
Loa Loa (eye worm)	hypothetical protein	0.0116	0.1478	0.207
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.001	0.0038	0.004
Brugia malayi	phosphofructokinase	0.0116	0.1478	0.207
Mycobacterium ulcerans	hypothetical protein	0.0116	0.1478	1
Brugia malayi	Aspartyl aminopeptidase	0.0527	0.7105	1
Brugia malayi	Muscleblind-like protein	0.0159	0.207	0.2904
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.015	0.1947	0.2731
Mycobacterium tuberculosis	Probable esterase LipL	0.0116	0.1478	0.147
Trichomonas vaginalis	phosphofructokinase, putative	0.0031	0.0324	0.0456
Mycobacterium tuberculosis	Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase)	0.0116	0.1478	0.147
Schistosoma mansoni	lamin	0.0031	0.0325	0.0445
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0116	0.1478	0.147
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0116	0.1478	0.207
Echinococcus multilocularis	lamin	0.0031	0.0325	0.0445
Echinococcus multilocularis	cpg binding protein	0.0035	0.0378	0.0521
Trichomonas vaginalis	Clan MH, family M18, aspartyl aminopeptidase-like metallopeptidase	0.0247	0.3275	0.461
Loa Loa (eye worm)	beta-lactamase	0.0116	0.1478	0.207
Treponema pallidum	diphosphate--fructose-6-phosphate 1-phosphotransferase	0.0031	0.0324	0.1175
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	0.002	0.017	0.0227
Giardia lamblia	Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit	0.0031	0.0324	1
Schistosoma mansoni	cpg binding protein	0.0035	0.0378	0.0521
Entamoeba histolytica	pyrophosphate-dependent phosphofructokinase	0.0031	0.0324	0.0222
Toxoplasma gondii	ABC1 family protein	0.0116	0.1478	1
Brugia malayi	beta-lactamase	0.0116	0.1478	0.207
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0016	0.0119	0.0154
Schistosoma mansoni	hypothetical protein	0.0016	0.0119	0.0154

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 710870