Detailed information for compound 713821

Basic information

Technical information
  • TDR Targets ID: 713821
  • Name: N-(2-fluoro-4-iodophenyl)-2-(phenoxy)propanam ide
  • MW: 385.172 | Formula: C15H13FINO2
  • H donors: 1 H acceptors: 1 LogP: 3.95 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(C(Oc1ccccc1)C)Nc1ccc(cc1F)I
  • InChi: 1S/C15H13FINO2/c1-10(20-12-5-3-2-4-6-12)15(19)18-14-8-7-11(17)9-13(14)16/h2-10H,1H3,(H,18,19)
  • InChiKey: UITNIAFXGDNGTL-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-(2-fluoro-4-iodo-phenyl)-2-(phenoxy)propanamide
  • N-(2-fluoro-4-iodo-phenyl)-2-(phenoxy)propionamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni sex comb on midleg homolog 0.0048 0.0017 0.0002
Trichomonas vaginalis glucosylceramidase, putative 0.0341 0.1244 0.5891
Loa Loa (eye worm) MBCTL1 0.0055 0.0045 0.0141
Toxoplasma gondii IMP dehydrogenas 0.0407 0.1521 1
Echinococcus granulosus Protein patched homolog 1 0.0085 0.0171 0.1025
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0148 0.0434 0.2285
Loa Loa (eye worm) RNA binding protein 0.0063 0.008 0.0317
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0055 0.0045 0.0028
Trichomonas vaginalis glucosylceramidase, putative 0.0341 0.1244 0.5891
Brugia malayi Niemann-Pick C1 protein precursor 0.0198 0.0643 0.3172
Mycobacterium ulcerans acyl-CoA synthetase 0.0071 0.0112 0.0132
Brugia malayi GMP reductase 0.0178 0.0561 0.2754
Echinococcus granulosus snurportin 1 0.0308 0.1106 0.7242
Loa Loa (eye worm) hypothetical protein 0.0053 0.0038 0.0103
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0092 0.0203 0.1236
Echinococcus granulosus Niemann Pick C1 protein 0.0282 0.0998 0.6526
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0148 0.0434 0.2856
Schistosoma mansoni inosine-5-monophosphate dehydrogenase 0.0407 0.1521 1
Trichomonas vaginalis glucosylceramidase, putative 0.052 0.1992 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0092 0.0203 0.0186
Onchocerca volvulus Glucosylceramidase homolog 0.0341 0.1244 1
Trypanosoma cruzi inosine-5'-monophosphate dehydrogenase, putative 0.0407 0.1521 1
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0055 0.0045 0.0142
Brugia malayi RNA recognition motif domain containing protein 0.0063 0.008 0.0318
Mycobacterium leprae Probable inosine-5'-monophosphate dehydrogenase GuaB2 (IMP dehydrogenase) (IMPDH) (IMPD) 0.0407 0.1521 0.2518
Echinococcus granulosus histone acetyltransferase MYST2 0.0055 0.0045 0.0185
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0201 0.0656 0.4252
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0198 0.0643 1
Loa Loa (eye worm) hypothetical protein 0.0053 0.0038 0.0103
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0092 0.0203 0.1236
Trypanosoma brucei inosine-5'-monophosphate dehydrogenase 0.0407 0.1521 1
Echinococcus multilocularis expressed conserved protein 0.0186 0.0593 0.0577
Echinococcus granulosus expressed conserved protein 0.0186 0.0593 0.3832
Trypanosoma brucei GMP reductase 0.0407 0.1521 1
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0189 0.0608 0.0592
Schistosoma mansoni tar DNA-binding protein 0.0063 0.008 0.0418
Trichomonas vaginalis glucosylceramidase, putative 0.0341 0.1244 0.5891
Loa Loa (eye worm) hypothetical protein 0.0053 0.0038 0.0103
Loa Loa (eye worm) IMP dehydrogenase 1 0.0407 0.1521 0.7613
Mycobacterium ulcerans hypothetical protein 0.0071 0.0112 0.0132
Loa Loa (eye worm) GMP reductase 0.0178 0.0561 0.2753
Brugia malayi mbt repeat family protein 0.0048 0.0017 0.0002
Brugia malayi TAR-binding protein 0.0063 0.008 0.0318
Trichomonas vaginalis glucosylceramidase, putative 0.0341 0.1244 0.5891
Leishmania major guanosine monophosphate reductase 0.0407 0.1521 1
Trichomonas vaginalis glucosylceramidase, putative 0.0341 0.1244 0.5891
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.052 0.1992 1
Loa Loa (eye worm) hypothetical protein 0.0053 0.0038 0.0103
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0148 0.0434 0.2856
Mycobacterium tuberculosis Probable inosine-5'-monophosphate dehydrogenase GuaB2 (imp dehydrogenase) (inosinic acid dehydrogenase) (inosinate dehydrogenase 0.0407 0.1521 0.2633
Echinococcus granulosus sterol regulatory element binding protein 0.0085 0.0171 0.1025
Echinococcus granulosus tar DNA binding protein 0.0063 0.008 0.0416
Echinococcus multilocularis Niemann Pick C1 protein 0.0198 0.0643 0.0627
Schistosoma mansoni hypothetical protein 0.0082 0.0159 0.0942
Schistosoma mansoni hypothetical protein 0.0082 0.0159 0.0942
Wolbachia endosymbiont of Brugia malayi IMP dehydrogenase 0.0407 0.1521 0.5
Echinococcus multilocularis inosine 5' monophosphate dehydrogenase 2 0.0407 0.1521 0.1506
Loa Loa (eye worm) hypothetical protein 0.0085 0.0171 0.078
Schistosoma mansoni tar DNA-binding protein 0.0063 0.008 0.0418
Echinococcus granulosus survival motor neuron protein 1 0.0235 0.08 0.5204
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0053 0.0038 0.0021
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0055 0.0045 0.0185
Echinococcus multilocularis survival motor neuron protein 1 0.0235 0.08 0.0784
Brugia malayi AMP-binding enzyme family protein 0.0071 0.0112 0.0483
Schistosoma mansoni tar DNA-binding protein 0.0063 0.008 0.0418
Echinococcus multilocularis sterol regulatory element binding protein 0.0085 0.0171 0.0154
Trypanosoma cruzi GMP reductase 0.0407 0.1521 1
Echinococcus multilocularis tar DNA binding protein 0.0063 0.008 0.0063
Plasmodium vivax inosine-5'-monophosphate dehydrogenase, putative 0.0403 0.1501 1
Schistosoma mansoni hypothetical protein 0.0082 0.0159 0.0942
Mycobacterium ulcerans transcriptional regulator 0.1407 0.5704 1
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0312 0.1122 0.7377
Trichomonas vaginalis glucosylceramidase, putative 0.052 0.1992 1
Brugia malayi AMP-binding enzyme family protein 0.0071 0.0112 0.0483
Brugia malayi inosine-5'-monophosphate dehydrogenase 0.0178 0.0561 0.2754
Brugia malayi RNA binding protein 0.0063 0.008 0.0318
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0063 0.008 0.0317
Loa Loa (eye worm) hypothetical protein 0.0071 0.0112 0.0481
Trichomonas vaginalis glucosylceramidase, putative 0.052 0.1992 1
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0312 0.1122 0.7377
Mycobacterium ulcerans AcrR family transcriptional regulator 0.1407 0.5704 1
Brugia malayi mbt repeat family protein 0.0048 0.0017 0.0002
Leishmania major inosine-5-monophosphate dehydrogenase 0.0407 0.1521 1
Echinococcus granulosus Niemann Pick C1 protein 0.0198 0.0643 0.4165
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0053 0.004 0.0264
Loa Loa (eye worm) hypothetical protein 0.0071 0.0112 0.0481
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0053 0.0038 0.5
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0092 0.0203 0.1238
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0092 0.0203 0.1238
Loa Loa (eye worm) hypothetical protein 0.0198 0.0643 0.3171
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0092 0.0203 0.1238
Mycobacterium tuberculosis Probable inosine-5'-monophosphate dehydrogenase GuaB3 (imp dehydrogenase) (inosinic acid dehydrogenase) (inosinate dehydrogenase 0.0225 0.0757 0.1288
Trichomonas vaginalis glucosylceramidase, putative 0.052 0.1992 1
Trypanosoma cruzi inosine-5'-monophosphate dehydrogenase, putative 0.0407 0.1521 1
Trichomonas vaginalis glucosylceramidase, putative 0.0341 0.1244 0.5891
Echinococcus multilocularis Niemann Pick C1 protein 0.0282 0.0998 0.0983
Echinococcus multilocularis histone acetyltransferase MYST2 0.0055 0.0045 0.0028
Loa Loa (eye worm) hypothetical protein 0.0104 0.0251 0.1184
Schistosoma mansoni myelin transcription factor 1 myt1 0.0055 0.0045 0.0187
Brugia malayi RNA, U transporter 1 0.0082 0.016 0.0724
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0092 0.0203 0.0186
Loa Loa (eye worm) hypothetical protein 0.0071 0.0112 0.0481
Mycobacterium ulcerans TetR family transcriptional regulator 0.1407 0.5704 1
Plasmodium falciparum inosine-5'-monophosphate dehydrogenase 0.0403 0.1501 1
Schistosoma mansoni tar DNA-binding protein 0.0063 0.008 0.0418
Loa Loa (eye worm) hypothetical protein 0.0235 0.08 0.3962
Trichomonas vaginalis glucosylceramidase, putative 0.052 0.1992 1
Trichomonas vaginalis glucosylceramidase, putative 0.0359 0.1321 0.6313
Leishmania major mitochondrial DNA polymerase beta 0.0312 0.1122 0.7168
Mycobacterium tuberculosis Transcriptional regulatory repressor protein (TetR-family) EthR 0.1407 0.5704 1
Echinococcus granulosus geminin 0.017 0.0526 0.3386
Mycobacterium ulcerans acyl-CoA synthetase 0.0071 0.0112 0.0132
Echinococcus multilocularis protein dispatched 1 0.0097 0.0222 0.0205
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0092 0.0203 0.0943
Onchocerca volvulus 0.0048 0.0017 0.0003
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0048 0.0017 0.0002
Trypanosoma cruzi GMP reductase 0.0407 0.1521 1
Echinococcus multilocularis geminin 0.017 0.0526 0.051
Schistosoma mansoni sex comb on midleg homolog 0.0048 0.0017 0.0002
Mycobacterium leprae Probable inosine-5'-monophosphate dehydrogenase GuaB3 (IMP dehydrogenase 2) (inosinic acid dehydrogenase) (inosinate dehydrogena 0.0225 0.0757 0.1153
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0048 0.0017 0.0003
Schistosoma mansoni patched 1 0.0085 0.0171 0.1027
Loa Loa (eye worm) TAR-binding protein 0.0063 0.008 0.0317
Mycobacterium ulcerans acyl-CoA synthetase 0.0071 0.0112 0.0132
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0071 0.0112 0.0132
Brugia malayi CHE-14 protein 0.0085 0.0171 0.0782
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0071 0.0112 0.0153
Trypanosoma cruzi inosine-5'-monophosphate dehydrogenase, putative 0.0407 0.1521 1
Schistosoma mansoni tar DNA-binding protein 0.0063 0.008 0.0418
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0312 0.1122 0.7377
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0085 0.0171 0.078
Loa Loa (eye worm) hypothetical protein 0.0053 0.0038 0.0103
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0071 0.0112 0.0132
Echinococcus granulosus inosine 5' monophosphate dehydrogenase 2 0.0407 0.1521 1
Schistosoma mansoni hypothetical protein 0.0082 0.0159 0.0942
Brugia malayi hypothetical protein 0.0235 0.08 0.3963
Schistosoma mansoni hypothetical protein 0.0292 0.1038 0.6788
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0071 0.0112 0.0132
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0308 0.1106 0.5513
Mycobacterium ulcerans hypothetical protein 0.0164 0.0504 0.0823
Loa Loa (eye worm) hypothetical protein 0.0055 0.0045 0.0141
Brugia malayi inosine-5'-monophosphate dehydrogenase family protein 0.0407 0.1521 0.7613
Trichomonas vaginalis glucosylceramidase, putative 0.0341 0.1244 0.5891
Schistosoma mansoni hypothetical protein 0.017 0.0526 0.3387
Mycobacterium tuberculosis Conserved hypothetical protein 0.0164 0.0504 0.0843
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.052 0.1992 1
Brugia malayi AMP-binding enzyme family protein 0.0071 0.0112 0.0483
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0092 0.0203 0.0941
Mycobacterium ulcerans inosine 5-monophosphate dehydrogenase 0.0182 0.058 0.0957
Echinococcus multilocularis protein patched 0.0085 0.0171 0.0154
Trichomonas vaginalis glucosylceramidase, putative 0.0359 0.1321 0.6313
Mycobacterium leprae PROBABLE INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE GUAB1(IMP DEHYDROGENASE) (IMPDH) (IMPD) 0.0182 0.058 0.0836
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0071 0.0112 0.0132
Schistosoma mansoni hypothetical protein 0.0308 0.1106 0.7242
Mycobacterium ulcerans inosine 5'-monophosphate dehydrogenase 0.0407 0.1521 0.2617
Onchocerca volvulus 0.0071 0.0112 0.0777
Mycobacterium leprae Probable transcriptional regulatory repressor protein (TetR-family) EthR 0.1407 0.5704 1
Schistosoma mansoni hypothetical protein 0.017 0.0526 0.3387
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0071 0.0112 0.0153
Mycobacterium ulcerans inosine 5-monophosphate dehydrogenase 0.0403 0.1501 0.2583
Trichomonas vaginalis glucosylceramidase, putative 0.052 0.1992 1
Echinococcus multilocularis snurportin 1 0.0308 0.1106 0.1091
Brugia malayi inosine-5'-monophosphate dehydrogenase 0.0178 0.0561 0.2754
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0189 0.0608 0.393
Onchocerca volvulus Putative GMP reductase 0.0178 0.0561 0.4433

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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