Detailed information for compound 713821

Basic information

Technical information
  • TDR Targets ID: 713821
  • Name: N-(2-fluoro-4-iodophenyl)-2-(phenoxy)propanam ide
  • MW: 385.172 | Formula: C15H13FINO2
  • H donors: 1 H acceptors: 1 LogP: 3.95 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(C(Oc1ccccc1)C)Nc1ccc(cc1F)I
  • InChi: 1S/C15H13FINO2/c1-10(20-12-5-3-2-4-6-12)15(19)18-14-8-7-11(17)9-13(14)16/h2-10H,1H3,(H,18,19)
  • InChiKey: UITNIAFXGDNGTL-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • N-(2-fluoro-4-iodo-phenyl)-2-(phenoxy)propanamide
  • N-(2-fluoro-4-iodo-phenyl)-2-(phenoxy)propionamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus Niemann Pick C1 protein 0.0282 0.0998 0.6526
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0055 0.0045 0.0185
Echinococcus multilocularis expressed conserved protein 0.0186 0.0593 0.0577
Mycobacterium ulcerans hypothetical protein 0.0071 0.0112 0.0132
Schistosoma mansoni hypothetical protein 0.0308 0.1106 0.7242
Trypanosoma cruzi inosine-5'-monophosphate dehydrogenase, putative 0.0407 0.1521 1
Loa Loa (eye worm) RNA binding protein 0.0063 0.008 0.0317
Leishmania major inosine-5-monophosphate dehydrogenase 0.0407 0.1521 1
Schistosoma mansoni hypothetical protein 0.0082 0.0159 0.0942
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0092 0.0203 0.0186
Trichomonas vaginalis glucosylceramidase, putative 0.0359 0.1321 0.6313
Schistosoma mansoni sex comb on midleg homolog 0.0048 0.0017 0.0002
Schistosoma mansoni tar DNA-binding protein 0.0063 0.008 0.0418
Brugia malayi AMP-binding enzyme family protein 0.0071 0.0112 0.0483
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0189 0.0608 0.393
Brugia malayi inosine-5'-monophosphate dehydrogenase 0.0178 0.0561 0.2754
Echinococcus granulosus tar DNA binding protein 0.0063 0.008 0.0416
Echinococcus granulosus sterol regulatory element binding protein 0.0085 0.0171 0.1025
Trichomonas vaginalis glucosylceramidase, putative 0.0341 0.1244 0.5891
Mycobacterium leprae PROBABLE INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE GUAB1(IMP DEHYDROGENASE) (IMPDH) (IMPD) 0.0182 0.058 0.0836
Schistosoma mansoni tar DNA-binding protein 0.0063 0.008 0.0418
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0048 0.0017 0.0002
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0092 0.0203 0.0941
Schistosoma mansoni myelin transcription factor 1 myt1 0.0055 0.0045 0.0187
Echinococcus granulosus geminin 0.017 0.0526 0.3386
Echinococcus multilocularis sterol regulatory element binding protein 0.0085 0.0171 0.0154
Loa Loa (eye worm) hypothetical protein 0.0085 0.0171 0.078
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.052 0.1992 1
Schistosoma mansoni inosine-5-monophosphate dehydrogenase 0.0407 0.1521 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0092 0.0203 0.1238
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0308 0.1106 0.5513
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0055 0.0045 0.0028
Schistosoma mansoni tar DNA-binding protein 0.0063 0.008 0.0418
Echinococcus granulosus Protein patched homolog 1 0.0085 0.0171 0.1025
Plasmodium falciparum inosine-5'-monophosphate dehydrogenase 0.0403 0.1501 1
Echinococcus granulosus histone acetyltransferase MYST2 0.0055 0.0045 0.0185
Schistosoma mansoni hypothetical protein 0.017 0.0526 0.3387
Echinococcus granulosus expressed conserved protein 0.0186 0.0593 0.3832
Schistosoma mansoni hypothetical protein 0.0292 0.1038 0.6788
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0312 0.1122 0.7377
Mycobacterium tuberculosis Conserved hypothetical protein 0.0164 0.0504 0.0843
Schistosoma mansoni hypothetical protein 0.0082 0.0159 0.0942
Trichomonas vaginalis glucosylceramidase, putative 0.052 0.1992 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0071 0.0112 0.0153
Trichomonas vaginalis glucosylceramidase, putative 0.0341 0.1244 0.5891
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0092 0.0203 0.0943
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0071 0.0112 0.0132
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0053 0.004 0.0264
Brugia malayi AMP-binding enzyme family protein 0.0071 0.0112 0.0483
Brugia malayi RNA binding protein 0.0063 0.008 0.0318
Trichomonas vaginalis glucosylceramidase, putative 0.052 0.1992 1
Schistosoma mansoni patched 1 0.0085 0.0171 0.1027
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0071 0.0112 0.0153
Schistosoma mansoni hypothetical protein 0.0082 0.0159 0.0942
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0055 0.0045 0.0142
Trichomonas vaginalis glucosylceramidase, putative 0.0341 0.1244 0.5891
Loa Loa (eye worm) hypothetical protein 0.0053 0.0038 0.0103
Brugia malayi GMP reductase 0.0178 0.0561 0.2754
Loa Loa (eye worm) MBCTL1 0.0055 0.0045 0.0141
Schistosoma mansoni sex comb on midleg homolog 0.0048 0.0017 0.0002
Trypanosoma brucei GMP reductase 0.0407 0.1521 1
Echinococcus multilocularis snurportin 1 0.0308 0.1106 0.1091
Mycobacterium ulcerans hypothetical protein 0.0164 0.0504 0.0823
Schistosoma mansoni hypothetical protein 0.0082 0.0159 0.0942
Echinococcus multilocularis histone acetyltransferase MYST2 0.0055 0.0045 0.0028
Mycobacterium ulcerans inosine 5-monophosphate dehydrogenase 0.0182 0.058 0.0957
Echinococcus multilocularis Niemann Pick C1 protein 0.0282 0.0998 0.0983
Loa Loa (eye worm) hypothetical protein 0.0055 0.0045 0.0141
Trypanosoma cruzi inosine-5'-monophosphate dehydrogenase, putative 0.0407 0.1521 1
Brugia malayi RNA, U transporter 1 0.0082 0.016 0.0724
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0092 0.0203 0.0186
Loa Loa (eye worm) hypothetical protein 0.0071 0.0112 0.0481
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0092 0.0203 0.1238
Brugia malayi inosine-5'-monophosphate dehydrogenase family protein 0.0407 0.1521 0.7613
Trypanosoma brucei inosine-5'-monophosphate dehydrogenase 0.0407 0.1521 1
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0148 0.0434 0.2285
Trichomonas vaginalis glucosylceramidase, putative 0.052 0.1992 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0092 0.0203 0.1236
Echinococcus multilocularis geminin 0.017 0.0526 0.051
Loa Loa (eye worm) hypothetical protein 0.0235 0.08 0.3962
Mycobacterium ulcerans transcriptional regulator 0.1407 0.5704 1
Mycobacterium tuberculosis Probable inosine-5'-monophosphate dehydrogenase GuaB3 (imp dehydrogenase) (inosinic acid dehydrogenase) (inosinate dehydrogenase 0.0225 0.0757 0.1288
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.052 0.1992 1
Mycobacterium leprae Probable transcriptional regulatory repressor protein (TetR-family) EthR 0.1407 0.5704 1
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0053 0.0038 0.0021
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0071 0.0112 0.0132
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0085 0.0171 0.078
Trichomonas vaginalis glucosylceramidase, putative 0.052 0.1992 1
Loa Loa (eye worm) TAR-binding protein 0.0063 0.008 0.0317
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0071 0.0112 0.0132
Loa Loa (eye worm) IMP dehydrogenase 1 0.0407 0.1521 0.7613
Brugia malayi mbt repeat family protein 0.0048 0.0017 0.0002
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0148 0.0434 0.2856
Trichomonas vaginalis glucosylceramidase, putative 0.0359 0.1321 0.6313
Onchocerca volvulus Glucosylceramidase homolog 0.0341 0.1244 1
Mycobacterium tuberculosis Transcriptional regulatory repressor protein (TetR-family) EthR 0.1407 0.5704 1
Echinococcus multilocularis protein patched 0.0085 0.0171 0.0154
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0201 0.0656 0.4252
Trypanosoma cruzi GMP reductase 0.0407 0.1521 1
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0148 0.0434 0.2856
Echinococcus granulosus survival motor neuron protein 1 0.0235 0.08 0.5204
Brugia malayi mbt repeat family protein 0.0048 0.0017 0.0002
Trichomonas vaginalis glucosylceramidase, putative 0.0341 0.1244 0.5891
Mycobacterium ulcerans TetR family transcriptional regulator 0.1407 0.5704 1
Loa Loa (eye worm) hypothetical protein 0.0104 0.0251 0.1184
Trypanosoma cruzi GMP reductase 0.0407 0.1521 1
Mycobacterium ulcerans inosine 5-monophosphate dehydrogenase 0.0403 0.1501 0.2583
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0053 0.0038 0.5
Echinococcus multilocularis protein dispatched 1 0.0097 0.0222 0.0205
Toxoplasma gondii IMP dehydrogenas 0.0407 0.1521 1
Loa Loa (eye worm) GMP reductase 0.0178 0.0561 0.2753
Leishmania major mitochondrial DNA polymerase beta 0.0312 0.1122 0.7168
Echinococcus multilocularis tar DNA binding protein 0.0063 0.008 0.0063
Trichomonas vaginalis glucosylceramidase, putative 0.052 0.1992 1
Leishmania major guanosine monophosphate reductase 0.0407 0.1521 1
Brugia malayi TAR-binding protein 0.0063 0.008 0.0318
Echinococcus granulosus inosine 5' monophosphate dehydrogenase 2 0.0407 0.1521 1
Mycobacterium tuberculosis Probable inosine-5'-monophosphate dehydrogenase GuaB2 (imp dehydrogenase) (inosinic acid dehydrogenase) (inosinate dehydrogenase 0.0407 0.1521 0.2633
Echinococcus granulosus snurportin 1 0.0308 0.1106 0.7242
Onchocerca volvulus 0.0048 0.0017 0.0003
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0048 0.0017 0.0003
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0092 0.0203 0.1236
Mycobacterium ulcerans acyl-CoA synthetase 0.0071 0.0112 0.0132
Loa Loa (eye worm) hypothetical protein 0.0071 0.0112 0.0481
Trichomonas vaginalis glucosylceramidase, putative 0.052 0.1992 1
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0063 0.008 0.0317
Onchocerca volvulus 0.0071 0.0112 0.0777
Brugia malayi RNA recognition motif domain containing protein 0.0063 0.008 0.0318
Loa Loa (eye worm) hypothetical protein 0.0053 0.0038 0.0103
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0198 0.0643 1
Loa Loa (eye worm) hypothetical protein 0.0071 0.0112 0.0481
Brugia malayi hypothetical protein 0.0235 0.08 0.3963
Echinococcus granulosus Niemann Pick C1 protein 0.0198 0.0643 0.4165
Mycobacterium leprae Probable inosine-5'-monophosphate dehydrogenase GuaB3 (IMP dehydrogenase 2) (inosinic acid dehydrogenase) (inosinate dehydrogena 0.0225 0.0757 0.1153
Loa Loa (eye worm) hypothetical protein 0.0198 0.0643 0.3171
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0312 0.1122 0.7377
Loa Loa (eye worm) hypothetical protein 0.0053 0.0038 0.0103
Echinococcus multilocularis inosine 5' monophosphate dehydrogenase 2 0.0407 0.1521 0.1506
Mycobacterium ulcerans inosine 5'-monophosphate dehydrogenase 0.0407 0.1521 0.2617
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0312 0.1122 0.7377
Brugia malayi Niemann-Pick C1 protein precursor 0.0198 0.0643 0.3172
Loa Loa (eye worm) hypothetical protein 0.0053 0.0038 0.0103
Mycobacterium ulcerans AcrR family transcriptional regulator 0.1407 0.5704 1
Echinococcus multilocularis survival motor neuron protein 1 0.0235 0.08 0.0784
Trichomonas vaginalis glucosylceramidase, putative 0.0341 0.1244 0.5891
Schistosoma mansoni tar DNA-binding protein 0.0063 0.008 0.0418
Mycobacterium leprae Probable inosine-5'-monophosphate dehydrogenase GuaB2 (IMP dehydrogenase) (IMPDH) (IMPD) 0.0407 0.1521 0.2518
Wolbachia endosymbiont of Brugia malayi IMP dehydrogenase 0.0407 0.1521 0.5
Trichomonas vaginalis glucosylceramidase, putative 0.0341 0.1244 0.5891
Echinococcus multilocularis Niemann Pick C1 protein 0.0198 0.0643 0.0627
Brugia malayi AMP-binding enzyme family protein 0.0071 0.0112 0.0483
Schistosoma mansoni hypothetical protein 0.017 0.0526 0.3387
Trypanosoma cruzi inosine-5'-monophosphate dehydrogenase, putative 0.0407 0.1521 1
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0071 0.0112 0.0132
Trichomonas vaginalis glucosylceramidase, putative 0.0341 0.1244 0.5891
Onchocerca volvulus Putative GMP reductase 0.0178 0.0561 0.4433
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0092 0.0203 0.1238
Mycobacterium ulcerans acyl-CoA synthetase 0.0071 0.0112 0.0132
Loa Loa (eye worm) hypothetical protein 0.0053 0.0038 0.0103
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0189 0.0608 0.0592
Brugia malayi inosine-5'-monophosphate dehydrogenase 0.0178 0.0561 0.2754
Schistosoma mansoni tar DNA-binding protein 0.0063 0.008 0.0418
Mycobacterium ulcerans acyl-CoA synthetase 0.0071 0.0112 0.0132
Brugia malayi CHE-14 protein 0.0085 0.0171 0.0782
Plasmodium vivax inosine-5'-monophosphate dehydrogenase, putative 0.0403 0.1501 1

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.