Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | jmjC domain-containing protein | 0.006 | 0.2764 | 0.2764 |
Trypanosoma cruzi | JmjC domain, hydroxylase, putative | 0.0015 | 0.0524 | 0.5 |
Echinococcus multilocularis | lysine specific demethylase 6a | 0.0015 | 0.0524 | 0.0631 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0126 | 0.6107 | 0.6107 |
Echinococcus granulosus | cpg binding protein | 0.003 | 0.1258 | 0.1516 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0008 | 0.015 | 0.015 |
Echinococcus multilocularis | cpg binding protein | 0.003 | 0.1258 | 0.1516 |
Trypanosoma cruzi | JmjC domain, hydroxylase, putative | 0.0015 | 0.0524 | 0.5 |
Schistosoma mansoni | phd/f-box containing protein | 0.0015 | 0.0524 | 0.0631 |
Brugia malayi | jmjC domain containing protein | 0.0058 | 0.2682 | 0.2682 |
Brugia malayi | MH1 domain containing protein | 0.0008 | 0.015 | 0.015 |
Echinococcus granulosus | GPCR family 2 | 0.0016 | 0.0535 | 0.0645 |
Trichomonas vaginalis | bromodomain-containing protein, putative | 0.0042 | 0.1891 | 1 |
Schistosoma mansoni | gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 | 0.0145 | 0.7058 | 0.8508 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.005 | 0.2256 | 0.2256 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0007 | 0.0096 | 0.0115 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0016 | 0.0535 | 0.0535 |
Mycobacterium ulcerans | hypothetical protein | 0.0105 | 0.5065 | 0.5 |
Echinococcus multilocularis | Transcription factor, JmjC domain containing protein | 0.0058 | 0.2682 | 0.3233 |
Schistosoma mansoni | TGF-beta signal transducer Smad2 | 0.0008 | 0.015 | 0.018 |
Echinococcus granulosus | smad | 0.0008 | 0.015 | 0.018 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.146 | 0.146 |
Echinococcus granulosus | jumonji domain containing 1A | 0.0015 | 0.0524 | 0.0631 |
Echinococcus multilocularis | jumonji domain containing 1A | 0.0015 | 0.0524 | 0.0631 |
Echinococcus multilocularis | GPCR, family 2 | 0.0016 | 0.0535 | 0.0645 |
Echinococcus granulosus | mixed lineage leukemia protein mll | 0.0007 | 0.0096 | 0.0115 |
Echinococcus multilocularis | smad | 0.0008 | 0.015 | 0.018 |
Loa Loa (eye worm) | CXXC zinc finger family protein | 0.0028 | 0.1176 | 0.1176 |
Echinococcus granulosus | lysine specific demethylase 6a | 0.0015 | 0.0524 | 0.0631 |
Schistosoma mansoni | cpg binding protein | 0.003 | 0.1258 | 0.1516 |
Brugia malayi | MH2 domain containing protein | 0.0008 | 0.015 | 0.015 |
Brugia malayi | jmjC domain containing protein | 0.0015 | 0.0524 | 0.0524 |
Loa Loa (eye worm) | hypothetical protein | 0.0016 | 0.0535 | 0.0535 |
Echinococcus granulosus | tar DNA binding protein | 0.0126 | 0.6107 | 0.7362 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.0524 | 0.0524 |
Echinococcus granulosus | histone acetyltransferase KAT2B | 0.0042 | 0.1891 | 0.228 |
Loa Loa (eye worm) | MH1 domain-containing protein | 0.0008 | 0.015 | 0.015 |
Echinococcus granulosus | histone lysine N methyltransferase MLL3 | 0.0009 | 0.0183 | 0.0221 |
Schistosoma mansoni | smad | 0.0008 | 0.015 | 0.018 |
Schistosoma mansoni | jumonji domain containing protein | 0.0058 | 0.2682 | 0.3233 |
Echinococcus granulosus | histone acetyltransferase KAT2B | 0.014 | 0.6853 | 0.8261 |
Schistosoma mansoni | hypothetical protein | 0.0169 | 0.8296 | 1 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0016 | 0.0535 | 0.0645 |
Brugia malayi | MH2 domain containing protein | 0.0119 | 0.5767 | 0.5767 |
Echinococcus granulosus | lysine specific demethylase 5A | 0.006 | 0.2764 | 0.3331 |
Echinococcus granulosus | TGF beta signal transducer SmadC | 0.0008 | 0.015 | 0.018 |
Echinococcus multilocularis | phd:f box containing protein | 0.0015 | 0.0524 | 0.0631 |
Brugia malayi | MH1 domain containing protein | 0.0008 | 0.015 | 0.015 |
Schistosoma mansoni | protein phosphatase 2C | 0.0015 | 0.0524 | 0.0631 |
Echinococcus multilocularis | TGF beta signal transducer SmadC | 0.0008 | 0.015 | 0.018 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0015 | 0.0524 | 0.0524 |
Echinococcus granulosus | JmjC domain containing protein 4 | 0.0015 | 0.0524 | 0.0631 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0119 | 0.5767 | 0.5767 |
Echinococcus granulosus | geminin | 0.0169 | 0.8296 | 1 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0016 | 0.0535 | 0.0535 |
Echinococcus granulosus | mothers against decapentaplegic 5 | 0.0008 | 0.015 | 0.018 |
Schistosoma mansoni | phosphatidylserine receptor | 0.0015 | 0.0524 | 0.0631 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.006 | 0.2764 | 0.3331 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.0524 | 0.0524 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0015 | 0.0524 | 0.0524 |
Loa Loa (eye worm) | histone methyltransferase | 0.0009 | 0.0183 | 0.0183 |
Schistosoma mansoni | hypothetical protein | 0.0016 | 0.0535 | 0.0645 |
Echinococcus multilocularis | histone lysine N methyltransferase MLL3 | 0.0007 | 0.0096 | 0.0115 |
Trypanosoma brucei | JmjC domain, hydroxylase, putative | 0.0015 | 0.0524 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0126 | 0.6107 | 0.7362 |
Echinococcus multilocularis | tar DNA binding protein | 0.0126 | 0.6107 | 0.7362 |
Brugia malayi | jmjC domain containing protein | 0.0015 | 0.0524 | 0.0524 |
Schistosoma mansoni | tar DNA-binding protein | 0.0126 | 0.6107 | 0.7362 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0016 | 0.0535 | 0.0645 |
Loa Loa (eye worm) | acetyltransferase | 0.0145 | 0.7058 | 0.7058 |
Schistosoma mansoni | hypothetical protein | 0.0016 | 0.0535 | 0.0645 |
Brugia malayi | Smad1 | 0.0008 | 0.015 | 0.015 |
Toxoplasma gondii | histone lysine acetyltransferase GCN5-A | 0.0042 | 0.1891 | 0.646 |
Schistosoma mansoni | cpg binding protein | 0.0028 | 0.1176 | 0.1417 |
Brugia malayi | MH2 domain containing protein | 0.0008 | 0.015 | 0.015 |
Loa Loa (eye worm) | TAR-binding protein | 0.0126 | 0.6107 | 0.6107 |
Brugia malayi | acetyltransferase, GNAT family protein | 0.0145 | 0.7058 | 0.7058 |
Echinococcus granulosus | Smad4 | 0.0008 | 0.015 | 0.018 |
Loa Loa (eye worm) | RNA binding protein | 0.0126 | 0.6107 | 0.6107 |
Schistosoma mansoni | hypothetical protein | 0.0169 | 0.8296 | 1 |
Brugia malayi | RNA binding protein | 0.0126 | 0.6107 | 0.6107 |
Schistosoma mansoni | Smad4 | 0.0008 | 0.015 | 0.018 |
Schistosoma mansoni | smad1 5 8 and | 0.0008 | 0.015 | 0.018 |
Leishmania major | hypothetical protein, conserved | 0.0015 | 0.0524 | 0.5 |
Entamoeba histolytica | acetyltransferase, GNAT family | 0.0039 | 0.1712 | 0.5 |
Toxoplasma gondii | histone lysine methyltransferase SET1 | 0.0057 | 0.2641 | 1 |
Schistosoma mansoni | jumonji domain containing protein | 0.0015 | 0.0524 | 0.0631 |
Plasmodium vivax | histone acetyltransferase GCN5, putative | 0.0042 | 0.1891 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0126 | 0.6107 | 0.7362 |
Echinococcus multilocularis | mothers against decapentaplegic 5 | 0.0008 | 0.015 | 0.018 |
Brugia malayi | TAR-binding protein | 0.0126 | 0.6107 | 0.6107 |
Brugia malayi | jmjC domain containing protein | 0.006 | 0.2764 | 0.2764 |
Plasmodium falciparum | histone acetyltransferase GCN5 | 0.0039 | 0.1712 | 1 |
Echinococcus multilocularis | mixed lineage leukemia protein mll | 0.0007 | 0.0096 | 0.0115 |
Echinococcus granulosus | phd:f box containing protein | 0.0015 | 0.0524 | 0.0631 |
Echinococcus granulosus | Jumonji AT rich interactive domain 1B | 0.0017 | 0.0605 | 0.073 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0126 | 0.6107 | 0.6107 |
Echinococcus multilocularis | lysine specific demethylase 5A | 0.0058 | 0.2682 | 0.3233 |
Brugia malayi | jmjC domain containing protein | 0.0015 | 0.0524 | 0.0524 |
Schistosoma mansoni | hypothetical protein | 0.0034 | 0.146 | 0.1759 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0169 | 0.8279 | 0.998 |
Schistosoma mansoni | smad1 5 8 and | 0.0008 | 0.015 | 0.018 |
Loa Loa (eye worm) | hypothetical protein | 0.0203 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0016 | 0.0535 | 0.0645 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0015 | 0.0524 | 0.0524 |
Giardia lamblia | Histone acetyltransferase GCN5 | 0.0039 | 0.1712 | 0.5 |
Echinococcus granulosus | histone lysine N methyltransferase MLL3 | 0.0007 | 0.0096 | 0.0115 |
Brugia malayi | jmjC domain containing protein | 0.0015 | 0.0524 | 0.0524 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0034 | 0.146 | 0.146 |
Trichomonas vaginalis | cat eye syndrome critical region protein 2, cscr2, putative | 0.0042 | 0.1891 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0126 | 0.6107 | 0.7362 |
Echinococcus granulosus | Transcription factor JmjC domain containing protein | 0.0058 | 0.2682 | 0.3233 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0169 | 0.8279 | 0.998 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0016 | 0.0535 | 0.0535 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0119 | 0.5767 | 0.5767 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.006 | 0.2787 | 0.336 |
Echinococcus multilocularis | geminin | 0.0169 | 0.8296 | 1 |
Brugia malayi | CXXC zinc finger family protein | 0.0028 | 0.1176 | 0.1176 |
Toxoplasma gondii | histone lysine acetyltransferase GCN5-B | 0.0042 | 0.1891 | 0.646 |
Echinococcus multilocularis | Smad4 | 0.0008 | 0.015 | 0.018 |
Schistosoma mansoni | smad1 5 8 and | 0.0008 | 0.015 | 0.018 |
Echinococcus multilocularis | JmjC domain containing protein 4 | 0.0015 | 0.0524 | 0.0631 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.005 | 0.2256 | 0.2256 |
Onchocerca volvulus | 0.0028 | 0.1176 | 0.5 | |
Echinococcus multilocularis | Jumonji, AT rich interactive domain 1B | 0.0017 | 0.0605 | 0.073 |
Schistosoma mansoni | hypothetical protein | 0.0016 | 0.0535 | 0.0645 |
Schistosoma mansoni | ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related | 0.0015 | 0.0524 | 0.0631 |
Loa Loa (eye worm) | Smad1 | 0.0008 | 0.015 | 0.015 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.006 | 0.2764 | 0.3331 |
Echinococcus multilocularis | histone lysine N methyltransferase MLL3 | 0.0009 | 0.0183 | 0.0221 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.0524 | 0.0524 |
Echinococcus multilocularis | gcn5proteinral control of amino acid synthesis | 0.0145 | 0.7058 | 0.8508 |
Brugia malayi | F/Y-rich N-terminus family protein | 0.0009 | 0.0178 | 0.0178 |
Schistosoma mansoni | cpg binding protein | 0.003 | 0.1258 | 0.1516 |
Schistosoma mansoni | tar DNA-binding protein | 0.0126 | 0.6107 | 0.7362 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.