Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | phenylalanyl tRNA synthetase alpha chain B | 0.036 | 0.2203 | 0.7193 |
Echinococcus multilocularis | polycomb protein SCMH1 | 0.005 | 0.0158 | 0.0276 |
Trichomonas vaginalis | phosphofructokinase, putative | 0.0114 | 0.0581 | 0.2532 |
Schistosoma mansoni | 6-phosphofructokinase | 0.0114 | 0.0581 | 0.212 |
Loa Loa (eye worm) | hypothetical protein | 0.0074 | 0.0318 | 0.1063 |
Onchocerca volvulus | 0.005 | 0.0158 | 0.5 | |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0063 | 0.0241 | 0.0557 |
Trichomonas vaginalis | phenylalanyl-tRNA synthetase alpha chain, putative | 0.0137 | 0.0734 | 0.3235 |
Echinococcus granulosus | SAM and MBT domain containing protein | 0.005 | 0.0158 | 0.0276 |
Plasmodium falciparum | phenylalanine--tRNA ligase | 0.0176 | 0.0991 | 0.4418 |
Brugia malayi | 6-phosphofructokinase | 0.0114 | 0.0581 | 0.2636 |
Onchocerca volvulus | Polycomb protein Sfmbt homolog | 0.005 | 0.0158 | 0.5 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0048 | 0.0144 | 0.023 |
Toxoplasma gondii | Ferredoxin-fold anticodon binding domain-containing protein | 0.0243 | 0.1434 | 0.6459 |
Giardia lamblia | Phenylalanyl-tRNA synthetase alpha chain | 0.036 | 0.2203 | 1 |
Plasmodium falciparum | phenylalanine--tRNA ligase alpha subunit | 0.036 | 0.2203 | 1 |
Brugia malayi | mbt repeat family protein | 0.005 | 0.0158 | 0.0717 |
Trichomonas vaginalis | phenylalanyl-tRNA synthetase alpha chain, putative | 0.0137 | 0.0734 | 0.3235 |
Echinococcus granulosus | 6 phosphofructokinase | 0.0114 | 0.0581 | 0.1706 |
Trichomonas vaginalis | phosphofructokinase, putative | 0.0114 | 0.0581 | 0.2532 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.011 | 0.0078 |
Entamoeba histolytica | phosphofructokinase, putative | 0.0114 | 0.0581 | 0.2532 |
Echinococcus granulosus | histone acetyltransferase MYST2 | 0.0057 | 0.0204 | 0.0431 |
Plasmodium vivax | phenylalanine--tRNA ligase, putative | 0.0243 | 0.1434 | 0.6459 |
Echinococcus granulosus | phenylalanyl tRNA synthetase | 0.0243 | 0.1434 | 0.4592 |
Loa Loa (eye worm) | mbt repeat family protein | 0.005 | 0.0158 | 0.0307 |
Echinococcus granulosus | polycomb protein SCMH1 | 0.005 | 0.0158 | 0.0276 |
Trichomonas vaginalis | phosphofructokinase, putative | 0.0114 | 0.0581 | 0.2532 |
Brugia malayi | C2-HC type zinc finger protein C.e-MyT1 | 0.0057 | 0.0204 | 0.0925 |
Entamoeba histolytica | phenylalanyl-tRNA synthetase alpha subunit, putative | 0.036 | 0.2203 | 1 |
Echinococcus multilocularis | neuropeptide s receptor | 0.0485 | 0.3033 | 1 |
Echinococcus multilocularis | SAM and MBT domain containing protein | 0.005 | 0.0158 | 0.0276 |
Brugia malayi | Bromodomain containing protein | 0.004 | 0.0093 | 0.0421 |
Mycobacterium ulcerans | 6-phosphofructokinase | 0.0114 | 0.0581 | 0.0501 |
Wolbachia endosymbiont of Brugia malayi | phenylalanyl-tRNA synthetase subunit alpha | 0.154 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0304 | 0.1837 | 0.8224 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0048 | 0.0144 | 0.023 |
Echinococcus multilocularis | 6 phosphofructokinase | 0.0114 | 0.0581 | 0.1706 |
Echinococcus granulosus | neuropeptide receptor A26 | 0.0485 | 0.3033 | 1 |
Echinococcus granulosus | endonuclease exonuclease phosphatase | 0.0197 | 0.113 | 0.3565 |
Schistosoma mansoni | scm-relatedprotein containing 4 mbt domains (sfmbt) | 0.005 | 0.0158 | 0.0066 |
Schistosoma mansoni | sex comb on midleg homolog | 0.005 | 0.0158 | 0.0066 |
Leishmania major | phenylalanyl-tRNA synthetase alpha chain, putative | 0.036 | 0.2203 | 1 |
Brugia malayi | 6-phosphofructokinase | 0.0114 | 0.0581 | 0.2636 |
Echinococcus granulosus | neuropeptide s receptor | 0.0485 | 0.3033 | 1 |
Schistosoma mansoni | myelin transcription factor 1 myt1 | 0.0057 | 0.0204 | 0.0288 |
Plasmodium falciparum | phenylalanine--tRNA ligase | 0.0243 | 0.1434 | 0.6459 |
Echinococcus multilocularis | neuropeptide receptor A26 | 0.0485 | 0.3033 | 1 |
Entamoeba histolytica | phosphofructokinase, putative | 0.0114 | 0.0581 | 0.2532 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0048 | 0.0144 | 0.023 |
Loa Loa (eye worm) | 6-phosphofructokinase | 0.0114 | 0.0581 | 0.2311 |
Echinococcus multilocularis | suppression of tumorigenicity 18 protein | 0.0057 | 0.0204 | 0.0431 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0063 | 0.0241 | 0.0557 |
Trichomonas vaginalis | phenylalanyl-tRNA synthetase alpha chain, putative | 0.036 | 0.2203 | 1 |
Schistosoma mansoni | 6-phosphofructokinase | 0.0114 | 0.0581 | 0.212 |
Entamoeba histolytica | phosphofructokinase, putative | 0.0114 | 0.0581 | 0.2532 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0048 | 0.0144 | 0.0655 |
Toxoplasma gondii | phenylalanyl-tRNA synthetase alpha chain A, putative | 0.036 | 0.2203 | 1 |
Schistosoma mansoni | phenylalanyl-tRNA synthetase mitochondrial | 0.0243 | 0.1434 | 0.6264 |
Echinococcus multilocularis | histone acetyltransferase MYST2 | 0.0057 | 0.0204 | 0.0431 |
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0.0158 | 0.0307 |
Schistosoma mansoni | sex comb on midleg homolog | 0.005 | 0.0158 | 0.0066 |
Loa Loa (eye worm) | hypothetical protein | 0.0057 | 0.0204 | 0.0523 |
Brugia malayi | Bromodomain containing protein | 0.0079 | 0.0347 | 0.1576 |
Brugia malayi | phenylalanyl (f) trna synthetase protein 1 | 0.036 | 0.2203 | 1 |
Loa Loa (eye worm) | phenylalanyl-tRNA synthetase | 0.0243 | 0.1434 | 0.6354 |
Loa Loa (eye worm) | phosphofructokinase | 0.0114 | 0.0581 | 0.2311 |
Brugia malayi | phenylalanyl-tRNA synthetase, mitochondrial precursor, putative | 0.0243 | 0.1434 | 0.6509 |
Echinococcus granulosus | suppression of tumorigenicity 18 protein | 0.0057 | 0.0204 | 0.0431 |
Brugia malayi | phosphofructokinase | 0.0114 | 0.0581 | 0.2636 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0048 | 0.0144 | 0.0242 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0048 | 0.0144 | 0.023 |
Mycobacterium tuberculosis | Probable phenylalanyl-tRNA synthetase, alpha chain PheS | 0.154 | 1 | 1 |
Plasmodium vivax | phenylalanine--tRNA ligase alpha subunit, putative | 0.036 | 0.2203 | 1 |
Trypanosoma brucei | phenylalanyl-tRNA synthetase alpha chain, putative | 0.036 | 0.2203 | 1 |
Echinococcus multilocularis | phenylalanyl tRNA synthetase alpha chain B | 0.036 | 0.2203 | 0.7193 |
Loa Loa (eye worm) | 6-phosphofructokinase | 0.0114 | 0.0581 | 0.2311 |
Treponema pallidum | diphosphate--fructose-6-phosphate 1-phosphotransferase | 0.0114 | 0.0581 | 0.2532 |
Mycobacterium tuberculosis | Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) | 0.0114 | 0.0581 | 0.0501 |
Mycobacterium ulcerans | phenylalanyl-tRNA synthetase subunit alpha | 0.154 | 1 | 1 |
Schistosoma mansoni | phenylalanyl-tRNA synthetase subunit alpha | 0.0137 | 0.0734 | 0.2862 |
Loa Loa (eye worm) | MBCTL1 | 0.0057 | 0.0204 | 0.0523 |
Trichomonas vaginalis | phosphofructokinase, putative | 0.0114 | 0.0581 | 0.2532 |
Brugia malayi | mbt repeat family protein | 0.005 | 0.0158 | 0.0717 |
Schistosoma mansoni | phenylalanyl-tRNA synthetase subunit alpha | 0.036 | 0.2203 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0045 | 0.0123 | 0.0141 |
Mycobacterium leprae | Probable phenylalanyl-tRNA synthetase, alpha chain PheS | 0.0222 | 0.1297 | 1 |
Echinococcus multilocularis | phenylalanyl tRNA synthetase | 0.0243 | 0.1434 | 0.4592 |
Schistosoma mansoni | bromodomain containing protein | 0.0066 | 0.0266 | 0.0591 |
Chlamydia trachomatis | phenylalanine--tRNA ligase subunit beta | 0.0039 | 0.0084 | 0.0054 |
Trypanosoma cruzi | phenylalanyl-tRNA synthetase alpha chain, putative | 0.036 | 0.2203 | 1 |
Treponema pallidum | phenylalanyl-tRNA synthetase subunit alpha | 0.036 | 0.2203 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.036 | 0.2203 | 1 |
Plasmodium vivax | phenylalanine--tRNA ligase, putative | 0.0137 | 0.0734 | 0.3235 |
Echinococcus multilocularis | endonuclease exonuclease phosphatase | 0.0197 | 0.113 | 0.3565 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.