Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | 6-phosphofructokinase | 0.0115 | 0.1251 | 0.5956 |
Onchocerca volvulus | Polycomb protein Sfmbt homolog | 0.005 | 0.0365 | 0.5 |
Trypanosoma brucei | phenylalanyl-tRNA synthetase alpha chain, putative | 0.0175 | 0.2078 | 1 |
Echinococcus granulosus | neuropeptide s receptor | 0.0487 | 0.6389 | 1 |
Onchocerca volvulus | 0.005 | 0.0365 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0.0365 | 0.0733 |
Echinococcus multilocularis | neuropeptide s receptor | 0.0487 | 0.6389 | 1 |
Schistosoma mansoni | 6-phosphofructokinase | 0.0115 | 0.1251 | 0.3222 |
Echinococcus multilocularis | SAM and MBT domain containing protein | 0.005 | 0.0365 | 0.0572 |
Loa Loa (eye worm) | hypothetical protein | 0.0175 | 0.2078 | 1 |
Trichomonas vaginalis | phenylalanyl-tRNA synthetase alpha chain, putative | 0.0175 | 0.2078 | 1 |
Brugia malayi | Bromodomain containing protein | 0.004 | 0.0229 | 0.0952 |
Loa Loa (eye worm) | hypothetical protein | 0.0045 | 0.0292 | 0.0336 |
Entamoeba histolytica | phenylalanyl-tRNA synthetase alpha subunit, putative | 0.0175 | 0.2078 | 1 |
Toxoplasma gondii | phenylalanyl-tRNA synthetase alpha chain A, putative | 0.0175 | 0.2078 | 1 |
Echinococcus multilocularis | polycomb protein SCMH1 | 0.005 | 0.0365 | 0.0572 |
Echinococcus granulosus | suppression of tumorigenicity 18 protein | 0.0057 | 0.0461 | 0.0722 |
Entamoeba histolytica | phosphofructokinase, putative | 0.0115 | 0.1251 | 0.5823 |
Trichomonas vaginalis | phenylalanyl-tRNA synthetase alpha chain, putative | 0.0066 | 0.0585 | 0.2454 |
Plasmodium falciparum | phenylalanine--tRNA ligase | 0.0116 | 0.1277 | 0.595 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0048 | 0.0337 | 0.0527 |
Schistosoma mansoni | hypothetical protein | 0.0306 | 0.3884 | 1 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0063 | 0.054 | 0.0845 |
Mycobacterium tuberculosis | Probable phenylalanyl-tRNA synthetase, alpha chain PheS | 0.0749 | 1 | 1 |
Schistosoma mansoni | phenylalanyl-tRNA synthetase subunit alpha | 0.0175 | 0.2078 | 0.5349 |
Plasmodium falciparum | phenylalanine--tRNA ligase alpha subunit | 0.0175 | 0.2078 | 1 |
Trichomonas vaginalis | phosphofructokinase, putative | 0.0115 | 0.1251 | 0.5823 |
Schistosoma mansoni | 6-phosphofructokinase | 0.0115 | 0.1251 | 0.3222 |
Giardia lamblia | Phenylalanyl-tRNA synthetase alpha chain | 0.0175 | 0.2078 | 1 |
Schistosoma mansoni | scm-relatedprotein containing 4 mbt domains (sfmbt) | 0.005 | 0.0365 | 0.0941 |
Echinococcus granulosus | 6 phosphofructokinase | 0.0115 | 0.1251 | 0.1959 |
Mycobacterium ulcerans | phenylalanyl-tRNA synthetase subunit alpha | 0.0749 | 1 | 1 |
Echinococcus granulosus | polycomb protein SCMH1 | 0.005 | 0.0365 | 0.0572 |
Brugia malayi | mbt repeat family protein | 0.005 | 0.0365 | 0.162 |
Echinococcus multilocularis | phenylalanyl tRNA synthetase | 0.0116 | 0.1277 | 0.1998 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0048 | 0.0337 | 0.0579 |
Echinococcus granulosus | histone acetyltransferase MYST2 | 0.0057 | 0.0461 | 0.0722 |
Echinococcus granulosus | SAM and MBT domain containing protein | 0.005 | 0.0365 | 0.0572 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0048 | 0.0337 | 0.0527 |
Echinococcus granulosus | neuropeptide receptor A26 | 0.0487 | 0.6389 | 1 |
Loa Loa (eye worm) | 6-phosphofructokinase | 0.0115 | 0.1251 | 0.5528 |
Toxoplasma gondii | Ferredoxin-fold anticodon binding domain-containing protein | 0.0116 | 0.1277 | 0.595 |
Echinococcus multilocularis | suppression of tumorigenicity 18 protein | 0.0057 | 0.0461 | 0.0722 |
Treponema pallidum | diphosphate--fructose-6-phosphate 1-phosphotransferase | 0.0115 | 0.1251 | 0.5823 |
Leishmania major | phenylalanyl-tRNA synthetase alpha chain, putative | 0.0175 | 0.2078 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0048 | 0.0337 | 0.0867 |
Brugia malayi | mbt repeat family protein | 0.005 | 0.0365 | 0.162 |
Loa Loa (eye worm) | phosphofructokinase | 0.0115 | 0.1251 | 0.5528 |
Schistosoma mansoni | bromodomain containing protein | 0.0067 | 0.0592 | 0.1523 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0048 | 0.0337 | 0.1481 |
Wolbachia endosymbiont of Brugia malayi | phenylalanyl-tRNA synthetase subunit alpha | 0.0749 | 1 | 0.5 |
Brugia malayi | phenylalanyl (f) trna synthetase protein 1 | 0.0175 | 0.2078 | 1 |
Schistosoma mansoni | phenylalanyl-tRNA synthetase mitochondrial | 0.0116 | 0.1277 | 0.3286 |
Brugia malayi | Bromodomain containing protein | 0.0079 | 0.0762 | 0.356 |
Plasmodium falciparum | phenylalanine--tRNA ligase | 0.0085 | 0.0839 | 0.3737 |
Treponema pallidum | phenylalanyl-tRNA synthetase subunit alpha | 0.0175 | 0.2078 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0048 | 0.0337 | 0.0867 |
Brugia malayi | phenylalanyl-tRNA synthetase, mitochondrial precursor, putative | 0.0116 | 0.1277 | 0.6079 |
Trypanosoma cruzi | phenylalanyl-tRNA synthetase alpha chain, putative | 0.0175 | 0.2078 | 1 |
Brugia malayi | C2-HC type zinc finger protein C.e-MyT1 | 0.0057 | 0.0461 | 0.2089 |
Brugia malayi | phosphofructokinase | 0.0115 | 0.1251 | 0.5956 |
Schistosoma mansoni | phenylalanyl-tRNA synthetase subunit alpha | 0.0066 | 0.0585 | 0.1505 |
Trichomonas vaginalis | phosphofructokinase, putative | 0.0115 | 0.1251 | 0.5823 |
Entamoeba histolytica | phosphofructokinase, putative | 0.0115 | 0.1251 | 0.5823 |
Echinococcus granulosus | endonuclease exonuclease phosphatase | 0.0198 | 0.2403 | 0.3761 |
Echinococcus granulosus | phenylalanyl tRNA synthetase alpha chain B | 0.0175 | 0.2078 | 0.3252 |
Brugia malayi | 6-phosphofructokinase | 0.0115 | 0.1251 | 0.5956 |
Loa Loa (eye worm) | MBCTL1 | 0.0057 | 0.0461 | 0.1252 |
Echinococcus multilocularis | histone acetyltransferase MYST2 | 0.0057 | 0.0461 | 0.0722 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0038 | 0.0194 | 0.0304 |
Schistosoma mansoni | myelin transcription factor 1 myt1 | 0.0057 | 0.0461 | 0.1188 |
Plasmodium vivax | phenylalanine--tRNA ligase, putative | 0.0066 | 0.0585 | 0.2454 |
Trichomonas vaginalis | phenylalanyl-tRNA synthetase alpha chain, putative | 0.0066 | 0.0585 | 0.2454 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.0264 | 0.0186 |
Echinococcus granulosus | phenylalanyl tRNA synthetase | 0.0116 | 0.1277 | 0.1998 |
Trichomonas vaginalis | phosphofructokinase, putative | 0.0115 | 0.1251 | 0.5823 |
Loa Loa (eye worm) | hypothetical protein | 0.0075 | 0.07 | 0.2543 |
Schistosoma mansoni | sex comb on midleg homolog | 0.005 | 0.0365 | 0.0941 |
Plasmodium vivax | phenylalanine--tRNA ligase, putative | 0.0116 | 0.1277 | 0.595 |
Entamoeba histolytica | phosphofructokinase, putative | 0.0115 | 0.1251 | 0.5823 |
Loa Loa (eye worm) | hypothetical protein | 0.0057 | 0.0461 | 0.1252 |
Plasmodium vivax | phenylalanine--tRNA ligase alpha subunit, putative | 0.0175 | 0.2078 | 1 |
Echinococcus multilocularis | endonuclease exonuclease phosphatase | 0.0198 | 0.2403 | 0.3761 |
Loa Loa (eye worm) | phenylalanyl-tRNA synthetase | 0.0116 | 0.1277 | 0.5664 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0038 | 0.0194 | 0.0304 |
Loa Loa (eye worm) | mbt repeat family protein | 0.005 | 0.0365 | 0.0733 |
Echinococcus multilocularis | neuropeptide receptor A26 | 0.0487 | 0.6389 | 1 |
Echinococcus multilocularis | phenylalanyl tRNA synthetase alpha chain B | 0.0175 | 0.2078 | 0.3252 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0048 | 0.0337 | 0.0527 |
Trichomonas vaginalis | phosphofructokinase, putative | 0.0115 | 0.1251 | 0.5823 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0063 | 0.054 | 0.0845 |
Schistosoma mansoni | sex comb on midleg homolog | 0.005 | 0.0365 | 0.0941 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0048 | 0.0337 | 0.0527 |
Mycobacterium leprae | PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) | 0.0115 | 0.1251 | 1 |
Echinococcus multilocularis | 6 phosphofructokinase | 0.0115 | 0.1251 | 0.1959 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0048 | 0.0337 | 0.0867 |
Loa Loa (eye worm) | 6-phosphofructokinase | 0.0115 | 0.1251 | 0.5528 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.