Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Bromodomain containing protein | 0.0076 | 0.0719 | 0.3331 |
Schistosoma mansoni | phenylalanyl-tRNA synthetase mitochondrial | 0.0119 | 0.1298 | 0.3541 |
Trypanosoma cruzi | phenylalanyl-tRNA synthetase alpha chain, putative | 0.0178 | 0.2093 | 1 |
Wolbachia endosymbiont of Brugia malayi | phenylalanyl-tRNA synthetase subunit alpha | 0.0762 | 1 | 0.5 |
Loa Loa (eye worm) | 6-phosphofructokinase | 0.011 | 0.1181 | 0.5137 |
Schistosoma mansoni | bromodomain containing protein | 0.0064 | 0.0558 | 0.1523 |
Entamoeba histolytica | phosphofructokinase, putative | 0.011 | 0.1181 | 0.5437 |
Trichomonas vaginalis | phosphofructokinase, putative | 0.011 | 0.1181 | 0.5437 |
Entamoeba histolytica | phenylalanyl-tRNA synthetase alpha subunit, putative | 0.0178 | 0.2093 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0055 | 0.0435 | 0.1164 |
Plasmodium falciparum | phenylalanine--tRNA ligase | 0.0086 | 0.0858 | 0.3824 |
Giardia lamblia | Phenylalanyl-tRNA synthetase alpha chain | 0.0178 | 0.2093 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0046 | 0.0318 | 0.0867 |
Toxoplasma gondii | Ferredoxin-fold anticodon binding domain-containing protein | 0.0119 | 0.1298 | 0.6022 |
Echinococcus multilocularis | suppression of tumorigenicity 18 protein | 0.0055 | 0.0435 | 0.0722 |
Echinococcus multilocularis | phenylalanyl tRNA synthetase alpha chain B | 0.0178 | 0.2093 | 0.3472 |
Loa Loa (eye worm) | MBCTL1 | 0.0055 | 0.0435 | 0.1164 |
Brugia malayi | phosphofructokinase | 0.011 | 0.1181 | 0.5572 |
Echinococcus granulosus | endonuclease exonuclease phosphatase | 0.019 | 0.2267 | 0.3761 |
Loa Loa (eye worm) | phenylalanyl-tRNA synthetase | 0.0119 | 0.1298 | 0.5761 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0249 | 0.0173 |
Trichomonas vaginalis | phenylalanyl-tRNA synthetase alpha chain, putative | 0.0067 | 0.0603 | 0.2548 |
Plasmodium vivax | phenylalanine--tRNA ligase, putative | 0.0067 | 0.0603 | 0.2548 |
Brugia malayi | C2-HC type zinc finger protein C.e-MyT1 | 0.0055 | 0.0435 | 0.1955 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0036 | 0.0183 | 0.0304 |
Schistosoma mansoni | myelin transcription factor 1 myt1 | 0.0055 | 0.0435 | 0.1188 |
Echinococcus granulosus | 6 phosphofructokinase | 0.011 | 0.1181 | 0.1959 |
Plasmodium vivax | phenylalanine--tRNA ligase, putative | 0.0119 | 0.1298 | 0.6022 |
Brugia malayi | mbt repeat family protein | 0.0048 | 0.0345 | 0.1516 |
Loa Loa (eye worm) | hypothetical protein | 0.0072 | 0.066 | 0.2363 |
Treponema pallidum | diphosphate--fructose-6-phosphate 1-phosphotransferase | 0.011 | 0.1181 | 0.5437 |
Loa Loa (eye worm) | hypothetical protein | 0.0178 | 0.2093 | 1 |
Leishmania major | phenylalanyl-tRNA synthetase alpha chain, putative | 0.0178 | 0.2093 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0046 | 0.0318 | 0.0867 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0036 | 0.0183 | 0.0304 |
Loa Loa (eye worm) | mbt repeat family protein | 0.0048 | 0.0345 | 0.0681 |
Echinococcus multilocularis | neuropeptide receptor A26 | 0.0469 | 0.6029 | 1 |
Plasmodium falciparum | phenylalanine--tRNA ligase | 0.0119 | 0.1298 | 0.6022 |
Echinococcus multilocularis | endonuclease exonuclease phosphatase | 0.019 | 0.2267 | 0.3761 |
Loa Loa (eye worm) | 6-phosphofructokinase | 0.011 | 0.1181 | 0.5137 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0046 | 0.0318 | 0.0527 |
Echinococcus multilocularis | 6 phosphofructokinase | 0.011 | 0.1181 | 0.1959 |
Schistosoma mansoni | 6-phosphofructokinase | 0.011 | 0.1181 | 0.3222 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0046 | 0.0318 | 0.0867 |
Brugia malayi | mbt repeat family protein | 0.0048 | 0.0345 | 0.1516 |
Trichomonas vaginalis | phosphofructokinase, putative | 0.011 | 0.1181 | 0.5437 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.006 | 0.0509 | 0.0845 |
Onchocerca volvulus | 0.0048 | 0.0345 | 0.5 | |
Echinococcus multilocularis | polycomb protein SCMH1 | 0.0048 | 0.0345 | 0.0572 |
Echinococcus granulosus | neuropeptide s receptor | 0.0469 | 0.6029 | 1 |
Schistosoma mansoni | phenylalanyl-tRNA synthetase subunit alpha | 0.0178 | 0.2093 | 0.5711 |
Onchocerca volvulus | Polycomb protein Sfmbt homolog | 0.0048 | 0.0345 | 0.5 |
Brugia malayi | 6-phosphofructokinase | 0.011 | 0.1181 | 0.5572 |
Schistosoma mansoni | scm-relatedprotein containing 4 mbt domains (sfmbt) | 0.0048 | 0.0345 | 0.0941 |
Loa Loa (eye worm) | phosphofructokinase | 0.011 | 0.1181 | 0.5137 |
Echinococcus multilocularis | neuropeptide s receptor | 0.0469 | 0.6029 | 1 |
Entamoeba histolytica | phosphofructokinase, putative | 0.011 | 0.1181 | 0.5437 |
Trichomonas vaginalis | phenylalanyl-tRNA synthetase alpha chain, putative | 0.0067 | 0.0603 | 0.2548 |
Echinococcus granulosus | suppression of tumorigenicity 18 protein | 0.0055 | 0.0435 | 0.0722 |
Echinococcus granulosus | SAM and MBT domain containing protein | 0.0048 | 0.0345 | 0.0572 |
Toxoplasma gondii | phenylalanyl-tRNA synthetase alpha chain A, putative | 0.0178 | 0.2093 | 1 |
Echinococcus granulosus | phenylalanyl tRNA synthetase alpha chain B | 0.0178 | 0.2093 | 0.3472 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.0276 | 0.0312 |
Trichomonas vaginalis | phenylalanyl-tRNA synthetase alpha chain, putative | 0.0178 | 0.2093 | 1 |
Brugia malayi | Bromodomain containing protein | 0.0039 | 0.0216 | 0.089 |
Treponema pallidum | phenylalanyl-tRNA synthetase subunit alpha | 0.0178 | 0.2093 | 1 |
Plasmodium vivax | phenylalanine--tRNA ligase alpha subunit, putative | 0.0178 | 0.2093 | 1 |
Mycobacterium tuberculosis | Probable phenylalanyl-tRNA synthetase, alpha chain PheS | 0.0762 | 1 | 1 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.006 | 0.0509 | 0.0845 |
Schistosoma mansoni | hypothetical protein | 0.0294 | 0.3665 | 1 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0046 | 0.0318 | 0.1385 |
Echinococcus multilocularis | phenylalanyl tRNA synthetase | 0.0119 | 0.1298 | 0.2153 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.0345 | 0.0681 |
Trypanosoma brucei | phenylalanyl-tRNA synthetase alpha chain, putative | 0.0178 | 0.2093 | 1 |
Trichomonas vaginalis | phosphofructokinase, putative | 0.011 | 0.1181 | 0.5437 |
Schistosoma mansoni | 6-phosphofructokinase | 0.011 | 0.1181 | 0.3222 |
Plasmodium falciparum | phenylalanine--tRNA ligase alpha subunit | 0.0178 | 0.2093 | 1 |
Echinococcus granulosus | phenylalanyl tRNA synthetase | 0.0119 | 0.1298 | 0.2153 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0046 | 0.0318 | 0.0538 |
Schistosoma mansoni | sex comb on midleg homolog | 0.0048 | 0.0345 | 0.0941 |
Mycobacterium ulcerans | phenylalanyl-tRNA synthetase subunit alpha | 0.0762 | 1 | 1 |
Schistosoma mansoni | sex comb on midleg homolog | 0.0048 | 0.0345 | 0.0941 |
Brugia malayi | 6-phosphofructokinase | 0.011 | 0.1181 | 0.5572 |
Echinococcus multilocularis | histone acetyltransferase MYST2 | 0.0055 | 0.0435 | 0.0722 |
Brugia malayi | phenylalanyl-tRNA synthetase, mitochondrial precursor, putative | 0.0119 | 0.1298 | 0.614 |
Trichomonas vaginalis | phosphofructokinase, putative | 0.011 | 0.1181 | 0.5437 |
Echinococcus granulosus | neuropeptide receptor A26 | 0.0469 | 0.6029 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0046 | 0.0318 | 0.0527 |
Echinococcus granulosus | polycomb protein SCMH1 | 0.0048 | 0.0345 | 0.0572 |
Echinococcus granulosus | histone acetyltransferase MYST2 | 0.0055 | 0.0435 | 0.0722 |
Mycobacterium leprae | Probable phenylalanyl-tRNA synthetase, alpha chain PheS | 0.011 | 0.1181 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0046 | 0.0318 | 0.0527 |
Schistosoma mansoni | phenylalanyl-tRNA synthetase subunit alpha | 0.0067 | 0.0603 | 0.1646 |
Echinococcus multilocularis | SAM and MBT domain containing protein | 0.0048 | 0.0345 | 0.0572 |
Brugia malayi | phenylalanyl (f) trna synthetase protein 1 | 0.0178 | 0.2093 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0046 | 0.0318 | 0.0527 |
Entamoeba histolytica | phosphofructokinase, putative | 0.011 | 0.1181 | 0.5437 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.