Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | Probable cytochrome P450 136 Cyp136 | 0.0012 | 0 | 0.5 |
Trypanosoma cruzi | ubiquitin carboxyl-terminal hydrolase, putative | 0.0084 | 1 | 1 |
Echinococcus multilocularis | dual specificity protein kinase clk2 | 0.0067 | 0.7672 | 0.7672 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0084 | 1 | 1 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0033 | 0.2936 | 0.2936 |
Leishmania major | protein kinase, putative | 0.0067 | 0.7672 | 0.7672 |
Entamoeba histolytica | ubiquitin carboxyl-terminal hydrolase domain containing protein | 0.0084 | 1 | 0.5 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0022 | 0.1348 | 0.1348 |
Trypanosoma cruzi | kinetoplastid kinetochore protein 19, putative | 0.0067 | 0.7672 | 0.7672 |
Mycobacterium tuberculosis | Probable cytochrome P450 144 Cyp144 | 0.0012 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable cytochrome P450 138 Cyp138 | 0.0012 | 0 | 0.5 |
Trichomonas vaginalis | Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase | 0.0084 | 1 | 1 |
Trypanosoma brucei | kinetoplastid kinetochore protein 19 | 0.0067 | 0.7672 | 0.7672 |
Loa Loa (eye worm) | hypothetical protein | 0.0067 | 0.7601 | 0.7601 |
Mycobacterium tuberculosis | Probable cytochrome P450 124 Cyp124 | 0.0012 | 0 | 0.5 |
Mycobacterium leprae | putative cytochrome p450 | 0.0012 | 0 | 0.5 |
Echinococcus granulosus | ubiquitin carboxyl terminal hydrolase 8 | 0.0084 | 1 | 1 |
Giardia lamblia | Ubiquitin carboxyl-terminal hydrolase 4 | 0.0084 | 1 | 1 |
Schistosoma mansoni | ubiquitin-specific peptidase 8 (C19 family) | 0.0084 | 1 | 1 |
Echinococcus multilocularis | Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 | 0.0084 | 1 | 1 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0022 | 0.1348 | 0.1348 |
Brugia malayi | Cytochrome P450 family protein | 0.0033 | 0.2936 | 0.2936 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0067 | 0.7672 | 0.7672 |
Echinococcus multilocularis | ubiquitin specific protease 41 | 0.0084 | 1 | 1 |
Mycobacterium tuberculosis | Probable cytochrome P450 monooxygenase 142 Cyp142 | 0.0012 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable cytochrome P450 132 Cyp132 | 0.0012 | 0 | 0.5 |
Echinococcus granulosus | hypothetical protein | 0.0067 | 0.7601 | 0.7601 |
Toxoplasma gondii | cell-cycle-associated protein kinase CLK, putative | 0.0067 | 0.7672 | 1 |
Mycobacterium tuberculosis | Probable cytochrome P450 128 Cyp128 | 0.0012 | 0 | 0.5 |
Brugia malayi | Cytochrome P450 family protein | 0.0022 | 0.1348 | 0.1348 |
Trypanosoma cruzi | kinetoplastid kinetochore protein 10, putative | 0.0067 | 0.7672 | 0.7672 |
Mycobacterium tuberculosis | Possible cytochrome P450 135B1 Cyp135B1 | 0.0012 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable cytochrome P450 139 Cyp139 | 0.0012 | 0 | 0.5 |
Mycobacterium tuberculosis | Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) | 0.0012 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable cytochrome P450 125 Cyp125 | 0.0012 | 0 | 0.5 |
Trypanosoma brucei | cytochrome P450, putative | 0.0022 | 0.1348 | 0.1348 |
Trichomonas vaginalis | Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase | 0.0084 | 1 | 1 |
Leishmania major | ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative | 0.0084 | 1 | 1 |
Mycobacterium tuberculosis | Possible cytochrome P450 126 Cyp126 | 0.0012 | 0 | 0.5 |
Schistosoma mansoni | ubiquitin-specific peptidase 2 (C19 family) | 0.0084 | 1 | 1 |
Mycobacterium tuberculosis | Probable cytochrome P450 123 Cyp123 | 0.0012 | 0 | 0.5 |
Plasmodium falciparum | protein serine/threonine kinase-1 | 0.0067 | 0.7672 | 0.5 |
Plasmodium vivax | serine/threonine kinase-1, putative | 0.0067 | 0.7672 | 0.5 |
Brugia malayi | Protein kinase domain containing protein | 0.0067 | 0.7672 | 0.7672 |
Trypanosoma cruzi | kinetoplastid kinetochore protein 19, putative | 0.0067 | 0.7672 | 0.7672 |
Mycobacterium tuberculosis | Probable cytochrome P450 143 Cyp143 | 0.0012 | 0 | 0.5 |
Leishmania major | cytochrome p450-like protein | 0.0022 | 0.1348 | 0.1348 |
Trypanosoma brucei | ubiquitin carboxyl-terminal hydrolase, putative | 0.0084 | 1 | 1 |
Loa Loa (eye worm) | CYP4Cod1 | 0.0022 | 0.1348 | 0.1348 |
Echinococcus granulosus | ubiquitin specific protease 41 | 0.0084 | 1 | 1 |
Trypanosoma cruzi | kinetoplastid kinetochore protein 10, putative | 0.0067 | 0.7672 | 0.7672 |
Echinococcus multilocularis | ubiquitin carboxyl terminal hydrolase 8 | 0.0084 | 1 | 1 |
Trypanosoma brucei | kinetoplastid kinetochore protein 10 | 0.0067 | 0.7672 | 0.7672 |
Mycobacterium ulcerans | cytochrome P450 185A4 Cyp185A4 | 0.0022 | 0.1348 | 1 |
Mycobacterium tuberculosis | Probable cytochrome P450 141 Cyp141 | 0.0012 | 0 | 0.5 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0067 | 0.7672 | 0.7672 |
Echinococcus granulosus | dual specificity protein kinase clk2 | 0.0067 | 0.7672 | 0.7672 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0022 | 0.1348 | 0.1348 |
Mycobacterium tuberculosis | Possible cytochrome P450 135A1 Cyp135A1 | 0.0012 | 0 | 0.5 |
Brugia malayi | Cytochrome P450 family protein | 0.0022 | 0.1348 | 0.1348 |
Mycobacterium tuberculosis | Probable cytochrome P450 137 Cyp137 | 0.0012 | 0 | 0.5 |
Echinococcus granulosus | Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 | 0.0084 | 1 | 1 |
Trypanosoma cruzi | ubiquitin carboxyl-terminal hydrolase, putative | 0.0084 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0084 | 1 | 1 |
Mycobacterium tuberculosis | Probable cytochrome P450 140 Cyp140 | 0.0012 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable cytochrome P450 130 Cyp130 | 0.0012 | 0 | 0.5 |
Mycobacterium tuberculosis | Cytochrome P450 121 Cyp121 | 0.0012 | 0 | 0.5 |
Mycobacterium leprae | Conserved hypothetical protein | 0.0012 | 0 | 0.5 |
Leishmania major | protein kinase, putative | 0.0067 | 0.7672 | 0.7672 |
Echinococcus multilocularis | 0.0067 | 0.7601 | 0.7601 | |
Trypanosoma cruzi | cytochrome P450, putative | 0.0022 | 0.1348 | 0.1348 |
Loa Loa (eye worm) | CMGC/CLK protein kinase | 0.0067 | 0.7672 | 0.7672 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.