Detailed information for compound 722633

Basic information

Technical information
  • TDR Targets ID: 722633
  • Name: N-[4-(3-bromophenyl)-1,3-thiazol-2-yl]-2-etho xybenzamide
  • MW: 403.293 | Formula: C18H15BrN2O2S
  • H donors: 1 H acceptors: 2 LogP: 4.81 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOc1ccccc1C(=O)Nc1scc(n1)c1cccc(c1)Br
  • InChi: 1S/C18H15BrN2O2S/c1-2-23-16-9-4-3-8-14(16)17(22)21-18-20-15(11-24-18)12-6-5-7-13(19)10-12/h3-11H,2H2,1H3,(H,20,21,22)
  • InChiKey: GSFQEVPBKOPVGE-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • N-[4-(3-bromophenyl)thiazol-2-yl]-2-ethoxy-benzamide
  • N-[4-(3-bromophenyl)-2-thiazolyl]-2-ethoxybenzamide
  • N-[4-(3-bromophenyl)-1,3-thiazol-2-yl]-2-ethoxy-benzamide
  • ZINC00689010
  • AK-968/40726881
  • ST5207034

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Toxoplasma gondii Ferredoxin-fold anticodon binding domain-containing protein 0.0239 0.1425 0.6374
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.0165 0.0745
Echinococcus multilocularis phenylalanyl tRNA synthetase 0.0239 0.1425 0.2695
Echinococcus granulosus SAM and MBT domain containing protein 0.0051 0.0178 0.0572
Loa Loa (eye worm) hypothetical protein 0.0357 0.2208 1
Plasmodium falciparum phenylalanine--tRNA ligase 0.0173 0.0991 0.4365
Brugia malayi phosphofructokinase 0.0116 0.0611 0.2713
Loa Loa (eye worm) hypothetical protein 0.0076 0.0342 0.1095
Plasmodium vivax phenylalanine--tRNA ligase, putative 0.0135 0.0739 0.3199
Mycobacterium tuberculosis Probable phenylalanyl-tRNA synthetase, alpha chain PheS 0.153 1 1
Schistosoma mansoni hypothetical protein 0.0171 0.0978 0.4432
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0201 0.1174 0.3761
Entamoeba histolytica phenylalanyl-tRNA synthetase alpha subunit, putative 0.0357 0.2208 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0049 0.0165 0.0311
Echinococcus multilocularis phenylalanyl tRNA synthetase alpha chain B 0.0357 0.2208 0.4176
Echinococcus multilocularis neuropeptide receptor A26 0.0494 0.3121 0.5902
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0049 0.0165 0.025
Trichomonas vaginalis phosphofructokinase, putative 0.0116 0.0611 0.2606
Entamoeba histolytica phosphofructokinase, putative 0.0116 0.0611 0.2606
Plasmodium vivax phenylalanine--tRNA ligase, putative 0.0239 0.1425 0.6374
Brugia malayi Bromodomain containing protein 0.008 0.0372 0.1622
Brugia malayi mbt repeat family protein 0.0051 0.0178 0.0738
Onchocerca volvulus 0.0051 0.0178 0.5
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0058 0.0225 0.0952
Leishmania major phenylalanyl-tRNA synthetase alpha chain, putative 0.0357 0.2208 1
Echinococcus granulosus phenylalanyl tRNA synthetase 0.0239 0.1425 0.4566
Echinococcus granulosus 6 phosphofructokinase 0.0116 0.0611 0.1959
Schistosoma mansoni sex comb on midleg homolog 0.0051 0.0178 0.0808
Schistosoma mansoni phenylalanyl-tRNA synthetase subunit alpha 0.0357 0.2208 1
Schistosoma mansoni hypothetical protein 0.031 0.1897 0.8593
Echinococcus granulosus geminin 0.0171 0.0978 0.3135
Chlamydia trachomatis phenylalanine--tRNA ligase subunit beta 0.0038 0.0092 0.0043
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0038 0.0095 0.018
Echinococcus multilocularis 6 phosphofructokinase 0.0116 0.0611 0.1156
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0049 0.0165 0.0311
Toxoplasma gondii phenylalanyl-tRNA synthetase alpha chain A, putative 0.0357 0.2208 1
Trypanosoma cruzi phenylalanyl-tRNA synthetase alpha chain, putative 0.0357 0.2208 1
Plasmodium vivax phenylalanine--tRNA ligase alpha subunit, putative 0.0357 0.2208 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.0165 0.0745
Loa Loa (eye worm) phosphofructokinase 0.0116 0.0611 0.2381
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0038 0.0095 0.0304
Loa Loa (eye worm) MBCTL1 0.0058 0.0225 0.0539
Wolbachia endosymbiont of Brugia malayi phenylalanyl-tRNA synthetase subunit alpha 0.153 1 1
Brugia malayi mbt repeat family protein 0.0051 0.0178 0.0738
Brugia malayi phenylalanyl-tRNA synthetase, mitochondrial precursor, putative 0.0239 0.1425 0.6426
Echinococcus granulosus neuropeptide s receptor 0.0494 0.3121 1
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0058 0.0225 0.0426
Entamoeba histolytica phosphofructokinase, putative 0.0116 0.0611 0.2606
Loa Loa (eye worm) hypothetical protein 0.0044 0.0129 0.008
Trichomonas vaginalis phenylalanyl-tRNA synthetase alpha chain, putative 0.0135 0.0739 0.3199
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.082 0.5288 1
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0049 0.0165 0.0674
Echinococcus granulosus polycomb protein SCMH1 0.0051 0.0178 0.0572
Brugia malayi phenylalanyl (f) trna synthetase protein 1 0.0357 0.2208 1
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0051 0.0178 0.5
Brugia malayi Bromodomain containing protein 0.0041 0.0112 0.0433
Mycobacterium ulcerans phenylalanyl-tRNA synthetase subunit alpha 0.153 1 1
Schistosoma mansoni 6-phosphofructokinase 0.0116 0.0611 0.2768
Echinococcus granulosus neuropeptide receptor A26 0.0494 0.3121 1
Trichomonas vaginalis phosphofructokinase, putative 0.0116 0.0611 0.2606
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0051 0.0178 0.0808
Mycobacterium leprae Probable phenylalanyl-tRNA synthetase, alpha chain PheS 0.0221 0.1309 1
Plasmodium falciparum phenylalanine--tRNA ligase alpha subunit 0.0357 0.2208 1
Schistosoma mansoni myelin transcription factor 1 myt1 0.0058 0.0225 0.102
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0049 0.0165 0.0527
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0116 0.0611 0.0524
Entamoeba histolytica phosphofructokinase, putative 0.0116 0.0611 0.2606
Trichomonas vaginalis phenylalanyl-tRNA synthetase alpha chain, putative 0.0135 0.0739 0.3199
Trichomonas vaginalis phenylalanyl-tRNA synthetase alpha chain, putative 0.0357 0.2208 1
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0064 0.0264 0.0499
Loa Loa (eye worm) mbt repeat family protein 0.0051 0.0178 0.0316
Brugia malayi 6-phosphofructokinase 0.0116 0.0611 0.2713
Loa Loa (eye worm) hypothetical protein 0.0046 0.0143 0.0145
Mycobacterium ulcerans 6-phosphofructokinase 0.0116 0.0611 0.0524
Schistosoma mansoni sex comb on midleg homolog 0.0051 0.0178 0.0808
Loa Loa (eye worm) phenylalanyl-tRNA synthetase 0.0239 0.1425 0.6263
Loa Loa (eye worm) hypothetical protein 0.0058 0.0225 0.0539
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0201 0.1174 0.222
Schistosoma mansoni hypothetical protein 0.0171 0.0978 0.4432
Loa Loa (eye worm) hypothetical protein 0.0051 0.0178 0.0316
Schistosoma mansoni 6-phosphofructokinase 0.0116 0.0611 0.2768
Loa Loa (eye worm) 6-phosphofructokinase 0.0116 0.0611 0.2381
Brugia malayi 6-phosphofructokinase 0.0116 0.0611 0.2713
Echinococcus granulosus histone acetyltransferase MYST2 0.0058 0.0225 0.0722
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.0165 0.0745
Echinococcus multilocularis histone acetyltransferase MYST2 0.0058 0.0225 0.0426
Echinococcus granulosus phenylalanyl tRNA synthetase alpha chain B 0.0357 0.2208 0.7075
Trichomonas vaginalis phosphofructokinase, putative 0.0116 0.0611 0.2606
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0116 0.0611 0.2606
Echinococcus multilocularis SAM and MBT domain containing protein 0.0051 0.0178 0.0338
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0058 0.0225 0.0722
Treponema pallidum phenylalanyl-tRNA synthetase subunit alpha 0.0357 0.2208 1
Echinococcus multilocularis neuropeptide s receptor 0.0494 0.3121 0.5902
Schistosoma mansoni bromodomain containing protein 0.0068 0.0289 0.1309
Schistosoma mansoni phenylalanyl-tRNA synthetase mitochondrial 0.0239 0.1425 0.6453
Plasmodium falciparum phenylalanine--tRNA ligase 0.0239 0.1425 0.6374
Schistosoma mansoni phenylalanyl-tRNA synthetase subunit alpha 0.0135 0.0739 0.3349
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0064 0.0264 0.0845
Echinococcus multilocularis geminin 0.0171 0.0978 0.185
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0049 0.0165 0.0527
Loa Loa (eye worm) 6-phosphofructokinase 0.0116 0.0611 0.2381
Trichomonas vaginalis phosphofructokinase, putative 0.0116 0.0611 0.2606
Echinococcus multilocularis polycomb protein SCMH1 0.0051 0.0178 0.0338
Giardia lamblia Phenylalanyl-tRNA synthetase alpha chain 0.0357 0.2208 1
Trypanosoma brucei phenylalanyl-tRNA synthetase alpha chain, putative 0.0357 0.2208 1

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.