Detailed information for compound 723502

Basic information

Technical information
  • TDR Targets ID: 723502
  • Name: N-[4-(cyanomethyl)phenyl]-2-[(4-methylphenyl) sulfonylamino]benzamide
  • MW: 405.47 | Formula: C22H19N3O3S
  • H donors: 2 H acceptors: 4 LogP: 3.85 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: N#CCc1ccc(cc1)NC(=O)c1ccccc1NS(=O)(=O)c1ccc(cc1)C
  • InChi: 1S/C22H19N3O3S/c1-16-6-12-19(13-7-16)29(27,28)25-21-5-3-2-4-20(21)22(26)24-18-10-8-17(9-11-18)14-15-23/h2-13,25H,14H2,1H3,(H,24,26)
  • InChiKey: UKKFMVZZKJGESY-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • ZINC05051484

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Plasmodium vivax ataxin-2 like protein, putative 0.0019 0.0089 0.1485
Loa Loa (eye worm) hypothetical protein 0.0062 0.0837 0.1471
Trypanosoma brucei Voltage-dependent calcium channel subunit, putative 0.005 0.0635 0.6217
Echinococcus granulosus voltage gated sodium channel Nav1 alpha subunit 0.0036 0.0381 0.0723
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0048 0.0599 0.1147
Trichomonas vaginalis chromobox protein, putative 0.0103 0.1575 0.17
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0028 0.0244 0.0302
Trypanosoma brucei unspecified product 0.0021 0.0117 0.0321
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0062 0.0837 0.1836
Loa Loa (eye worm) hypothetical protein 0.0028 0.0244 0.0426
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0037 0.0407 0.0786
Schistosoma mansoni hypothetical protein 0.0133 0.21 0.4859
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0471 0.8075 1
Entamoeba histolytica CAAX prenyl protease family 0.0069 0.0967 0.1198
Echinococcus granulosus dna polymerase eta 0.003 0.0283 0.0483
Mycobacterium tuberculosis Toxin MazF9 0.0108 0.1653 0.4332
Loa Loa (eye worm) voltage-dependent calcium channel 0.0019 0.0085 0.0147
Trypanosoma cruzi DNA polymerase kappa, putative 0.003 0.0283 0.221
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0037 0.0407 0.0673
Echinococcus granulosus voltage dependent calcium channel 0.0081 0.1175 0.2661
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.023 0.3816 0.5
Mycobacterium tuberculosis Possible toxin MazF5 0.0108 0.1653 0.4332
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0471 0.8075 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0048 0.0599 0.1147
Brugia malayi Bromodomain containing protein 0.0025 0.0185 0.0172
Toxoplasma gondii 'chromo' (CHRromatin Organization MOdifier) domain-containing protein 0.0028 0.0244 0.4077
Brugia malayi hypothetical protein 0.0028 0.0244 0.0278
Loa Loa (eye worm) hypothetical protein 0.0028 0.0244 0.0426
Brugia malayi jmjC domain containing protein 0.0081 0.1179 0.195
Echinococcus granulosus Chromo domain 0.0028 0.0244 0.0388
Echinococcus multilocularis chromobox protein 1 0.0171 0.2777 0.2678
Loa Loa (eye worm) latrophilin receptor protein 2 0.0062 0.0837 0.1471
Brugia malayi Valyl-tRNA synthetase 0.0028 0.0244 0.0278
Schistosoma mansoni jumonji/arid domain-containing protein 0.003 0.0277 0.0351
Mycobacterium ulcerans hypothetical protein 0.0108 0.1653 0.4332
Plasmodium falciparum chromodomain-helicase-DNA-binding protein 1 homolog, putative 0.0028 0.0244 1
Schistosoma mansoni chromobox protein 0.0171 0.2777 0.6532
Echinococcus multilocularis dna polymerase eta 0.003 0.0283 0.015
Trypanosoma brucei DNA polymerase IV, putative 0.003 0.0283 0.221
Plasmodium vivax hypothetical protein, conserved 0.0028 0.0244 0.4077
Loa Loa (eye worm) hypothetical protein 0.0052 0.0662 0.1162
Brugia malayi Latrophilin receptor protein 2 0.0062 0.0837 0.1339
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0028 0.0244 0.0388
Trichomonas vaginalis conserved hypothetical protein 0.0068 0.095 0.0902
Mycobacterium tuberculosis Toxin MazF2 0.0108 0.1653 0.4332
Echinococcus multilocularis chromobox protein 2 0.0028 0.0244 0.0111
Mycobacterium tuberculosis Possible toxin MazF7 0.0108 0.1653 0.4332
Trypanosoma brucei DNA polymerase kappa, putative 0.003 0.0283 0.221
Leishmania major DNA polymerase eta, putative 0.003 0.0283 0.221
Entamoeba histolytica hypothetical protein 0.0028 0.0244 0.0302
Schistosoma mansoni chromobox protein 0.0171 0.2777 0.6532
Brugia malayi ImpB/MucB/SamB family protein 0.003 0.0283 0.0347
Loa Loa (eye worm) PHD-finger family protein 0.0025 0.0185 0.0323
Treponema pallidum fructose-bisphosphate aldolase 0.0471 0.8075 1
Loa Loa (eye worm) hypothetical protein 0.0028 0.0244 0.0426
Brugia malayi Voltage-dependent L-type calcium channel beta-2 subunit 0.0241 0.402 0.7034
Loa Loa (eye worm) hypothetical protein 0.0075 0.1079 0.1898
Echinococcus multilocularis Chromobox protein 3 0.0028 0.0244 0.0111
Brugia malayi ImpB/MucB/SamB family protein 0.003 0.0283 0.0347
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.003 0.0283 0.015
Trypanosoma brucei DNA polymerase kappa, putative 0.003 0.0283 0.221
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0037 0.0407 0.0786
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0117 0.0321
Loa Loa (eye worm) hypothetical protein 0.0133 0.21 0.3697
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0028 0.0244 0.0111
Mycobacterium ulcerans DNA polymerase IV 0.003 0.0283 0.0742
Loa Loa (eye worm) hypothetical protein 0.0022 0.0135 0.0234
Loa Loa (eye worm) hypothetical protein 0.0028 0.0244 0.0426
Plasmodium vivax hypothetical protein, conserved 0.0025 0.0185 0.3093
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0028 0.0244 0.0302
Schistosoma mansoni hypothetical protein 0.0062 0.0837 0.1736
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0081 0.1179 0.2671
Echinococcus multilocularis sodium channel protein 0.0036 0.0381 0.025
Loa Loa (eye worm) hypothetical protein 0.0069 0.0967 0.1701
Schistosoma mansoni transient receptor potential channel 0.0056 0.0745 0.1508
Toxoplasma gondii PHD-finger domain-containing protein 0.0025 0.0185 0.3093
Brugia malayi Intermediate filament tail domain containing protein 0.0022 0.0135 0.0083
Schistosoma mansoni hypothetical protein 0.0028 0.0244 0.027
Trypanosoma cruzi DNA polymerase eta, putative 0.003 0.0283 0.221
Echinococcus granulosus jumonji domain containing protein 0.0034 0.0356 0.0661
Trypanosoma brucei DNA polymerase IV, putative 0.003 0.0283 0.221
Echinococcus granulosus geminin 0.025 0.418 1
Loa Loa (eye worm) hypothetical protein 0.0028 0.0241 0.042
Schistosoma mansoni transient receptor potential channel 0.0056 0.0745 0.1508
Echinococcus multilocularis chromobox protein 1 0.0171 0.2777 0.2678
Trypanosoma brucei unspecified product 0.0021 0.0117 0.0321
Trichomonas vaginalis set domain proteins, putative 0.0381 0.6497 0.7985
Entamoeba histolytica deoxycytidyl transferase, putative 0.003 0.0283 0.0351
Schistosoma mansoni DNA polymerase eta 0.003 0.0283 0.0366
Loa Loa (eye worm) CHromoDomain protein family member 0.0028 0.0244 0.0426
Loa Loa (eye worm) hypothetical protein 0.0084 0.1237 0.2176
Loa Loa (eye worm) hypothetical protein 0.0028 0.0244 0.0426
Onchocerca volvulus 0.0028 0.0244 0.0171
Schistosoma mansoni hypothetical protein 0.0042 0.049 0.0877
Schistosoma mansoni family U48 unassigned peptidase (U48 family) 0.0069 0.0967 0.2058
Toxoplasma gondii chromodomain helicase DNA binding protein CHD1/SWI2/SNF2 0.0028 0.0244 0.4077
Loa Loa (eye worm) hypothetical protein 0.0033 0.0324 0.0567
Echinococcus granulosus chromobox protein 2 0.0028 0.0244 0.0388
Trypanosoma cruzi DNA polymerase kappa, putative 0.003 0.0283 0.221
Loa Loa (eye worm) hypothetical protein 0.0081 0.1175 0.2066
Mycobacterium tuberculosis Toxin MazF6 0.0108 0.1653 0.4332
Echinococcus granulosus chromobox protein 1 0.0171 0.2777 0.6574
Leishmania major DNA polymerase kappa, putative 0.003 0.0283 0.221
Echinococcus multilocularis jumonji domain containing protein 0.0034 0.0356 0.0224
Onchocerca volvulus 0.0028 0.0244 0.0171
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0062 0.0837 0.0712
Loa Loa (eye worm) jmjC domain-containing protein 0.0051 0.065 0.1142
Echinococcus multilocularis lysine specific demethylase 5A 0.003 0.0277 0.0144
Schistosoma mansoni family U48 unassigned peptidase (U48 family) 0.0069 0.0967 0.2058
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0081 0.1175 0.1054
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0471 0.8075 1
Schistosoma mansoni transient receptor potential channel 0.0084 0.1237 0.2725
Echinococcus granulosus histone lysine methyltransferase setb 0.0048 0.0599 0.1254
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.003 0.0283 0.0366
Echinococcus multilocularis PHD finger protein rhinoceros 0.0025 0.0185 0.0051
Brugia malayi PHD-finger family protein 0.0025 0.0185 0.0172
Plasmodium falciparum ataxin-2 like protein, putative 0.0019 0.0089 0.3644
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0028 0.0244 0.027
Trypanosoma brucei DNA polymerase kappa, putative 0.003 0.0283 0.221
Schistosoma mansoni transient receptor potential channel 4 0.0084 0.1237 0.2725
Brugia malayi latrophilin 2 splice variant baaae 0.0133 0.21 0.3599
Trypanosoma brucei DNA polymerase kappa, putative 0.003 0.0283 0.221
Schistosoma mansoni terminal deoxycytidyl transferase 0.003 0.0283 0.0366
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0037 0.0407 0.0276
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0048 0.0599 0.047
Trichomonas vaginalis DNA polymerase eta, putative 0.003 0.0283 0.005
Echinococcus granulosus intermediate filament protein 0.0022 0.0135 0.0121
Brugia malayi Voltage-gated calcium channel, L-type, alpha subunit. C. elegans egl-19 ortholog 0.0081 0.1175 0.1943
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0194 0.3189 0.5547
Plasmodium vivax heterochromatin protein 1, putative 0.0028 0.0244 0.4077
Giardia lamblia Hypothetical protein 0.0069 0.0967 0.0991
Loa Loa (eye worm) hypothetical protein 0.0028 0.0244 0.0426
Trichomonas vaginalis chromobox protein, putative 0.0171 0.2777 0.3235
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel alpha 1 0.0081 0.1175 0.2661
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.003 0.0283 0.0495
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0103 0.1575 0.2263
Trypanosoma brucei DNA polymerase kappa, putative 0.003 0.0283 0.221
Loa Loa (eye worm) helicase 0.0028 0.0244 0.0426
Schistosoma mansoni hypothetical protein 0.0025 0.0185 0.0124
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0028 0.0244 0.027
Schistosoma mansoni high voltage-activated calcium channel Cav1 0.0081 0.1175 0.2571
Trichomonas vaginalis Clan U, family U48, CaaX prenyl peptidase 2-like 0.0069 0.0967 0.0924
Brugia malayi Pre-SET motif family protein 0.0335 0.5677 1
Trypanosoma brucei DNA polymerase eta, putative 0.003 0.0283 0.221
Trichomonas vaginalis chromobox protein, putative 0.0171 0.2777 0.3235
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0037 0.0407 0.0276
Plasmodium vivax hypothetical protein, conserved 0.0028 0.0244 0.4077
Brugia malayi Protein cec-1. 0.0028 0.0244 0.0278
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0048 0.0599 0.047
Echinococcus granulosus PHD finger protein rhinoceros 0.0025 0.0185 0.0244
Brugia malayi Heterochromatin protein 1 0.0171 0.2777 0.481
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0046 0.0568 0.1178
Trypanosoma brucei DNA polymerase IV, putative 0.003 0.0283 0.221
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0471 0.8075 1
Onchocerca volvulus 0.0075 0.1079 0.1484
Echinococcus multilocularis high voltage activated calcium channel beta 0.0117 0.1821 0.1709
Brugia malayi Type III restriction enzyme, res subunit family protein 0.0028 0.0244 0.0278
Brugia malayi Transient-receptor-potential like protein 0.0033 0.0324 0.0421
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0471 0.8075 1
Mycobacterium ulcerans DNA polymerase IV 0.003 0.0283 0.0742
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0471 0.8075 1
Mycobacterium tuberculosis Conserved protein 0.0108 0.1653 0.4332
Loa Loa (eye worm) hypothetical protein 0.0042 0.0497 0.0872
Brugia malayi Associated with TFs and helicases family protein 0.0028 0.0244 0.0278
Schistosoma mansoni jumonji/arid domain-containing protein 0.003 0.0277 0.0351
Brugia malayi MH2 domain containing protein 0.0178 0.2891 0.5014
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0037 0.0407 0.0673
Brugia malayi jmjC domain containing protein 0.003 0.0277 0.0337
Echinococcus granulosus dna polymerase kappa 0.003 0.0283 0.0483
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0194 0.3189 0.5615
Schistosoma mansoni hypothetical protein 0.025 0.418 1
Trichomonas vaginalis chromobox protein, putative 0.0103 0.1575 0.17
Schistosoma mansoni voltage-gated cation channel 0.0081 0.1175 0.2571
Trichomonas vaginalis conserved hypothetical protein 0.0096 0.1446 0.1535
Schistosoma mansoni high voltage-activated calcium channel Cav2A 0.0081 0.1175 0.2571
Echinococcus multilocularis short transient receptor potential channel 6 0.0056 0.0745 0.0618
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0081 0.1175 0.1054
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0037 0.0407 0.0673
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0062 0.0837 0.0712
Brugia malayi chromobox protein homolog 3 0.0096 0.1446 0.2428
Trichomonas vaginalis conserved hypothetical protein 0.0068 0.095 0.0902
Brugia malayi M-phase phosphoprotein, mpp8 0.0028 0.0244 0.0278
Echinococcus multilocularis short transient receptor potential channel 6 0.0056 0.0745 0.0618
Echinococcus multilocularis Chromo domain 0.0028 0.0244 0.0111
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0028 0.0244 0.0302
Echinococcus granulosus GPCR family 2 0.0062 0.0837 0.1836
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0471 0.8075 1
Brugia malayi intermediate filament protein 0.0022 0.0135 0.0083
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0081 0.1175 0.1054
Echinococcus multilocularis CAAX prenyl protease 2 0.0069 0.0967 0.0844
Loa Loa (eye worm) jmjC domain-containing protein 0.003 0.0277 0.0484
Echinococcus granulosus peregrin 0.0025 0.0185 0.0244
Echinococcus granulosus TRP transient receptor potential channel 0.0033 0.0324 0.0583
Schistosoma mansoni chromobox protein 0.0028 0.0244 0.027
Entamoeba histolytica hypothetical protein 0.0028 0.0244 0.0302
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0335 0.5677 1
Brugia malayi Pre-SET motif family protein 0.0048 0.0599 0.0912
Schistosoma mansoni high voltage-activated calcium channel beta subunit 2 0.0117 0.1821 0.4168
Trypanosoma brucei DNA polymerase kappa, putative 0.003 0.0283 0.221
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel|voltage dependent L type calcium channel subu 0.0081 0.1175 0.2661
Leishmania major CAAX prenyl protease 2, putative,peptidase with unknown catalytic mechanism (family U48) 0.0069 0.0967 1
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.023 0.3816 1
Brugia malayi Calcitonin receptor-like protein seb-1 0.0194 0.3189 0.5547
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0022 0.0135 0.0234
Onchocerca volvulus 0.0076 0.1095 0.1508
Loa Loa (eye worm) intermediate filament protein 0.0022 0.0135 0.0234
Echinococcus multilocularis voltage dependent calcium channel 0.0081 0.1175 0.1054
Loa Loa (eye worm) voltage-dependent calcium channel beta 2a subunit 0.0241 0.402 0.7079
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0028 0.0244 0.027
Toxoplasma gondii LsmAD domain-containing protein 0.0019 0.0089 0.1485
Echinococcus multilocularis chromodomain helicase DNA binding protein 1 0.0028 0.0244 0.0111
Loa Loa (eye worm) hypothetical protein 0.0019 0.0089 0.0153
Entamoeba histolytica hypothetical protein 0.0028 0.0244 0.0302
Loa Loa (eye worm) hypothetical protein 0.0048 0.0599 0.1051
Trypanosoma brucei DNA polymerase kappa, putative 0.003 0.0283 0.221
Echinococcus granulosus short transient receptor potential channel 6 0.0056 0.0745 0.1611
Trypanosoma brucei CAAX amino terminal protease, putative 0.0069 0.0967 1
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0037 0.0407 0.0569
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0062 0.0837 0.1339
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0471 0.8075 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.003 0.0283 0.221
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0028 0.0244 0.027
Trichomonas vaginalis conserved hypothetical protein 0.0096 0.1446 0.1535
Echinococcus multilocularis GPCR, family 2 0.0062 0.0837 0.0712
Giardia lamblia Fructose-bisphosphate aldolase 0.0471 0.8075 1
Mycobacterium tuberculosis Possible toxin MazF4 0.0108 0.1653 0.4332
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0096 0.1446 0.2061
Trypanosoma cruzi peptidase with unknown catalytic mechanism (family U48) 0.0069 0.0967 1
Trypanosoma cruzi Voltage-dependent calcium channel subunit, putative 0.005 0.0635 0.6217
Schistosoma mansoni chromobox protein 0.0028 0.0244 0.027
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0471 0.8075 1
Echinococcus granulosus short transient receptor potential channel 6 0.0056 0.0745 0.1611
Loa Loa (eye worm) hypothetical protein 0.003 0.0283 0.0495
Echinococcus multilocularis TRP (transient receptor potential) channel 0.0033 0.0324 0.0191
Echinococcus multilocularis transient receptor potential ion channel A 0.0079 0.1154 0.1033
Schistosoma mansoni jumonji domain containing protein 0.0064 0.0885 0.1854
Echinococcus granulosus voltage dependent L type calcium channel subunit|voltage dependent calcium channel 0.0081 0.1175 0.2661
Toxoplasma gondii 'chromo' (CHRromatin Organization MOdifier) domain-containing protein 0.0028 0.0244 0.4077
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0025 0.0185 0.0124
Echinococcus granulosus high voltage activated calcium channel beta 0.0117 0.1821 0.4239
Plasmodium falciparum ataxin-2 like protein, putative 0.0019 0.0089 0.3644
Schistosoma mansoni hypothetical protein 0.0062 0.0837 0.1736
Echinococcus multilocularis transient receptor potential gamma protein 0.0084 0.1237 0.1117
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.023 0.3816 1
Toxoplasma gondii hypothetical protein 0.0014 0.0002 0.0036
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0028 0.0244 1
Loa Loa (eye worm) hypothetical protein 0.0025 0.0185 0.0323
Mycobacterium tuberculosis Toxin MazF3 0.0108 0.1653 0.4332
Trypanosoma brucei DNA polymerase kappa, putative 0.003 0.0283 0.221
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0081 0.1175 0.1054
Brugia malayi SET domain containing protein 0.003 0.0275 0.0334
Loa Loa (eye worm) hypothetical protein 0.0019 0.0085 0.0147
Onchocerca volvulus Alhambra homolog 0.0025 0.0185 0.0079
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.003 0.0283 0.0742
Loa Loa (eye worm) MH2 domain-containing protein 0.0178 0.2891 0.5091
Echinococcus granulosus transient receptor potential gamma protein 0.0084 0.1237 0.2813
Brugia malayi CHD4 protein 0.0028 0.0244 0.0278
Schistosoma mansoni hypothetical protein 0.025 0.418 1
Echinococcus granulosus lamin dm0 0.0022 0.0135 0.0121
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0471 0.8075 1
Trypanosoma brucei DNA polymerase kappa, putative 0.003 0.0283 0.221
Toxoplasma gondii transporter, cation channel family protein 0.0019 0.0085 0.1427
Echinococcus granulosus lamin 0.0022 0.0135 0.0121
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0076 0.1095 0.2372
Schistosoma mansoni hypothetical protein 0.0062 0.0837 0.1736
Trypanosoma brucei unspecified product 0.003 0.0283 0.221
Onchocerca volvulus 0.0381 0.6497 1
Loa Loa (eye worm) calcium channel 0.0081 0.1175 0.2066
Schistosoma mansoni hypothetical protein 0.0062 0.0837 0.1736
Brugia malayi CAAX amino terminal protease family protein 0.0069 0.0967 0.1572
Mycobacterium tuberculosis Possible toxin MazF1 0.0108 0.1653 0.4332
Mycobacterium tuberculosis Conserved hypothetical protein 0.003 0.0283 0.0742
Echinococcus granulosus chromobox protein 1 0.0171 0.2777 0.6574
Echinococcus multilocularis voltage dependent calcium channel 0.0081 0.1175 0.1054
Loa Loa (eye worm) hypothetical protein 0.0096 0.1446 0.2544
Toxoplasma gondii PHD-finger domain-containing protein 0.0025 0.0185 0.3093
Chlamydia trachomatis hypothetical protein 0.0014 0 0.5
Echinococcus granulosus CAAX prenyl protease 2 0.0069 0.0967 0.2154
Echinococcus granulosus Chromobox protein 3 0.0028 0.0244 0.0388
Echinococcus granulosus lysine specific demethylase 5A 0.003 0.0277 0.0468
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0117 0.0321
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0048 0.0599 1
Plasmodium falciparum phd finger protein, putative 0.0025 0.0185 0.7586
Loa Loa (eye worm) hypothetical protein 0.0194 0.3189 0.5615
Loa Loa (eye worm) transcription factor SMAD2 0.0178 0.2891 0.5091
Echinococcus granulosus transient receptor potential ion channel A 0.0079 0.1154 0.261
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0081 0.1179 0.1058
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.003 0.0283 0.005
Plasmodium falciparum heterochromatin protein 1 0.0028 0.0244 1
Echinococcus granulosus chromodomain helicase DNA binding protein 1 0.0028 0.0244 0.0388
Plasmodium vivax SET domain protein, putative 0.0048 0.0599 1
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0062 0.0837 0.1836
Loa Loa (eye worm) heterochromatin protein 1 0.0171 0.2777 0.4889
Trypanosoma cruzi DNA polymerase kappa, putative 0.003 0.0283 0.221
Trypanosoma cruzi CAAX prenyl protease 2, putative 0.0069 0.0967 1
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.003 0.0283 0.0483
Echinococcus multilocularis geminin 0.025 0.418 0.41
Echinococcus multilocularis peregrin 0.0025 0.0185 0.0051
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.003 0.0283 0.221
Loa Loa (eye worm) hypothetical protein 0.0021 0.0128 0.0222
Loa Loa (eye worm) hypothetical protein 0.0028 0.0244 0.0426
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0037 0.0407 0.0714
Trypanosoma brucei DNA polymerase kappa, putative 0.003 0.0283 0.221
Giardia lamblia DINP protein human, muc B family 0.003 0.0283 0.0124
Echinococcus multilocularis dna polymerase kappa 0.003 0.0283 0.015
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0117 0.0321
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0048 0.0599 0.1147

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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