Detailed information for compound 723504

Basic information

Technical information
  • TDR Targets ID: 723504
  • Name: 1-(3-ethoxy-4-fluorophenyl)sulfonylazepane
  • MW: 301.377 | Formula: C14H20FNO3S
  • H donors: 0 H acceptors: 2 LogP: 2.71 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOc1cc(ccc1F)S(=O)(=O)N1CCCCCC1
  • InChi: 1S/C14H20FNO3S/c1-2-19-14-11-12(7-8-13(14)15)20(17,18)16-9-5-3-4-6-10-16/h7-8,11H,2-6,9-10H2,1H3
  • InChiKey: ZCRHTRDFEQDRIU-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

  • 1-(3-ethoxy-4-fluoro-phenyl)sulfonylazepane
  • ZINC00528767
  • 1-[(3-ethoxy-4-fluorophenyl)sulfonyl]azepane
  • MLS000531434
  • SMR000136412

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Trypanosoma cruzi cysteine peptidase, putative Starlite/ChEMBL No references
Homo sapiens GNAS complex locus Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium yoelii berghepain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-3 Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cathepsin L-like protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) papain family cysteine protease containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cysteine peptidase A (CBA) Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania donovani cysteine peptidase A (CBA) Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) ctsf protein Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cruzipain precursor, putative Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium vivax vivapain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Papain family cysteine protease containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin L-like proteinase precursor, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium vivax vivapain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium berghei berghepain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l1 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-4 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cathepsin L-like protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Toxoplasma gondii cathepsin CPL Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum expressed protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 2b Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin F homolog Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin L cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum ko:K01373 cathepsin F [EC3.4.22.41], putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Brugia malayi Cathepsin L-like cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Neospora caninum Cathepsin L, related Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Cryptosporidium hominis cryptopain precursor Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l1 Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) fibroinase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin L cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin L homolog Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 3 Get druggable targets OG5_126607 All targets in OG5_126607
Cryptosporidium parvum cryptopain - cysteine proteinase secreted, possible transmembrane domain near N-terminus Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
Onchocerca volvulus Cathepsin L homolog Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin L cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 2a Get druggable targets OG5_126607 All targets in OG5_126607
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi cathepsin L-like precursor 0.0014 0.0002 0.0002
Onchocerca volvulus Cathepsin L homolog 0.002 0.0268 0.0324
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0088 0.2982 0.6516
Loa Loa (eye worm) papain family cysteine protease containing protein 0.002 0.0268 0.0268
Loa Loa (eye worm) hypothetical protein 0.0043 0.1161 0.1161
Loa Loa (eye worm) ctsf protein 0.002 0.0268 0.0268
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.2532 1
Onchocerca volvulus 0.0024 0.0417 0.0505
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0036 0.0906 0.11
Echinococcus multilocularis cysteine protease 0.002 0.0268 0.0587
Brugia malayi Cathepsin L-like precursor 0.002 0.0268 0.0268
Echinococcus multilocularis lamin 0.0024 0.0417 0.091
Echinococcus multilocularis PHD finger protein rhinoceros 0.0027 0.054 0.118
Echinococcus multilocularis lamin dm0 0.0024 0.0417 0.091
Loa Loa (eye worm) hypothetical protein 0.0092 0.3136 0.3136
Loa Loa (eye worm) voltage-dependent calcium channel 0.0021 0.0294 0.0294
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.2532 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0268 0.0268
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.2532 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0268 0.0324
Brugia malayi PHD-finger family protein 0.0027 0.054 0.054
Schistosoma mansoni chromobox protein 0.0065 0.2038 0.4453
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0268 0.0324
Loa Loa (eye worm) hypothetical protein 0.0057 0.1716 0.1716
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0268 0.0324
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0088 0.2982 0.6516
Echinococcus granulosus jumonji domain containing protein 0.0038 0.0962 0.2103
Echinococcus multilocularis jumonji domain containing protein 0.0038 0.0962 0.2103
Schistosoma mansoni chromobox protein 0.0065 0.2038 0.4453
Brugia malayi Cathepsin L-like precursor 0.002 0.0268 0.0268
Echinococcus granulosus transient receptor potential ion channel A 0.0087 0.293 0.6404
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.1664 0.3636
Echinococcus granulosus intermediate filament protein 0.0024 0.0417 0.091
Onchocerca volvulus Cathepsin F homolog 0.002 0.0268 0.0324
Echinococcus granulosus voltage dependent calcium channel 0.0088 0.2982 0.6516
Onchocerca volvulus 0.0024 0.0417 0.0505
Leishmania major cathepsin L-like protease 0.0077 0.2532 1
Echinococcus multilocularis musashi 0.0024 0.0417 0.091
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0043 0.1161 0.1161
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0055 0.1664 0.1664
Loa Loa (eye worm) hypothetical protein 0.0036 0.0906 0.0906
Echinococcus multilocularis lysine specific demethylase 5A 0.0033 0.0767 0.1676
Schistosoma mansoni hypothetical protein 0.0027 0.054 0.118
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0024 0.0417 0.0417
Brugia malayi Transient-receptor-potential like protein 0.0036 0.0883 0.0883
Loa Loa (eye worm) jmjC domain-containing protein 0.0033 0.0767 0.0767
Schistosoma mansoni high voltage-activated calcium channel Cav2A 0.0088 0.2982 0.6516
Loa Loa (eye worm) hypothetical protein 0.0028 0.0566 0.0566
Loa Loa (eye worm) hypothetical protein 0.0014 0.0002 0.0002
Schistosoma mansoni cathepsin F (C01 family) 0.0014 0.0002 0.0004
Trypanosoma cruzi cysteine peptidase, putative 0.0077 0.2532 1
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0193 0.7154 0.7154
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0268 0.0324
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.2532 1
Brugia malayi Papain family cysteine protease containing protein 0.002 0.0268 0.0268
Trichomonas vaginalis chromobox protein, putative 0.0039 0.1016 0.1234
Trypanosoma cruzi cysteine peptidase, putative 0.0077 0.2532 1
Onchocerca volvulus Alhambra homolog 0.0027 0.054 0.0655
Echinococcus multilocularis cathepsin l cysteine peptidase 0.002 0.0268 0.0587
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0028 0.0566 0.1237
Echinococcus granulosus cathepsin l cysteine peptidase 0.002 0.0268 0.0587
Loa Loa (eye worm) jmjC domain-containing protein 0.0056 0.1687 0.1687
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.2532 1
Loa Loa (eye worm) hypothetical protein 0.0016 0.0089 0.0089
Plasmodium vivax SET domain protein, putative 0.0028 0.0566 1
Trichomonas vaginalis chromobox protein, putative 0.0065 0.2038 0.2478
Echinococcus multilocularis short transient receptor potential channel 6 0.0062 0.1921 0.4199
Echinococcus granulosus chromobox protein 1 0.0065 0.2038 0.4453
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel|voltage dependent L type calcium channel subu 0.0088 0.2982 0.6516
Trypanosoma cruzi Voltage-dependent calcium channel subunit, putative 0.0055 0.165 0.6103
Onchocerca volvulus 0.002 0.0268 0.0324
Echinococcus granulosus cathepsin l1 0.002 0.0268 0.0587
Schistosoma mansoni cathepsin F (C01 family) 0.002 0.0268 0.0587
Loa Loa (eye worm) hypothetical protein 0.0021 0.0294 0.0294
Schistosoma mansoni transient receptor potential channel 0.0092 0.3136 0.6853
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0028 0.0566 0.1237
Echinococcus granulosus high voltage activated calcium channel beta 0.0128 0.4576 1
Echinococcus multilocularis cathepsin L cysteine protease 0.002 0.0268 0.0587
Loa Loa (eye worm) PHD-finger family protein 0.0027 0.054 0.054
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0268 0.0324
Schistosoma mansoni hypothetical protein 0.0046 0.1292 0.2824
Echinococcus granulosus cathepsin l1 0.0014 0.0002 0.0004
Echinococcus granulosus short transient receptor potential channel 6 0.0062 0.1921 0.4199
Schistosoma mansoni lamin 0.0024 0.0417 0.091
Schistosoma mansoni cathepsin F (C01 family) 0.002 0.0268 0.0587
Brugia malayi Cathepsin L-like cysteine proteinase 0.0014 0.0002 0.0002
Loa Loa (eye worm) intermediate filament protein 0.0024 0.0417 0.0417
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0268 0.0324
Entamoeba histolytica cysteine proteinase, putative 0.002 0.0268 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0268 0.0324
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0268 0.0324
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0028 0.0566 0.1237
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0043 0.1161 0.1161
Loa Loa (eye worm) hypothetical protein 0.0014 0.0002 0.0002
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.2532 1
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0088 0.2982 0.6516
Loa Loa (eye worm) hypothetical protein 0.0046 0.131 0.131
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0485 0.0587
Schistosoma mansoni intermediate filament proteins 0.0024 0.0417 0.091
Onchocerca volvulus 0.0028 0.0594 0.0721
Plasmodium falciparum phd finger protein, putative 0.0027 0.054 1
Loa Loa (eye worm) heterochromatin protein 1 0.0065 0.2038 0.2038
Loa Loa (eye worm) hypothetical protein 0.0014 0.0002 0.0002
Schistosoma mansoni hypothetical protein 0.0029 0.0624 0.1363
Schistosoma mansoni lamin 0.0024 0.0417 0.091
Onchocerca volvulus 0.002 0.0268 0.0324
Loa Loa (eye worm) hypothetical protein 0.0016 0.0089 0.0089
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.2532 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0028 0.0566 0.1237
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.2532 1
Brugia malayi Cathepsin L-like precursor 0.0014 0.0002 0.0002
Echinococcus granulosus voltage dependent L type calcium channel subunit|voltage dependent calcium channel 0.0088 0.2982 0.6516
Brugia malayi latrophilin 2 splice variant baaae 0.0029 0.0624 0.0624
Brugia malayi Cathepsin L-like precursor 0.002 0.0268 0.0268
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.2532 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0268 0.0324
Loa Loa (eye worm) hypothetical protein 0.003 0.0677 0.0677
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0268 0.0324
Echinococcus multilocularis short transient receptor potential channel 6 0.0062 0.1921 0.4199
Loa Loa (eye worm) calcium channel 0.0088 0.2982 0.2982
Trichomonas vaginalis set domain proteins, putative 0.022 0.8217 1
Echinococcus granulosus cathepsin L cysteine proteinase 0.002 0.0268 0.0587
Onchocerca volvulus 0.002 0.0268 0.0324
Onchocerca volvulus 0.0038 0.0987 0.1199
Onchocerca volvulus 0.002 0.0268 0.0324
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0028 0.0566 0.1237
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.0906 0.11
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0089 0.2992 0.6538
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0268 0.0324
Toxoplasma gondii transporter, cation channel family protein 0.0021 0.0294 0.4304
Loa Loa (eye worm) hypothetical protein 0.0029 0.0624 0.0624
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.0906 0.11
Echinococcus multilocularis cathepsin L cysteine protease 0.002 0.0268 0.0587
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0268 0.0324
Echinococcus granulosus histone lysine methyltransferase setb 0.0028 0.0566 0.1237
Loa Loa (eye worm) hypothetical protein 0.0088 0.2982 0.2982
Entamoeba histolytica cysteine proteinase, putative 0.002 0.0268 1
Echinococcus multilocularis chromobox protein 1 0.0065 0.2038 0.4453
Schistosoma mansoni jumonji/arid domain-containing protein 0.0033 0.0767 0.1676
Brugia malayi Cathepsin L-like precursor 0.002 0.0268 0.0268
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0027 0.054 0.118
Onchocerca volvulus 0.002 0.0268 0.0324
Leishmania major cathepsin L-like protease 0.0077 0.2532 1
Schistosoma mansoni jumonji/arid domain-containing protein 0.0033 0.0767 0.1676
Echinococcus multilocularis cysteine protease 0.002 0.0268 0.0587
Brugia malayi Intermediate filament tail domain containing protein 0.0024 0.0417 0.0417
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0088 0.2982 0.6516
Brugia malayi intermediate filament protein 0.0024 0.0417 0.0417
Brugia malayi Pre-SET motif family protein 0.0193 0.7154 0.7154
Trypanosoma cruzi cruzipain precursor, putative 0.0077 0.2532 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0268 0.0324
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0268 0.0324
Echinococcus multilocularis high voltage activated calcium channel beta 0.0128 0.4576 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0268 0.0324
Loa Loa (eye worm) hypothetical protein 0.0024 0.0399 0.0399
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel alpha 1 0.0088 0.2982 0.6516
Echinococcus multilocularis transient receptor potential gamma protein 0.0092 0.3136 0.6853
Echinococcus granulosus chromobox protein 1 0.0065 0.2038 0.4453
Loa Loa (eye worm) cysteine protease 0.002 0.0268 0.0268
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.1664 0.3636
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.1664 0.3636
Echinococcus multilocularis cathepsin l cysteine peptidase 0.002 0.0268 0.0587
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0268 0.0324
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0027 0.0525 0.1148
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.2532 1
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0039 0.1016 0.1234
Brugia malayi Cathepsin L-like precursor 0.002 0.0268 0.0268
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.002 0.0268 0.0268
Trypanosoma cruzi cysteine peptidase, putative 0.0077 0.2532 1
Echinococcus granulosus lamin dm0 0.0024 0.0417 0.091
Trypanosoma cruzi major cysteine proteinase, putative 0.0061 0.1875 0.7098
Echinococcus multilocularis chromobox protein 1 0.0065 0.2038 0.4453
Trichomonas vaginalis chromobox protein, putative 0.0065 0.2038 0.2478
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.1664 0.3636
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0268 0.0324
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0268 0.0324
Brugia malayi Voltage-gated calcium channel, L-type, alpha subunit. C. elegans egl-19 ortholog 0.0088 0.2982 0.2982
Onchocerca volvulus 0.002 0.0268 0.0324
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.1664 0.3636
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0089 0.2992 0.6538
Onchocerca volvulus 0.022 0.8217 1
Echinococcus granulosus peregrin 0.0027 0.054 0.118
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.002 0.0268 0.0324
Schistosoma mansoni high voltage-activated calcium channel beta subunit 2 0.0128 0.4576 1
Echinococcus multilocularis sodium channel protein 0.0039 0.1024 0.2238
Onchocerca volvulus 0.002 0.0268 0.0324
Toxoplasma gondii cathepsin CPL 0.002 0.0268 0.3767
Schistosoma mansoni transient receptor potential channel 0.0062 0.1921 0.4199
Echinococcus multilocularis peregrin 0.0027 0.054 0.118
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0055 0.1664 0.1664
Loa Loa (eye worm) fibroinase 0.002 0.0268 0.0268
Echinococcus granulosus voltage dependent calcium channel 0.0021 0.0294 0.0643
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0268 0.0324
Echinococcus granulosus short transient receptor potential channel 6 0.0062 0.1921 0.4199
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.2532 1
Schistosoma mansoni voltage-gated cation channel 0.0088 0.2982 0.6516
Echinococcus granulosus lamin 0.0024 0.0417 0.091
Brugia malayi chromobox protein homolog 3 0.0036 0.0906 0.0906
Echinococcus multilocularis voltage dependent calcium channel 0.0088 0.2982 0.6516
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0485 0.0587
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.007 0.2266 0.8824
Toxoplasma gondii PHD-finger domain-containing protein 0.0027 0.054 0.946
Schistosoma mansoni high voltage-activated calcium channel Cav1 0.0088 0.2982 0.6516
Echinococcus granulosus lysine specific demethylase 5A 0.0033 0.0767 0.1676
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0268 0.0324
Brugia malayi Bromodomain containing protein 0.0027 0.054 0.054
Plasmodium vivax hypothetical protein, conserved 0.0027 0.054 0.9134
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0268 0.0324
Brugia malayi Calcitonin receptor-like protein seb-1 0.0043 0.1161 0.1161
Echinococcus granulosus voltage gated sodium channel Nav1 alpha subunit 0.0039 0.1024 0.2238
Brugia malayi Cathepsin L-like precursor 0.0014 0.0002 0.0002
Echinococcus granulosus PHD finger protein rhinoceros 0.0027 0.054 0.118
Brugia malayi jmjC domain containing protein 0.0033 0.0767 0.0767
Entamoeba histolytica cysteine protease, putative 0.002 0.0268 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.1664 0.3636
Loa Loa (eye worm) hypothetical protein 0.0027 0.054 0.054
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.1664 0.3636
Echinococcus multilocularis transient receptor potential ion channel A 0.0087 0.293 0.6404
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0268 0.0324
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0038 0.0987 0.2158
Echinococcus granulosus transient receptor potential gamma protein 0.0092 0.3136 0.6853
Giardia lamblia PHD finger protein 15 0.0027 0.054 0.5
Schistosoma mansoni jumonji domain containing protein 0.007 0.2266 0.4953
Loa Loa (eye worm) hypothetical protein 0.0024 0.0417 0.0417
Echinococcus multilocularis TRP (transient receptor potential) channel 0.0036 0.0883 0.1929
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0268 0.0324
Loa Loa (eye worm) hypothetical protein 0.0028 0.0594 0.0594
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0028 0.0566 1
Schistosoma mansoni transient receptor potential channel 0.0062 0.1921 0.4199
Schistosoma mansoni transient receptor potential channel 4 0.0092 0.3136 0.6853
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.002 0.0268 0.0324
Brugia malayi Heterochromatin protein 1 0.0065 0.2038 0.2038
Onchocerca volvulus Cathepsin L homolog 0.002 0.0268 0.0324
Echinococcus multilocularis voltage dependent calcium channel 0.0088 0.2982 0.6516
Loa Loa (eye worm) voltage-dependent calcium channel beta 2a subunit 0.0264 1 1
Brugia malayi Pre-SET motif family protein 0.0028 0.0566 0.0566
Loa Loa (eye worm) hypothetical protein 0.0036 0.0883 0.0883
Trichomonas vaginalis chromobox protein, putative 0.0039 0.1016 0.1234
Brugia malayi jmjC domain containing protein 0.0089 0.2992 0.2992
Leishmania major cathepsin L-like protease 0.0077 0.2532 1
Toxoplasma gondii PHD-finger domain-containing protein 0.0027 0.054 0.946
Brugia malayi Cathepsin L-like precursor 0.002 0.0268 0.0268
Echinococcus granulosus TRP transient receptor potential channel 0.0036 0.0883 0.1929

Activities

Activity type Activity value Assay description Source Reference
EC50 (functional) > 29.9 um PUBCHEM_BIOASSAY: Dose response cell-based high-throughput screening assay for agonists of the transient receptor potential channel ML3 (TRPML3). (Class of assay: confirmatory) [Related pubchem assays: 1526, 1424, 1448 ] ChEMBL. No reference
EC50 (functional) > 29.9 um PUBCHEM_BIOASSAY: Fluorescence counterscreen assay for TRPML3 agonists: dose response cell-based high-throughput screening assay to identify agonists of the transient receptor potential channel N1 (TRPN1). (Class of assay: confirmatory) [Related pubchem assays: 1526, 1424, 1448 ] ChEMBL. No reference
Potency (functional) = 3.9811 um PUBCHEM_BIOASSAY: qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (without detergent). (Class of assay: confirmatory) [Related pubchem assays: 2158 (Confirmation qHTS Assay for Inhibitors of Cruzain), 2249 (Probe Development Summary of Promiscuous Inhibitors (Artifacts) of Cruzain), 2161 (qHTS Assay for Inhibitors of Papain: Counterscreen for Cruzain Assay), 1478 (qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (with detergent))] ChEMBL. No reference
Potency (functional) 3.9811 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 9.285 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (binding) = 35.4813 um PUBCHEM_BIOASSAY: qHTS Assay for Identification of Novel General Anesthetics. In this assay, a GABAergic mimetic model system, apoferritin and a profluorescent 1-aminoanthracene ligand (1-AMA), was used to construct a competitive binding assay for identification of novel general anesthetics (Class of assay: confirmatory) [Related pubchem assays: 2385 (Probe Development Summary for Identification of Novel General Anesthetics), 2323 (Validation apoferritin assay run on SigmaAldrich LOPAC1280 collection)] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771] ChEMBL. No reference
Potency (functional) 100 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference
Potency (functional) 112.2018 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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