Detailed information for compound 730694

Basic information

Technical information
  • TDR Targets ID: 730694
  • Name: methyl 2-[[1-(4-bromophenyl)sulfonylpiperidin e-3-carbonyl]amino]benzoate
  • MW: 481.36 | Formula: C20H21BrN2O5S
  • H donors: 1 H acceptors: 4 LogP: 3.49 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: COC(=O)c1ccccc1NC(=O)C1CCCN(C1)S(=O)(=O)c1ccc(cc1)Br
  • InChi: 1S/C20H21BrN2O5S/c1-28-20(25)17-6-2-3-7-18(17)22-19(24)14-5-4-12-23(13-14)29(26,27)16-10-8-15(21)9-11-16/h2-3,6-11,14H,4-5,12-13H2,1H3,(H,22,24)
  • InChiKey: UXFOJMVQSNYADJ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 2-[[[1-(4-bromophenyl)sulfonyl-3-piperidinyl]-oxomethyl]amino]benzoic acid methyl ester
  • 2-[[1-(4-bromophenyl)sulfonylpiperidine-3-carbonyl]amino]benzoic acid methyl ester
  • methyl 2-[[1-(4-bromophenyl)sulfonylpiperidin-3-yl]carbonylamino]benzoate
  • CBKinase1_022420
  • CBKinase1_010020

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni hypothetical protein 0.0048 0.0814 0.0861
Brugia malayi hypothetical protein 0.0016 0.0123 0.0265
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0173 0.0184
Brugia malayi glutathione reductase 0.0046 0.0772 0.1668
Schistosoma mansoni cpg binding protein 0.0031 0.0439 0.0457
Mycobacterium ulcerans ornithine aminotransferase RocD1 and RocD2 0.0022 0.0244 0.0423
Loa Loa (eye worm) CXXC zinc finger family protein 0.0031 0.0439 0.067
Brugia malayi beta-lactamase family protein 0.0074 0.1371 0.2962
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0173 0.0446
Echinococcus granulosus GTP binding nuclear protein Ran 0.0022 0.0235 0.025
Echinococcus granulosus importin subunit beta 1 0.0029 0.0402 0.043
Loa Loa (eye worm) hypothetical protein 0.0105 0.2025 0.3105
Loa Loa (eye worm) hypothetical protein 0.0074 0.1371 0.2102
Plasmodium vivax SET domain protein, putative 0.0033 0.048 0.289
Trypanosoma cruzi trypanothione reductase, putative 0.0046 0.0772 0.5222
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0016 0.0117 0.0124
Schistosoma mansoni cpg binding protein 0.0033 0.0477 0.0498
Brugia malayi Latrophilin receptor protein 2 0.0048 0.0814 0.1758
Loa Loa (eye worm) hypothetical protein 0.01 0.1927 0.2956
Echinococcus granulosus sterol regulatory element binding protein 0.0043 0.0696 0.0746
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0048 0.0814 0.0873
Entamoeba histolytica hypothetical protein 0.0024 0.0283 0.0623
Entamoeba histolytica hypothetical protein 0.0072 0.1325 0.6567
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.009 0.1716 0.1844
Trichomonas vaginalis penicillin-binding protein, putative 0.0074 0.1371 0.242
Echinococcus multilocularis Aminotransferase class III 0.0022 0.0244 0.026
Brugia malayi Thioredoxin reductase 0.0046 0.0772 0.1668
Mycobacterium ulcerans acetylornithine aminotransferase 0.0022 0.0244 0.0423
Brugia malayi MH2 domain containing protein 0.0121 0.2371 0.512
Loa Loa (eye worm) hypothetical protein 0.0074 0.1371 0.2102
Trichomonas vaginalis acetylornithine aminotransferase, putative 0.0154 0.3101 0.5758
Loa Loa (eye worm) hypothetical protein 0.0053 0.0922 0.1411
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0048 0.0814 0.0873
Brugia malayi Importin beta-1 subunit 0.0029 0.0402 0.0868
Mycobacterium tuberculosis Probable hydrolase 0.0074 0.1371 0.1269
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0316 0.3034
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.048 0.0501
Mycobacterium ulcerans hypothetical protein 0.0074 0.1371 0.4203
Echinococcus multilocularis GPCR, family 2 0.0048 0.0814 0.0873
Echinococcus multilocularis thioredoxin glutathione reductase 0.0046 0.0772 0.0828
Onchocerca volvulus 0.0074 0.1371 0.1919
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0074 0.1371 0.1269
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0173 0.0446
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0048 0.0814 0.0873
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0011 0.0015 0.0013
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.009 0.1716 0.3706
Echinococcus granulosus expressed conserved protein 0.0094 0.1797 0.1931
Brugia malayi latrophilin 2 splice variant baaae 0.0105 0.2025 0.4373
Trichomonas vaginalis D-aminoacylase, putative 0.0074 0.1371 0.242
Mycobacterium tuberculosis Probable glutamate-1-semialdehyde 2,1-aminomutase HemL (GSA) (glutamate-1-semialdehyde aminotransferase) (GSA-at) 0.0022 0.0244 0.0128
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0022 0.0235 0.0939
Mycobacterium ulcerans adenosylmethionine-8-amino-7-oxononanoate aminotransferase 0.0154 0.3101 1
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0173 0.0374
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0106 0.2056 0.1962
Echinococcus granulosus ornithine aminotransferase 0.0022 0.0244 0.026
Echinococcus multilocularis expressed conserved protein 0.0094 0.1797 0.1931
Loa Loa (eye worm) hypothetical protein 0.0025 0.0316 0.0481
Mycobacterium tuberculosis Conserved protein 0.0074 0.1371 0.1269
Plasmodium falciparum thioredoxin reductase 0.0046 0.0772 1
Plasmodium falciparum importin beta, putative 0.0029 0.0402 0.4346
Schistosoma mansoni cellular tumor antigen P53 0.0053 0.0922 0.0977
Trypanosoma brucei hypothetical protein, conserved 0.0074 0.1371 1
Echinococcus multilocularis protein patched 0.0043 0.0696 0.0746
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0106 0.2056 0.6342
Mycobacterium ulcerans 4-aminobutyrate aminotransferase 0.0022 0.0244 0.0423
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.009 0.1716 0.1844
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0074 0.1371 0.1269
Schistosoma mansoni ran 0.0022 0.0235 0.0237
Toxoplasma gondii ornithine aminotransferase, mitochondrial precursor, putative 0.0022 0.0244 0.1007
Toxoplasma gondii thioredoxin reductase 0.0046 0.0772 0.5222
Schistosoma mansoni hypothetical protein 0.0048 0.0814 0.0861
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0016 0.0117 0.0254
Entamoeba histolytica Ran family GTPase 0.0022 0.0235 0.0353
Echinococcus granulosus thioredoxin glutathione reductase 0.0046 0.0772 0.0828
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0033 0.048 0.0501
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0033 0.048 0.0514
Mycobacterium ulcerans glutamate-1-semialdehyde aminotransferase 0.0022 0.0244 0.0423
Brugia malayi hypothetical protein 0.0025 0.0316 0.0683
Schistosoma mansoni hypothetical protein 0.0041 0.0663 0.0698
Brugia malayi beta-lactamase family protein 0.0074 0.1371 0.2962
Treponema pallidum exodeoxyribonuclease (exoA) 0.0019 0.0173 1
Echinococcus granulosus Niemann Pick C1 protein 0.01 0.1927 0.2072
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0106 0.2056 0.1962
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0173 0.0446
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0019 0.0173 0.4744
Plasmodium vivax glutathione reductase, putative 0.0046 0.0772 0.5222
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0074 0.1371 0.1462
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.0235 0.0939
Echinococcus multilocularis tumor protein p63 0.0365 0.7637 0.8217
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0019 0.0173 0.0057
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.009 0.1716 0.1844
Echinococcus multilocularis ornithine aminotransferase 0.0022 0.0244 0.026
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0074 0.1371 0.2962
Schistosoma mansoni hypothetical protein 0.0441 0.9293 1
Schistosoma mansoni hypothetical protein 0.0041 0.0663 0.0698
Echinococcus multilocularis ornithine aminotransferase 0.0022 0.0244 0.026
Loa Loa (eye worm) hypothetical protein 0.0074 0.1371 0.2102
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0033 0.048 0.0514
Schistosoma mansoni hypothetical protein 0.0048 0.0814 0.0861
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0102 0.1961 0.2097
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0106 0.2056 0.1962
Plasmodium vivax importin-beta 2, putative 0.0029 0.0402 0.2269
Plasmodium vivax thioredoxin reductase, putative 0.0046 0.0772 0.5222
Echinococcus granulosus histone lysine methyltransferase setb 0.0033 0.048 0.0514
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0074 0.1371 0.4203
Onchocerca volvulus 0.0033 0.048 0.0084
Trichomonas vaginalis penicillin-binding protein, putative 0.0074 0.1371 0.242
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0019 0.0173 0.4423
Echinococcus granulosus dnaJ subfamily B 0.0441 0.9293 1
Toxoplasma gondii ABC1 family protein 0.0074 0.1371 1
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0173 0.0184
Mycobacterium leprae Probable lipase LipE 0.0074 0.1371 0.3947
Loa Loa (eye worm) hypothetical protein 0.0033 0.048 0.0733
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0173 0.0446
Mycobacterium tuberculosis Probable dehydrogenase 0.0106 0.2056 0.1962
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.01 0.1927 1
Brugia malayi 4-aminobutyrate aminotransferase, mitochondrial precursor 0.0022 0.0244 0.0526
Echinococcus multilocularis sterol regulatory element binding protein 0.0043 0.0696 0.0746
Mycobacterium tuberculosis Conserved protein 0.0074 0.1371 0.1269
Echinococcus granulosus Aminotransferase class III 0.0022 0.0244 0.026
Plasmodium falciparum ornithine aminotransferase 0.0022 0.0244 0.1929
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0696 0.1116
Chlamydia trachomatis glutamate-1-semialdehyde-2,1-aminomutase 0.0022 0.0244 1
Schistosoma mansoni ornithine--oxo-acid transaminase 0.0022 0.0244 0.0247
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0031 0.044 0.047
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0072 0.1325 0.1424
Onchocerca volvulus 0.0256 0.5299 1
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0012 0.0025 0.0055
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0016 0.0117 0.011
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0043 0.0696 0.1065
Loa Loa (eye worm) hypothetical protein 0.0053 0.0904 0.1384
Loa Loa (eye worm) hypothetical protein 0.0048 0.0814 0.1246
Echinococcus multilocularis protein dispatched 1 0.0049 0.0827 0.0887
Loa Loa (eye worm) thioredoxin reductase 0.0046 0.0772 0.1182
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0012 0.0025 0.0055
Schistosoma mansoni hypothetical protein 0.0313 0.6515 0.7006
Wolbachia endosymbiont of Brugia malayi acetylornithine transaminase protein 0.0022 0.0244 1
Mycobacterium tuberculosis Probable aminotransferase 0.0154 0.3101 0.3019
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.009 0.1716 0.2631
Loa Loa (eye worm) hypothetical protein 0.0074 0.1371 0.2102
Mycobacterium tuberculosis Probable lipase LipD 0.0074 0.1371 0.1269
Loa Loa (eye worm) latrophilin receptor protein 2 0.0048 0.0814 0.1246
Trichomonas vaginalis set domain proteins, putative 0.0256 0.5299 1
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0022 0.0235 0.0357
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0153 0.3068 0.6627
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0016 0.0117 0.0124
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0048 0.0814 0.0873
Echinococcus granulosus cpg binding protein 0.0033 0.0477 0.0511
Loa Loa (eye worm) beta-lactamase 0.0074 0.1371 0.2102
Schistosoma mansoni hypothetical protein 0.0105 0.2025 0.2166
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0067 0.1214 0.1292
Onchocerca volvulus 0.0053 0.0922 0.0993
Mycobacterium tuberculosis Probable ornithine aminotransferase (N-terminus part) RocD1 (ornithine--oxo-acid aminotransferase) 0.0022 0.0244 0.0128
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.0235 0.0939
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0022 0.0235 1
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0316 0.3034
Echinococcus multilocularis Niemann Pick C1 protein 0.0143 0.2853 0.3068
Onchocerca volvulus 0.0074 0.1371 0.1919
Leishmania major GTP-binding protein, putative 0.0022 0.0235 0.0939
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0033 0.048 0.289
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0022 0.0235 0.0939
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0074 0.1371 0.2102
Schistosoma mansoni hypothetical protein 0.0041 0.0663 0.0698
Echinococcus multilocularis importin subunit beta 1 0.0029 0.0402 0.043
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.009 0.1716 0.1833
Echinococcus multilocularis cpg binding protein 0.0033 0.0477 0.0511
Brugia malayi CHE-14 protein 0.0043 0.0696 0.1503
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0022 0.0235 0.0508
Mycobacterium tuberculosis Probable reductase 0.0106 0.2056 0.1962
Mycobacterium ulcerans beta-lactamase 0.0074 0.1371 0.4203
Mycobacterium ulcerans hypothetical protein 0.0154 0.3101 1
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0283 0.0319
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0316 0.1584
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0173 0.0262
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0118 0.2311 0.222
Mycobacterium tuberculosis Probable lipase LipE 0.0074 0.1371 0.1269
Echinococcus granulosus beta LACTamase domain containing family member 0.0074 0.1371 0.1473
Brugia malayi Calcitonin receptor-like protein seb-1 0.0153 0.3068 0.6627
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0283 0.0319
Trichomonas vaginalis ran, putative 0.0022 0.0235 0.0227
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0046 0.0772 0.0663
Echinococcus granulosus GPCR family 2 0.0048 0.0814 0.0873
Mycobacterium tuberculosis Adenosylmethionine-8-amino-7-oxononanoate aminotransferase BioA 0.0154 0.3101 0.3019
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0173 0.0108
Trichomonas vaginalis importin beta-1, putative 0.0024 0.0283 0.0319
Loa Loa (eye worm) hypothetical protein 0.0074 0.1371 0.2102
Schistosoma mansoni transcription factor LCR-F1 0.0072 0.1325 0.1412
Mycobacterium tuberculosis Probable L-lysine-epsilon aminotransferase Lat (L-lysine aminotransferase) (lysine 6-aminotransferase) 0.0022 0.0244 0.0128
Mycobacterium tuberculosis Probable esterase LipL 0.0074 0.1371 0.1269
Trypanosoma cruzi importin beta-1 subunit, putative 0.0024 0.0283 0.1316
Brugia malayi CXXC zinc finger family protein 0.0031 0.0439 0.0948
Entamoeba histolytica hypothetical protein 0.0072 0.1325 0.6567
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0225 0.463 0.7106
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0316 0.1584
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.048 0.0501
Leishmania major importin beta-1 subunit, putative 0.0024 0.0283 0.1316
Loa Loa (eye worm) hypothetical protein 0.0029 0.0402 0.0613
Mycobacterium ulcerans esterase/lipase LipP 0.0074 0.1371 0.4203
Entamoeba histolytica hypothetical protein 0.0072 0.1325 0.6567
Leishmania major trypanothione reductase 0.0046 0.0772 0.5222
Toxoplasma gondii histone lysine methyltransferase SET1 0.006 0.1062 0.7536
Onchocerca volvulus 0.0074 0.1371 0.1919
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0022 0.0235 0.0939
Mycobacterium tuberculosis Probable acetylornithine aminotransferase ArgD 0.0022 0.0244 0.0128
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0011 0.0015 0.0013
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0118 0.2311 0.222
Trypanosoma brucei trypanothione reductase 0.0046 0.0772 0.5222
Leishmania major hypothetical protein, conserved 0.0025 0.0316 0.1584
Echinococcus granulosus tumor protein p63 0.0365 0.7637 0.8217
Leishmania major hypothetical protein, conserved 0.0074 0.1371 1
Echinococcus granulosus Protein patched homolog 1 0.0043 0.0696 0.0746
Loa Loa (eye worm) hypothetical protein 0.0074 0.1371 0.2102
Brugia malayi Pre-SET motif family protein 0.0225 0.463 1
Mycobacterium tuberculosis Probable oxidoreductase 0.0118 0.2311 0.222
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.009 0.1716 0.1833
Plasmodium vivax ornithine aminotransferase, putative 0.0022 0.0244 0.1007
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0153 0.3068 0.4708
Schistosoma mansoni ran 0.0022 0.0235 0.0237
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0106 0.2056 0.1962
Entamoeba histolytica hypothetical protein 0.0072 0.1325 0.6567
Mycobacterium leprae PROBABLE ADENOSYLMETHIONINE-8-AMINO-7-OXONONANOATE AMINOTRANSFERASE BIOA 0.0154 0.3101 1
Schistosoma mansoni importin beta-1 0.0029 0.0402 0.0417
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0048 0.0814 0.1758
Brugia malayi beta-lactamase 0.0074 0.1371 0.2962
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0173 0.0108
Mycobacterium leprae conserved hypothetical protein 0.0074 0.1371 0.3947
Schistosoma mansoni hypothetical protein 0.0041 0.0663 0.0698
Trichomonas vaginalis D-aminoacylase, putative 0.0074 0.1371 0.242
Echinococcus granulosus snurportin 1 0.0313 0.6515 0.701
Schistosoma mansoni ap endonuclease 0.0019 0.0173 0.0171
Plasmodium falciparum glutathione reductase 0.0046 0.0772 1
Trypanosoma cruzi hypothetical protein, conserved 0.0074 0.1371 1
Mycobacterium tuberculosis Conserved protein 0.0074 0.1371 0.1269
Echinococcus multilocularis dnaJ subfamily B 0.0441 0.9293 1
Trichomonas vaginalis D-aminoacylase, putative 0.0074 0.1371 0.242
Plasmodium vivax hypothetical protein, conserved 0.0074 0.1371 1
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0173 0.0446
Schistosoma mansoni cpg binding protein 0.0033 0.0477 0.0498
Loa Loa (eye worm) glutathione reductase 0.0046 0.0772 0.1182
Schistosoma mansoni hypothetical protein 0.0072 0.1325 0.1412
Toxoplasma gondii HEAT repeat-containing protein 0.0029 0.0402 0.2269
Echinococcus multilocularis Niemann Pick C1 protein 0.01 0.1927 0.2072
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0118 0.2311 0.7235
Mycobacterium ulcerans 4-aminobutyrate aminotransferase 0.0022 0.0244 0.0423
Echinococcus multilocularis beta LACTamase domain containing family member 0.0074 0.1371 0.1473
Loa Loa (eye worm) MH2 domain-containing protein 0.0121 0.2371 0.3636
Schistosoma mansoni ap endonuclease 0.0019 0.0173 0.0171
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0173 0.0853
Brugia malayi hypothetical protein 0.0072 0.1325 0.2862
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0074 0.1371 0.1462
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0072 0.1325 0.1424
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.009 0.1716 0.1833
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0402 0.2269
Trichomonas vaginalis esterase, putative 0.0074 0.1371 0.242
Schistosoma mansoni patched 1 0.0043 0.0696 0.0734
Brugia malayi Niemann-Pick C1 protein precursor 0.01 0.1927 0.4163
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0316 0.1584
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0313 0.6515 1
Schistosoma mansoni hypothetical protein 0.0048 0.0814 0.0861
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0402 0.2269
Mycobacterium ulcerans L-lysine aminotransferase 0.0022 0.0244 0.0423
Toxoplasma gondii exonuclease III APE 0.0019 0.0173 0.0446
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0316 0.1584
Loa Loa (eye worm) transcription factor SMAD2 0.0121 0.2371 0.3636
Echinococcus multilocularis snurportin 1 0.0313 0.6515 0.701
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0022 0.0235 0.1798
Loa Loa (eye worm) hypothetical protein 0.0153 0.3068 0.4708
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.048 0.0501
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0316 0.1584
Mycobacterium ulcerans lipase LipD 0.0074 0.1371 0.4203
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.009 0.1716 0.1844
Brugia malayi RNA, U transporter 1 0.0083 0.1567 0.3384
Trypanosoma cruzi hypothetical protein, conserved 0.0074 0.1371 1
Brugia malayi Pre-SET motif family protein 0.0033 0.048 0.1036
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0022 0.0235 0.025
Loa Loa (eye worm) hypothetical protein 0.0043 0.0696 0.1065
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0019 0.0173 0.0187
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0074 0.1371 0.1269
Echinococcus granulosus Niemann Pick C1 protein 0.0143 0.2853 0.3068

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.