Detailed information for compound 737886

Basic information

Technical information
  • TDR Targets ID: 737886
  • Name: N-[3-[(1,3-dioxoisoindol-2-yl)methyl]-4-metho xyphenyl]benzenesulfonamide
  • MW: 422.454 | Formula: C22H18N2O5S
  • H donors: 1 H acceptors: 4 LogP: 2.89 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1CN1C(=O)c2c(C1=O)cccc2)NS(=O)(=O)c1ccccc1
  • InChi: 1S/C22H18N2O5S/c1-29-20-12-11-16(23-30(27,28)17-7-3-2-4-8-17)13-15(20)14-24-21(25)18-9-5-6-10-19(18)22(24)26/h2-13,23H,14H2,1H3
  • InChiKey: ZYKDFLVHFKTZGA-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-[3-[(1,3-dioxoisoindolin-2-yl)methyl]-4-methoxy-phenyl]benzenesulfonamide
  • N-[3-[(1,3-dioxo-2-isoindolinyl)methyl]-4-methoxyphenyl]benzenesulfonamide
  • N-[3-[(1,3-diketoisoindolin-2-yl)methyl]-4-methoxy-phenyl]benzenesulfonamide
  • N-[3-[(1,3-dioxoisoindol-2-yl)methyl]-4-methoxy-phenyl]benzenesulfonamide
  • ZINC01121751

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni glucose transport protein 0.043 0.2238 0.2886
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.0694 0.3711 0.3708
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.015 0.0682 1
Echinococcus granulosus GPCR family 2 0.0034 0.0036 0.0046
Leishmania major glucose transporter/membrane transporter D2, putative 0.0133 0.0587 0.8508
Mycobacterium tuberculosis Probable conserved integral membrane transport protein 0.006 0.0181 0.1238
Trichomonas vaginalis sugar transporter, putative 0.006 0.0181 0.0614
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.015 0.0682 1
Schistosoma mansoni hypothetical protein 0.0034 0.0036 0.0039
Trichomonas vaginalis sugar transporter, putative 0.006 0.0181 0.0614
Trypanosoma brucei glucose transporter, putative 0.0133 0.0587 0.8508
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.0694 0.3711 0.5615
Echinococcus multilocularis microtubule associated protein 2 0.1417 0.7738 1
Trypanosoma brucei glucose transporter 1E 0.0133 0.0587 0.8508
Trichomonas vaginalis sugar transporter, putative 0.0133 0.0587 0.2466
Leishmania major myo-inositol/proton symporter (MIT) 0.006 0.0181 0.212
Mycobacterium tuberculosis Probable dicarboxylic acid transport integral membrane protein KgtP (dicarboxylate transporter) 0.006 0.0181 0.1238
Trichomonas vaginalis conserved hypothetical protein 0.0133 0.0587 0.2466
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0129 0.0563 0.072
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.043 0.2238 0.2892
Trichomonas vaginalis sugar transporter, putative 0.006 0.0181 0.0614
Brugia malayi Pre-SET motif family protein 0.0201 0.0967 0.4305
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0096 0.0379 0.1517
Mycobacterium ulcerans prolyl-tRNA synthetase 0.0046 0.0099 0.1558
Echinococcus granulosus solute carrier family 22 0.006 0.0181 0.0234
Onchocerca volvulus 0.006 0.0181 0.1573
Trichomonas vaginalis sugar transport protein, putative 0.006 0.0181 0.0614
Echinococcus multilocularis solute carrier family 22 0.006 0.0181 0.0227
Trichomonas vaginalis sugar transporter, putative 0.0133 0.0587 0.2466
Toxoplasma gondii sugar transporter ST1 0.006 0.0181 0.0266
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0096 0.0379 1
Schistosoma mansoni hypothetical protein 0.043 0.2238 0.2886
Schistosoma mansoni lysyl-tRNA synthetase 0.0096 0.0379 0.0483
Trichomonas vaginalis sugar transporter, putative 0.006 0.0181 0.0614
Trichomonas vaginalis sugar transporter, putative 0.006 0.0181 0.0614
Leishmania major glucose transporter, lmgt3 0.0133 0.0587 0.8508
Plasmodium falciparum calcium-dependent protein kinase 3 0.0132 0.0578 0.0404
Leishmania major glucose transporter, lmgt2 0.0133 0.0587 0.8508
Brugia malayi Sugar transporter family protein 0.043 0.2238 1
Schistosoma mansoni serine/threonine protein kinase 0.0132 0.0578 0.0739
Schistosoma mansoni sugar transporter 0.006 0.0181 0.0227
Schistosoma mansoni glucose transporter 0.006 0.0181 0.0227
Trypanosoma cruzi hexose transporter, putative 0.006 0.0181 0.212
Brugia malayi Calcitonin receptor-like protein seb-1 0.0108 0.0448 0.1982
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0047 0.0053
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0132 0.0578 0.0573
Loa Loa (eye worm) hypothetical protein 0.006 0.0181 0.0787
Brugia malayi Major Facilitator Superfamily protein 0.006 0.0181 0.0787
Schistosoma mansoni hypothetical protein 0.0036 0.0044 0.005
Echinococcus multilocularis solute carrier family 22 0.006 0.0181 0.0227
Trichomonas vaginalis conserved hypothetical protein 0.006 0.0181 0.0614
Trichomonas vaginalis sugar transporter, putative 0.006 0.0181 0.0614
Trypanosoma brucei glucose transporter 2A 0.0133 0.0587 0.8508
Plasmodium falciparum mitogen-activated protein kinase 2 0.0694 0.3711 0.3595
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0132 0.0578 0.0573
Brugia malayi Latrophilin receptor protein 2 0.0034 0.0036 0.0134
Echinococcus granulosus calcium dependent protein kinase 0.0123 0.0532 0.0688
Trypanosoma brucei sugar transporter, putative 0.006 0.0181 0.212
Trypanosoma brucei THT1 - hexose transporter, putative 0.0133 0.0587 0.8508
Schistosoma mansoni glucose transport protein 0.043 0.2238 0.2886
Onchocerca volvulus 0.0036 0.0047 0.0367
Loa Loa (eye worm) beta-lactamase 0.0036 0.0047 0.0183
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.043 0.2238 0.2886
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0034 0.0036 0.0046
Onchocerca volvulus 0.006 0.0181 0.1573
Trichomonas vaginalis sugar transporter, putative 0.006 0.0181 0.0614
Brugia malayi hypothetical protein 0.006 0.0181 0.0787
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.0129 0.0563 1
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0108 0.0448 0.1982
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0084 0.0313 0.1216
Onchocerca volvulus 0.006 0.0181 0.1573
Schistosoma mansoni sugar transporter 0.006 0.0181 0.0227
Echinococcus granulosus solute carrier family 22 0.006 0.0181 0.0234
Trichomonas vaginalis set domain proteins, putative 0.0229 0.1122 0.4906
Plasmodium vivax hypothetical protein, conserved 0.0036 0.0047 0.0041
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0132 0.0578 0.2562
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0132 0.0578 0.836
Plasmodium falciparum hexose transporter 0.043 0.2238 0.2094
Trichomonas vaginalis glucose transporter, putative 0.0133 0.0587 0.2466
Plasmodium falciparum calcium-dependent protein kinase 4 0.0132 0.0578 0.0404
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.0129 0.0563 0.0727
Brugia malayi Cam kinase protein 1 0.0132 0.0578 0.2562
Schistosoma mansoni hypothetical protein 0.0034 0.0036 0.0039
Entamoeba histolytica protein kinase, putative 0.0132 0.0578 1
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0132 0.0578 0.0867
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.0129 0.0563 0.9722
Onchocerca volvulus 0.0229 0.1122 1
Trichomonas vaginalis sugar transporter, putative 0.0133 0.0587 0.2466
Trichomonas vaginalis sugar transporter, putative 0.006 0.0181 0.0614
Loa Loa (eye worm) hypothetical protein 0.0096 0.0379 0.1672
Echinococcus multilocularis beta LACTamase domain containing family member 0.0036 0.0047 0.0053
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0034 0.0036 0.0134
Echinococcus multilocularis lysyl tRNA synthetase 0.0096 0.0379 0.0483
Trichomonas vaginalis sugar transporter, putative 0.006 0.0181 0.0614
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.015 0.0682 1
Trichomonas vaginalis sugar transporter, putative 0.006 0.0181 0.0614
Brugia malayi Major Facilitator Superfamily protein 0.006 0.0181 0.0787
Treponema pallidum prolyl-tRNA synthetase 0.0046 0.0099 0.5
Trichomonas vaginalis conserved hypothetical protein 0.006 0.0181 0.0614
Mycobacterium ulcerans sugar-transport integral membrane protein SugI 0.006 0.0181 0.4052
Onchocerca volvulus 0.006 0.0181 0.1573
Plasmodium falciparum proline--tRNA ligase 0.015 0.0682 0.051
Loa Loa (eye worm) hypothetical protein 0.0108 0.0448 0.1982
Leishmania major glucose transporter, lmgt1 0.0133 0.0587 0.8508
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0132 0.0578 0.0739
Mycobacterium ulcerans integral membrane transport protein 0.006 0.0181 0.4052
Echinococcus multilocularis calcium dependent protein kinase 0.0123 0.0532 0.0681
Trichomonas vaginalis sugar transporter, putative 0.006 0.0181 0.0614
Trichomonas vaginalis sugar transporter, putative 0.006 0.0181 0.0614
Trypanosoma cruzi glucose transporter, putative 0.006 0.0181 0.212
Plasmodium falciparum calcium-dependent protein kinase 2 0.0132 0.0578 0.0404
Echinococcus granulosus solute carrier family 22 0.006 0.0181 0.0234
Loa Loa (eye worm) hypothetical protein 0.006 0.0181 0.0787
Schistosoma mansoni lysyl-tRNA synthetase 0.0096 0.0379 0.0483
Trypanosoma brucei myo-inositol/proton symporter (MIT) 0.006 0.0181 0.212
Trypanosoma brucei glucose transporter, putative 0.0133 0.0587 0.8508
Onchocerca volvulus 0.006 0.0181 0.1573
Trichomonas vaginalis conserved hypothetical protein 0.0133 0.0587 0.2466
Loa Loa (eye worm) latrophilin receptor protein 2 0.0034 0.0036 0.0134
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0129 0.0563 0.072
Trypanosoma brucei glucose transporter, putative 0.0133 0.0587 0.8508
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.043 0.2238 0.2892
Trichomonas vaginalis sugar transporter, putative 0.006 0.0181 0.0614
Loa Loa (eye worm) hypothetical protein 0.0036 0.0047 0.0183
Onchocerca volvulus 0.006 0.0181 0.1573
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0036 0.0047 0.0183
Trypanosoma brucei glucose transporter, putative 0.0133 0.0587 0.8508
Onchocerca volvulus 0.006 0.0181 0.1573
Schistosoma mansoni sugar transporter 0.006 0.0181 0.0227
Wolbachia endosymbiont of Brugia malayi major facilitator superfamily permease 0.006 0.0181 0.5
Trypanosoma cruzi hexose transporter, putative 0.0133 0.0587 0.8508
Trichomonas vaginalis sugar transporter, putative 0.006 0.0181 0.0614
Entamoeba histolytica hypothetical protein 0.0096 0.0379 0.6277
Brugia malayi hypothetical protein 0.006 0.0181 0.0787
Onchocerca volvulus 0.006 0.0181 0.1573
Trichomonas vaginalis sugar transporter, putative 0.006 0.0181 0.0614
Echinococcus granulosus lysyl tRNA synthetase 0.0096 0.0379 0.049
Loa Loa (eye worm) hypothetical protein 0.0105 0.0428 0.1892
Trichomonas vaginalis sugar transporter, putative 0.006 0.0181 0.0614
Trichomonas vaginalis sugar transporter, putative 0.006 0.0181 0.0614
Giardia lamblia Prolyl-tRNA synthetase 0.0129 0.0563 1
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0034 0.0036 0.0046
Toxoplasma gondii lysine-tRNA ligase 0.0096 0.0379 0.0565
Schistosoma mansoni hypothetical protein 0.0034 0.0036 0.0039
Loa Loa (eye worm) hypothetical protein 0.0129 0.0563 0.2495
Plasmodium falciparum lysine--tRNA ligase 0.0096 0.0379 0.0201
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.0129 0.0563 0.2495
Onchocerca volvulus 0.0036 0.0047 0.0367
Plasmodium falciparum calcium-dependent protein kinase 1 0.0132 0.0578 0.0404
Onchocerca volvulus 0.006 0.0181 0.1573
Onchocerca volvulus 0.006 0.0181 0.1573
Mycobacterium ulcerans fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT 0.006 0.0181 0.4052
Trypanosoma cruzi hexose transporter, putative 0.0073 0.0251 0.321
Trichomonas vaginalis sugar transporter, putative 0.006 0.0181 0.0614
Schistosoma mansoni hypothetical protein 0.0074 0.0257 0.0325
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0132 0.0578 0.0573
Loa Loa (eye worm) hypothetical protein 0.0036 0.0047 0.0183
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0036 0.0044 0.0057
Loa Loa (eye worm) hypothetical protein 0.006 0.0181 0.0787
Toxoplasma gondii transporter, major facilitator family protein 0.006 0.0181 0.0266
Entamoeba histolytica protein kinase, putative 0.0132 0.0578 1
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.043 0.2238 0.2892
Loa Loa (eye worm) hypothetical protein 0.0132 0.0578 0.2562
Trichomonas vaginalis sugar transporter, putative 0.006 0.0181 0.0614
Trypanosoma cruzi sugar transporter, putative 0.006 0.0181 0.212
Trypanosoma cruzi hexose transporter 0.0133 0.0587 0.8508
Trichomonas vaginalis glucose transporter, putative 0.0133 0.0587 0.2466
Trichomonas vaginalis sugar transporter, putative 0.006 0.0181 0.0614
Loa Loa (eye worm) major facilitator superfamily transporter 0.006 0.0181 0.0787
Echinococcus granulosus histone lysine methyltransferase setb 0.0029 0.0006 0.0008
Plasmodium vivax calcium-dependent protein kinase, putative 0.0132 0.0578 0.0573
Trichomonas vaginalis sugar transporter, putative 0.006 0.0181 0.0614
Echinococcus granulosus Sugar transporter ERD6 protein 0.006 0.0181 0.0234
Loa Loa (eye worm) hypothetical protein 0.006 0.0181 0.0787
Onchocerca volvulus 0.006 0.0181 0.1573
Plasmodium vivax hexose transporter 0.043 0.2238 0.2233
Loa Loa (eye worm) hypothetical protein 0.006 0.0181 0.0787
Trichomonas vaginalis sugar transporter, putative 0.006 0.0181 0.0614
Trichomonas vaginalis conserved hypothetical protein 0.043 0.2238 1
Trichomonas vaginalis sugar transporter, putative 0.006 0.0181 0.0614
Onchocerca volvulus 0.006 0.0181 0.1573
Toxoplasma gondii protein kinase, putative 0.1214 0.6605 1
Echinococcus granulosus beta LACTamase domain containing family member 0.0036 0.0047 0.0061
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0132 0.0578 0.0739
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0231 0.1134 1
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0132 0.0578 0.2562
Brugia malayi beta-lactamase family protein 0.0036 0.0047 0.0183
Trichomonas vaginalis sugar transporter, putative 0.006 0.0181 0.0614
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX 0.0081 0.0299 0.2315
Echinococcus multilocularis solute carrier family 22 0.006 0.0181 0.0227
Schistosoma mansoni glucose transport protein 0.043 0.2238 0.2886
Brugia malayi beta-lactamase 0.0036 0.0047 0.0183
Leishmania major lysyl-tRNA synthetase, putative 0.0096 0.0379 0.5233
Echinococcus multilocularis solute carrier family 22 0.006 0.0181 0.0227
Giardia lamblia Lysyl-tRNA synthetase 0.0096 0.0379 0.5182
Trichomonas vaginalis sugar transporter, putative 0.006 0.0181 0.0614
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0132 0.0578 0.0739
Trichomonas vaginalis sugar transporter, putative 0.006 0.0181 0.0614
Loa Loa (eye worm) hypothetical protein 0.006 0.0181 0.0787
Echinococcus multilocularis GPCR, family 2 0.0034 0.0036 0.0039
Schistosoma mansoni microtubule-associated protein tau 0.1417 0.7738 1
Trichomonas vaginalis CAMK family protein kinase 0.0132 0.0578 0.2423
Brugia malayi major facilitator superfamily protein 0.006 0.0181 0.0787
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0081 0.0299 0.2315
Onchocerca volvulus 0.006 0.0181 0.1573
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.015 0.0682 1
Trichomonas vaginalis sugar transporter, putative 0.006 0.0181 0.0614
Schistosoma mansoni protein kinase 0.0132 0.0578 0.0739
Loa Loa (eye worm) bifunctional aminoacyl-tRNA synthetase 0.0053 0.014 0.0599
Loa Loa (eye worm) hypothetical protein 0.0036 0.0047 0.0183
Loa Loa (eye worm) hypothetical protein 0.0074 0.0257 0.1126
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.043 0.2238 0.2892
Loa Loa (eye worm) hypothetical protein 0.0036 0.0047 0.0183
Plasmodium vivax sugar transporter, putative 0.006 0.0181 0.0176
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0132 0.0578 0.0747
Trypanosoma brucei glucose transporter, putative 0.0133 0.0587 0.8508
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.015 0.0682 0.1024
Echinococcus granulosus microtubule associated protein 2 0.1417 0.7738 1
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0132 0.0578 0.0739
Trichomonas vaginalis sugar transporter, putative 0.006 0.0181 0.0614
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0096 0.0379 0.5233
Trichomonas vaginalis myo-inositol transporter, putative 0.006 0.0181 0.0614
Trichomonas vaginalis glucose transporter, putative 0.006 0.0181 0.0614
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0047 0.0053
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0201 0.0967 0.4305
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0132 0.0578 0.0867
Trichomonas vaginalis sugar transporter, putative 0.006 0.0181 0.0614
Brugia malayi Sugar transporter family protein 0.006 0.0181 0.0787
Loa Loa (eye worm) hypothetical protein 0.006 0.0181 0.0787
Onchocerca volvulus 0.0036 0.0047 0.0367
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.015 0.0682 1
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0096 0.0379 1
Trypanosoma cruzi hexose transporter, putative 0.0133 0.0587 0.8508
Plasmodium vivax proline--tRNA ligase, putative 0.015 0.0682 0.0676
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0108 0.0448 0.1982
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0096 0.0379 0.5233
Loa Loa (eye worm) hypothetical protein 0.0129 0.0563 0.2495
Chlamydia trachomatis lysine--tRNA ligase 0.0096 0.0379 1
Loa Loa (eye worm) sugar transporter 0.043 0.2238 1
Trichomonas vaginalis sugar transporter, putative 0.006 0.0181 0.0614
Echinococcus granulosus synaptic vesicle 2 protein 0.006 0.0181 0.0234
Echinococcus multilocularis synaptic vesicle 2 protein 0.006 0.0181 0.0227
Trichomonas vaginalis conserved hypothetical protein 0.006 0.0181 0.0614
Trichomonas vaginalis sugar transporter, putative 0.006 0.0181 0.0614
Trypanosoma brucei glucose transporter, putative 0.0133 0.0587 0.8508
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.043 0.2238 0.2886
Echinococcus multilocularis Sugar transporter ERD6 protein 0.006 0.0181 0.0227
Loa Loa (eye worm) hypothetical protein 0.0036 0.0047 0.0183
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.043 0.2238 0.2886
Brugia malayi Major Facilitator Superfamily protein 0.006 0.0181 0.0787
Toxoplasma gondii sugar transporter ST2 0.006 0.0181 0.0266
Trichomonas vaginalis conserved hypothetical protein 0.006 0.0181 0.0614
Echinococcus granulosus General substrate transporter 0.0369 0.1901 0.2457
Loa Loa (eye worm) hypothetical protein 0.006 0.0181 0.0787
Plasmodium vivax CDK-related protein kinase 6, putative 0.1823 1 1
Loa Loa (eye worm) hypothetical protein 0.006 0.0181 0.0787
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0034 0.0036 0.0039
Onchocerca volvulus Putative transporter 0.006 0.0181 0.1573
Schistosoma mansoni hypothetical protein 0.0034 0.0036 0.0039
Toxoplasma gondii facilitative glucose transporter GT1 0.043 0.2238 0.3382
Toxoplasma gondii sugar transporter ST3 0.006 0.0181 0.0266
Trichomonas vaginalis sugar transporter, putative 0.006 0.0181 0.0614
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0036 0.0047 0.0183
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0034 0.0036 0.0039
Schistosoma mansoni protein kinase 0.0132 0.0578 0.0739
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0132 0.0578 0.0747
Loa Loa (eye worm) hypothetical protein 0.0036 0.0047 0.0183
Leishmania major protein kinase, putative 0.0132 0.0578 0.836
Trypanosoma cruzi hexose transporter, putative 0.0133 0.0587 0.8508
Brugia malayi major facilitator superfamily protein 0.006 0.0181 0.0787
Plasmodium falciparum protein kinase 7 0.1214 0.6605 0.6542
Trichomonas vaginalis sugar transporter, putative 0.006 0.0181 0.0614
Mycobacterium leprae Probable lysyl-tRNA synthase LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0081 0.0299 0.4879
Schistosoma mansoni sugar transporter 0.006 0.0181 0.0227
Trichomonas vaginalis sugar transporter, putative 0.006 0.0181 0.0614
Loa Loa (eye worm) hypothetical protein 0.006 0.0181 0.0787
Loa Loa (eye worm) hypothetical protein 0.006 0.0181 0.0787
Loa Loa (eye worm) hypothetical protein 0.0034 0.0036 0.0134
Mycobacterium ulcerans sugar transporter 0.006 0.0181 0.4052
Echinococcus multilocularis General substrate transporter 0.0369 0.1901 0.2451
Plasmodium vivax lysine--tRNA ligase, putative 0.0096 0.0379 0.0373
Onchocerca volvulus 0.006 0.0181 0.1573
Loa Loa (eye worm) hypothetical protein 0.006 0.0181 0.0787
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0132 0.0578 0.0747
Trichomonas vaginalis sugar transporter, putative 0.006 0.0181 0.0614
Echinococcus granulosus solute carrier family 22 0.006 0.0181 0.0234
Schistosoma mansoni transcription factor LCR-F1 0.0036 0.0044 0.005
Brugia malayi Sugar transporter family protein 0.006 0.0181 0.0787
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.043 0.2238 0.2886
Loa Loa (eye worm) hypothetical protein 0.006 0.0181 0.0787
Plasmodium falciparum calcium-dependent protein kinase 5 0.0132 0.0578 0.0404
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.0129 0.0563 0.2355
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0132 0.0578 0.2562
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0132 0.0578 0.0747
Brugia malayi beta-lactamase family protein 0.0036 0.0047 0.0183
Onchocerca volvulus 0.006 0.0181 0.1573
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0132 0.0578 0.0867
Brugia malayi hypothetical protein 0.006 0.0181 0.0787
Brugia malayi lysyl-tRNA synthetase 0.0096 0.0379 0.1672
Trypanosoma brucei THT1 - hexose transporter, putative 0.0133 0.0587 0.8508
Loa Loa (eye worm) hypothetical protein 0.006 0.0181 0.0787
Loa Loa (eye worm) major facilitator superfamily transporter 0.006 0.0181 0.0787
Trichomonas vaginalis conserved hypothetical protein 0.006 0.0181 0.0614
Brugia malayi hypothetical protein 0.0036 0.0044 0.0172
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.0129 0.0563 0.072
Schistosoma mansoni protein kinase 0.0132 0.0578 0.0739
Schistosoma mansoni nuclear transcription factor X-box binding 1 (nfx1) 0.006 0.0181 0.0227
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0129 0.0563 0.2495
Leishmania major hypothetical protein, conserved 0.006 0.0181 0.212
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0096 0.0379 0.6439
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0036 0.0044 0.005
Trypanosoma brucei glucose transporter, putative 0.0133 0.0587 0.8508
Loa Loa (eye worm) hypothetical protein 0.006 0.0181 0.0787
Trypanosoma brucei glucose transporter, putative 0.0133 0.0587 0.8508
Brugia malayi latrophilin 2 splice variant baaae 0.0074 0.0257 0.1126
Onchocerca volvulus 0.006 0.0181 0.1573
Trypanosoma brucei THT1 - hexose transporter, putative 0.0133 0.0587 0.8508
Loa Loa (eye worm) sugar transporter 0.006 0.0181 0.0787
Toxoplasma gondii ABC1 family protein 0.0036 0.0047 0.0062

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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